80,620 results match your criteria phenotype induced

Effects of high-dose bisphenol A on the mouse oral mucosa: A possible link with oral cancers.

Environ Pollut 2021 May 4;286:117296. Epub 2021 May 4.

Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address:

Bisphenol A (BPA) is an endocrine disrupting chemical able to promote hormone-responsive tumors. The major route of BPA contamination being oral, the aim of the present study was to investigate BPA effects on oral cells. Here, we evaluated the impact of sub-chronic in vivo exposure to BPA and its in vitro effects on neoplastic and non-neoplastic oral cells. Read More

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Environmental Temperature, but Not Male Age, Affects Wolbachia and Prophage WO Thereby Modulating Cytoplasmic Incompatibility in the Parasitoid Wasp, Habrobracon Hebetor.

Microb Ecol 2021 May 10. Epub 2021 May 10.

Department of Entomology, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran.

Wolbachia is an endosymbiotic bacterium found in many species of arthropods and manipulates its host reproduction. Cytoplasmic incompatibility (CI) is one of the most common manipulations that is induced when an uninfected female mates with a Wolbachia-infected male. The CI factors (cifA and cifB genes) are encoded by phage WO that naturally infects Wolbachia. Read More

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Cardiac tissue engineering using human stem cell-derived cardiomyocytes for disease modeling and drug discovery.

Drug Discov Today Dis Models 2012 21;9(4):e219-e227. Epub 2012 Dec 21.

Cardiovascular Research Center, Mount Sinai School of Medicine, New York, NY.

Cardiovascular disease (CVD) is the most prevalent health problem in the world, and the high mortality rate associated with irreversibly injured heart muscle motivates an urgent need for the development of novel therapies to treat damaged myocardium. Recently, human engineered cardiac tissues (hECT) have been created using cardiomyocytes derived from human embryonic stem cells and human induced pluripotent stem cells. Although a healthy adult phenotype remains elusive, such hECT display structural and functional properties that recapitulate key aspects of natural human myocardium, including dose related responses to compounds with known chronotropic, inotropic and arrhythmogenic effects. Read More

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December 2012

The Fate of Activated Group 2 Innate Lymphoid Cells.

Front Immunol 2021 22;12:671966. Epub 2021 Apr 22.

Terry Fox Laboratory, British Columbia Cancer, Vancouver, BC, Canada.

Group 2 innate lymphoid cells (ILC2s) reside in both mucosal and non-mucosal tissues and play critical roles in the first line of defense against parasites and irritants such as allergens. Upon activation by cytokines released from epithelial and stromal cells during tissue damage or stimulation, ILC2s produce copious amounts of IL-5 and IL-13, leading to type 2 inflammation. Over the past 10 years, ILC2 involvement in a variety of human diseases has been unveiled. Read More

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Effects of Real-Ambient PM Exposure on Lung Damage Modulated by Nrf2.

Front Pharmacol 2021 23;12:662664. Epub 2021 Apr 23.

School of Public Health, Qingdao University, Qingdao, China.

Previous studies have shown that long-term exposure to fine particulate matter (PM) increases the morbidity and mortality of pulmonary diseases such as asthma, chronic obstructive pulmonary disease and pulmonary emphysema. Oxidative stress and inflammation play key roles in pulmonary damage caused by PM. Nuclear factor erythroid 2-related factor 2 (Nrf2) could regulate the expression of antioxidant and anti-inflammatory genes and is pivotal for protection against PM-induced oxidative stress. Read More

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Cyclic RGD Pentapeptide Cilengitide Enhances Efficacy of Gefitinib on TGF-β1-Induced Epithelial-to-Mesenchymal Transition and Invasion in Human Non-Small Cell Lung Cancer Cells.

Front Pharmacol 2021 24;12:639095. Epub 2021 Mar 24.

Department of Medical Laboratory Science, School of Health Science, Dankook University, Cheonan, Korea.

During non-small cell lung cancer (NSCLC) progression, transforming growth factor (TGF)-β mediated epithelial-to-mesenchymal transition (EMT) is an important process leading to high mortality and poor prognosis. The EMT is a fundamental process for morphogenesis characterized by the transformation of cancer cells into invasive forms that can be transferred to other organs during human lung cancer progression. Gefitinib, an epidermal growth factor receptor (EGFR) inhibitor, has shown anti-proliferative effects in EGFR-mutated NSCLC cells and an inhibitory effect on migration and invasion of NSCLC cells to other organs. Read More

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Repurposing Nintedanib for Pathological Cardiac Remodeling and Dysfunction.

