2,481 results match your criteria phosphate granules


Injectable tricalcium phosphate/calcium sulfate granule enhances bone repair by reversible setting reaction.

Biochem Biophys Res Commun 2021 Apr 14;557:151-158. Epub 2021 Apr 14.

Department of Engineering Sciences: Applied Materials Sciences, The Ångström Laboratory, SE-751 21, Uppsala, Sweden. Electronic address:

Towards repairing bone defects, calcium sulfate and calcium phosphate cement have been recognized as promising bone grafts. However, the current bone cements are generally lack of proper porosity for cell migration and new tissue formation. On the other hand, porous scaffold cannot be delivered by injection, which limits its use its clinical use. Read More

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Changes in the multi-scale structure and physicochemical properties of starch during potato growth.

J Sci Food Agric 2021 Apr 5. Epub 2021 Apr 5.

School of Food Engineering, Anhui Science and Technology University, Fengyang, China.

Background: Growth stage contributes critically to the physicochemical properties of starches, which make achieving desired functional properties by controlling the growth period possible. Thus, this study investigated the changes in multiscale structure and physicochemical properties of potatoes starches harvested at different growth stages.

Results: The amylose and phosphate content varied over the growth period, with the ranges 2. Read More

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Monetite, an important calcium phosphate compound-Its synthesis, properties and applications in orthopedics.

Acta Biomater 2021 Mar 31. Epub 2021 Mar 31.

Department of Mechanical Engineering, Cleveland State University, Cleveland, OH, USA. Electronic address:

This review recognizes a unique calcium phosphate (CaP) phase known as monetite or dicalcium phosphate anhydrous (DCPA, CaHPO), and presents an overview of its properties, processing, and applications in orthopedics. The motivation for the present effort is to highlight the state-of-the-art research and development of monetite and propel the research community to explore more of its potentials in orthopedics. After a brief introduction of monetite, we provide a summary of its various synthesis routes like dehydration, solvent-based, energy-assisted processes and also discuss the formation of different crystal structures with respect to the synthesis conditions. Read More

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Ex Vivo and In Vivo Analyses of Novel 3D-Printed Bone Substitute Scaffolds Incorporating Biphasic Calcium Phosphate Granules for Bone Regeneration.

Int J Mol Sci 2021 Mar 30;22(7). Epub 2021 Mar 30.

Department of Ceramic Materials, Chair of Advanced Ceramic Materials, Institute for Materials Science and Technologies, Technical University Berlin, 10623 Berlin, Germany.

(1) Background: The aim of this study was examining the ex vivo and in vivo properties of a composite made from polycaprolactone (PCL) and biphasic calcium phosphate (BCP) (synprint, ScientiFY GmbH) fabricated via fused deposition modelling (FDM); (2) Methods: Scaffolds were tested ex vivo for their mechanical properties using porous and solid designs. Subcutaneous implantation model analyzed the biocompatibility of PCL + BCP and PCL scaffolds. Calvaria implantation model analyzed the osteoconductive properties of PCL and PCL + BCP scaffolds compared to BCP as control group. Read More

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Toward the discovery of biological functions associated with the mechanosensor Mtl1p of Saccharomyces cerevisiae via integrative multi-OMICs analysis.

Sci Rep 2021 Apr 1;11(1):7411. Epub 2021 Apr 1.

Department of Biochemistry, Medical Sciences Campus, University of Puerto Rico, San Juan, PR, 00936-5067, USA.

Functional analysis of the Mtl1 protein in Saccharomyces cerevisiae has revealed that this transmembrane sensor endows yeast cells with resistance to oxidative stress through a signaling mechanism called the cell wall integrity pathway (CWI). We observed upregulation of multiple heat shock proteins (HSPs), proteins associated with the formation of stress granules, and the phosphatase subunit of trehalose 6-phosphate synthase which suggests that mtl1Δ strains undergo intrinsic activation of a non-lethal heat stress response. Furthermore, quantitative global proteomic analysis conducted on TMT-labeled proteins combined with metabolome analysis revealed that mtl1Δ strains exhibit decreased levels of metabolites of carboxylic acid metabolism, decreased expression of anabolic enzymes and increased expression of catabolic enzymes involved in the metabolism of amino acids, with enhanced expression of mitochondrial respirasome proteins. Read More

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Responses of Chlamydomonas reinhardtii during the transition from P-deficient to P-sufficient growth (the P-overplus response): The roles of the vacuolar transport chaperones and polyphosphate synthesis.

