23,779 results match your criteria physicochemical biological


3D Printing of dynamic tissue scaffold by combining self-healing hydrogel and self-healing ferrogel.

Colloids Surf B Biointerfaces 2021 Sep 12;208:112108. Epub 2021 Sep 12.

Department of Bioengineering, Hanyang University, Seoul 04763, Republic of Korea; Institute of Nano Science and Technology, Hanyang University, Seoul 04763, Republic of Korea. Electronic address:

Hydrogels have been widely utilized in tissue engineering applications as functional and biological synthetic extracellular matrices (ECMs) can be created with gels. However, typical hydrogels cannot be exploited in 3D printing, especially in extrusion printing, unless post-cross-linking after printing is provided. Additionally, dynamic tissue scaffolds that can mimic ECM environments in the body have been demonstrated to be useful in tissue engineering. Read More

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September 2021

Influence of surfactants on biomolecular conjugation of magnetic nanoparticles.

J Biomol Struct Dyn 2021 Sep 20:1-13. Epub 2021 Sep 20.

Department of Chemistry, University of Mumbai, Vidyanagari, Mumbai, India.

Here, we report the physicochemical interaction among iron oxide nanoparticles (MNPs) and essential biomolecules, namely, serum albumin (BSA, HSA), collagen and deoxyribonucleic acid (DNA) in the presence of various cationic, anionic and non-ionic surfactants. Iron oxide nanoparticles are synthesized by the wet chemical process and are characterized by X-ray powder diffraction analysis (XRD), Fourier transform infrared spectroscopic, UV-Vis spectroscopy, scanning electron microscopy and energy-dispersive X-ray spectroscopy mapping studies . The conjugation of MNPs protein was analyzed using UV-Vis spectroscopy, fluorescence spectroscopy, circular dichroism technique and gel electrophoresis. Read More

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September 2021

Bioinspired supramolecular nanofiber hydrogel through self-assembly of biphenyl-tripeptide for tissue engineering.

Bioact Mater 2022 Feb 11;8:396-408. Epub 2021 Jun 11.

National Engineering Research Center for Biomaterials, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan, 610064, PR China.

Supramolecular nanofiber peptide assemblies had been used to construct functional hydrogel biomaterials and achieved great progress. Here, a new class of biphenyl-tripeptides with different C-terminal amino acids sequences transposition were developed, which could self-assemble to form robust supramolecular nanofiber hydrogels from 0.7 to 13. Read More

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February 2022

Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy.

Bioact Mater 2022 Feb 10;8:309-324. Epub 2021 Jul 10.

Department of Orthopaedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, China.

Polyetheretherketone (PEEK) has been widely used as orthopedic and dental materials due to excellent mechanical and physicochemical tolerance. However, its biological inertness, poor osteoinduction, and weak antibacterial activity make the clinical applications in a dilemma. Inspired by the mussel adhesion mechanism, here we reported a biomimetic surface strategy for rational integration and optimization of anti-infectivity and osteo-inductivity onto PEEK surfaces using a mussel foot proteins (Mfps)-mimic peptide with clickable azido terminal. Read More

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February 2022

Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics.

Bioact Mater 2022 Feb 6;8:267-295. Epub 2021 Jul 6.

Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, 31116, Republic of Korea.

Polymeric hydrogels are fascinating platforms as 3D scaffolds for tissue repair and delivery systems of therapeutic molecules and cells. Among others, methacrylated gelatin (GelMA) has become a representative hydrogel formulation, finding various biomedical applications. Recent efforts on GelMA-based hydrogels have been devoted to combining them with bioactive and functional nanomaterials, aiming to provide enhanced physicochemical and biological properties to GelMA. Read More

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February 2022

Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer.

Front Mol Biosci 2021 1;8:649395. Epub 2021 Sep 1.

Chair and Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University, Medical College, Kraków, Poland.

Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Read More

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September 2021

Physicochemical indicators coupled with multivariate analysis for comprehensive evaluation of matcha sensory quality.

Food Chem 2021 Sep 8;371:131100. Epub 2021 Sep 8.

School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, PR China. Electronic address:

The sensory quality of matcha is a pivotal factor in determining consumer acceptance. However, the human sensory panel test is difficult to popularize by virtue of professional requirements and inability to evaluate large samples. The analysis showed that physicochemical indicators of matcha were significantly related to sensory quality. Read More

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September 2021

Vulnerability of municipal solid waste: An emerging threat to aquatic ecosystems.

