87,889 results match your criteria pharmaceutical industries


Sydney's 'last drinks' laws: A content analysis of news media coverage of views and arguments about a preventive health policy.

Drug Alcohol Rev 2021 Sep 22. Epub 2021 Sep 22.

Prevention Research Collaboration, School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Introduction: News media representation of preventive health policies can influence public discussion and political decision making, impacting policy implementation and sustainability. This study analysed news media coverage of the contested 'last drinks' alcohol laws in Sydney, Australia, to understand the arguments made by different 'actors' (stakeholders) regarding the laws and provide insights on how preventive health policies are positioned within media discourse.

Methods: We identified print and online news media articles discussing the laws from 2014 to 2020. Read More

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September 2021

Impeding Virulence of Candida albicans by Candesartan and Domperidone.

Curr Microbiol 2021 Sep 22. Epub 2021 Sep 22.

Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt.

Candida albicans is the most common human fungal pathogen that has developed extensive virulence factors which allows successful colonization and infection of the host. Anti-virulence agents can alleviate the pathogenesis of fungi and help the immune system to eradicate them easily. This study aimed to explore the anti-virulence effect of domperidone and candesartan against C. Read More

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September 2021

Genome analysis of the salt-resistant Paludifilum halophilum DSM 102817 reveals genes involved in flux-tuning of ectoines and unexplored bioactive secondary metabolites.

World J Microbiol Biotechnol 2021 Sep 22;37(10):178. Epub 2021 Sep 22.

Laboratoire de Biodiversité Marine et Environnement (LR18ES30), Faculté des Sciences de Sfax, Université de Sfax, BP 1171, 3000, Sfax, Tunisia.

Paludifilum halophilum DSM 102817 is the first member of the genus Paludifilum in the Thermoactinomycetaceae family. The thermohalophilic bacterium was isolated from the solar saltern of Sfax, Tunisia and was shown to be able to produce ectoines with a relatively high-yield and to cope with salt stress conditions. In this study, the whole genome of P. Read More

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September 2021

Engineering robust microorganisms for organic acid production.

J Ind Microbiol Biotechnol 2021 Sep 21. Epub 2021 Sep 21.

Department of Chemical and Biomolecular Engineering, U.S. Department of Energy Center for Bioenergy and Bioproducts Innovation (CABBI), Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States.

Organic acids are an important class of compounds that can be produced by microbial conversion of renewable feedstocks and have huge demands and broad applications in food, chemical, and pharmaceutical industries. An economically viable fermentation process for production of organic acids requires robust microbial cell factories with excellent tolerance to low pH conditions, high concentrations of organic acids, and lignocellulosic inhibitors. In this review, we summarize various strategies to engineer robust microorganisms for organic acid production and highlight their applications in a few recent examples. Read More

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September 2021

Paving New Roads Towards Biodiversity-Based Drug Development in Brazil: Lessons from the Past and Future Perspectives.

Rev Bras Farmacogn 2021 Sep 17:1-14. Epub 2021 Sep 17.

Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, Campus Pampulha, CEP 31.270-901, MG Belo Horizonte, Brazil.

Although Brazil gathers two fundamental features to occupy a leading position on the development of biodiversity-based medicines, the largest flora on earth and a broad tradition on the use of medicinal plants, the number of products derived from the national genetic heritage is so far modest, either as single drugs or as herbal medicines. This article highlights some aspects that may have contributed to the low rates of success and proposes new insights for innovation. We initially approach the use of medicinal plants in Brazil, molded by its ethnic diversity, and the development of the local pharmaceutical industry. Read More

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September 2021

Electrochemical degradation of a methyl paraben and propylene glycol mixture: Interference effect of competitive oxidation and pH stability.

Chemosphere 2021 Sep 15;287(Pt 3):132229. Epub 2021 Sep 15.

São Carlos Institute of Chemistry, University of São Paulo, P.O. Box 780, CEP 13560-970, São Carlos, SP, Brazil. Electronic address:

Endocrine disrupting compounds (EDCs) are one of the many classes of harmful pollutants frequently found in water resources. Even at low concentrations, EDCs might accumulate in the organisms and interfere on numerous processes controlled by hormones. Parabens, for example, are preservatives widely used in pharmaceutical and cosmetic industries, but several studies related them to human breast cancer. Read More

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September 2021

Enantioselective Reductive Oligomerization of Carbon Dioxide into l-Erythrulose via a Chemoenzymatic Catalysis.

J Am Chem Soc 2021 Sep 21. Epub 2021 Sep 21.

LCC-CNRS, Université de Toulouse, CNRS, F-31077 Toulouse Cedex 4, France.

A cell-free enantioselective transformation of the carbon atom of CO has never been reported. In the urgent context of transforming CO into products of high value, the enantiocontrolled synthesis of chiral compounds from CO would be highly desirable. Using an original hybrid chemoenzymatic catalytic process, we report herein the reductive oligomerization of CO into C (dihydroxyacetone, DHA) and C (l-erythrulose) carbohydrates, with perfect enantioselectivity of the latter chiral product. Read More

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September 2021

Transcriptomic and Metabolomic Analyses Provide Insights into the Enhancement of Torulene and Torularhodin Production in ZHK under Moderate Salt Conditions.