J Phycol 2021 Mar 29. Epub 2021 Mar 29.

School of Food and Advanced Technology, Massey University, Private Bag 11222, Palmerston North, New Zealand.

Phosphorus (P) assimilation and polyphosphate (polyP) synthesis were investigated in Chlamydomonas reinhardtii by supplying phosphate (PO ; 10 mg P·L ) to P-depleted cultures of wildtypes, mutants with defects in genes involved in the vacuolar transporter chaperone (VTC) complex, and VTC-complemented strains. Wildtype C. reinhardtii assimilated PO and stored polyP within minutes of adding PO to cultures that were P-deprived, demonstrating that these cells were metabolically primed to assimilate and store PO . Read More

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Study of Octacalcium Phosphate Behavior in Different Model Solutions.

ACS Omega 2021 Mar 9;6(11):7487-7498. Epub 2021 Mar 9.

Ceramic Composite Materials, A.A. Baikov Institute of Metallurgy and Materials Science RAS, Leninskiy Prospect 49, Moscow 119334, Russia.

Octacalcium phosphate (OCP), a new-generation bone substitute material, is a considered precursor of the biological bone apatite. The two-layered structure of OCP contains the apatitic and hydrated layers and is intensively involved in ion-exchange surface reactions, which results in OCP hydrolysis to hydroxyapatite and adsorption of ions or molecular groups presented in the environment. During various procedures, such as biomaterial solubility, additive release studies, or the functionalization technique, several model solutions are applied. Read More

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Microalgal-bacterial granular sludge process for non-aerated aquaculture wastewater treatment.

Bioprocess Biosyst Eng 2021 Mar 27. Epub 2021 Mar 27.

Agriculture Ministry Key Laboratory of Healthy Freshwater Aquaculture, Key Laboratory of Fish Health and Nutrition of Zhejiang Province, Zhejiang Institute of Freshwater Fisheries, Huzhou, 313001, China.

Microalgal-bacterial granular sludge (MBGS) process has become a focal point in treating municipal wastewater. However, it remains elusive whether the emerging process can be applied for the treatment of aquaculture wastewater, which contains considerable concentrations of nitrate and nitrite. This study evaluated the feasibility of MBGS process for aquaculture wastewater treatment. Read More

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Fabrication and Evaluation of Layered Double Hydroxide-Enriched ß-Tricalcium Phosphate Nanocomposite Granules for Bone Regeneration: In Vitro Study.

Mol Biotechnol 2021 Mar 23. Epub 2021 Mar 23.

Department of Stem Cell and Regenerative Medicine, Institute of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology, 14965/161, Tehran, Iran.

One of the most important challenges facing tissue engineering researches is the scaffold design with optimum physical and mechanical properties for growth and proliferation of cells, and tissue formation. The aim of this study was to produce a novel nanocomposite containing β-tricalcium phosphate and layered double hydroxide (β-TCP-LDH) and analyzing the capacity of its osteogenic activity in vitro. In this paper, β-tricalcium phosphate and layered double hydroxide powders were synthesized by co-precipitation processes. Read More

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Recovered granular sludge extracellular polymeric substances as carrier for bioaugmentation of granular sludge reactor.

Chemosphere 2021 Feb 24;275:130037. Epub 2021 Feb 24.

Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005, Porto, Portugal.

An increasing amount of industrial chemicals are being released into wastewater collection systems and indigenous microbial communities in treatment plants are not always effective for their removal. In this work, extracellular polymeric substances (EPS) recovered from aerobic granular sludge (AGS) were used as a natural carrier to immobilize a specific microbial strain, Rhodococcus sp. FP1, able to degrade 2-fluorophenol (2-FP). Read More

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February 2021

Comparative responses of Sinopotamon henanense to acute and sub-chronic Cd exposure.