Pharmacol Res 2021 May 6:105605. Epub 2021 May 6.

Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, AL 35294-1913, USA. Electronic address:

Heart Failure (HF) is the leading cause of death worldwide. Myocardial fibrosis, one of the clinical manifestations implicated in almost every form of heart disease, contributes significantly to HF development. However, there is no approved drug specifically designed to target cardiac fibrosis. Read More

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Induction of spontaneous phenotype conversion in Ralstonia solanacearum by addition of iron compounds in liquid medium.

J Microbiol Methods 2021 May 6:106233. Epub 2021 May 6.

Graduate School of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Tsukide 3-1-100, Higashi-ku, Kumamoto 862-8502, Japan.

Ralstonia solanacearum is a soil-borne pathogen that causes bacterial wilt in plants. The wild-type strain of R. solanacearum undergoes spontaneous phenotype conversion (PC), from a fluidal to non-fluidal colony morphology. Read More

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Differentiation of human dental pulp stem cells into functional motor neuron: In vitro and ex vivo study.

Tissue Cell 2021 Apr 18;72:101542. Epub 2021 Apr 18.

ENT and Head & Neck Research Center and Department, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

There are several therapeutic options for spinal cord injury (SCI), among these strategies stem cell therapy is a potential treatment. The stem cells based therapies have been investigating in acute phase of clinical trials for promoting spinal repair in humans through replacement of functional neuronal and glial cells. The aim of this study was to evaluate the differentiation of Human Dental Pulp Stem Cells (hDPSCs) into functional motor neuron like cells (MNLCs) and promote neuroregeneration by stimulating local neurogenesis in the adult spinal cord slice culture. Read More

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Functional overlap of two major facilitator superfamily transporter, ZIF1, and ZIFL1 in zinc and iron homeostasis.

Biochem Biophys Res Commun 2021 May 5;560:7-13. Epub 2021 May 5.

Department of Biological Sciences, Dartmouth College, Hanover, NH, 03755, USA.

Zinc and iron are essential micronutrients for plant growth, and their homeostasis must be tightly regulated. Previously, it has been shown that Zinc-Induced Facilitator 1 (ZIF1) is involved in basal Zn tolerance by controlling the vacuolar storage of nicotianamine (NA). However, knowledge of the functional roles of two ZIF1 paralogs, ZIF-LIKE1 (ZIFL1) and ZIFL2, in metal homeostasis remains limited. Read More

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Cocktail strategy for 'cold' tumors therapy via active recruitment of CD8+ T cells and enhancing their function.

J Control Release 2021 May 5. Epub 2021 May 5.

College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, PR China. Electronic address:

In immunotherapy, 'cold' tumors, with low T cells infiltration, hardly benefit from the treatment of immune checkpoint inhibitors (ICIs). To address this issue, we screened two 'cold' tumor models for mice with high expression of galectin-3 (Gal-3) and designed a cocktail strategy to actively recruit CD8+ T cells into the tumor microenvironment (TME), which reversed 'cold' tumors into 'hot' and remarkably elevated their ICIs-responsiveness. Gal-3, an important driving force of tumorigenesis, inhibits T cell infiltration into tumor tissue that shapes 'cold' tumor phenotype, and promotes tumor metastasis. Read More

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Carbonyl Reductase 1 Attenuates Ischemic Brain Injury by Reducing Oxidative Stress and Neuroinflammation.

Transl Stroke Res 2021 May 8. Epub 2021 May 8.

Department of Neurology, The Second Affiliated Hospital; Key Laboratory of Cerebral Microcirculation in Universities of Shandong; Brain Science Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, Shandong, China.

Oxidative stress and neuroinflammatory response after the ischemic injury are important pathophysiologic mechanisms that cause brain tissue loss and neurological deficit. This study aims to observe the expression and role of carbonyl reductase 1 (CBR1), an NADPH-dependent oxidoreductase with specificity for carbonyl compounds such as 4-hydroxynonenal (4-HNE), in the brain after ischemic injury and to investigate the influence of CBR1 on ischemia-induced neuroinflammation. CBR1 expresses in the neurons, astrocyte, and microglia in the normal brain. Read More

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Carbon monoxide alleviates senescence in diabetic nephropathy by improving autophagy.

