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Postexercise hypotension due to resistance exercise is not mediated by autonomic control: A systematic review and meta-analysis.

Auton Neurosci 2021 May 27;234:102825. Epub 2021 May 27.

Department of Kinesiology, University of Connecticut, Storrs, CT, USA.

Changes in autonomic control have been suggested to mediate postexercise hypotension (PEH). We investigated through meta-analysis the after-effects of acute resistance exercise (RE) on blood pressure (BP) and autonomic activity in individuals with normal and elevated BP. Electronic databases were searched for trials including: adults; exclusive RE interventions; and BP and autonomic outcomes measured pre- and postintervention for at least 30 min. Read More

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Quantitative detection of aflatoxin B using quantum dots-based immunoassay in a recyclable gravity-driven microfluidic chip.

Biosens Bioelectron 2021 Jun 2;190:113394. Epub 2021 Jun 2.

Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, China; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China. Electronic address:

To achieve rapid and sensitive detection of aflatoxin B (AFB), we developed a polydimethylsiloxane gravity-driven cyclic microfluidic chip using the two-signal mode strategy. The structural design of the chip, together with the two-wavelength quantum dot ratio fluorescence, effectively eliminates the influence of environmental factors, improves the signal stability, and ensures that the final detection result positively correlates with the target concentration. Moreover, the theoretical analysis performed for the established physical model of the three-dimensional reaction interface inside the chip confirmed the improved reaction rate of immune adsorption in the microfluidic strategy. Read More

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Computer modelling of heat strain responses of exercising personnel in tropical climate.

Comput Biol Med 2021 May 29;134:104530. Epub 2021 May 29.

Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, 117575, Singapore.

Physiologically based thermoregulatory models are useful for deriving predictions of heat strain for pragmatic applications such as planning of continuous exercise/work-rest protocols. The SCENARIO model is an example of a thermoregulatory model that predicts heat strain including body core temperature (Tc) from individual characteristics, physical activity, clothing properties and environmental conditions. This paper presents work to optimize and enhance the SCENARIO model for prediction of Tc during high intensity load carriage tasks under predominantly tropical climate conditions. Read More

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Collision avoidance behaviours between older adult and young adult walkers.

Gait Posture 2021 Jun 9;88:210-215. Epub 2021 Jun 9.

Univ Rennes, Inria, CNRS, IRISA, M2S, France.

Background: Collision avoidance between two walkers requires a mutual adaptation based on visual information in order to be successful. Age-related changes to visuomotor processing, kinesthetic input, and intersegmental dynamics increases the risk of collision and falls in older adults. However, few studies examine behavioural strategies in older adults during collision avoidance tasks with another pedestrian. Read More

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Hormonal stress responses of growth hormone and insulin-like growth factor-I in highly resistance trained women and men.

Growth Horm IGF Res 2021 Jun 6;59:101407. Epub 2021 Jun 6.

Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, USA.

The purpose of this study was to examine the responses of growth hormone (GH) and insulin-like growth factor-I (IGFI) to intense heavy resistance exercise in highly trained men and women to determine what sex-dependent responses may exist. Subjects were highly resistance trained men (N = 8, Mean ± SD; age, yrs., 21 ± 1, height, cm, 175. Read More

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Improved SARS-CoV-2 M inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies.

Eur J Med Chem 2021 May 30;222:113584. Epub 2021 May 30.

Department of Chemistry, University of Alberta, Edmonton AB, T6G 2G2, Canada. Electronic address:

Replication of SARS-CoV-2, the coronavirus causing COVID-19, requires a main protease (M) to cleave viral proteins. Consequently, M is a target for antiviral agents. We and others previously demonstrated that GC376, a bisulfite prodrug with efficacy as an anti-coronaviral agent in animals, is an effective inhibitor of M in SARS-CoV-2. Read More

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Drug and sexual HIV-risk behaviors among adolescents and young adults with opioid use disorder.

J Subst Abuse Treat 2021 May 19;130:108477. Epub 2021 May 19.

Friends Research Institute, Inc., 1040 Park Avenue, Suite 103, Baltimore, MD 21201, United States of America.

