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Primary mental health care for older persons in India: how age-inclusive are public policies?

Health Policy Plan 2021 Jun 17. Epub 2021 Jun 17.

Department of Health Services Research and Nursing Science, School of Public Health, Bielefeld University, Universitaetsstrasse 25, Bielefeld 33651, Germany.

The need to improve the primary mental healthcare system in India has gained increasing public health attention. Concomitantly, efforts to frame and develop appropriate public mental health care through legislation and related strategies and programmes have been undertaken. Because older people in India are particularly prone to mental health problems, this study explores the inclusiveness of Indian public policies in addressing the primary mental health care needs of older people from a cross-policy perspective. Read More

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Tail control enhances gliding in arboreallizards: an integrative study using a 3D geometric model and numerical simulation.

Integr Comp Biol 2021 May 19. Epub 2021 May 19.

Department of Evolution, Ecology, and Organismal Biology, University of California, Riverside, CA92521, USA.

The ability to glide through an arboreal habitat has been acquired by several mammals, amphibians, snakes, lizards, and even invertebrates. Lizards of the genus Draco possess specialized morphological structures for gliding, including a patagium, throat lappets, and modified hindlimbs. Despite being among the most specialized reptilian gliders, it is currently unknown how Draco are able to maneuver effectively during flight. Read More

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Betacoronaviruses genome analysis reveals evolution toward specific codons usage: Implications for SARS-CoV-2 mitigation strategies.

J Med Virol 2021 May 2. Epub 2021 May 2.

Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Since the start of the coronavirus disease 2019 (COVID-19) pandemic, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly widespread worldwide becoming one of the major global public health issues of the last centuries. Currently, COVID-19 vaccine rollouts are finally upon us carrying the hope of herd immunity once a sufficient proportion of the population has been vaccinated or infected, as a new horizon. However, the emergence of SARS-CoV-2 variants brought concerns since, as the virus is exposed to environmental selection pressures, it can mutate and evolve, generating variants that may possess enhanced virulence. Read More

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Consistency in Motion Event Encoding Across Languages.

Front Psychol 2021 30;12:625153. Epub 2021 Mar 30.

Department of Linguistics, Stockholm University, Stockholm, Sweden.

Syntactic templates serve as schemas, allowing speakers to describe complex events in a systematic fashion. Motion events have long served as a prime example of how different languages favor different syntactic frames, in turn biasing their speakers toward different event conceptualizations. However, there is also variability in how motion events are syntactically framed within languages. Read More

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The Survey of the Health of Wisconsin (SHOW) Program: An infrastructure for Advancing Population Health Sciences.

medRxiv 2021 Apr 7. Epub 2021 Apr 7.

Purpose: The Survey of the Health of Wisconsin (SHOW) was established in 2008 by the University of Wisconsin (UW) School of Medicine and Public Health (SMPH) with the goals of 1) providing a timely and accurate picture of the health of the state residents; and 2) serving as an agile resource infrastructure for ancillary studies. Today SHOW continues to serve as a vital population health research infrastructure.

Participants: SHOW currently includes 5,846 adult and 980 minor participants recruited between 2008-2019 in four primary waves. Read More

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Bálint syndrome.

Handb Clin Neurol 2021 ;178:233-255

Trajectoires, Centre de Recherche en Neurosciences de Lyon, Inserm, CNRS, Université Lyon 1, Bron, France; Plateforme "Mouvement et Handicap", Hôpital Henry-Gabrielle, Hospices Civils de Lyon, Saint-Genis-Laval, France.

This chapter starts by reviewing the various interpretations of Bálint syndrome over time. We then develop a novel integrative view in which we propose that the various symptoms, historically reported and labeled by various authors, result from a core mislocalization deficit. This idea is in accordance with our previous proposal that the core deficit of Bálint syndrome is attentional (Pisella et al. Read More

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January 2021

A visual approach to the economic evaluation of vaccines: opening the health economic black box.

Expert Rev Pharmacoecon Outcomes Res 2021 Mar 18:1-10. Epub 2021 Mar 18.

Department of Management Science, University of Strathclyde, Glasgow, UK.

