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New daily persistent headache after SARS-CoV-2 infection: a report of two cases.

Neurol Sci 2021 Jul 15. Epub 2021 Jul 15.

Department of Neuroscience, Imaging and Clinical Science, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.

Background: The 2019 Coronavirus (SARS-CoV-2) is a novel respiratory virus which causes Coronavirus Disease19 (COVID-19). Although the predominant clinical picture of COVID-19 is represented by respiratory symptoms, neurological manifestations are being increasingly recognized. Headache, in particular migraine-like and tension types, has been largely reported in patients suffering from COVID-19 both in the acute and the healing phase of the infection. Read More

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Endoscopic versus Surgical Intervention for Painful Obstructive Chronic Pancreatitis: A Systematic Review and Meta-Analysis.

J Clin Med 2021 Jun 15;10(12). Epub 2021 Jun 15.

Division of Gastroenterology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea.

There is limited evidence on the standard care for painful obstructive chronic pancreatitis (CP), while comparisons of endoscopic and surgical modes for pain relief have yielded conflicting results from small sample sizes. We aimed to obtain a clear picture of the matter by a meta-analysis of these results. We searched the Pubmed, Embase, and Cochrane Library databases to identify studies comparing endoscopic and surgical treatments for painful obstructive CP. Read More

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Why Young Adults Obtain a Medical Marijuana Card: Associations with Health Symptoms and Heaviness of Use.

Cannabis 2021 Apr;4(1):27-39

RAND Corporation, 1776 Main Street, PO Box 2138, Santa Monica, CA 90407.

Objective: Prior studies documenting more frequent and problematic use among young adults who have acquired medical marijuana (MM) cards have broadly compared those who use medically to those who use recreationally. Gaining a better picture of how health symptoms and problematic use vary both within those who have a MM card for specific condition domains and between those who do not have a MM card can provide key information for medical practitioners and states interested in adopting or updating MM policies.

Method: The current study categorizes young adults authorized to use MM into three mutually exclusive groups based on endorsements of qualifying conditions: (1) Physical Health only (e. Read More

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Is sclerotherapy with polidocanol a better treatment option for aneurysmal bone cyst compared to conventional curettage and bone grafting?

J Orthop 2021 May-Jun;25:265-270. Epub 2021 May 21.

Dept. of Orthopaedics, Amala Institute of Medical Sciences, India.

Background: The standard treatment of Aneurysmal bone cyst is curettage and grafting and is associated with high morbidity. Hence minimal invasive alternative treatment methods such as sclerotherapy are gaining much popularity. Though sclerotherapy has been attributed to reasonable cure rates, undetermined tissue diagnosis often impedes with initiation of treatment. Read More

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The nasal region of the ~417 ka Sima de los Huesos (Sierra de Atapuerca, Spain) Hominin: New terminology and implications for later human evolution.

Anat Rec (Hoboken) 2021 Jun 24. Epub 2021 Jun 24.

Centro Mixto UCM-ISCII de Evolución y Comportamiento Humanos, Madrid, Spain.

Circum-nasal and nasal cavity morphology add to the picture of the Sima de los Huesos specimens as, at one level, representing a distinct morph and, at another, displaying individual variation. They developed a robust, midline-grooved, three-dimensional spinal ridge lying anteriorly in the nasal cavity floor that was distended posteriorly over the nasal cavity floor, and, typically, an expansive, three-dimensional patch of rugose bone on the nasal cavity wall where a conchal crest would otherwise lie. They vary, for example, in degree of topographic relief of the nasal cavity wall, expression of the spinal ridge, and development of nasal crests and fossae. Read More

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Bizarre Parosteal Osteochondromatous Proliferation (Nora Lesion) in Upper and Lower Limbs: A Report of Three Cases and Review of Literature.

J Orthop Case Rep 2021 Feb;11(2):24-28

Department of Orthopaedics, Consultant Hand and Upper Limb Surgeon, Sunshine Hospital, Secunderabad, Telangana, India.

