243 results match your criteria phellinus linteus

Hispolon Induces Apoptosis, Suppresses Migration and Invasion of Glioblastoma Cells and Inhibits GBM Xenograft Tumor Growth In Vivo.

Molecules 2021 Jul 26;26(15). Epub 2021 Jul 26.

Department of Research, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung 427, Taiwan.

Hispolon, a polyphenol compound isolated from , has been reported to exhibit antioxidant, antiproliferative, and antitumor activities. This study aimed to explore the antitumor effects of hispolon on glioblastoma multiforme (GBM) cells in vitro and in vivo. The results revealed that hispolon significantly inhibited GBM cell proliferation and induced apoptosis through caspase-9 and caspase-3 activation and PARP cleavage. Read More

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Hispidin inhibits LPS-induced nitric oxide production in BV-2 microglial cells via ROS-dependent MAPK signaling.

Exp Ther Med 2021 Sep 7;22(3):970. Epub 2021 Jul 7.

Primate Resources Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup, Jeonbuk 56216, Republic of Korea.

Neuroinflammation is associated with many neurodegenerative diseases. Abnormal activation of microglial cells in the central nervous system (CNS) is a major characteristic of neuroinflammation. Nitric oxide (NO) free radicals are produced by activated microglia and prolonged presence of large quantities of NO in the CNS can lead to neuroinflammation and disease. Read More

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September 2021

Water Extract of Mixed Mushroom Mycelia Grown on a Solid Barley Medium Is Protective against Experimental Focal Cerebral Ischemia.

Curr Issues Mol Biol 2021 Jun 15;43(1):365-383. Epub 2021 Jun 15.

Department of Anatomy, College of Medicine, Konyang University, Daejeon 35365, Korea.

Although the individual consumption of medicinal mushrooms, including (PL), (GL), and (IO), is known to be neuroprotective, the associated mechanisms underlying their therapeutic synergism on focal cerebral ischemia (fCI) have yet to be elucidated. This study aimed to demonstrate the neuroprotective effects of mixed mushroom mycelia (MMM) against experimental fCI. The water-fractions, ethanolic-fractions, and ethyl acetate-fractions of the MMM (PL, GL, and IO) grown in a barley medium using solid-state fermentation techniques were prepared and their protective effects against glutamate-induced excitotoxicity were compared in PC-12 cells. Read More

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Purification of polysaccharides from by using an aqueous two-phase system and evaluation of the physicochemical and antioxidant properties of polysaccharides .

Prep Biochem Biotechnol 2021 May 3:1-10. Epub 2021 May 3.

School of Food & Biological Engineering, Jiangsu University, Zhenjiang, China.

In this study, polysaccharides (PLPS) and proteins were simultaneously separated from . mycelia by using an aqueous two-phase system (ATPS) based on choline chloride ([Chol]Cl)/KHPO, and the physicochemical and antioxidant properties of PLPS after ATPS extraction were evaluated. Results demonstrated that the maximal extraction efficiencies of 68. Read More

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Potential Protective Activities of Extracts of and the Altered Expressions of on Age-Related Cataract.

Evid Based Complement Alternat Med 2021 21;2021:4313805. Epub 2021 Jan 21.

Graduate Institute of Biotechnology and Biomedical Engineering, College of Health Science, Central Taiwan University of Science and Technology, No. 666 Buzih Road, Beitun District, Taichung City 40601, Taiwan.

Age-related cataract (ARC) is one of the leading causes of visual impairment and blindness worldwide among the elderly. Here, we used sodium selenite-induced cataract mouse model, which shares with similarities with human senile cataract to investigate whether the extracts of (PLE) could have the potential protective effects of ARC or not. The mice pups were randomly divided into 4 treatment groups ( = 7): (1) normal saline on postpartum day 26; (2) Na selenite injected s. Read More

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January 2021

The Antimicrobial Activities of Silver Nanoparticles Synthesized from Medicinal Mushrooms.

Int J Med Mushrooms 2020 ;22(9):869-883

Plant Research International, Wageningen University and Research, Bornsesteeg 1, 6708PD, Wageningen, The Netherlands.