Opioid use disorder (OUD) among adolescents and young adults (youth) is associated with drug use and sexual HIV-related risk behaviors and opioid overdose. This mixed methods analysis assesses risk behaviors among a sample of 15-21-year-olds (N = 288) who were being treated for OUD in a residential drug treatment program in Baltimore, Maryland. Participants were enrolled in a parent study in which they received either extended-release naltrexone (XR-NTX) or Treatment as Usual (TAU), consisting of outpatient counseling with or without buprenorphine, prior to discharge. Read More

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Cognitive insight, medication adherence and methamphetamine cessation in people enrolled in a pharmacotherapy trial for methamphetamine use.

J Subst Abuse Treat 2021 May 15;130:108473. Epub 2021 May 15.

National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia.

Background: The current study examined correlates of cognitive insight in people enrolled in a methamphetamine pharmacotherapy trial; whether cognitive insight at the start of the trial predicted medication adherence and reductions in methamphetamine use during the trial; and, whether insight would remain stable over the trial or improve with reductions in methamphetamine use.

Methods: A subset of people enrolled in a 12-week randomised placebo-controlled pharmacotherapy trial for methamphetamine dependence completed the Beck Cognitive Insight Scale, comprising subscales for Self-Reflection and Self-Certainty, at baseline (n = 152) and at week 12 (n = 79). Medication adherence was expressed as the percentage of non-missed doses measured using eCAP™ technology. Read More

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Nanoplastics adsorption and removal efficiency by granular activated carbon used in drinking water treatment process.

Sci Total Environ 2021 Jun 1;791:148175. Epub 2021 Jun 1.

Group of Environmental Physical Chemistry, Department F.-A. Forel for Environmental and Aquatic Sciences, University of Geneva, Uni Carl Vogt, 66, boulevard Carl-Vogt, CH-1211 Geneva 4, Switzerland. Electronic address:

In this study Granular Activated Carbon (GAC) used in drinking water treatment processes is evaluated for its capacity to adsorb and remove polystyrene (PS) nanoplastics. Batch experiments are conducted in ultrapure and surface water from Lake Geneva, currently used as drinking water resources. Equilibrium and kinetic studies are conducted to understand adsorption mechanisms and limiting factors. Read More

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Cross-sectional associations of leisure and transport related physical activity with depression and anxiety.

J Psychiatr Res 2021 Jun 4;140:228-234. Epub 2021 Jun 4.

Departmento de Clínica Médica, Faculdade de Medicina da USP & Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil; Laboratory of Neurosciences (LIM-27), Institute of Psychiatry, Hospital das Clínicas da Faculdade de Medicina da USP, Brazil.

Background: Previous evidence supports the notion that the physical activity (PA) domain (leisure-time or transport), and the amount of time spent in PA, influence the association of PA with depressive and anxiety symptoms. However, no study evaluated the associations of different volumes of leisure-time PA (LTPA) and transport PA (TPA) with prevalent depression, anxiety, and co-occurring depression and anxiety (D&A) disorders.

Aim: To investigate the associations between different volumes of LTPA and TPA with prevalent depression, anxiety, and D&A. Read More

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Mental health mediators of subjective cognitive concerns among World Trade Center responders.

J Psychiatr Res 2021 Jun 2;140:187-196. Epub 2021 Jun 2.

Icahn School of Medicine at Mount Sinai, Department of Environmental Medicine and Public Health, World Trade Center Health Program General Responder Data Center, 1 Gustave L. Levy Place, New York, NY, 10029, USA.

Decline in cognitive functioning among rescue and recovery workers who responded in the aftermath of the September 11, 2001, World Trade Center (WTC) attacks is of emerging interest. Responders are vulnerable to cognitive decline from exposure to airborne toxins present at the WTC site, as well as from WTC-related mental and physical health conditions. To better understand the relationship between occupational WTC exposure, mental health, physical health and subjective cognitive functioning, we examined the mediating role of health status in the association between exposure and subjective cognitive concerns in a multi-site, longitudinal investigation of the WTC General Responder cohort (n = 16,380 responders; n = 58,575 visits) for the period 2002-2015. Read More

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Production of an electro-biological particle electrode (EBPE) from lithium slag and its removal performance to salicylic acid in a three-dimensional electrocatalytic biological coupling reactor (3D-EBCR).

Chemosphere 2021 Jun 2;282:131020. Epub 2021 Jun 2.

School of Civil Engineering and Architecture, University of Jinan, Jinan, 250022, China.