Environ Sci Pollut Res Int 2021 Mar 4. Epub 2021 Mar 4.

School of Life Science, Shanxi University, Taiyuan, 030006, China.

Studies on the freshwater crab Sinopotamon henanense have shown that acute and sub-chronic Cd exposure induced differential alterations in the respiratory physiology and gill morphology. To elucidate Cd toxicity under these two exposure conditions, crabs were acutely exposed to 7.14, 14. Read More

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Cabbage cultivars influence transfer and toxicity of cadmium in soil-Chinese flowering cabbage Brassica campestris-cutworm Spodoptera litura larvae.

Ecotoxicol Environ Saf 2021 Apr 24;213:112076. Epub 2021 Feb 24.

Guangdong Provincial Key Laboratory of Eco-Circular Agriculture, South China Agricultural University, Guangzhou 510642, China; Key Laboratory of Agro-Environment in the Tropics, Ministry of Agriculture, South China Agricultural University, Guangzhou 510642, China; Guangdong Engineering Research Centre for Modern Eco-Agriculture, Guangzhou 510642, China; Department of Ecology, College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, China. Electronic address:

We executed a pot experiment to examine the differences of absorption, chemical forms, subcellular distribution, and toxicity of Cd between two cultivars of Chinese flowering cabbage Brassica campestris [Lvbao701 (low-Cd cultivar) and Chicaixin No.4 (high-Cd cultivar)]. Compared to Chicaixin No. Read More

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Phosphorus retention by granulated apatite: assessing maximum retention capacity, kinetics and retention processes.

Water Sci Technol 2021 Feb;83(4):792-802

Inrae, REVERSAAL Research Unit, 5 rue de la Doua, Villeurbanne 69100, France E-mail:

Natural apatites have previously shown a great capacity for phosphate retention from wastewater. However, its fine particle size distribution may lead to a premature clogging of the filter. Accordingly, a granulated apatite product was developed and manufactured in order to control the particle size distribution of the media. Read More

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February 2021

Mitochondrial Calcification.

Immunometabolism 2021 29;3(1). Epub 2021 Jan 29.

Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA 98195, USA.

One of the most fascinating aspects of mitochondria is their remarkable ability to accumulate and store large amounts of calcium in the presence of phosphate leading to mitochondrial calcification. In this paper, we briefly address the mechanisms that regulate mitochondrial calcium homeostasis followed by the extensive review on the formation and characterization of intramitochondrial calcium phosphate granules leading to mitochondrial calcification and its relevance to physiological and pathological calcifications of body tissues. Read More

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January 2021

Calcium phosphate granules formation: Key to high rate of mesophilic UASB treatment of toilet wastewater.

Sci Total Environ 2021 Jun 30;773:144972. Epub 2021 Jan 30.

Department of Civil and Environmental Engineering, University of Alberta, Edmonton, Canada. Electronic address:

Toilet wastewater, a rich source of organic matter and nutrients, can be treated anaerobically to recover energy and resources at mesophilic conditions (35 °C) using an upflow anaerobic sludge blanket (UASB) digester. However, low organic loading rates (OLR) have often been reported, which may be attributed to the flocs biomass applied in previous studies. In the present study, CaP granules were developed in the UASB reactor during the reactor operation of 250 days, which accounted for 89. Read More

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Impact of simultaneous hydrolysis of OCP and PLGA on bone induction of a PLGA-OCP composite scaffold in a rat femoral defect.

Acta Biomater 2021 04 5;124:358-373. Epub 2021 Feb 5.

Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan. Electronic address:

Effect of the simultaneous hydrolysis of octacalcium phosphate (OCP) and poly (lactic-co-glycolic acid) (PLGA) was investigated on its osteoconductivity. PLGA soaked in phosphate buffered saline with 0%, 20%, and 40% OCP at 37°C for eight weeks indicated that when the OCP dose was increased, 1) the weight loss of PLGA increased, 2) the glass transition temperature of the PLGAs decreased, 3) the saturation degree in the saline moved to nearly saturated condition with respect to hydroxyapatite (HA) but was undersaturated with respect to OCP, and 4) OCP tended to convert to HA by X-ray diffraction and Fourier transform infrared spectroscopy. OCP/PLGA composites of 20% and 40% with more than 92% porosity were produced by combining OCP granules with 1,4-dioxane-solubilizing PLGA followed by lyophilization and then subjected to four- and eight-week in vivo implantation tests in 3 mm diameter rat femora defects. Read More

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The Use of Biphasic Calcium Phosphate Substitute (BCP) in Mandibular Defects in Dogs: Use of CBCT to Evaluate Bone Healing.

J Vet Dent 2020 Dec 8;37(4):210-219. Epub 2021 Feb 8.

Azurvet Veterinary Referal Center, Saint Laurent du Var, France.

This study aimed to assess the use of cone beam computed tomography (CBCT) to follow-up bone healing of mandibular bone defects in dogs, filled with a combination of autologous blood and millimetric BCP granules. CBCT was performed ≥4 weeks postoperatively. CBCT gray-scale values were measured from multiplanar reconstructions of the defects and compared to that of normal contralateral mandibular bone and to pure BCP/blood composite time 0 (T0) value. Read More

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December 2020

Faster bone union progression and less sclerosis at the osteotomy margin after medial opening-wedge high tibial osteotomy using highly porous β-tricalcium phosphate granules versus allogeneic bone chips: A matched case-control study.

Knee 2021 Feb 3;29:33-41. Epub 2021 Feb 3.

Department of Orthopedic Surgery, Seoul National University Hospital, Seoul, South Korea. Electronic address:

Background: This study compared bone union progression using highly porous (80% porosity) β-tricalcium phosphate (β-TCP) granules or allogeneic bone chips in the gap created by medial opening-wedge high tibial osteotomy (MOWHTO).

Methods: The study population consisted of 54 patients who received MOWHTO with locking plate fixation: 27 patients using highly porous β-TCP granules, and 27 age- and sex-matched patients using allogeneic bone chips. Bone union progression was evaluated 1, 3, 6, and 12 months postoperatively. Read More

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February 2021

Formation Mechanism of hydroxyapatite encapsulation in Anammox-HAP Coupled Granular Sludge.

Water Res 2021 Apr 22;193:116861. Epub 2021 Jan 22.

Graduate School of Environmental Studies, Tohoku University, 6-6-06 Aza-Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8579, Japan.; Department of Civil and Environmental Engineering, Graduate School of Engineering, Tohoku University, 6-6-06 Aza-Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8579, Japan. Electronic address:

The potential of the formation of anammox-hydroxyapatite (HAP) granule composites as a cost-effective approach to removing nitrogen and phosphorus in the treatment of wastewater has been recently reported. Before these annamox granules, which consist of an anammox biofilm layer and an HAP crystallizing layer, can be used in applications, the formation mechanism of hydroxyapatite (HAP) encapsulation in the granules needs to be further studied. In this work, the role of extracellular polymeric substance (EPS) secreted by microorganisms and HAP core in Ca and P removal in anammox-HAP coupled granular sludge was investigated. Read More

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Protuberances are organized distinct regions of long-term callus: histological and transcriptomic analyses in kiwifruit.

Plant Cell Rep 2021 Apr 5;40(4):637-665. Epub 2021 Feb 5.

Department of Plant Cytology and Embryology, Faculty of Biology, Institute of Botany, The Jagiellonian University in Kraków, Gronostajowa 9, 30-387, Kraków, Poland.

