1,100,982 results match your criteria phase


Hot-melt extruded copper sulfate affects the growth performance, meat quality, and copper bioavailability of broiler chickens.

Anim Biosci 2021 Jun 24. Epub 2021 Jun 24.

College of Animal Life Sciences, Kangwon National University, Chuncheon 24341, Korea.

Objective: This study was conducted to evaluate the effects of the supplementation of diets of broiler chickens with hot-melt extruded CuSO4 (HME-Cu) on their growth performance, nutrient digestibility, gut microbiota, small intestinal morphology, meat quality, and copper (Cu) bioavailability.

Methods: A total of 225 broilers (Ross 308), one-day old and initial weight 39.14 g, were weighed and distributed between 15 cages (15 birds per cage) in a completely randomized experimental design with 3 treatments (diets) and 5 replicates per treatment. Read More

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Tocilizumab for the Management of Thyroid-Associated Orbitopathy.

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

The Pacific Center for Oculofacial and Aesthetic Plastic Surgery, San Francisco, California, U.S.A. California Pacific Medical Center, San Francisco, California, U.S.A. University of California San Francisco, San Francisco, California, U.S.A.

Purpose: To describe the efficacy of tocilizumab in the treatment of a cohort of patients with active thyroid-associated orbitopathy.

Methods: Patients were identified with active thyroid-associated orbitopathy who were intolerant of or had progression of disease despite systemic corticosteroids and subsequently were treated with tocilizumab between January 2015 and December 2020. Clinical Activity Score, Thyroid-Associated Ophthalmopathy Scale score, and thyroid-stimulating immunoglobulin levels were assessed prior to initiation of tocilizumab, following the first dose, and after the completion of treatment. Read More

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Ferric Citrate Dosing in Iron Deficiency Anemia in Nondialysis-Dependent Chronic Kidney Disease.

Am J Nephrol 2021 Jul 22:1-10. Epub 2021 Jul 22.

Akebia Therapeutics, Inc., Cambridge, Massachusetts, USA.

Introduction: Ferric citrate (FC) is indicated as an oral iron replacement for iron deficiency anemia in adult patients with chronic kidney disease (CKD) not on dialysis. The recommended starting dose is one 1-g tablet three times daily (TID). This study investigated long-term efficacy and safety of different FC dosing regimens for treating anemia in nondialysis-dependent CKD (NDD-CKD). Read More

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Validation of proton dose calculation on scattercorrected 4D cone beam computed tomographyusing a porcine lung phantom.

Phys Med Biol 2021 Jul 22. Epub 2021 Jul 22.

Department of Radiation Oncology, University Hospital Munich, Munich, Bavaria, GERMANY.

Proton therapy treatment for lungs remains challenging as images enabling the detection of inter- and intra-fractional motion, which could be used for proton dose adaptation, are not readily available. 4D computed tomography (4DCT) provides high image quality but is rarely available in-room, while in-room 4D cone beam computed tomography (4DCBCT) suffers from image quality limitations stemming mostly from scatter detection. This study investigated the feasibility of using virtual 4D computed tomography (4DvCT) as a prior for a phase-per-phase scatter correction algorithm yielding a 4D scatter corrected cone beam computed tomography image (4DCBCT), which can be used for proton dose calculation. Read More

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Improvement of exhausted cerebral autoregulation in patients with idiopathic intracranial hypertension benefit of venous sinus stenting.

Physiol Meas 2021 Jul 22. Epub 2021 Jul 22.

Neurology, Beijing Tiantan Hospital, Beijing, CHINA.

Objective: Utilizing transfer function analysis to assess the cerebral autoregulation in patients with idiopathic intracranial hypertension (IIH), and to explore its improvement after venous sinus stenting.

Approach: In total, 15 consecutive IIH patients with venous sinus stenosis and 15 controls were recruited. All the patients underwent digital subtraction angiography and venous manometry. Read More

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A CMOS-compatible morphotropic phase boundary.