Electro-biological particle electrode (EBPE) prepared by lithium slag was used to remove salicylic acid in a three-dimensional electrocatalytic biological coupling reactor (3D-EBCR). The physical and chemical properties of the EBPE, the removal performance of salicylic acid and the degradation mechanism were studied. Results revealed as follows: (1) the EBPE prepared by lithium slag contained effective catalytic components including FeO, SnO, ZnO, MnO, RbO and TiO, with stable structure and good adsorption performance; (2) the 3D-EBCR with EBPE had strong adaptability to the current intensity in the range of 0. Read More

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Health of African refugee children outside Africa: A scoping review.

J Pediatr Nurs 2021 Jun 9;61:199-206. Epub 2021 Jun 9.

Department of Educational Psychology, University of Alberta, Edmonton, Alberta T6G 2G5, Canada. Electronic address:

Problem: Africa is the largest source continent of refugee children. However, we found no published synthesis of the literature on the health of African refugee children outside Africa. Conducting a review of the literature on this particular population will help illuminate the particular contextual health issues faced by African child refugees who live outside Africa. Read More

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Evaluation of an in-hospital recreation room for hospitalised children and their families.

J Pediatr Nurs 2021 Jun 9;61:191-198. Epub 2021 Jun 9.

School of Women's and Children's Health, UNSW Sydney, Kensington, New South Wales 2031, Australia; Kids Cancer Centre, Sydney Children's Hospital, High Street, Randwick, New South Wales 2031, Australia.

Objective: Many children's hospitals have established 'recreation rooms' to help reduce distress among hospitalised children and families. We investigated recreation rooms in two Australian children's hospitals to determine: 1) families' first use of the room (including discovery and delays); 2) characteristics of families accessing the room; 3) parents' positive and negative associations with the room; and 4) parents' most and least valued aspects of the room.

Method: Using a concurrent mixed methods design, parents completed questionnaires (Restorative Experiences Tool, Parenting Stress Index-Short Form, Paediatric Quality of Life Inventory) and an optional interview. Read More

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Unraveling the influence of substrate on the growth rate, morphology and covalent structure of surface adherent polydopamine films.

Colloids Surf B Biointerfaces 2021 Jun 2;205:111897. Epub 2021 Jun 2.

Department of Chemistry and Physics of Surfaces and Interfaces, Institute of Macromolecular Chemistry, Czech Academy of Sciences, 162 06, Prague 6, Czech Republic. Electronic address:

Polydopamine (PDA), also known as synthetic melanin, is widely used as a biomimetic anchoring layer for the modification of various solid substrates. PDA is utilized for a wide range of biomedical, sensing and tribological applications, even though the polymer's precise covalent structure has not been completely revealed yet. Even more, it is not evident to which extent the chemical nature of the substrate, on which the layer is formed, influences and predetermines the covalent structure of resulting PDA. Read More

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Recent advances in technologies for removal and recovery of selenium from (waste)water: A systematic review.

J Environ Manage 2021 Jun 9;294:112926. Epub 2021 Jun 9.

Faculty of Bioscience Engineering, Coupure Links 653, 9000, Gent, Belgium. Electronic address:

Selenium (Se) is distributed into different environmental compartments by natural and anthropogenic activities, and generally discharged in the form of selenate [SeO] and selenite [SeO], which are both toxic. Physical-chemical and biological treatment processes have been reported to exhibit good treatment efficiencies for Se from aqueous streams, only a few demonstrated to achieve effluent concentrations <5 μg/L. Moreover, there are only a few numbers of studies that describe the progress in technological developments over the last decade. Read More

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Lesion loci of impaired affective prosody: A systematic review of evidence from stroke.

Brain Cogn 2021 Jun 9;152:105759. Epub 2021 Jun 9.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; Department of Cognitive Science, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD 21218, United States.

Affective prosody, or the changes in rate, rhythm, pitch, and loudness that convey emotion, has long been implicated as a function of the right hemisphere (RH), yet there is a dearth of literature identifying the specific neural regions associated with its processing. The current systematic review aimed to evaluate the evidence on affective prosody localization in the RH. One hundred and ninety articles from 1970 to February 2020 investigating affective prosody comprehension and production in patients with focal brain damage were identified via database searches. Read More

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Personalised Accelerometer Cut-point Prediction for Older Adults' Movement Behaviours using a Machine Learning approach.

Comput Methods Programs Biomed 2021 May 18;208:106165. Epub 2021 May 18.