Chemosphere 2021 Sep 11;287(Pt 3):132223. Epub 2021 Sep 11.

CAS-Key Laboratory of Crust-Mantle Materials and the Environments, School of Earth and Space Sciences, University of Science and Technology of China, Hefei, 230026, China; Environmental Engineering Department, Middle East Technical University, Ankara, 06800, Turkey. Electronic address:

Dumping waste materials into aquatic ecosystems leads to pollution, which directly and indirectly poses a danger to all life forms. Currently, huge quantities of wastes are generated at a global scale with varying constituents, including organic fractions, emerging contaminants and toxic metals. These wastes release concentrated contaminants (leachates), which are lethal for all ecosystems around the globe because they contain varying concentrations of chemical constituents with BOD and COD in the order of 2 × 10-2. Read More

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September 2021

Organoselenium-chitosan derivative: Synthesis via "click" reaction, characterization and antioxidant activity.

Int J Biol Macromol 2021 Sep 16;191:19-26. Epub 2021 Sep 16.

Laboratório de Tecnologia e Desenvolvimento de Compósitos e Materiais Poliméricos (LaCoPol), Universidade Federal de Pelotas (UFPel), Campus Capão do Leão s/n, 96010-900 Pelotas, RS, Brazil. Electronic address:

The derivatization of chitosan (CS) is widely exploited to endow this polysaccharide with enhanced physicochemical and biological properties. Beyond the synthetic route, the nature of the compounds used to functionalize the CS-derivatives exerts a pivotal role in their final properties. Making use of a simple "click" reaction, we synthesized for the first time an organoselenium-CS derivative through a 1,2,3-triazole formation. Read More

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September 2021

Strategies and advances in the pretreatment of microalgal biomass.

J Biotechnol 2021 Sep 16. Epub 2021 Sep 16.

Centre for Energy and Environmental Sustainability, Lucknow-226 001, Uttar Pradesh, India; Centre for Innovation and Translational Research, CSIR-Indian Institute of Toxicology Research, Lucknow 226001, Uttar Pradesh, India. Electronic address:

Modification of structural components, especially the cell wall, through adequate pretreatment strategies is critical to the bioconversion efficiency of algal biomass to biorefinery products. Over the years, several physical, physicochemical, chemical and green pretreatment methods have been developed to achieve maximum productivity of desirable by-products to sustain a circular bioeconomy. The effectiveness of the pretreatment methods is however, species specific due to diversity in the innate nature of the microalgal cell wall. Read More

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September 2021

Hydrolysable tannins change physicochemical parameters of lipid nano-vesicles and reduce DPPH radical - Experimental studies and quantum chemical analysis.

Biochim Biophys Acta Biomembr 2021 Sep 16:183778. Epub 2021 Sep 16.

Laboratory of Molecular Biophysics, Department of Microbiology and Biotechnology, Faculty of Biology, University of Bialystok, Konstanty Ciolkowski Street 1J, 15-245 Bialystok, Poland.

Tannins belong to plant secondary metabolites exhibiting a wide range of biological activity. One of the important aspects of the realization of the biological effects of tannins is the interaction with lipids of cell membranes. In this work we studied the interaction of two hydrolysable tannins: 1,2,3,4,5-penta-O-galloyl-β-d-glucose (PGG) and 1,2-di-O-galloyl-4,6-valoneoyl-β-d-glucose (T1) which had the same number of both aromatic rings (5) and hydroxyl groups (15) but differing in flexibility due to the presence of valoneoyl group in the T1 molecule with DMPC (dimyristoylphosphatidylcholine) lipid nano-vehicles (liposomes). Read More

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September 2021

Unifying coarse-grained force fields for folded and disordered proteins.

Curr Opin Struct Biol 2021 Sep 15;72:63-70. Epub 2021 Sep 15.

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address:

Liquid-liquid phase separation drives the formation of biological condensates that play essential roles in transcriptional regulation and signal sensing. Computational modeling could provide high-resolution structural characterizations of these condensates and help uncover physicochemical interactions that dictate their stability. However, many protein molecules involved in phase separation often contain multiple ordered domains connected with flexible, structureless linkers. Read More

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September 2021

Photocrosslinkable gelatin/collagen based bioinspired polyurethane-acrylate bone adhesives with tunable elasticity and biodegradability.