Introduction: Bizarre parosteal osteochondromatous proliferation (BPOP) is a rare bone pathology affecting small bones of hand and feet. This benign lesion needs to be distinguished from many malignant bone tumors as it poses a diagnostic dilemma due to its clinical, radiological, and histological picture. We report three cases of BPOP affecting the hand and foot. Read More

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February 2021

Picture fuzzy set-based decision-making approach using Dempster-Shafer theory of evidence and grey relation analysis and its application in COVID-19 medicine selection.

Soft comput 2021 Jun 5:1-15. Epub 2021 Jun 5.

Department of Mathematics, NIT Durgapur, Durgapur, 713209 India.

To offer better treatment for a COVID-19 patient, preferable medicine selection has become a challenging task for most of the medical practitioners as there is no such proven information regarding it. This article proposes a decision-making approach for preferable medicine selection using picture fuzzy set (PFS), Dempster-Shafer (D-S) theory of evidence and grey relational analysis (GRA). PFS is an extended version of the intuitionistic fuzzy set, where in addition to membership and non-membership grade, neutral and refusal membership grades are used to solve uncertain real-life problems more efficiently. Read More

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Effects of Cannabidiol Chewing Gum on Perceived Pain and Well-Being of Irritable Bowel Syndrome Patients: A Placebo-Controlled Crossover Exploratory Intervention Study with Symptom-Driven Dosing.

Cannabis Cannabinoid Res 2021 Feb 11. Epub 2021 Feb 11.

Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.

Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders. Its pathophysiology is diverse and variable, involving disturbed gut-brain interactions, altered motility and secretion, visceral hypersensitivity, increased intestinal permeability, immune activation, and changes in gut microbiota. Complaints experienced by patients suffering from IBS and its co-morbidities strongly impair quality of life (QoL), and available treatments are often unsatisfactory. Read More

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February 2021


Georgian Med News 2021 Mar(312):7-14

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of the Russian Federation.

The aim of the study was to study the effectiveness of complex treatment of decompensated chronic venous insufficiency (CVI) using innovative techniques and proteolysis inhibitors with a wide spectrum of activity in patients with SARS-CoV-2 (COVID-19) in COVID hospital. This study was performed in the surgical department of COVID hospital on the basis of the Clinical Hospital No. 4 of the First Moscow State Medical University named I. Read More

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Defensive impact of propolis against CCl actuated rats' testicular damage.

Aml S Hashem

J Adv Vet Anim Res 2021 Mar 5;8(1):70-77. Epub 2021 Mar 5.

Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Egypt.

Objective: The paper's primary goal is to report the devastating impact of carbon tetrachloride (CCl) on rat testicular tissue and the possible protecting function of propolis against CCl based on its free radical scavenging and inflammatory relief properties.

Materials And Methods: A total of 24 adult male albino rats had been classified into four groups (six rats/group). Rats of group 1 served as control, whereas groups 2-4 received propolis (200 mg/kg/day), CCl (3 ml/kg/day), and propolis/CCl, respectively. Read More

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Are return to work beliefs, psychological well-being and perceived health related to return-to-work intentions among women on long-term sick leave for common mental disorders? A cross-sectional study based on the theory of planned behaviour.

BMC Public Health 2021 03 19;21(1):535. Epub 2021 Mar 19.

Department of Caring Sciences, University of Gävle, Kungsbäcksvägen 47, 801 76, Gävle, Sweden.

Background: Long-term sick leave due to common mental disorders (CMDs) is a great burden in society today, especially among women. A strong intention to return to work (RTW) as well as symptom relief may facilitate RTW in this group. However, there is a lack of knowledge regarding what constitutes a strong intention. Read More

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Extreme opioid-induced constipation in advanced cancer: successful management.

BMJ Support Palliat Care 2021 Mar 17. Epub 2021 Mar 17.

Home Palliative Care, SAMOT, Palermo, Italy.

Unrecognised and untreated constipation may be a serious risk for complications, including definitive obstruction due to faecal impact or perforation due to the hypertensive intraluminal state. An intensive approach in an acute supportive palliative care unit may resolve the clinical picture allowing the resumption of intestinal transit in a short period of time. Read More

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How German health insurance providers use social online networks to promote healthy lifestyles: a content analysis of Facebook® accounts.