Department of Computer Science, Edge Hill University, Ormskirk, L39 4QP, United Kingdom. Electronic address:

Background And Objectives: Body-worn accelerometers are the most popular method for objectively assessing physical activity in older adults. Many studies have developed generic accelerometer cut-points for defining activity intensity in metabolic equivalents for older adults. However, methodological diversity in current studies has led to a great deal of variation in the resulting cut-points, even when using data from the same accelerometer. Read More

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Individuals with recurrent low back pain exhibit further altered frontal plane trunk control in remission than when in pain.

Clin Biomech (Bristol, Avon) 2021 May 28;87:105391. Epub 2021 May 28.

Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA.

Background: Movement alterations due to low back pain (LBP) could lead to long-term adverse consequences if they do not resolve after symptoms subside. This study aims to determine if altered trunk control associated with recurrent low back pain persists beyond symptom duration.

Methods: Twenty young adults with recurrent LBP were tested once during an LBP episode and once in symptom remission, and twenty matched back-healthy participants served as controls. Read More

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Memory effects in polymer brushes showing co-nonsolvency effects.

Adv Colloid Interface Sci 2021 May 17;294:102442. Epub 2021 May 17.

Leibniz-Institut für Polymerforschung Dresden e.V, Hohe Straße 6, Dresden 01069, Germany; Max-Planck-Institut für Polymerforschung, Ackermannweg 10, Mainz 55128, Germany. Electronic address:

Densely packed polymer chains grafted to a substrate, especially polymer brushes, have been studied intensively. Of special interest are systems that react to changes in external conditions or"remember" previous conditions. With this focus, we explore the properties of PNiPAAm brushes and relate published work to own results. Read More

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Short-term and Long-term Psychological Impact and Quality of Life of Patients Undergoing Orthognathic Surgery.

Biomed J 2021 Jun 9. Epub 2021 Jun 9.

Department of Craniofacial Research Center, Chang Gung Memorial Hospital and College of Medicine, Taoyuan, Taiwan.

Background: Orthognathic Surgery (OGS) is a surgery for patients with dento-facial deformity but not all patients are satisfied with its outcome. The purpose of this study is to find out the short-term and long-term psychological impact and quality-of-life of OGS.

Methods: 77 participants receiving OGS and 32 age and gender-matched controls were enrolled. Read More

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A review of the physiological impact of rare earth elements and their uses in biomedical Mg alloys.

Acta Biomater 2021 Jun 9. Epub 2021 Jun 9.

School of Engineering, RMIT University, Melbourne, Victoria 3001, Australia.

Magnesium (Mg) is well-tolerated by the body, displaying exceedingly low toxicity, rapid excretion, and numerous bioactive effects, including improved bone formation and protection against oxidative stresses; further, Mg alloys can be degraded in vivo to allow complete removal of an implant without surgical intervention, avoiding revision surgery and thrombosis concerns seen with permanent implants. Rare earth elements (REEs) have been of particular interest in alloying Mg alloys for nearly a century due to their unique chemical and physical properties but have attracted increasing attention in recent decades. The REEs contribute greatly to the mechanical and biological properties of metal alloys, and so are common in Mg alloys in a wide variety of applications; in particular, they represent the dominant alloying additions in current, clinically applied Mg alloys. Read More

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Menstrual Phase Does Not Influence Ventilatory Responses to Group III/IV Afferent Signaling in Eumenorrheic Young Females.

Respir Physiol Neurobiol 2021 Jun 9:103712. Epub 2021 Jun 9.

Division of Physical Therapy, University of Minnesota, 420 Delaware St. SE, Minneapolis, MN, 55455, United States; Division of Rehabilitation Science, University of Minnesota, 420 Delaware St. SE, Minneapolis, MN, 55455, United States.

Estrogen can reduce sympathetic activity, but its effects on minute ventilation (V) with group III/IV afferent activation remain unclear. This study examined the influence of estrogen on V during lower-extremity exercise with group III/IV activation. Females completed two identical visits in follicular and ovulatory menstrual phases. Read More

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Does Loss of Spondylolisthesis Reduction Impact Clinical and Radiographic Outcomes after Minimally Invasive Transforaminal Lumbar Interbody Fusion.

Spine J 2021 Jun 9. Epub 2021 Jun 9.