Key Message: Macroscopic, ultrastructural, and molecular features-like a ball shape, the presence of starch granules, and the up-regulation of genes involved in carbohydrate metabolism and secondary metabolite biosynthesis-distinguish PT regions within a callus. The modification of the mass of pluripotent cells into de novo shoot bud regeneration is highly relevant to developmental biology and for agriculture and biotechnology. This study deals with protuberances (PT), structures that appear during the organogenic long-term culturing of callus (OC) in kiwifruit. Read More

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The impact of the size of bone substitute granules on macrophage and osteoblast behaviors in vitro.

Clin Oral Investig 2021 Feb 4. Epub 2021 Feb 4.

Department of Cranio-Maxillofacial Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Objective: Bone substitute (BS) size might influence the clinical outcomes of guided bone regeneration (GBR) procedures. The aim of the present study was to investigate the influence of BS size on macrophage (Mφ) and osteoblast behaviors in vitro.

Materials And Methods: Two different granule sizes (S and M/L) were assessed for four different commercial BSs: deproteinized bovine bone mineral (DBBM), biphasic calcium phosphate type 1 (BCP1), BCP type 2 (BCP2), and carbonate apatite (COAp). Read More

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February 2021

Biodegradation of natural and synthetic endocrine-disrupting chemicals by aerobic granular sludge reactor: Evaluating estrogenic activity and estrogens fate.

Environ Pollut 2021 Apr 25;274:116551. Epub 2021 Jan 25.

Chemical Engineering Program, COPPE, Federal University of Rio de Janeiro, P.O. Box 68502, 21941-972, Rio de Janeiro, Brazil.

In this study, the biodegradation of endocrine-disrupting chemicals (EDCs) (namely the natural and synthetic estrogens 17β-estradiol (E2) and 17α-ethinylestradiol (EE2), respectively) was assessed in an aerobic granular sludge (AGS) sequencing batch reactor (SBR) treating simulated domestic sewage. To better understand the fate of these compounds, their concentrations were determined in both liquid and solid (biomass) samples. Throughout the operation of the reactor, subjected to alternating anaerobic and aerated conditions, the removal of the hormones, both present in the influent at a concentration of 20 μg L, amounted to 99% (for E2) and 93% (for EE2), with the latter showing higher resistance to biodegradation. Read More

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The effect of synthetic bone graft substitutes on bone formation in rabbit calvarial defects.

J Mater Sci Mater Med 2021 Jan 21;32(1):14. Epub 2021 Jan 21.

Department of Cranio-Maxillofacial Surgery, Faculty of Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

The aim of this study was to evaluate the influence of the intensity of the biomimetic hydroxyapatite (HA) coating of α-tricalcium phosphate (α-TCP) on biomaterial degradation and bone formation. Twenty-four female NZW rabbits of approximately 12 weeks of age were used. Critical size defects were randomly treated with 3%:97% HA:α-TCP (BBCP1), 12%:88% HA:α-TCP (BBCP2), and 23%:77% HA:α-TCP (BBCP3), respectively or sham. Read More

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January 2021

Influence of Uranium Concentration and pH on U-Phosphate Biomineralization by OR37.

Environ Sci Technol 2021 02 20;55(3):1626-1636. Epub 2021 Jan 20.

Uranium contamination of soils and groundwater in the United States represents a significant health risk and will require multiple remediation approaches. Microbial phosphatase activity coupled to the addition of an organic P source has recently been studied as a remediation strategy that provides an extended release of inorganic P (Pi) into U-contaminated sites, resulting in the precipitation of -autunite minerals. Previous laboratory- and field-based biomineralization studies have investigated environments with relatively high U concentrations (>20 μM). Read More

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February 2021

Core-Shell Bioactive Ceramic Robocasting: Tuning Component Distribution Beneficial for Highly Efficient Alveolar Bone Regeneration and Repair.

ACS Biomater Sci Eng 2020 04 18;6(4):2376-2387. Epub 2020 Mar 18.

Bio-nanomaterials and Regenerative Medicine Research Division, Zhejiang-California International Nanosystem Institute, Zhejiang University, Hangzhou 310058, China.