Cell Prolif 2021 May 7:e13052. Epub 2021 May 7.

Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Laboratory of Environment and Health and MOE Key Laboratory of Environment and Health, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, State Key Laboratory of Environment Health (Incubation), Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objectives: Senescence, characterized by permanent cycle arrest, plays an important role in diabetic nephropathy (DN). However, the mechanism of renal senescence is still unclear, and the treatment targeting it remains to be further explored.

Materials And Methods: The DN mice were induced by HFD and STZ, and 3 types of renal cells were treated with high glucose (HG) to establish in vitro model. Read More

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COVID-19 and endocrine and metabolic diseases. An updated statement from the European Society of Endocrinology.

Endocrine 2021 May 8. Epub 2021 May 8.

Institute of Endocrine and Metabolic Sciences, Vita-Salute San Raffaele University, IRCCS San Raffaele Hospital, Milano, Italy.

Background: COVID-19 has completely changed our daily clinical practice as well as our social relations. Many organs and biological systems are involved in SARS-Cov-2 infection, either due to direct virus-induced damage or to indirect effects that can have systemic consequences. Endocrine system is not only an exception but its involvement in COVID-19 is so relevant that an "endocrine phenotype" of COVID-19 has progressively acquired clinical relevance. Read More

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IL-15 mediated expansion of rare durable memory T cells following adoptive cellular therapy.

J Immunother Cancer 2021 May;9(5)

Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA, USA

Background: Synovial sarcoma (SS) and myxoid/round cell liposarcoma (MRCL) are ideal solid tumors for the development of adoptive cellular therapy (ACT) targeting NY-ESO-1, as a high frequency of tumors homogeneously express this cancer-testes antigen. Data from early phase clinical trials have shown antitumor activity after the adoptive transfer of NY-ESO-1-specific T cells. In these studies, persistence of NY-ESO-1 specific T cells is highly correlated with response to ACT, but patients often continue to have detectable transferred cells in their peripheral blood following progression. Read More

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Redd1 knockdown prevents doxorubicin-induced cardiac senescence.

Aging (Albany NY) 2021 May 6;13. Epub 2021 May 6.

Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.

Regulated in development and DNA damage response-1 (Redd1) is a stress-response gene that is transcriptionally induced by diverse stressful stimuli to influence cellular growth and survival. Although evidence suggests that aging may drive Redd1 expression in skeletal muscles, the expression patterns and functions of Redd1 in senescent cardiomyocytes remain unspecified. To address this issue, and models of cardiomyocyte senescence were established by administration of doxorubicin (Dox). Read More

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Rapid progression is associated with lymphoid follicle dysfunction in SIV-infected infant rhesus macaques.

PLoS Pathog 2021 May 7;17(5):e1009575. Epub 2021 May 7.

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America.

HIV-infected infants are at an increased risk of progressing rapidly to AIDS in the first weeks of life. Here, we evaluated immunological and virological parameters in 25 SIV-infected infant rhesus macaques to understand the factors influencing a rapid disease outcome. Infant macaques were infected with SIVmac251 and monitored for 10 to 17 weeks post-infection. Read More

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Light Promotes Neural Correlates of Fear Memory via Enhancing Brain-Derived Neurotrophic Factor (BDNF) Expression in the Prelimbic Cortex.

ACS Chem Neurosci 2021 May 7. Epub 2021 May 7.

Behavioral Neuroscience Laboratory, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550001, China.

Exposure to light has been shown to enhance vigilance and improve working memory, possibly due to changes in prefrontal function. Ample evidence supports the critical role of prefrontal cortex (PFC) in fear memory performance. However, the effects of light on memory processing and its potential mechanisms remain unclear. Read More

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Role of Exercise as a Modulating Factor in Arrhythmogenic Cardiomyopathy.

Curr Cardiol Rep 2021 May 7;23(6):57. Epub 2021 May 7.

Department of Cardiac, Thoracic, and Vascular Sciences and Public Health, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.