Department of Orthopaedic Surgery, Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, USA; Weill Cornell Medical College, 1300 York Ave, New York, NY, 10065, USA. Electronic address:

Background Context: Minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) is a common operative approach to address degenerative lumbar stenosis and spondylolisthesis which has failed nonoperative care. Compared to open TLIF, MI-TLIF relies to a greater extent on indirect decompression resulting in a heightened awareness of spondylolisthesis reduction among MI surgeons. To what extent intraoperative reduction is achieved as well as the rate and clinical impact of loss or reduction and slip recurrence remain unknown. Read More

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Development of a novel model of intervertebral disc degeneration by the intradiscal application of monosodium iodoacetate (MIA) in rat Degenerative change in monosodium iodoacetate (MIA)-injected intervertebral disc.

Spine J 2021 Jun 9. Epub 2021 Jun 9.

Department of Physiology, Korea University, Seoul, Republic of Korea. Electronic address:

Background Context: Low back pain is one of the most common musculoskeletal disorders. While the pathology of intervertebral disc (IVD) degeneration has been modeled using various biological methods, these models are inadequate for simulating similar pathological states in humans.

Purpose: This study investigated whether monosodium iodoacetate (MIA) injection into the IVD of rats could generate a reliable model of IVD degeneration. Read More

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Mind-body Practices and Cognitive Function in Middle-Aged and Older Adults: Findings from the Midlife in the United States (MIDUS) Study.

Complement Ther Med 2021 Jun 9:102751. Epub 2021 Jun 9.

Florida Policy Exchange Center on Aging, School of Aging Studies, University of South Florida, Tampa, FL, USA.

Objectives: Cognitive function is a key component of healthy aging. While conventional physical activities (walking, jogging, etc.) have been shown to support health in late-life, including cognitive health, it remains unclear whether traditional Eastern mind-body practices (MBP) have long-term cognitive benefits above and beyond conventional leisure physical activities. Read More

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Tai Chi for health and well-being: A bibliometric analysis of published clinical studies between 2010 and 2020.

Complement Ther Med 2021 Jun 9:102748. Epub 2021 Jun 9.

NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia.

The objective of this bibliometric review was to identify the volume, breadth, and characteristics of clinical studies evaluating Tai Chi published between January 2010 and January 2020. Five English and four Chinese language databases were searched. Following independent screening, 1018 eligible publications representing 987 studies were identified, which was a three-fold increase from the previous decade. Read More

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Revealing transcriptional and post-transcriptional regulatory mechanisms of γ-glutamyl transferase and keratin isoforms as novel cooperative biomarkers in low-grade glioma and glioblastoma multiforme.

Genomics 2021 Jun 9. Epub 2021 Jun 9.

Laboratory of Systems Biology and Bioinformatics (LBB), Department of Bioinformatics, University of Tehran, Kish International Campus, Kish, Iran; Laboratory of Systems Biology and Bioinformatics (LBB), Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran. Electronic address:

Gamma-glutamyltransferase (GGT) and keratins (KRT) are key factors in regulating tumor progression rely on emerging evidence. However, the prognostic values of GGT and KRT isoforms and their regulation patterns at transcriptional and post-transcriptional levels have been rarely studied. In this study, we aimed to identify cooperative prognostic biomarker signature conducted by GGT and KRT genes for overall survival prediction and discrimination in patients with low-grade glioma (LGG) and glioblastoma multiforme (GBM). Read More

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Barriers to and Facilitators of Sustained Employment: A Qualitative Study of Experiences in Dutch Patients With CKD.

Am J Kidney Dis 2021 Jun 9. Epub 2021 Jun 9.

Department of Health Sciences, Applied Health Research, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Rationale & Objective: Although patients with chronic kidney disease (CKD) are at risk for work disability and work loss, not all experience work disruption. We aimed to describe the experienced barriers to and facilitators of sustained employment among Dutch patients with CKD.

Study Design: Qualitative study using semi-structured interviews. Read More

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The lipid paradox in neuroprogressive disorders: Causes and consequences.

Neurosci Biobehav Rev 2021 Jun 9. Epub 2021 Jun 9.

C.A.R., Cambridge, UK. Electronic address:

Chronic systemic inflammation is associated with an increased risk of cardiovascular disease in an environment of low low-density lipoprotein (LDL) and low total cholesterol and with the pathophysiology of neuroprogressive disorders. The causes and consequences of this lipid paradox are explored. Circulating activated neutrophils can release inflammatory molecules such as myeloperoxidase and the pro-inflammatory cytokines interleukin-1 beta, interleukin-6 and tumour necrosis factor-alpha. Read More

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