Nanotechnology 2021 Jul 22. Epub 2021 Jul 22.

Pohang University of Science and Technology, Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH) 77 Cheongam-Ro, Nam-Gu, Pohang, Gyungbuk, Korea, Pohang, Pohang, 37673, Korea (the Republic of).

Morphotropic phase boundaries (MPBs) show substantial piezoelectric and dielectric responses, which have practical applications. The predicted existence of MPB in HfO2-ZrO2 solid solution thin film has provided a new way to increase the dielectric properties of a silicon-compatible device. Here, we present a new fabrication design by which the density of MPB ρ_(MPB )and consequently the dielectric constant ϵr of HfO2-ZrO2 thin film was considerably increased. Read More

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Thermodynamic Anomalies in Silicon and the Relationship to the Phase Diagram.

J Phys Condens Matter 2021 Jul 22. Epub 2021 Jul 22.

Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, OXFORD, OX1 3QZ, Oxford, OX13QZ, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

The evolution of thermodynamic anomalies are investigated in the pressure-temperature (pT) plane for silicon using the well-established Stillinger-Weber potential. Anomalies are observed in the density, compressibility and heat capacity. The relationships between these anomalies and between the anomalies and the liquid stability limit are investigated and related to the known ther- modynamic constraints. Read More

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Iron-rich microstructure records of high temperature multi-component silicate melt behavior in nuclear fallout.

J Environ Radioact 2021 Jul 19;237:106700. Epub 2021 Jul 19.

Department of Nuclear Engineering, University of California, Berkeley, USA.

Above-ground nuclear explosions that interact with the surface of the earth entrain materials from the surrounding environment, influencing the resulting physical and chemical evolution of the fireball, which can affect the final chemical phase and mobility of hazardous radionuclides that are dispersed in the environment as fallout particles. The interaction of iron with a nuclear explosion is of specific interest due to the potential for iron to act as a redox buffer and because of the likelihood of significant masses of metals to be present in urban environments. We investigated fallout from a historic surface interacting nuclear explosion conducted on a steel tower and report the discovery of widespread and diverse iron-rich micro-structures preserved within the samples, including crystalline dendrites and micron-scale iron-rich spheres with liquid immiscibility textures. Read More

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A qualitative study exploring the career mindset of a group of early career academic nurses as they deployed 'Habits of Mind' to sustain their career journey.

Nurse Educ Pract 2021 Jul 14;55:103149. Epub 2021 Jul 14.

Vice-Chancellor and Principal, The Vice-Chancellor's Unit, Building 36, University of Wollongong, Australia. Electronic address:

Aim: This study aimed to explore the qualities that sustain a career mindset in a group of early career academics in one Australian university.

Background: Building an academic career is a lengthy, convoluted and complex journey requiring a mindset prepared to make informed and timely decisions. Success is predicated to a large extent on the ability of persons to process information effectively before actions are taken. Read More

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Optimizing the microstructure of a new machinable bioactive glass-ceramic.

J Mech Behav Biomed Mater 2021 Jul 13;122:104695. Epub 2021 Jul 13.

Vitreous Materials Laboratory, Materials Engineering Department, Federal University of São Carlos, São Carlos, SP, Brazil.

Objectives: This study aimed to optimize the crystallization process and the microstructure of a new bioactive glass-ceramic (GC) previously developed by our research group to obtain machinable glass-ceramics.

Methods: Differential scanning calorimetry (DSC) analyses were conducted to explore the characteristic temperatures and construct a semi-quantitative nucleation curve. The GC specimens were characterized by X-ray diffraction (XRD) and Rietveld refinement. Read More

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Structural insights in galectin-1-glycan recognition: Relevance of the glycosidic linkage and the N-acetylation pattern of sugar moieties.

Bioorg Med Chem 2021 Jul 14;44:116309. Epub 2021 Jul 14.