Int J Biol Macromol 2021 Sep 15. Epub 2021 Sep 15.

İnönü University, Science Faculty, Department of Chemistry, Malatya, Turkey. Electronic address:

Hard or soft tissue adhesives have been presented as a promising candidate to replace traditional wound closure methods. A series of hard tissue bioadhesive formulations based on natural polymers have recently been designed and investigated in our laboratory. In current work, we produced an UV-curable polyurethane-acrylate formulations as a bioadhesive. Read More

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September 2021

Expanding the toolbox of exosome-based modulators of cell functions.

Biomaterials 2021 Sep 12;277:121129. Epub 2021 Sep 12.

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, 90089, USA; Department of Chemistry, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA, 90089, USA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, 90089, USA; Research Center for Liver Diseases, University of Southern California, Los Angeles, CA, 90089, USA. Electronic address:

Exosomes are cell-derived extracellular vesicles and play important roles in mediating intercellular communications. Due to their unique advantages in transporting a variety of biomolecules, exosomes have been emerging as a new class of nanocarriers with great potential for therapeutic applications. Despite advancements in loading chemotherapeutics and interfering RNAs into exosomes, active incorporation of protein molecules into exosomes remains challenging owing to their distinctive physicochemical properties and/or a lack of knowledge of cargo sorting during exosome biogenesis. Read More

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September 2021

Non-alkylator anti-glioblastoma agents induced cell cycle G2/M arrest and apoptosis:Design, In silico physicochemical and SAR Studies of 2-Aminoquinoline-3-carboxamides.

Bioorg Med Chem Lett 2021 Sep 14:128371. Epub 2021 Sep 14.

Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China; School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China. Electronic address:

Malignant gliomas are the most common brain tumors, with generally dismal prognosis, early clinical deterioration and high mortality. Recently, 2-aminoquinoline scaffold derivatives have shown pronounced activity in central nervous system disorders. We herein reported a series of 2-aminoquinoline-3-carboxamides as novel non-alkylator anti-glioblastoma agents. Read More

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September 2021

Enhanced antibacterial activity of lysozyme loaded quaternary ammonium chitosan nanoparticles functionalized with cellulose nanocrystals.

Int J Biol Macromol 2021 Sep 14;191:71-78. Epub 2021 Sep 14.

School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China; Shanghai Veterinary Bio-tech Key Laboratory, Shanghai 200240, China. Electronic address:

In this study, cellulose nanocrystals (CNC) as functional cross-linker and Pickering emulsifier was used to stabilize Lysozyme (Lys) encapsulated in quaternary ammonium chitosan nanoparticles (QC NPs) via ionic gelation method. Physicochemical, structural, and antibacterial properties of the CNC stabilized Lys loaded QC NPs were also evaluated. Particle size, particle size distribution, Zeta potential (ZP), and spectroscopic analyses showed the successful encapsulation of Lys. Read More

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September 2021

Physicochemical and biological evaluation of curdlan-poly(lactic-co-glycolic acid) nanoparticles as a host-directed therapy against Mycobacterium tuberculosis.

J Pharm Sci 2021 Sep 14. Epub 2021 Sep 14.

School of Pharmacy, Faculty of Natural Sciences, University of the Western Cape, Cape Town, South Africa. Electronic address:

Nanoparticles (NPs) that can activate macrophages infected with the tuberculosis causative pathogen Mycobacterium tuberculosis, could be an effective host directed therapy for the disease. In this study, curdlan was conjugated to poly(lactic-co-glycolic acid) (PLGA) to produce immunotherapeutic NPs. Various physicochemical characterizations were used to evaluate the curdlan-PLGA copolymer and the NPs. Read More

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September 2021

Size-segregated physicochemical properties of inhalable particulate matter in a tunnel-ventilated layer house in China.

Environ Res 2021 Sep 15;204(Pt B):112064. Epub 2021 Sep 15.

College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China. Electronic address:

This study investigated the physicochemical properties of the particles in a typical commercial laying hen barn in Southeast China. Mass concentrations and size distributions of the particulate matter (PM) and the key components (incl. organic carbon (OC), element carbon (EC), and the water-soluble inorganic ions (WSIIs)) were analyzed. Read More

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September 2021

Characterization of functional sweetened condensed milk formulated with flavoring and sugar substitute.