Purpose Of Review: The review addresses the role of exercise in triggering ventricular arrhythmias and promoting disease progression in arrhythmogenic cardiomyopathy (AC) patients and gene-mutation carriers, the differential diagnosis between AC and athlete's heart and current recommendations on exercise activity in AC.

Recent Findings: AC is an inherited heart muscle disease caused by genetically defective cell-to-cell adhesion structures (mainly desmosomes). The pathophysiological hallmark of the disease is progressive myocyte loss and replacement by fibro-fatty tissue, which creates the substrates for ventricular arrhythmias. Read More

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Hyperhaemolysis in a pregnant woman with a homozygous β -thalassemia mutation and two genetic modifiers.

Mol Genet Genomic Med 2021 May 7:e1696. Epub 2021 May 7.

Prenatal Diagnostic Center, Dongguan Maternal & Children Health Hospital, Dongguan, China.

Introduction: Patients with a homozygous β -thalassemia mutation usually have a transfusion-dependent β-thalassemia major phenotype. However, some β-thalassemia patients present with a relatively mild and even normal phenotype and always have a high level of Hb F induced by genetic modifiers.

Methods: In this study, we identified a homozygous β -thalassemia mutation (HBB: c. Read More

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Transplantation of tauroursodeoxycholic acid-inducing M2-phenotype macrophages promotes an anti-neuroinflammatory effect and functional recovery after spinal cord injury in rats.

Cell Prolif 2021 May 7:e13050. Epub 2021 May 7.

Department of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam-si, Korea.

Objectives: In this study, we study the transplantation of tauroursodeoxycholic acid (TUDCA)-induced M2-phenotype (M2) macrophages and their ability to promote anti-neuroinflammatory effects and functional recovery in a spinal cord injury (SCI) model.

Methods: To this end, compared to the granulocyte-macrophage colony-stimulating factor (GM-CSF), we evaluated whether TUDCA effectively differentiates bone marrow-derived macrophages (BMDMs) into M2 macrophages.

Results: The M2 expression markers in the TUDCA-treated BMDM group were increased more than those in the GM-CSF-treated BMDM group. Read More

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Patient-specific induced pluripotent stem cells as "disease-in-a-dish" models for inherited cardiomyopathies and channelopathies - 15 years of research.

World J Stem Cells 2021 Apr;13(4):281-303

Cell and Tissue Engineering Laboratory, Institute of Cellular Biology and Pathology "Nicolae Simionescu", Bucharest 050568, Romania.

Among inherited cardiac conditions, a special place is kept by cardiomyopathies (CMPs) and channelopathies (CNPs), which pose a substantial healthcare burden due to the complexity of the therapeutic management and cause early mortality. Like other inherited cardiac conditions, genetic CMPs and CNPs exhibit incomplete penetrance and variable expressivity even within carriers of the same pathogenic deoxyribonucleic acid variant, challenging our understanding of the underlying pathogenic mechanisms. Until recently, the lack of accurate physiological preclinical models hindered the investigation of fundamental cellular and molecular mechanisms. Read More

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DNA Hypermethylation Induced by L-Methionine Leads to Oligodendroglial and Myelin Deficits and Schizophrenia-Like Behaviors in Adolescent Mice.

Front Neurosci 2021 20;15:659853. Epub 2021 Apr 20.

Department of Histology and Embryology, Institute of Brain and Intelligence, Army Medical University (Third Military Medical University), Chongqing, China.

Increasing evidence has demonstrated that in addition to dysfunction of neuronal circuitry, oligodendroglial dysfunction and/or disruption of white matter integrity are found in the brains of patients with schizophrenia. DNA methylation, a well-established risk factor for schizophrenia, has been demonstrated to cause neuronal dysfunction; however, whether dysregulation of DNA methylation contributes to oligodendroglial/myelin deficits in the pathogenesis of schizophrenia remains unclear. In the present study, by using L-methionine-treated mice, we confirmed that mice with DNA hypermethylation exhibited an anxious phenotype, impaired sociability, and sensorimotor gating deficits. Read More

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BRAF-induced senescence drives Langerhans cell histiocytosis pathophysiology.

Nat Med 2021 May 6. Epub 2021 May 6.