Objectives: The economic evaluation of vaccines has attracted a great deal of controversy. In the academic literature, several vaccination advocates argue that the evaluation frame for vaccines should be expanded to give a more complete picture of their benefits. We seek to contribute to the debate and facilitate informed dialogue about vaccine assessment using visualization, as able to support both deliberation by technical committees about the substance of evaluation and communication of the underlying rationale to non-experts. Read More

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Multi-channel photodissociation and XUV-induced charge transfer dynamics in strong-field-ionized methyl iodide studied with time-resolved recoil-frame covariance imaging.

Faraday Discuss 2021 May;228(0):571-596

J. R. Macdonald Laboratory, Department of Physics, Kansas State University, Manhattan, KS 66506, USA.

The photodissociation dynamics of strong-field ionized methyl iodide (CH3I) were probed using intense extreme ultraviolet (XUV) radiation produced by the SPring-8 Angstrom Compact free electron LAser (SACLA). Strong-field ionization and subsequent fragmentation of CH3I was initiated by an intense femtosecond infrared (IR) pulse. The ensuing fragmentation and charge transfer processes following multiple ionization by the XUV pulse at a range of pump-probe delays were followed in a multi-mass ion velocity-map imaging (VMI) experiment. Read More

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Functional analysis of p.ser605del variant: the aging phenotype of MDPL syndrome is associated with an impaired DNA repair capacity.

Aging (Albany NY) 2021 02 22;13(4):4926-4945. Epub 2021 Feb 22.

Department of Biomedicine and Prevention, Tor Vergata University, Rome 00133, Italy.

Mandibular hypoplasia, Deafness and Progeroid features with concomitant Lipodystrophy define a rare systemic disorder, named MDPL Syndrome, due to almost always a variant in gene, encoding the DNA polymerase δ. We report a MDPL female heterozygote for the recurrent p.Ser605del variant. Read More

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February 2021

Functional Context Affects Scene Processing.

J Cogn Neurosci 2021 Feb 11:1-13. Epub 2021 Feb 11.

Carnegie Mellon University, Pittsburgh, PA.

Rapid visual perception is often viewed as a bottom-up process. Category-preferred neural regions are often characterized as automatic, default processing mechanisms for visual inputs of their categorical preference. To explore the sensitivity of such regions to top-down information, we examined three scene-preferring brain regions, the occipital place area (OPA), the parahippocampal place area (PPA), and the retrosplenial complex (RSC) and tested whether the processing of outdoor scenes is influenced by the functional contexts in which they are seen. Read More

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February 2021

Cytoplasmic movements of the early human embryo: imaging and artificial intelligence to predict blastocyst development.

Reprod Biomed Online 2021 Mar 24;42(3):521-528. Epub 2020 Dec 24.

Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, Via Ferrata, 9 27100, Italy; Centre for Health Technology, University of Pavia, Pavia, Italy. Electronic address:

Research Question: Can artificial intelligence and advanced image analysis extract and harness novel information derived from cytoplasmic movements of the early human embryo to predict development to blastocyst?

Design: In a proof-of-principle study, 230 human preimplantation embryos were retrospectively assessed using an artificial neural network. After intracytoplasmic sperm injection, embryos underwent time-lapse monitoring for 44 h. For comparison, standard embryo assessment of each embryo by a single embryologist was carried out to predict development to blastocyst stage based on a single picture frame taken at 42 h of development. Read More

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Central nervous activity during implicit processing of emotional face expressions in fibromyalgia syndrome.

Brain Res 2021 May 2;1758:147333. Epub 2021 Feb 2.

UMIT Tirol - University for Health Sciences, Medical Informatics and Technology, Austria. Electronic address:

Objective: Fibromyalgia syndrome (FMS) is characterized by chronic widespread pain accompanied by symptoms like fatigue, insomnia, depression, anxiety and cognitive impairments. In addition to central nervous pain sensitization, emotional dysregulation may be involved in FMS pathogenesis. This study investigated central nervous correlates of affective and attentional processing in FMS using an implicit task. Read More

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A real-time health notification system aimed at enhancing the interaction between animal care staff and researchers promotes animal welfare.