Food Sci Nutr 2021 Sep 21;9(9):5119-5130. Epub 2021 Jul 21.

Department of Food Science and Technology Faculty of Biological Sciences North Tehran Branch Islamic Azad University Tehran Iran.

In the present study, the effect of sugar replacement and enrichment with cinnamon extract (CE) on the physicochemical, functional, and organoleptic properties of sweetened condensed milk (SCM) and the production of flavored functional dairy dessert was investigated. The results demonstrated that by adding CE (0.5 and 1%) and fructose sugar (50 and 100% replacement) in the formulation containing maltodextrin, the physicochemical, functional, and organoleptic properties of SCM samples were improved. Read More

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September 2021

Corrigendum: Bioactive Sr/Feco-substituted hydroxyapatite in cryogenically 3D printed porous scaffolds for bone tissue engineering. Liang Yang 2021  035007.

Biofabrication 2021 Sep 16. Epub 2021 Sep 16.

Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei, 430000, CHINA.

Developing multi-doped bioceramics that possess biological multifunctionality is becoming increasingly attractive and promising for bone tissue engineering. In this view innovative Sr/Feco-substituted nano-hydroxyapatite with gradient doping concentrations fixed at 10 mol% has been deliberately designed previously. Herein, to evaluate their therapeutic potentials for bone healing, novel gradient SrFeHA/PCL scaffolds are fabricated by extrusion cryogenic 3D printing technology with subsequent lyophilization. Read More

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September 2021

Metagenomic insights into co-proliferation of Vibrio spp. and dinoflagellates Prorocentrum during a spring algal bloom in the coastal East China Sea.

Water Res 2021 Sep 3;204:117625. Epub 2021 Sep 3.

Department of Civil and Environmental Engineerimng, KAIST, Daejeon, 34141, Republic of Korea. Electronic address:

Coastal harmful algal blooms (HABs), commonly termed 'red tides', have severe undesirable consequences to the marine ecosystems and local fishery and tourism industries. Increase in nitrogen and/or phosphorus loading is often regarded as the major culprits of increasing frequency and intensity of the coastal HAB; however, fundamental understanding is lacking as to the causes and mechanism of bloom formation despite decades of intensive investigation. In this study, we interrogated the prokaryotic microbiomes of surface water samples collected at two neighboring segments of East China Sea that contrast greatly in terms of the intensity and frequency of Prorocentrum-dominated HAB. Read More

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September 2021

Recent biopharmaceutical applications of capillary electrophoresis methods on recombinant DNA technology-based products.

Electrophoresis 2021 Sep 16. Epub 2021 Sep 16.

Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, Ankara, 06560, Turkey.

Biopharmaceuticals (recombinant technology-based products, vaccines, whole blood and blood components, gene therapy, cells, tissues, etc.,) are described as biological medical products produced from various living sources such as human, microbial, animal, etc. by manufacturing, extraction, or semi-synthesis. Read More

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September 2021

Ant nests as a microbial hot spots in a long-term heavy metal-contaminated soils.

Environ Sci Pollut Res Int 2021 Sep 16. Epub 2021 Sep 16.

Department of Zoology and Animal Welfare, University of Agriculture in Krakow, Mickiewicza 21, 31-120, Kraków, Poland.

Interactions between soil fauna and soil microorganisms are not fully recognized, especially in extreme environments, such as long-term metal-polluted soils. The purpose of the study was to assess how the presence of Lasius niger ants affected soil microbial characteristics in a long-term metal-polluted area (Upper Silesia in Poland). Paired soil samples were taken from bulk soil and from ant nests and analysed for a range of soil physicochemical properties, including metal content (zinc, cadmium, and lead). Read More

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September 2021

Arachis hypogaea L. from Acid Soils of Nanyang (China) Is Frequently Associated with Bradyrhizobium guangdongense and Occasionally with Bradyrhizobium ottawaense or Three Bradyrhizobium Genospecies.

Microb Ecol 2021 Sep 15. Epub 2021 Sep 15.

Faculty of Agriculture and Life Sciences, Lincoln University, Lincoln, 7647, New Zealand.

Henan Province is a major area of peanut production in China but the rhizobia nodulating the crop in this region have not been described. A collection of 217 strains of peanut rhizobia was obtained from six field sites across four soil types in Henan Province, North China, by using peanut as a trap host under glasshouse conditions. The 217 strains separated into 8 distinct types on PCR-RFLP analysis of their IGS sequences. Read More

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September 2021

Microbial Communities and Physicochemical Characteristics of Traditional Dajiang and Sufu in North China Revealed by High-Throughput Sequencing of 16S rRNA.