BMC Med Inform Decis Mak 2021 02 18;21(1):64. Epub 2021 Feb 18.

Medical Sociology, Faculty of Medicine, University of Regensburg, Regensburg, Germany.

Background: Social networking sites such as Facebook® can contribute to health promotion and behaviour change activities, but are currently underused for this purpose. In Germany, health insurance companies are relevant public health agencies that are responsible for health promotion, primary prevention, and health education. We intended to analyse the Facebook® accounts of health insurance providers to explore the range of prevention topics addressed, identify the communication formats used, and analyse user activity stimulated by prevention-related posts. Read More

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February 2021

Mechanical thumb pain in a systemic sclerosis patient: simple first carpometacarpal osteoarthritis?

Rheumatology (Oxford) 2021 Feb 6. Epub 2021 Feb 6.

CHU de Poitiers, Rheumatology department, Poitiers, France.

A 70-year-old female patient treated with methotrexate for diffuse cutaneous systemic sclerosis (SSc) came up with mechanical pain over the left thumb for several months. SSc was diagnosed based on a clinical picture associating puffy fingers, skin sclerosis, wrist arthralgia, pulmonary hypertension, presence of antinuclear factors and antibodies against Topoisomerase-I. Her complaint was attributed to first carpometacarpal joint osteoarthritis and treated with orthesis, which did not provide pain relief after 5 months of regular use. Read More

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February 2021

Rapid genome-wide sequencing in a neonatal intensive care unit: A retrospective qualitative exploration of parental experiences.

J Genet Couns 2021 Apr 1;30(2):616-629. Epub 2020 Nov 1.

Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Genome-wide sequencing (GWS) is increasingly being used in neonatal intensive care units. While studies have explored its clinical utility, little is known about parental experiences with this testing post-return of results. We conducted a qualitative study, using an interpretive description framework and thematic analysis, to gain further insight into parents' perceptions of the value and utility of GWS for their infant. Read More

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Data and cooperation required for Venezuela's refugee crisis during COVID-19.

Global Health 2020 10 22;16(1):103. Epub 2020 Oct 22.

Center for Global Health Science and Security, Georgetown University, Washington DC, USA.

The deteriorating political and economic situation in Venezuela has ramifications far beyond the Latin American country's borders as almost five million Venezuelans fled and migrated into countries in the region due to the crisis at home. The scarcity of health services, the lack of information sharing, and the absence of reliable data in Venezuela create challenges for confronting developing health emergencies and disease outbreaks. The need for accurate data is especially dire given the current COVID-19 pandemic and evolving movement of refugees. Read More

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October 2020

[Retrograde mechanochemical ablation of the great saphenous vein in treatment of stage III chronic venous insufficiency].

Angiol Sosud Khir 2020 ;26(3):69-73

2nd Department of Surgical Diseases, Belarusian State Medical University, Minsk, Republic of Belarus.

Presented herein is a clinical case report regarding successful treatment of a trophic ulcer of the right tibia by means of endovenous mechanochemical ablation of the great saphenous vein using the FlebogrifTM device. According to ultrasonography findings, the patient was found to have insufficiency of the saphenofemoral junction, axial truncal reflux, and the absence of incompetent perforator veins in the area of trophic disorders. Taking into account the clinical and ultrasound picture of the disease, the decision was made on the feasibility of performing crossectomy and retrograde mechanochemical ablation of the great saphenous vein. Read More

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October 2020

Conversations With Dr. Oleh Hornykiewicz, Founding Father of the Dopamine Era in Parkinson's: How Do You Wish to Be Remembered?

Mov Disord 2020 11 14;35(11):1922-1932. Epub 2020 Oct 14.

McGovern Institute for Brain Research, Cambridge, Massachusetts, USA.

On May 26, 2020, Dr. Oleh Hornykiewicz died at the age of 93 years. His twin discoveries in the early 1960s of dopamine deficiency in the brains of subjects with Parkinson's disease and the amelioration of patients' symptoms by levodopa therapy represent milestone events in the history of medicine. Read More

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November 2020

[The effectiveness of recombinant interferon alpha-2b in the treatment of chronic recurrent bacterial prostatitis].