Crude polysaccharide extracts derived from Agaricus bisporus (A), A. brasiliensis (B), and Phellinus linteus (P) were used for the synthesis of silver nanoparticles (AgNPs, labeled AAgNP, BAgNP, PAgNP, respectively). UV and FT-IR spectra, size distribution, and zeta potential of the respective particles were recorded, and TEM and SEM-EDS characterization was done. Read More

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Dehydroxyhispolon Methyl Ether, A Hispolon Derivative, Inhibits WNT/β-Catenin Signaling to Elicit Human Colorectal Carcinoma Cell Apoptosis.

Int J Mol Sci 2020 Nov 22;21(22). Epub 2020 Nov 22.

Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 40227, Taiwan.

Colorectal cancer (CRC) is the fourth leading cause of cancer mortality worldwide. Aberrant activation of WNT/β-catenin signaling present in the vast majority of CRC cases is indispensable for CRC initiation and progression, and thus is a promising target for CRC therapeutics. Hispolon is a fungal-derived polyphenol with a pronounced anticancer effect. Read More

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November 2020

Active ingredients and mechanisms of Phellinus linteus (grown on Rosa multiflora) for alleviation of Type 2 diabetes mellitus through network pharmacology.

Gene 2021 Feb 26;768:145320. Epub 2020 Nov 26.

Department of Bio-Health Convergence, College of Biomedical Science, Kangwon National University, Chuncheon 24341, South Korea. Electronic address:

Phellinus linteus (mushroom) grown on Rosa multiflora ([email protected]), exposed beneficial effect and safety on Type 2 diabetes mellitus (T2DM) from Korean folk remedies. However, its active chemical constituents and mechanism(s) against T2DM have not been confirmed. Hence, we deciphered the active compounds and mechanism(s) of [email protected] against T2DM through network pharmacology. Read More

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February 2021

Novel Antihypertension Mechanism of β-Glucan by Corin and ANP-Mediated Natriuresis in Mice.

Mycobiology 2020 Sep 8;48(5):399-409. Epub 2020 Sep 8.

Department of Life Science, University of Seoul, Seoul, Republic of Korea.

Many of the β-glucans are known to have antihypertensive activities, but, except for angiotensin-converting enzyme II inhibition, the underlying mechanisms remain unclear. Corin is an atrial natriuretic peptide (ANP)-converting enzyme. Activated corin cleaves pro-ANP to ANP, which regulates water-sodium balance and lowers blood pressure. Read More

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September 2020

Protective Effects of Mycelium on the Development of Osteoarthritis after Monosodium Iodoacetate Injection.

Evid Based Complement Alternat Med 2020 15;2020:7240858. Epub 2020 Aug 15.

Department of Herbology, Korean Medicine of College, Daegu Haany University, 136, Shinchendong-ro, Suseong-gu, Deagu 42158, Republic of Korea.

Objective: The aim of this study was to identify the protective effects of mycelium (PLM) and its possible mechanisms in a model of monosodium iodoacetate- (MIA-) induced osteoarthritis (OA).

Methods: Intra-articular injection of MIA was injected to 50 L with 80 mg/mL using a 0.3 mL insulin syringe into the right knee joint. Read More

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Influences of carbon and nitrogen source addition, water content, and initial pH of grain medium on hispidin production of Phellinus linteus by solid-state fermentation.

J Biosci Bioeng 2020 Dec 28;130(6):616-621. Epub 2020 Aug 28.

Department of Medicinal Botanicals and Health Applications, Da-Yeh University, Changhua 515, Taiwan; Department of Bioresources, Da-Yeh University, Changhua 515, Taiwan. Electronic address:

This study aimed to evaluate the effects of certain grain medium conditions, such as carbon and nitrogen source addition, water content, and initial pH, on the hispidin production of Phellinus linteus using solid-state fermentation. The results showed that the highest hispidin yield, specific productivity of hispidin, and total content of hispidin were associated with sucrose and malt extract addition, 55% water content, and an initial pH of 5.5, which resulted in 0. Read More

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December 2020

Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways.

Environ Res 2020 11 6;190:110017. Epub 2020 Aug 6.

The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun, 130024, China.

Nature as an infinite treasure of chemotypes and pharmacophores will continue to play an imperative role in the drug discovery. Natural products (NPs) such as plant and fungal metabolites have emerged as leads in drug discovery during recent years due to their efficacy, safety and selectivity. The current review summarizes natural sources as well as pharmacological potential of hispolon which is a major constituent of traditional medicinal mushroom Phellinus linteus. Read More

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November 2020

Extracts of , Bamboo () Leaf and Chaga Mushroom () Exhibit Antitumor Activity through Activating Innate Immunity.