Laboratorio de Bioquímica, Departamento de Biociencias, Facultad de Química, UdelaR, Gral. Flores, 2124, 11800 Montevideo, Uruguay. Electronic address:

Galectins, soluble lectins widely expressed intra- and extracellularly in different cell types, play major roles in deciphering the cellular glycocode. Galectin-1 (Gal-1), a prototype member of this family, presents a carbohydrate recognition domain (CRD) with specific affinity for β-galactosides such as N-acetyllactosamine (β-d-Galp-(1 → 4)-d-GlcpNAc), and mediate numerous physiological and pathological processes. In this work, Gal-1 binding affinity for β-(1 → 6) galactosides, including β-d-Galp-(1 → 6)-β-d-GlcpNAc-(1 → 4)-d-GlcpNAc was evaluated, and their performance was compared to that of β-(1 → 4) and β-(1 → 3) galactosides. Read More

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Flow inside a bone scaffold: Visualization using 3D phase contrast MRI and comparison with numerical simulations.

J Biomech 2021 Jul 12;126:110625. Epub 2021 Jul 12.

Department of Mechanical and Industrial Engineering, University of Massachusetts, Amherst, MA, USA. Electronic address:

We report on results of experimental flow measurements inside a bone scaffold model, subjected to a uniform incoming flow (applied perfusion). Understanding the flow behavior inside a tissue engineered scaffold is essential for mechanistic studies of mechanobiology, particularly flow-sensitive bone cells. Nearly all existing studies that quantify interstitial flow inside engineered bone scaffolds have been based on numerical results, in part due to the difficulties associated with quantitative measurements and visualization of flow inside large, opaque bone or bone mimics. Read More

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Onion component, isoalliin, stimulates feeding and activates the arcuate nucleus neuropeptide Y, ghrelin- and Ninjin'yoeito-responsive neurons.

Neuropeptides 2021 Jul 10;89:102180. Epub 2021 Jul 10.

Center for Integrative Physiology, Division of Integrative Physiology, Kansai Electric Power Medical Research Institute, 1-5-6 Minatojimaminamimachi, Chuou-ku, Kobe 650-0047, Japan; Division of Diabetes, Metabolism and Endocrinology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-Cho, Chuo-Ku, Kobe 650-0017, Japan; Pharmacological Department of Herbal Medicine, Kagoshima University Graduate School of Medical & Dental Sciences, Kagoshima 890-8544, Japan. Electronic address:

Appetite loss or anorexia substantially decreases the quality of life in patients with cancer, depression and gastrointestinal disorders, and can lead to sarcopenia and frailty. Foods that restore appetite have been sought-for but are not currently available. Historically, onion intake was adopted to treat a variety of diseases with reduced appetite including cancer and gastrointestinal disturbances. Read More

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Ant colony optimization with Cauchy and greedy Levy mutations for multilevel COVID 19 X-ray image segmentation.

Comput Biol Med 2021 Jul 3;136:104609. Epub 2021 Jul 3.

Department of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; Key Laboratory of IntelligentTreatment and Life Support for Critical Diseases of Zhejiang Provincial, Wenzhou, China; Wenzhou Key Laboratory of Critical Care and Artificial Intelligence, Wenzhou, China. Electronic address:

This paper focuses on the study of multilevel COVID-19 X-ray image segmentation based on swarm intelligence optimization to improve the diagnostic level of COVID-19. We present a new ant colony optimization with the Cauchy mutation and the greedy Levy mutation, termed CLACO, for continuous domains. Specifically, the Cauchy mutation is applied to the end phase of ant foraging in CLACO to enhance its searchability and to boost its convergence rate. Read More

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Precipitation and transformation of σ phase in a selective laser melted high-chromium superalloy subjected to heat treatment.

Micron 2021 Jul 15;149:103113. Epub 2021 Jul 15.

State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, PR China.