Lab Anim 2021 Jun 1;55(3):281-289. Epub 2021 Feb 1.

University of Turku, Central Animal Laboratory (UTUCAL), Finland.

Regardless of the microbiological status of an animal facility, research animals may experience health problems, leading to pain, suffering and distress. Simple and efficient tools are needed to collect data systematically, allowing researchers to react and resolve animals' health issues. We have developed a real-time notification method for recording clinical observations, which caretakers can input into the ELLI record-keeping system, accompanied by a picture or video. Read More

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Joint Image Encryption and Screen-Cam Robust Two Watermarking Scheme.

Sensors (Basel) 2021 Jan 20;21(3). Epub 2021 Jan 20.

Key Laboratory of Virtual Geographic Environment (Nanjing Normal University), Ministry of Education, Nanjing 210023, China.

This paper proposes a joint encryption and screen-cam robust watermarking scheme. This method combines the advantages of smartphone, encryption and watermarking technologies, thereby achieving watermark extraction with a smartphone, partial decryption and tracking leakage from sneak shots. We design a dual watermarking algorithm to achieve watermark detection from both encrypted and decrypted images. Read More

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January 2021

[Research on first aid measures based on convolutional neural network recognition human actions].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2020 Nov;32(11):1385-1387

School of Software, Xinjiang University, Urumqi 830091, Xinjiang Uygur Autonomous Region, China.

Objective: To explore the application of human behavior recognition based on convolutional neural network (CNN) in the new generation of pre-hospital first aid.

Methods: Sixty videos were obtained from the Montreal Falling Video Data base, and divided into model training data and evaluation test data at a ratio of 5:1. (1) Data model training: singular value decomposition was used to clarify the picture, the target boundary of the human body in the picture was identified through target detection and Fourier transform, then the human body curve was described; OpenCv computer vision and machine learning software library to estimate the body pose were used to mark the important parts of the human body (such as hips, knees), the angle between the line of important parts and the horizontal direction and the length and width ratio of the detection frame were calculated, and whether the human body had abnormal behavior was identified. Read More

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November 2020

Occurrence and distribution of antimicrobial resistance genes in the soil of an industrial park in China: A metagenomics survey.

Environ Pollut 2021 Jan 8;273:116467. Epub 2021 Jan 8.

College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. Electronic address:

As zoned areas of industries, industrial parks have great impacts on the environment. Several studies have demonstrated that chemical compounds and heavy metals released from industrial parks can contaminate soil, water, and air. However, as an emerging pollutant, antimicrobial resistance genes (ARGs) in industrial parks have not yet been investigated. Read More

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January 2021

Alternative Polyadenylation in response to temperature stress contributes to gene regulation in Populus trichocarpa.

BMC Genomics 2021 Jan 14;22(1):53. Epub 2021 Jan 14.

State Key Laboratory of Tree Genetics and Breeding, Research Institute of Subtropical Forestry, Chinese Academy of Forestry, Hangzhou, 311400, Zhejiang, China.

Background: Genome-wide change of polyadenylation (polyA) sites (also known as alternative polyadenylation, APA) is emerging as an important strategy of gene regulation in response to stress in plants. But little is known in woody perennials that are persistently dealing with multiple abiotic stresses.

Results: Here, we performed a genome-wide profiling of polyadenylation sites under heat and cold treatments in Populus trichocarpa. Read More

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January 2021

Method to eliminate thermal disturbance errors in digital image correlation measurement based on projection speckle.

Appl Opt 2020 Nov;59(33):10474-10482

Digital image correlation (DIC) technology is an optical measurement method of material strain displacement based on visible light illumination. With the increasing application of DIC technology in the field of high-temperature measurement, however, the effect of thermal disturbance on measurement accuracy becomes more and more serious. To solve this problem, a method to eliminate thermal disturbance in material measurements based on projection speckle is proposed. Read More

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November 2020

Misdiagnosis of leprosy in Brazil in the period 2003 - 2017: spatial pattern and associated factors.

Acta Trop 2021 Mar 11;215:105791. Epub 2020 Dec 11.