J Agric Food Chem 2021 Sep 21. Epub 2021 Sep 21.

Innovative Institute for Plant Health, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, People's Republic of China.

Carotenoids are a group of tetraterpene pigments widely used in the food, pharmaceutical, and cosmetic industries. Torulene, torularhodin, and β-carotene, three principal carotenoids synthesized by ZHK, possess strong health-promoting properties such as antioxidant, provitamin A, and antitumor. Here, the effect of different salt conditions on carotenoids production of ZHK was investigated. Read More

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September 2021

A new approach to produce IgG-like bispecific antibodies.

Sci Rep 2021 Sep 20;11(1):18630. Epub 2021 Sep 20.

China State Institute of Pharmaceutical Industry, Shanghai, 201203, China.

While achieving rapid developments in recent years, bispecific antibodies are still difficult to design and manufacture, due to mispair of both heavy and light chains. Here we report a novel technology to make bispecific molecules. The knob-into-hole method was used to pair two distinct heavy chains as a heterodimer. Read More

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September 2021

Clinical researchers' lived experiences with data quality monitoring in clinical trials: a qualitative study.

BMC Med Res Methodol 2021 Sep 20;21(1):187. Epub 2021 Sep 20.

School of Medicine, Faculty of Science, Medicine and Health, University of Wollongong, Northfields Ave, Wollongong, NSW, 2522, Australia.

Background: Fundamental to the success of clinical research that involves human participants is the quality of the data that is generated. To ensure data quality, clinical trials must comply with the Good Clinical Practice guideline which recommends data monitoring. To date, the guideline is broad, requires technology for enforcement, follows strict industry standards, mostly designed for drug-registration trials and based on informal consensus. Read More

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September 2021

Small footprint liquid chromatography-mass spectrometry for pharmaceutical reaction monitoring and automated process analysis.

J Chromatogr A 2021 Sep 10;1656:462545. Epub 2021 Sep 10.

ARC Training Centre for Portable Analytical Separation Technologies (ASTech), School of Natural Sciences, University of Tasmania, Private Bag 75, Hobart, Tasmania 7001, Australia; Australian Centre for Research on Separation Science (ACROSS), School of Natural Sciences, University of Tasmania, Private Bag 75, Hobart, Tasmania 7001, Australia. Electronic address:

Liquid chromatography (LC) has broad applicability in the pharmaceutical industry, from the early stages of drug discovery to reaction monitoring and process control. However, small footprint, truly portable LC systems have not yet been demonstrated and fully evaluated practically for on-line, in-line or at-line pharmaceutical analysis. Herein, a portable, briefcase-sized capillary LC fitted with a miniature multi-deep UV-LED detector has been developed and interfaced with a portable mass spectrometer for on-site pharmaceutical analysis. Read More

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September 2021

[Development and validation of a course concept for Tactical Medical Mining Rescue : Standardized training curriculum for mine rescue teams].

Med Klin Intensivmed Notfmed 2021 Sep 20. Epub 2021 Sep 20.

Sächsisches Oberbergamt, Freiberg, Deutschland.

Background: Structural changes in modern mining industry increase the potential for medical emergencies. Furthermore, rescue times in mining are prolonged and public medical resources are not consistently available.

Objectives: We sought to train mine rescue brigade lay people to cover medical emergencies in mining. Read More

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September 2021

Seasonal variation on the major bioactive compounds: total phenolic and flavonoids contents, and antioxidant activity of rosemary from shiraz.

Nat Prod Res 2021 Sep 20:1-6. Epub 2021 Sep 20.

Department of food science and technology, Yasooj Branch, Islamic Azad University, Yasooj, Iran.

The rich bioactive compounds of medicinal rosemary, as well as their antioxidant activity has led to its wider application in the pharmaceutical, cosmetic and food industries. In the present work, seasonal variations of phenolic, flavonoid content and antioxidant activity were evaluated. This experiment was performed based on a complete randomised design with three replications. Read More

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September 2021

Mapping the scientific knowledge of antimicrobial resistance in food-producing animals.

One Health 2021 Dec 9;13:100324. Epub 2021 Sep 9.

Departamento de Biologia & CESAM, Universidade de Aveiro, Campus de Santiago, 3810-193, Aveiro, Portugal.

Antimicrobial resistance (AMR) can be highlighted as one of the most significant health concerns among the last decades, for which antimicrobial drug use in food-producing animals has contributed as one of the major drivers. Food-producing animals are one of the most important and rapidly expanding commercial agricultural sectors worldwide but there is currently limited knowledge on the temporal and geographical distribution of scientific research on antimicrobial resistance in food-producing animals. We provide a global overview of the spatial and temporal trends of scientific knowledge on AMR in food-producing animals. Read More

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December 2021

A Review on Extraction, Characterization, and Applications of Bioactive Peptides From Pressed Black Cumin Seed Cake.