A commercial high-chromium contained GH648 superalloy was fabricated by selective laser melting (SLM), followed by solution treatment at 1140 °C for 1 h and subsequent aging treatment at 900 °C for 16 h. The precipitation and transformation of σ phase has been characterized. It has been shown that σ precipitates formed after solution treatment, attributed to the segregation of Mo element in the subgrain boundaries and also the difference between the diffusion ability of subgrain boundaries and lattice. Read More

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An in vitro assessment for human skin exposure to parabens using magnetic solid phase extraction coupled with HPLC.

Chemosphere 2021 Jul 17;286(Pt 1):131593. Epub 2021 Jul 17.

State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan, 430074, China. Electronic address:

Skin contact was a significant source of human exposure to parabens during the use of personal care products. In this study, a novel and simple in vitro evaluation method for human skin exposure to parabens was established for the first time. Firstly, magnetic porous carbon (MPC) derived from discarded cigarette butts was prepared as an adsorbent of magnetic solid-phase extraction (MSPE), which provided a fast and efficient sample preparation method with satisfactory extraction performance for parabens in cosmetics and was easy to couple with high performance liquid chromatography. Read More

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Methylcellulose/tannic acid complex particles coated on alginate hydrogel scaffold via Pickering for removal of methylene blue from aqueous and quinoline from non-aqueous media.

Chemosphere 2021 Jul 17;286(Pt 1):131597. Epub 2021 Jul 17.

Department of Energy Science and Technology, Environmental Waste Recycle Institute, Myongji University, Yongin, Gyeonggi-do 17058, Republic of Korea. Electronic address:

Adsorbents reported for liquid phase decontamination under both aqueous and non-aqueous media are all dispersed phase sorbents that further require a tedious separation step post adsorption. Herein, a monolith, highly porous, and mechanically robust scaffold was synthesized for the adsorption of pollutants from both aqueous and non-aqueous media with facile separation and regeneration. Methylcellulose-tannic acid complex particles were prepared and systematically decorated on the surface of interpenetrating polymer network (IPN) scaffold via Pickering emulsion. Read More

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Effects of various alcohol sacrificial agents on hydrogen evolution based on [email protected] nanomaterials and its mechanism.

Chemosphere 2021 Jul 13;286(Pt 1):131558. Epub 2021 Jul 13.

College of Water Sciences, Beijing Normal University, Beijing, 100875, PR China. Electronic address:

Visible light induced photocatalysis converted solar energy to chemical energy in the form of hydrogen. g-CN modified by thermal oxidation etching, doped S, and nonprecious metal cocatalyst CoS ([email protected]) were used for photocatalytic hydrogen production. And then the charge transfer behavior and mechanism of various alcohol sacrificial agents on hydrogen evolution was analyzed by optical characterization, impedance analysis, Mott-Schottky, and photocurrent tests. Read More

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Safflomin A: A novel chemical marker for Carthamus tinctorius L. (Safflower) monofloral honey.

Food Chem 2021 Jul 13;366:130584. Epub 2021 Jul 13.

Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, China. Electronic address:

Monofloral safflower honey (MSH), produced from nectar of the medicinal Carthamus tinctorius L., has been shown with excellent nutritional value and biological activity. However, current MSH authenticity verification is insufficient. Read More

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Porous carbon nanotube microspheres with tailorable surface wettability areas for oil adsorption.

J Colloid Interface Sci 2021 Jul 15;604:737-745. Epub 2021 Jul 15.

Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, No.8 South 3rd Street Zhongguancun, Beijing 100190, China; School of Physical Sciences, University of Chinese Academy of Sciences, No.1 Yanqihu East Road, Huairou District, Beijing 100049, China; Wenzhou Institute, University of Chinese Academy of Sciences, No.1 Jianlian Road, Longwan District, Wenzhou, Zhejiang 325001, China; Songshan Lake Materials Laboratory, Songshan Lake Scenic Area, Dongguan, Guangdong 523808, China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), No.1 Jianlian Road, Longwan District, Wenzhou, Zhejiang 325001, China. Electronic address:

Hypothesis: Oil adsorption is significant for water purification and environmental protection. However, the conventional bulk sorbents face the predicament of uncontrollable motion as well as hydrophobic nature the whole body, which largely restricts their uptake capacity underwater. Hence, novel adsorbent material for high-efficient oil uptake both at the surface and under the water is urgently required. Read More

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Closed form approximations to predict retention times and peak widths in gradient elution under conditions of sample volume overload and sample solvent mismatch.

J Chromatogr A 2021 Jul 1;1653:462376. Epub 2021 Jul 1.

Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, PA, 15260, USA.

Closed form expressions for the prediction of retention times and peak widths for gradient liquid chromatography are particularly useful in understanding, rationalizing and optimizing separations. These expressions are obtained by integrating differential equations, in conjunction with a model of the variation of the retention factor as a function of mobile phase composition. Two of these models, the linear solvent strength (LSS) model and the Neue-Kuss (NK) model are explored in the present work. Read More

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Biomechanical evaluation of syndesmotic fixation techniques via finite element analysis: Screw vs. suture button.

Comput Methods Programs Biomed 2021 Jul 13;208:106272. Epub 2021 Jul 13.

M2BE-Multiscale in Mechanical and Biological Engineering, Instituto de Investigación en Ingeniería de Aragón (I3A), Aragón Institute of Health Science (IACS), Universidad de Zaragoza, Campus Río Ebro, c/María de Luna s/n, 50018-Zaragoza, España, Spain. Electronic address:

Background And Objective: Tibiofibular syndesmotic injuries may cause degenerative changes, reduction in ankle function and compromising ankle stability. Different fixation techniques try to restore its functionality. Screw-fixation is the gold-standard. Read More

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Combining tumor deposits with the number of lymph node metastases to improve the prognostic accuracy in stage III colon cancer: a post hoc analysis of the CALGB/SWOG 80702 phase III study (Alliance).

Ann Oncol 2021 Jul 19. Epub 2021 Jul 19.

Department of Medical Oncology, Dana-Farber/Partners Cancer Care, Boston, MA, USA.

Background: In colon cancer, tumor deposits (TD) are considered in assigning prognosis and staging only in the absence of lymph node metastasis (i.e., stage III pN1c tumors). Read More

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Pembrolizumab for locally advanced and recurrent/metastatic cutaneous squamous cell carcinoma (KEYNOTE-629 Study): an open-label, nonrandomized, multicenter, phase 2 trial.

Ann Oncol 2021 Jul 19. Epub 2021 Jul 19.

Service de Dermatologie et Cancérologie Cutanée, Aix-Marseille University, Marseille, France.

Background: Pembrolizumab demonstrated clinically meaningful and durable antitumor activity with a manageable safety profile in recurrent/metastatic (R/M) cutaneous squamous cell carcinoma (cSCC).

Patients And Methods: KEYNOTE-629 was a global, open-label, nonrandomized, phase 2 trial of patients with locally advanced (LA) or R/M cSCC conducted at 59 centers. Eligible patients received intravenous pembrolizumab 200 mg every three weeks for up to 35 cycles. Read More

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Sinusoidal analysis reveals a non-linear and dopamine-dependent relationship between ambient illumination and motor activity in larval zebrafish.

Neurosci Lett 2021 Jul 19:136121. Epub 2021 Jul 19.

Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA; Geriatric Research Education and Clinical Center, Pittsburgh VA Healthcare System, Pittsburgh, PA, USA. Electronic address:

Larval zebrafish show stereotyped motor responses to changes in ambient illumination. The responses can be evaluated in 96-well plates, and are used widely to assess neurological function in zebrafish models. However, the square-wave (on/off) light stimuli commonly employed in these studies do not allow analysis of the relationship between motor activity and illumination intensity or its rate of change. Read More

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Liquid-liquid phase separation as a common organizing principle of intracellular space and biomembranes providing dynamic adaptive responses.