Program of Master and Doctoral Studies in Health Science, Federal University of Mato Grosso (UFMT), Cuiabá, Brazil; Program of Master and Doctoral Studies in Environmental Sciences, State University of Mato Grosso (UNEMAT), Cáceres, Brazil.

Background: Leprosy causes a range of symptoms, and most diagnoses are established based on the clinical picture. Therefore, false negative and positive diagnoses are relatively common. We analyzed the spatial pattern of leprosy misdiagnosis and associated factors in Brazil. Read More

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Improving the use of focus group discussions in low income settings.

BMC Med Res Methodol 2020 11 30;20(1):287. Epub 2020 Nov 30.

University College London, Institute for Global Health, London, UK.

Background: The quality of data obtained through Focus Group Discussions (FGDs) is highly dependent on appropriate design and facilitation. In low-income settings steep power gradients between researcher and participants, as well as conversational norms, could reduce the ability of participants to voice personal opinions. Activity-oriented exercises have been suggested as a way overcoming these challenges, however little evidence exists - to date - on their use in low-income settings. Read More

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November 2020

Three different scenarios for epileptic spasms.

Epilepsy Behav 2020 12 25;113:107531. Epub 2020 Nov 25.

Intensive Neurological Diagnostic Unit, Neuroscience Department, Bambino Gesù Children's Hospital, Rome, Italy.

Epileptic Spasms (ES) is a type of seizure usually occurring in the context of a severe childhood epileptic syndrome associated to significant Electroencephalogram (EEG) abnormalities. There are three scenarios in which ES may occur. The first one is represented by West Syndrome (WS): ES occur in a previously non encephalopathic infant in association with the development of a hypsarrhythmic EEG pattern. Read More

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December 2020

Transcriptional programs of infectious spleen and kidney necrosis virus (ISKNV) in vitro and in vivo.

Virus Genes 2020 Dec 8;56(6):749-755. Epub 2020 Oct 8.

State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, P. R. China.

Infectious spleen and kidney necrosis virus (ISKNV), causing serious infectious diseases to marine and freshwater fishes, is the type species of the genus Megalocytivirus, family Iridoviridae. In this study, the transcriptional programs of ISKNV in vitro (MFF-1 cells) and in vivo (spleens from mandarin fish) were investigated using real-time PCR. Transcription of all the putative open reading frames (ORFs) of ISKNV was verified. Read More

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December 2020

Early posterior negativity in humans to pictures of snakes and spiders: effects of proximity.

Exp Brain Res 2020 Dec 3;238(12):2795-2804. Epub 2020 Oct 3.

Erasmus School of Social and Behavioral Sciences, Brain and Cognition, Erasmus University Rotterdam, PO Box 1738, 3000 DR, Rotterdam, The Netherlands.

Snakes have proven to drive early attentional capture due to their evolutionary importance, as reflected by the early posterior negativity (EPN). The EPN snake effect might be partly driven by the proximity of the animal. In this study, by employing full-body (medium shot) and head-focused (close-up) pictures, we investigated whether the relative nearness (proximity) of the animal on the picture affects the snake EPN effect. Read More

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December 2020

Ten years since the introduction of therapeutic hypothermia in neonates with perinatal hypoxic-ischaemic encephalopathy in Spain.

Neurologia (Engl Ed) 2020 Sep 25. Epub 2020 Sep 25.

Servicio de Neonatología, Hospital Puerta del Mar, Cádiz, España; Fundación NeNe, España; Grupo Cerebro Neonatal.

Introduction: More than a decade has passed since therapeutic hypothermia (TH) was introduced in Spain; this is the only neuroprotective intervention that has become standard practice in the treatment of perinatal hypoxic-ischaemic encephalopathy (HIE). This article aims to provide a current picture of the technique and to address the controversies surrounding its use.

Development: In the last 10 years, TH has been successfully implemented in the vast majority of tertiary hospitals in Spain, and more than 85% of newborns with moderate or severe HIE currently receive the treatment. Read More

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September 2020

Distinct alpha-Synuclein species induced by seeding are selectively cleared by the Lysosome or the Proteasome in neuronally differentiated SH-SY5Y cells.