Nutrients 2020 Jul 29;12(8). Epub 2020 Jul 29.

Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan.

Natural products have attracted great interest for some time as alternative methods against cancers by fulfilling immunomodulating properties. In this study, we investigated the activity of hot water extracts (120 °C, >30 min) of fresh leaves of Kumaizasa bamboo and Chaga mushroom which we called MeshimaMax, for cancer prevention and treatment by using different solid tumor models. In the implanted mouse sarcoma S180 tumor, MeshimaMax treatment significantly inhibited tumor growth when it was applied at the early stage of tumor inoculation. Read More

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Functional Cordyceps Coffee Containing Cordycepin and β-Glucan.

Hyo-Nam Song

Prev Nutr Food Sci 2020 Jun;25(2):184-193

School of Food and Nutrition Science for Bioindustry, Semyung University, Chungbuk 27136, Korea.

Cordyceps coffee, containing Cordycepin and β-glucan, was developed to improve quality and functionality of coffee. We evaluated its biological activities and quality characteristics. We treated green coffee beans with mixed extracts from three medicinal mushrooms, Cordyceps mushroom (), Phellinus mushroom (), and Chaga mushroom (). Read More

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Vasodilatory Effect of Extract in Rat Mesenteric Arteries.

Molecules 2020 Jul 10;25(14). Epub 2020 Jul 10.

Department of Physiology, College of Medicine, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University, 50 Yeonseiro, Seodaemun-gu, Seoul 03722, Korea.

is a well-known medicinal mushroom that is widely used in Asian countries. In several experimental models, extracts were reported to have various biological effects, including anti-inflammatory, anti-cancer, hepatoprotective, anti-diabetic, neuroprotective, and anti-angiogenic activity. In the present study, several bioactive compounds, including palmitic acid ethyl ester and linoleic acid, were identified in . Read More

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Elucidating the anti-melanoma effect and mechanisms of Hispolon.

Life Sci 2020 Sep 6;256:117702. Epub 2020 May 6.

Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, AL 36849. Electronic address:

There is a rapid increase in the incidence of melanoma which has led to a global crisis. Thus, there is a great need for developing novel, safe and effective drugs for the treatment of melanoma. Hispolon is a small molecular weight polyphenol derived from Phellinus linteus, which has antioxidant, anti-inflammatory and anti-proliferative activities. Read More

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September 2020

Optimized production and safety evaluation of hispidin-enriched mycelia.

Food Sci Nutr 2020 Apr 3;8(4):1864-1873. Epub 2020 Mar 3.

Biotech Research Institute Grape King Bio Ltd Taoyuan Taiwan.

, also known as the sanghuang mushroom, is a medicinal mushroom that has been recognized as beneficial to health for more thousands of years. Among its diverse valuable secondary metabolites, the yellow-brown styrylpyrone pigment hispidin has garnered significant attention due to its various pharmacological effects. However, recently after detailed morphological and molecular phylogenetic studies, the correct scientific name of the true sanghuang strains was shown not to be but . Read More

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Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials.

Appl Microbiol Biotechnol 2020 Jun 9;104(11):4675-4703. Epub 2020 Apr 9.

State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen, Guangdong, China.

This article reviews mushrooms with anti-breast cancer activity. The mushrooms covered which are better known include the following: button mushroom Agaricus bisporus, Brazilian mushroom Agaricus blazei, Amauroderma rugosum, stout camphor fungus Antrodia camphorata, Jew's ear (black) fungus or black wood ear fungus Auricularia auricula-judae, reishi mushroom or Lingzhi Ganoderma lucidum, Ganoderma sinense, maitake mushroom or sheep's head mushroom Grifola frondosa, lion's mane mushroom or monkey head mushroom Hericium erinaceum, brown beech mushroom Hypsizigus marmoreus, sulfur polypore mushroom Laetiporus sulphureus, Lentinula edodes (shiitake mushroom), Phellinus linteus (Japanese "meshimakobu," Chinese "song gen," Korean "sanghwang," American "black hoof mushroom"), abalone mushroom Pleurotus abalonus, king oyster mushroom Pleurotus eryngii, oyster mushroom Pleurotus ostreatus, tuckahoe or Fu Ling Poria cocos, and split gill mushroom Schizophyllum commune. Antineoplastic effectiveness in human clinical trials and mechanism of anticancer action have been reported for Antrodia camphorata, Cordyceps sinensis, Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, and Lentinula edodes. Read More

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Dietary Mixed Cereal Grains Ameliorate the Azoxymethane and Dextran Sodium Sulfate-Induced Colonic Carcinogenesis in C57BL/6J Mice.