Front Microbiol 2021 30;12:665243. Epub 2021 Aug 30.

Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, China.

The process of soybean fermentation has been practiced for more than 3,000 years. Although Dajiang and Sufu are two popular fermented soybean products consumed in North China, limited information is available regarding their microbial composition. Hence, the current study sought to investigate, and compare, the physicochemical indicators and microbial communities of traditional Dajiang and Sufu. Read More

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Physicochemical, antioxidant properties of carotenoids and its optoelectronic and interaction studies with chlorophyll pigments.

Authors:
Ruby Srivastava

Sci Rep 2021 Sep 15;11(1):18365. Epub 2021 Sep 15.

CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.

The physicochemical and antioxidant properties of seven carotenoids: antheraxanthin, β-carotene, neoxanthin, peridinin, violaxanthin, xanthrophyll and zeaxanthin were studied by theoretical means. Then the Optoelectronic properties and interaction of chlorophyll-carotenoid complexes are analysed by TDDFT and IGMPLOT. Global reactivity descriptors for carotenoids and chlorophyll (Chla, Chlb) are calculated via conceptual density functional theory (CDFT). Read More

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September 2021

Engineered macroalgal and microalgal adsorbents: Synthesis routes and adsorptive performance on hazardous water contaminants.

J Hazard Mater 2021 Aug 16;423(Pt A):126921. Epub 2021 Aug 16.

Korea Biochar Research Center, APRU Sustainable Waste Management Program & Division of Environmental Science and Ecological Engineering, Korea University, Seoul, 02841, Republic of Korea.

Colourants, micropollutants and heavy metals are regarded as the most notorious hazardous contaminants found in rivers, oceans and sewage treatment plants, with detrimental impacts on human health and environment. In recent development, algal biomass showed great potential for the synthesis of engineered algal adsorbents suitable for the adsorptive management of various pollutants. This review presents comprehensive investigations on the engineered synthesis routes focusing mainly on mechanical, thermochemical and activation processes to produce algal adsorbents. Read More

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Challenges and recent trends with the development of hydrogel fiber for biomedical applications.

Chemosphere 2021 Aug 23;287(Pt 1):131956. Epub 2021 Aug 23.

Department of Chemical and Environmental Engineering, Faculty Science and Engineering, University of Nottingham, Malaysia, 43500, Semenyih, Selangor Darul Ehsan, Malaysia. Electronic address:

Hydrogel is the most emblematic soft material which possesses significantly tunable and programmable characteristics. Polymer hydrogels possess significant advantages including, biocompatible, simple, reliable and low cost. Therefore, research on the development of hydrogel for biomedical applications has been grown intensely. Read More

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Recent advances in PCB removal from historically contaminated environmental matrices.

Chemosphere 2021 Aug 30;287(Pt 1):132096. Epub 2021 Aug 30.

Institute for Environmental Studies, Faculty of Science, Charles University, Benátská 2, 12801, Prague 2, Czech Republic; Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, 14220, Prague 4, Czech Republic. Electronic address:

Despite being drastically restricted in the 1970s, polychlorinated biphenyls (PCBs) still belong among the most hazardous contaminants. The chemical stability and dielectric properties of PCBs made them suitable for a number of applications, which then lead to their ubiquitous presence in the environment. PCBs are highly bioaccumulative and persistent, and their teratogenic, carcinogenic, and endocrine-disrupting features have been widely reported in the literature. Read More

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Oxidized LDL-regulated microRNAs for evaluating vascular endothelial function: molecular mechanisms and potential biomarker roles in atherosclerosis.

Crit Rev Clin Lab Sci 2021 Sep 15:1-14. Epub 2021 Sep 15.

Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

As a simple monolayer, vascular endothelial cells can respond to physicochemical stimuli. In addition to promoting the formation of foam cells, oxidized low-density lipoprotein (ox-LDL) contributes to the atherosclerotic process through different mechanisms, including endothelial cell dysfunction. As conserved noncoding RNAs, microRNAs (miRNAs) naturally lie in different genomic positions and post-transcriptionally regulate the expression of many genes. Read More

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September 2021