Eur J Anaesthesiol 2021 Sep 15. Epub 2021 Sep 15.
From the Department of Peri-operative Services, Intensive Care and Pain Medicine, Turku University Hospital (AJN, LTL, TTL, REK, JMS, KJV, HS), Department of Internal Medicine, Turku University Hospital, Turku (AJN), Turku PET Centre, University of Turku and Turku University Hospital (LTL, HS), Department of Psychology and Speech-Language Pathology and Turku Brain and Mind Center, University of Turku, Turku (REK, KJV, AR), Department of Intensive Care, Tampere University Hospital, Tampere (JWL), Department of Clinical Medicine, Biostatistics, University of Turku and Turku University Hospital, Turku (TJV), Nightingale Health Ltd, Helsinki, Finland (HTK, VA), Department of Cognitive Neuroscience and Philosophy, School of Bioscience, University of Skövde, Skövde, Sweden (KJV, AR), Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital (MN), Individualized Drug Therapy Research Program, Faculty of Medicine, University of Helsinki (MN), Finnish Institute for Health and Welfare (MP), Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki (MP), and Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland (HS).
Background: Pharmacometabolomics uses large-scale data capturing methods to uncover drug-induced shifts in the metabolic profile. The specific effects of anaesthetics on the human metabolome are largely unknown.
Objective: We aimed to discover whether exposure to routinely used anaesthetics have an acute effect on the human metabolic profile. Read More