Biochim Biophys Acta Mol Cell Res 2021 Jul 19:119102. Epub 2021 Jul 19.

Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Institutskiy pereulok, 9, Dolgoprudny, 141700, Russia; Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC07, Tampa, FL 33612, USA. Electronic address:

This work is devoted to the phenomenon of liquid-liquid phase separation (LLPS), which has come to be recognized as fundamental organizing principle of living cells. We distinguish separation processes with different dimensions. Well-known 3D-condensation occurs in aqueous solution and leads to membraneless organelle (MLOs) formation. Read More

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Efficacy and safety of once-weekly semaglutide 2·0 mg versus 1·0 mg in patients with type 2 diabetes (SUSTAIN FORTE): a double-blind, randomised, phase 3B trial.

Lancet Diabetes Endocrinol 2021 Jul 19. Epub 2021 Jul 19.

Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

Background: Semaglutide is an effective treatment for type 2 diabetes; however, 20-30% of patients given semaglutide 1·0 mg do not reach glycaemic treatment goals. We aimed to investigate the efficacy and safety of once-weekly semaglutide 2·0 mg versus 1·0 mg in adults with inadequately controlled type 2 diabetes on a stable dose of metformin with or without a sulfonylurea.

Methods: We did a 40-week, randomised, active-controlled, parallel-group, double-blind, phase 3B trial (SUSTAIN FORTE) at 125 outpatient clinics in ten countries. Read More

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Inhaled corticosteroid prescriptions in the ED for recurrent asthma using IT clinical decision support: Revisit after cessation of an incentive program.

J Asthma 2021 Jul 22:1-9. Epub 2021 Jul 22.

Statistics Department, Phoenix Children's Hospital, Phoenix, AZ, USA.

The objective of this study was to assess whether inhaled corticosteroid (ICS) prescription rates for patients with poorly controlled asthma presenting to the emergency department (ED) remained high with a clinical support system in place, after a financial incentive program ended. This study is the second phase of a previous study done at our institution. The first phase demonstrated that the introduction of an electronic alert system advising providers to prescribe ICS to patients with poorly controlled asthma, along with a financial incentive, increased ICS prescription rates from 2% to 77%. Read More

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Phase Analysis of Australian Uranium Ore Concentrates Determined by Variable Temperature Synchrotron Powder X-ray Diffraction.

Inorg Chem 2021 Jul 22. Epub 2021 Jul 22.

College of Science and Engineering, Flinders University, Adelaide, South Australia 5001, Australia.

The chemical speciation of uranium oxides is sensitive to the provenance of the samples and their storage conditions. Here, we use diffraction methods to characterize the phases found in three aged (>10 years) uranium ore concentrates of different origins as well as in situ analysis of the thermally induced structural transitions of these materials. The structures of the crystalline phases found in the three samples have been refined, using high-resolution synchrotron X-ray diffraction data. Read More

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Moral distress in frontline healthcare workers in the initial epicenter of the COVID-19 pandemic in the United States: Relationship to PTSD symptoms, burnout, and psychosocial functioning.

Depress Anxiety 2021 Jul 22. Epub 2021 Jul 22.

Executive Division, U.S. Department of Veterans Affairs National Center for PTSD, Wasington, D.C., USA.

Introduction: Little is known about the relationship between moral distress and mental health problems. We examined moral distress in 2579 frontline healthcare workers (FHCWs) caring for coronavirus disease 2019 (COVID-19) patients during the height of the spring 2020 pandemic surge in New York City. The goals of the study were to identify common dimensions of COVID-19 moral distress; and to examine the relationship between moral distress, and positive screen for COVID-19-related posttraumatic stress disorder (PTSD) symptoms, burnout, and work and interpersonal functional difficulties. Read More

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