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Langerhans cell histiocytosis (LCH) is a potentially fatal condition characterized by granulomatous lesions with characteristic clonal mononuclear phagocytes (MNPs) harboring activating somatic mutations in mitogen-activated protein kinase (MAPK) pathway genes, most notably BRAF. We recently discovered that the BRAF mutation can also affect multipotent hematopoietic progenitor cells (HPCs) in multisystem LCH disease. How the BRAF mutation in HPCs leads to LCH is not known. Read More

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Increased RET activity coupled with a reduction in the gene dosage causes intestinal aganglionosis in mice.

eNeuro 2021 May 6. Epub 2021 May 6.

Division for Neural Differentiation and Regeneration, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan

Mutations of the gene encoding the tyrosine kinase causes Hirschsprung disease (HSCR) and medullary thyroid carcinoma (MTC). Current consensus holds that HSCR and MTC are induced by inactivating and activating RET mutations, respectively. However, it remains unknown whether activating mutations in the gene have adverse effects on ENS development in vivo. Read More

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High endothelial venules (HEVs) in immunity, inflammation and cancer.

Angiogenesis 2021 May 6. Epub 2021 May 6.

Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.

High endothelial venules (HEVs) are specialized blood vessels mediating lymphocyte trafficking to lymph nodes (LNs) and other secondary lymphoid organs. By supporting high levels of lymphocyte extravasation from the blood, HEVs play an essential role in lymphocyte recirculation and immune surveillance for foreign invaders (bacterial and viral infections) and alterations in the body's own cells (neoantigens in cancer). The HEV network expands during inflammation in immune-stimulated LNs and is profoundly remodeled in metastatic and tumor-draining LNs. Read More

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Genome-wide Screening of Genes Associated with Momilactone B Sensitivity in the Fission Yeast.

G3 (Bethesda) 2021 May 6. Epub 2021 May 6.

Agro-Biotechnology Research Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.

Momilactone B is a natural product with dual biological activities, including antimicrobial and allelopathic properties, and play a major role in plant chemical defense against competitive plants and pathogens. The pharmacological effects of momilactone B on mammalian cells have also been reported. However, little is known about the molecular and cellular mechanisms underlying its broad bioactivity. Read More

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Polymorphisms in eicosanoid-related biosynthesis enzymes associated with acute urticaria/angioedema induced by nonsteroidal anti-inflammatory drug hypersensitivity.

Br J Dermatol 2021 May 6. Epub 2021 May 6.

Allergy Research Group, Instituto de Investigación Biomédica de Málaga-IBIMA, ARADyAL, Malaga, Spain.

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs), probably the most consumed medicines, are the main triggers of drug hypersensitivity, being NSAID-induced acute urticaria/angioedema (NIUA) the most frequent phenotype. NSAID-hypersensitivity is bred by cyclooxygenase (COX)-1 inhibition, which leads to an imbalance in prostaglandin (PG) and cysteinyl-leukotriene (CysLT) synthesis. As only susceptible individuals develop NSAID-hypersensitivity, genetic factors are believed to participate; however, no study has assessed the overall genetic variability of key enzymes in PG and CysLT synthesis in NSAID-hypersensitivity. Read More

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LILRA3 is related to monocyte-derived dendritic cell maturation and activation.

Iran J Basic Med Sci 2021 Feb;24(2):196-202

Department of Rheumatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, China.

Objectives: Previously we reported functional leukocyte immunoglobulin-like receptor A3 () leads to susceptibility and sub-phenotypes of several autoimmune diseases. LILRA3 levels in blood serum and CD14 monocytes enhanced in systemic lupus erythematosus and resulted in disease severity. However, the mechanism of LILRA3 in the pathogenesis of autoimmunity remains elusive. Read More

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February 2021

Exercise alleviates cardiac remodelling in diabetic cardiomyopathy via the miR-486a-5p-Mst1 pathway.

Iran J Basic Med Sci 2021 Feb;24(2):150-159

Department of Cardiology, Xijing Hospital, Air Force Medical University of PLA, Xi'an 710032, P.R. China.

Objectives: Physical exercise has emerged as an effective therapy to mitigate cardiac remodelling in diabetic cardiomyopathy (DCM). The results of our previous studies revealed mammalian sterile 20-like kinase 1 (Mst1) is a key regulator of the progression of DCM. However, the precise molecular mechanism of physical exercise-induced cardiac protection and its association with Mst1 inhibition remain unclear. Read More

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February 2021