J Med Food 2020 Apr 18;23(4):440-452. Epub 2020 Mar 18.

Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing, China.

The chemopreventive effects of various mixed cereal grain (MCG) samples on azoxymethane (AOM, 10 mg/kg) and dextran sulfate sodium (DSS, 0.02 g/mL)-induced colorectal cancer (CRC) in C57BL/6J mice were studied. The main MCG preparation consisted of fermented brown rice (FBR), glutinous brown rice, glutinous , glutinous , , and black soybean at an appropriate mixing ratio. Read More

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A clinical pilot study to evaluate the efficacy of oral intake of phellinus linteus (sanghuang) extract on knee joint and articular cartilage: Study protocol clinical trial (SPIRIT Compliant).

Medicine (Baltimore) 2020 Feb;99(8):e18912

Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Daejeon University.

Background: Knee osteoarthritis (KOA) is the most common form of degenerative arthritis. We used Phellinus linteus (PL), which has been well-known anti-inflammatory function. In this study, we will evaluate if PL extract improves symptoms with KOA. Read More

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February 2020

Biochemical Properties and Effects on Mitochondrial Respiration of Aqueous Extracts of Basidiomycete Mushrooms.

Cell Biochem Biophys 2020 Mar 15;78(1):111-119. Epub 2020 Feb 15.

Department of Biochemistry, State University of Maringá, Maringá, Brazil.

There are different varieties of mushrooms not yet studied spread all over the planet. The objective of this study was to evaluate biochemical properties and effects on mitochondrial respiration of eight Basidiomycete mushrooms: Flaviporus venustus EF30, Hydnopolyporus fimbriatus EF41 and EF44, Inonotus splitgerberi EF46, Oudemansiella canarii EF72, Perenniporia sp. EF79, Phellinus linteus EF81, and Pleurotus albidus EF84. Read More

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The Biofunctional Effects of Mesima as a Radiosensitizer for Hepatocellular Carcinoma.

Int J Mol Sci 2020 Jan 29;21(3). Epub 2020 Jan 29.

Department of Biochemistry, School of Medicine, Daegu Catholic University, 33, 17-gil, Duryugongwon-ro, Nam-gu, Daegu 705-718, Korea.

The tropical basidiomycete fungus Phellinus linteus (Mesima) exhibits anti-tumor, anti-angiogenic, and immunomodulatory properties in various cancers including prostate, colon, and lung cancer along with melanoma by, for example, inducing apoptosis or cell cycle arrest. However, whether medina also facilitates treatment of hepatocellular carcinoma (HCC), the third global cause of cancer deaths, remains unknown. Here, we examined its potential as a radiosensitizer in HCC radiotherapy using human HCC Hep3B and HepG2 cell lines and xenograft tumors. Read More

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January 2020

Efficacy of Phellinus linteus (sanghuang) extract for improving immune functions: Study protocol for a randomized, double-blinded, placebo-controlled pilot trial.

Medicine (Baltimore) 2020 Jan;99(3):e18829

Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Daejeon University.

Background: With the increase in the prevalence of chronic diseases, enhancing immunity has become an important challenge. Health functional foods, such as Phellitus linteus (PL), are known to improve immune function. In previous laboratory studies, it has been reported that PL has anticancer activities. Read More

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January 2020

Phellinus linteus polysaccharide extract improves insulin resistance by regulating gut microbiota composition.

FASEB J 2020 01 28;34(1):1065-1078. Epub 2019 Nov 28.

State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, P.R. China.