Biodegradable ceramic (composite) scaffolds have inspired worldwide efforts in bone regenerative medicine. However, balancing the biodegradation with the bone's natural healing time scale remains difficult; in particularl, there is a lack of strategy to control component distribution and bioactive ion release favorable for stimulating alveolar bone tissue ingrowth in situ within an expected time window. Here we aimed to develop the robocasting core-shell bioceramic scaffolds and investigate their physicochemical properties and osteostimulative capability in beagle alveolar bone defect model. Read More

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The mitochondrial permeability transition phenomenon elucidated by cryo-EM reveals the genuine impact of calcium overload on mitochondrial structure and function.

Sci Rep 2021 Jan 13;11(1):1037. Epub 2021 Jan 13.

Physiology, Michigan State University, East Lansing, MI, 48824, USA.

Mitochondria have a remarkable ability to uptake and store massive amounts of calcium. However, the consequences of massive calcium accumulation remain enigmatic. In the present study, we analyzed a series of time-course experiments to identify the sequence of events that occur in a population of guinea pig cardiac mitochondria exposed to excessive calcium overload that cause mitochondrial permeability transition (MPT). Read More

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January 2021

In Vitro and In Vivo Evaluation of Nanostructured Biphasic Calcium Phosphate in Granules and Putty Configurations.

Int J Environ Res Public Health 2021 01 11;18(2). Epub 2021 Jan 11.

Orthodontics Department, Universidade Federal Fluminense, Niteroi 24020-140, Brazil.

Synthetic biphasic calcium phosphate (BCP) granules and powder are biocompatible biomaterials with a well-known capacity for osteoconduction, presenting very satisfactory clinical and histological results. It remains unanswered if the putty configuration impacts the biological response to the material. In this study, we aimed to compare the cytocompatibility and biocompatibility of nanostructured BCP in the putty configuration (moldable nanostructured calcium phosphate, MnCaP) on the healing of critical-sized bone defects (8 mm) in rat calvaria. Read More

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January 2021

Phosphate bags as energy storage materials for enhancement of solar still performance.

Environ Sci Pollut Res Int 2021 Jan 7. Epub 2021 Jan 7.

Department of Mechanical Engineering, KPR Institute of Engineering and Technology, Arasur, Coimbatore, Tamil Nadu, 641407, India.

In this experimental work, the effect of cotton bags filled with phosphate on solar distillery performance has been investigated. In this study, 25 phosphate bags are evenly distributed (5 × 5) with a length equal to 50 cm in a wooden box called the modified solar still (MSS). This system was compared with the conventional solar still (CSS) in the same climatic conditions. Read More

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January 2021

Microwave-Assisted Fabrication of Mesoporous Silica-Calcium Phosphate Composites for Dental Application.

Polymers (Basel) 2020 Dec 25;13(1). Epub 2020 Dec 25.

Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, Hallera 107, 80-416 Gdańsk, Poland.

Herein, the microwave-assisted wet precipitation method was used to obtain materials consisting of mesoporous silica (SBA-15) and calcium orthophosphates (CaP). Composites were prepared through immersion of mesoporous silica in different calcification coating solutions and then exposed to microwave radiation. The composites were characterized in terms of molecular structure, crystallinity, morphology, chemical composition, and mineralization potential by Fourier-transform infrared spectroscopy (FTIR), powder X-ray diffraction (XRD), and scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy (SEM-EDX). Read More

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December 2020

[Efficacy and safety of Kangbingdu granules in the treatment of influenza: a randomized, double-blind, double-dummy, positive-drug parallel control multicenter clinical trial].

Zhonghua Yi Xue Za Zhi 2021 Jan;101(3):205-211

Technical Center for Drug Research and Evaluation of China Association of Traditional Chinese Medicine, Beijing 100101, China.

To observe the efficacy and safety of Kangbingdu granules (KBD) in the treatment of influenza. A multicenter, randomized, double-blind, double-dummy, and positive-drug parallel control trial was conducted in 27 Grade ⅢA hospitals in China and the subjects were randomly assigned to the KBD test group or the oseltamivir phosphate capsule control group at a ratio of 1∶1. 200 subjects were planned to be enrolled in each group. Read More

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January 2021