J Neurochem 2021 03 22;156(6):880-896. Epub 2020 Sep 22.

Biomedical Research Foundation of the Academy of Athens, Athens, Greece.

A major pathological feature of Parkinson's disease (PD) is the aberrant accumulation of misfolded assemblies of alpha-synuclein (α-Syn). Protein clearance appears as a regulator of the 'α-Syn burden' underlying PD pathogenesis. The picture emerging is that a combination of pathways with complementary roles, including the Proteasome System and the Autophagy-Lysosome Pathway, contributes to the intracellular degradation of α-Syn. Read More

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Reorienting rabies research and practice: Lessons from India.

Palgrave Commun 2019 Dec;5:152

Department of History, University of Liverpool, England, United Kingdom.

In this article, we reflect on the institutional and everyday realities of people-street dog relations in India to develop a case for decolonised approaches to rabies and other zoonoses. Dog-mediated rabies in Asia and Africa continues be a major concern in transnational public health agendas despite extensive research and knowledge on its prevention. In India, which carries 35% of the global rabies burden and has large street dog populations, One Health-oriented dog population management programmes have been central to the control of this zoonotic disease. Read More

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December 2019

Activation energies and the extended jump model: How temperature affects reorientation and hydrogen-bond exchange dynamics in water.

J Chem Phys 2020 Aug;153(7):074110

Department of Chemistry, University of Kansas, Lawrence, Kansas 66045, USA.

Hydrogen-bond exchanges drive many dynamical processes in water and aqueous solutions. The extended jump model (EJM) provides a quantitative description of OH reorientation in water based on contributions from hydrogen-bond exchanges, or jumps, and the "frame" reorientation of intact hydrogen-bond pairs. Here, we show that the activation energies of OH reorientation in bulk water can be calculated accurately from the EJM and that the model provides a consistent picture of hydrogen-bond exchanges based on molecular interactions. Read More

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Face-Specific Perceptual Distortions Reveal A View- and Orientation-Independent Face Template.

Curr Biol 2020 10 13;30(20):4071-4077.e4. Epub 2020 Aug 13.

Neurology Department and Dementia Clinic, Centro Hospitalar e Universitário de Coimbra, Coimbra 3000-075, Portugal; Centre for Neuroscience and Cell Biology (CNC), University of Coimbra, Coimbra 3004-504, Portugal; Faculty of Medicine, University of Coimbra, Coimbra 3004-504, Portugal.

The spatial coordinate system in which a stimulus representation is embedded is known as its reference frame. Every visual representation has a reference frame [1], and the visual system uses a variety of reference frames to efficiently code visual information [e.g. Read More

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October 2020

Microstructural analysis of sheared polydisperse polyhedral grains.

Phys Rev E 2020 Jun;101(6-1):062901

Department of Mechanical Engineering, Chiang Mai University, 239 Huay Kaew Road, Chiang Mai, Thailand.

This article presents an analysis of the shear strength of numerical samples composed of polyhedra presenting a grain size dispersion. Previous numerical studies using, for instance, disks, polygons, and spheres, have consistently shown that microstructural properties linked to the fabric and force transmission allow granular media to exhibit a constant shear resistance although packing fraction can dramatically change as a broader grain-size distribution is considered. To have a complete picture of such behavior, we developed a set of numerical experiments in the frame of the discrete element method to test the shear strength of polydisperse samples composed of polyhedral grains. Read More

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Does nuclear permutation symmetry allow dynamical localization in symmetric double-well achiral molecules?

J Chem Phys 2020 Jun;152(24):244308

Institut für Chemie, Universität Potsdam, Karl-Liebknecht-Str. 24-25, D-14476 Potsdam-Golm, Germany.

We discuss the effect of molecular symmetry on coherent tunneling in symmetric double-well potentials whose two molecular equilibrium configurations are interconverted by nuclear permutations. This is illustrated with vibrational tunneling in ammonia molecules, electronic tunneling in the dihydrogen cation, and laser-induced rotational tunneling of homonuclear diatomics. In this contribution, we reexamine the textbook picture of coherent tunneling in such potentials, which is depicted with a wavepacket shuttling back and forth between the two potential-wells. Read More

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