Urologiia 2020 Sep(4):21-26

Department of Urology and Human Reproductive Health, Rostov State Medical University, Ministry of Health of Russia, Rostov-on-don, Russia.

Introduction: Chronic recurrent bacterial prostatitis (HRBP) affects the reproductive function and negatively affects the quality of life of men. The multifactorial pathogenesis of this disease causes the failure of antibiotic therapy and some cases, requires an in-depth study of the mechanisms of disease development and additional treatment methods.

Objectives: of the study: to study of the effectiveness of immunoactive therapy (recombinant interferon alpha-2b with an antioxidant complex) in combination with antibacterial therapy in patients with HRBP. Read More

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September 2020

[How severe is the effect of the coronavirus pandemic on the department of surgery of a university hospital? : An analysis of the first 7 weeks].

Chirurg 2020 Sep;91(9):755-761

Klinik und Poliklinik für Viszeral‑, Transplantations‑, Thorax- und Gefäßchirurgie, Universitätsklinikum Leipzig AöR, Leipzig, Deutschland.

Background: The corona pandemic poses enormous financial challenges for hospitals. Using the example of a clinic for visceral, transplantation, thorax and vascular surgery (VTTG), the performance development of inpatient care in the first 7 weeks in comparison to the previous year as well as an evaluation of the compensation measures laid down by law were evaluated.

Methodology: Based on the performance figures, a comparison was made between the period from 16 March to 3 May 2019 and the same period in 2020. Read More

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September 2020

An Atypical Case of a Common Pregnancy Issue: Appendicitis-Like Hyperemesis Gravidarum.

Case Rep Med 2020 19;2020:6959605. Epub 2020 Jul 19.

Department of Internal Medicine, Saint Joseph's Hospital and Medical Center, Phoenix, AZ, USA.

Hyperemesis gravidarum (HG) is a severe subtype of nausea and vomiting in pregnancy (NVP) that typically affects women in their first trimester of pregnancy. Because HG is a diagnosis of exclusion, a thorough work-up ruling out organic causes must be performed. Herein, we describe a case of a pregnant woman with HG who presented with intractable pain mimicking appendicitis. Read More

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[Chronic pancreatitis with IBS-like syndrome: approach to therapy].

Ter Arkh 2020 Apr 27;92(2):61-66. Epub 2020 Apr 27.

Sechenov First Moscow State Medical University (Sechenov University).

Aim: To determine approaches of the exacerbations treatment of chronic pancreatitis (CP) with IBS (irritable bowel syndrome)-like syndrome.

Materials And Methods: 312 patients with exacerbation of CP were observed and received standard therapy: antispasmodics, enzymes, proton pump inhibitors. 85 (27. Read More

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Exploring Australian pharmacists' perceptions and attitudes toward codeine up-scheduling from over-the-counter to prescription only.

Pharm Pract (Granada) 2020 Apr-Jun;18(2):1904. Epub 2020 Jun 1.

Department of Pharmacy and Biomedical Science, College of Science, Health & Engineering, La Trobe University. Bendigo, Vic (Australia).

Objective: Explore the perceptions, attitudes and experiences of pharmacists relating to the up-scheduling of low dose codeine containing analgesics and the impact on pharmacy practice.

Methods: A mixed design method was used consisting of an anonymous online questionnaire survey to quantitatively capture broad pre-scheduling change perceptions paired with a series of in-depth post-scheduling semi-structured interviews to provide a qualitative picture of the impact of codeine up-scheduling on pharmacy practice in Australia.

Results: A total of 191 pharmacists completed the quantitative survey and 10 participated in the in-depth interview. Read More

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Opiate analgesics and testing of post traumatic amnesia in school-aged children.

Brain Inj 2020 06 4;34(7):914-920. Epub 2020 Jun 4.

The School of Psychology, University of Sydney , Sydney, Australia.

Objective: To assess the validity of the Westmead PTA scale in school-aged children treated with opiate analgesics.