The hypoglycemic effect of Phellinus linteus polysaccharide extract (PLPE) has been documented in several previous studies, but the functional interactions among PLPE, gut microbiota, and the hypoglycemic effect remain unclear. We examined the regulatory effect of PLPE on gut microbiota, and the molecular mechanism underlying improvement of insulin resistance, using a type 2 diabetic rat model. Here, 24 male Sprague-Dawley rats were randomly divided into four groups that were subjected to intervention of saline (normal and model control group), metformin (120 mg/kg. Read More

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January 2020

Hispolon induces apoptosis against prostate DU145 cancer cells via modulation of mitochondrial and STAT3 pathways.

Pak J Pharm Sci 2019 Sep;32(5(Supplementary)):2237-2243

The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun, China.

Hispolon, a bioactive polyphenolic entity extracted from Phellinus linteus, possesses anticancer, antiinflammatory and anti-oxidant properties. Despite the reported therapeutic effects of this natural chemical entity, inhibitory potential of hispolon towards prostate carcinoma DU145 cells and mechanism of its action are yet to be explicated. Deregulated STAT3 pathway performs multifaceted functions in facilitating the development of cancer. Read More

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September 2019

Grown on Germinated Brown Rice Inhibits IgE-Mediated Allergic Activity through the Suppression of FcRI-Dependent Signaling Pathway and .

Evid Based Complement Alternat Med 2019 29;2019:1485015. Epub 2019 Nov 29.

Department of Food Science and Biotechnology, College of BioNano, Gachon University, 1342 Seongnan-daero, Sujeong-gu, Seongnam-si, Gyenoggi-do 461-701, Republic of Korea.

(PL) has been used as a traditional herbal medicine owing to its immune regulatory activity. Previous studies reported that PL grown on germinated brown rice (PBR) exerted immunomodulatory, anticancer, and anti-inflammatory activities. However, role of PBR on type I hypersensitive reactions has not been studied yet. Read More

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November 2019

Hepatoprotective effect of Phellinus linteus mycelia polysaccharide (PL-N1) against acetaminophen-induced liver injury in mouse.

Int J Biol Macromol 2020 Jul 20;154:1276-1284. Epub 2019 Nov 20.

Chinese-German Joint Laboratory for Natural Product Research, College of Biological Science and Engineering, Shaanxi University of Technology, East on the 1st Ring Road, Hanzhong, Shaanxi Province 723000, China; Centre of Molecular and Environmental Biology (CBMA), University of Minho, Department of Biology, Campus de Gualtar, Braga 4710-057, Portugal. Electronic address:

Edible and medicinal fungi are one of the major sources for extraction and identification of polysaccharides, which are important biological response modifiers with notable antitumor, hepatoprotective effect and other pharmacological activities. This study aimed to evaluate the hepatoprotective effect of isolated Phellinus linteus polysaccharide (PL-N1) against acetaminophen (APAP) induced liver injury in mice. Mice were treated intragastrical with PL-N1 (10, 50 and 100 mg/kg) and APAP (300 mg/kg) injection. Read More

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The protective effect of Phellinus linteus decoction on podocyte injury in the kidney of FSGS rats.

BMC Complement Altern Med 2019 Oct 21;19(1):272. Epub 2019 Oct 21.

Department of Nephrology (Key laboratory of Zhejiang province, management of kidney disease), Guang Xing Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, 310007, Tiyuchang Road 453, People's Republic of China.

Background: This study aimed to investigate the effect of the Phellinus linteus (Mesima) decoction on podocyte injury in a rat model of focal and segmental glomerulosclerosis (FSGS) and evaluate the potential mechanisms.

Methods: FSGS resembling primary FSGS in humans was established in rats by uninephrectomy and the repeated injection of doxorubicin. The FSGS rats were randomly divided into the model group, low-dose group of P. Read More

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October 2019

The Protective Effect of Hispidin against Hydrogen Peroxide-Induced Oxidative Stress in ARPE-19 Cells via Nrf2 Signaling Pathway.

Biomolecules 2019 08 19;9(8). Epub 2019 Aug 19.

Department of Research, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung 42743, Taiwan.

Hispidin, a polyphenol compound isolated from , has been reported to possess antioxidant activities. In this study, we aimed to investigate the mechanisms underlying the protective effect of hispidin against hydrogen peroxide (HO)-induced oxidative stress on Adult Retinal Pigment Epithelial cell line-19 (ARPE-19) cells. Hispidin was not cytotoxic to ARPE-19 cells at concentrations of less than 50 μM. Read More

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