Pharmaceutics 2021 Mar 19;13(3). Epub 2021 Mar 19.
School of Pharmaceutical Science, São Paulo State University (UNESP), Araraquara, Road Araraquara-Jaú, Km 01, Araraquara, São Paulo 14801-902, Brazil.
Polymer blends of gellan gum (GG)/retrograded starch(RS) and GG/pectin (P) were cross-linked with calcium, aluminum, or both to prepare mucoadhesive microparticles as oral carriers of drugs or nano systems. Cross-linking with different cations promoted different effects on each blend, which can potentially be explored as novel strategies for modulating physical-chemical and mucoadhesive properties of microparticles. Particles exhibited spherical shapes, diameters from 888 to 1764 µm, and span index values lower than 0. Read More