Method: Twenty-eight hospitalized children without brain injury, aged between 8 and 16 years treated with opiate analgesics for pain relief following surgery were tested on the Westmead PTA scale. Pain and stress levels were also self-reported each day. Read More

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The illustrates visual segmentation of shape by cause.

Proc Natl Acad Sci U S A 2020 05 15;117(21):11735-11743. Epub 2020 May 15.

Department of Psychology, Justus-Liebig-University Giessen, 35394 Giessen, Germany.

Three-dimensional (3D) shape perception is one of the most important functions of vision. It is crucial for many tasks, from object recognition to tool use, and yet how the brain represents shape remains poorly understood. Most theories focus on purely geometrical computations (e. Read More

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Retrospective analysis of the clinical characteristics of adefovir dipivoxil-induced Fanconi's syndrome in the Chinese population.

J Clin Pharm Ther 2020 Aug 14;45(4):722-728. Epub 2020 May 14.

Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, China.

What Is Known And Objective: To explore the clinical characteristics of adefovir dipivoxil-induced Fanconi's syndrome in the Chinese population and provide a reference for rational drug use in the clinic.

Methods: By searching the CNKI, Wanfang, Chinese VIP, PubMed/MEDLINE, Web of Knowledge, Ovid, Elsevier and SpringerLink databases during 1 January 2008 to 31 December 2019, 78 studies of ADV-induced Fanconi's syndrome involving a total of 110 patients were collected and analysed retrospectively.

Results And Discussion: Prolonged usage of adefovir dipivoxil at low doses to treat hepatitis B might cause Fanconi's syndrome as the first symptom, especially for use over 12 months. Read More

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Innate lymphoid cells in treatment-induced gastrointestinal pathogenesis.

Curr Opin Support Palliat Care 2020 06;14(2):135-141

Department of Experimental Immunology, Amsterdam University Medical Centers location AMC, University of Amsterdam.

Purpose Of Review: Tissue injury often occurs as collateral damage after chemotherapy and radiotherapy and is associated with significant comorbidity and mortality. The arsenal of options to prevent tissue injury other than dose reduction is limited, and treatment is mostly aimed at symptom relief and prevention of complications, such as bacterial translocation and malnourishment. Novel approaches directed at prevention and early repair of damaged tissues are highly anticipated. Read More

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Winter syndrome: about an uncommon case report.

BMC Womens Health 2020 04 21;20(1):76. Epub 2020 Apr 21.

Gynaecology-Obstetrics and Endoscopy Department, Maternity Souissi, University Hospital Center IBN SINA, University Mohammed V, Rabat, Morocco.

Background: Congenital genital tract outflow obstruction may occur at different levels and with different clinical presentations. Winter syndrome was first described in 1968 as an association of renal, genital and middle ear anomalies. This syndrome is characterized by autosomal recessive transmission, unilateral or bilateral renal hypoplasia, distal vaginal atresia, and moderate to severe conductive hearing loss with malformation of the ossicles. Read More

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Use of magnetic resonance imaging to determine laterality of meniscal size in healthy volunteers.

PLoS One 2020 23;15(1):e0228040. Epub 2020 Jan 23.

University of Jordan, Department of Anatomy, Queen Rania Street, Amman, Jordan.

Introduction: The menisci are responsible for several functions. They are shock absorbers during dynamic loading on the knee and provide a broader surface area on which to distribute stress evenly to the tibia and femur. These functions allow for smoother movement and greater stability of the knee joint. Read More

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Sport-Related Concussion Preceding Adrenal Insufficiency and Hypopituitarism.

Curr Sports Med Rep 2020 Jan;19(1):8-10

Department of Neurosurgery, University of North Carolina at Chapel Hill, NC.

A 49-year-old female with history of daily inhaled corticosteroid use for asthma presented to a concussion clinic 7 wk after sport-related head injury with headache, visual blurring, dizziness, nausea, fatigue, polydipsia, and polyuria. Examination revealed difficulty with vestibuloocculomotor testing due to nausea and visual straining. Cranial computed tomography/magnetic resonance imaging was unremarkable. Read More

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January 2020