Front Nutr 2021 1;8:743909. Epub 2021 Sep 1.

State Key Laboratory of Biobased Material and Green Papermaking, College of Food Science and Engineering, Shandong Academy of Science, Qilu University of Technology, Jinan, China.

Plenty of black cumin cake was generated as a natural waste material after pressing the oil. (black cumin) seeds and cakes are of precious nutritional value as they contain proteins, phenolics, essential amino acids, and bioactive compounds. Owing to their antioxidant properties, scientists and food manufacturers have extensively developed them. Read More

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September 2021

Activity of the Novel Copper Product HA + Cu(II) Based on a Biocompatible Drug Delivery System on Vine Physiology and Trials for the Control of Botryosphaeria Dieback.

Front Plant Sci 2021 3;12:693995. Epub 2021 Sep 3.

Université de Reims Champagne-Ardenne, Unité Résistance Induite et Bioprotection des Plantes RIBP EA 4707, USC INRAE 1488, SFR Condorcet CNRS 3417, BP1039, Reims, France.

The growing concerns on human and environment health are forcing the plant protection industry toward the formulation of more eco-sustainable plant protection products (PPP), both efficient and innovative in their approach to disease control. A large number of these innovative formulations now rely on a combination of pathogens antagonistic properties and stimulation of natural plant defense to pathogens. The formulation HA + Cu(II), in which copper is delivered to the plants by the drug-delivery molecule hydroxyapatite (HA), was found efficient against the grapevine pathogens and and able to induce the host-plant defense system. Read More

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September 2021

The Binary Model of Chronic Diseases Applied to COVID-19.

Authors:
Zeev Elkoshi

Front Immunol 2021;12:716084. Epub 2021 Sep 3.

Research and Development Department, Taro Pharmaceutical Industries Ltd, Haifa, Israel.

A binary model for the classification of chronic diseases has formerly been proposed. The model classifies chronic diseases as "high Treg" or "low Treg" diseases according to the extent of regulatory T cells (Treg) activity (frequency or function) observed. The present paper applies this model to severe acute respiratory syndrome coronavirus 2 (SARSCoV2) infection. Read More

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September 2021

Genome-wide detection and classification of terpene synthase genes in .

Physiol Mol Biol Plants 2021 Aug 5;27(8):1711-1729. Epub 2021 Aug 5.

Department of Bioengineering and Technology, Gauhati University, Guwahati, Assam 781014 India.

Agarwood, one of the precious woods in the globe, is produced by Aquilaria plant species during an upshot of wounding and infection. Produced as a defence response, the dark, fragrant resin gets secreted in the plant's duramen, which is impregnated with fragrant molecules with the due course. Agarwood has gained worldwide popularity due to its high aromatic oil, fragrance, and pharmaceutical value, which makes it highly solicited by numerous industries. Read More

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RAMPART: A model for a regulatory-ready academic-led phase III trial in the adjuvant renal cell carcinoma setting.

Contemp Clin Trials 2021 Sep 16;108:106481. Epub 2021 Sep 16.

MRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, 2nd Floor 90 High Holborn, London WC1V 6LJ.

The development of therapeutics in oncology is a highly active research area for the pharmaceutical and biotechnology industries, but also has a strong academic base. Many new agents have been developed in recent years, most with specific biological targets. This has mandated the need to look at different ways to streamline the evaluation of new agents. Read More

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September 2021

SWiVIA - Sliding window variographic image analysis for real-time assessment of heterogeneity indices in blending processes monitored with hyperspectral imaging.

Anal Chim Acta 2021 Oct 16;1180:338852. Epub 2021 Jul 16.

Chemometrics Group, Department of Chemical Engineering and Analytical Chemistry, Universitat de Barcelona, Diagonal 645, 08028, Barcelona, Spain. Electronic address:

Controlling blending processes of solid material using advanced real-time sensing technologies tools is crucial to guarantee the quality attributes of manufactured products from diverse industries. The use of process analytical technology (PAT) tools based on chemical imaging systems are useful to assess heterogeneity information during mixing processes. Recently, a powerful procedure for heterogeneity assessment based on the combination of off-line acquired chemical images and variographic analysis has been proposed to provide specific heterogeneity indices related to global and distributional heterogeneity. Read More

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October 2021

Recyclable europium functionalized metal-organic fluorescent probe for detection of tryptophan in biological fluids and food products.

Anal Chim Acta 2021 Oct 31;1180:338897. Epub 2021 Jul 31.

Institute of Functional Materials and Agricultural Applied Chemistry, Jiangxi Agricultural University, Nanchang, 330045, PR China. Electronic address:

An europium functionalized metal-organic fluorescent probe, [email protected] was constructed by post-synthetic modification through coordination interactions. [email protected] displayed high selectivity and sensitivity toward Tryptophan (Trp) among all the 20 natural amino acids and other general compounds in food and biological samples, with a wide linear concentration range (0-1000 μM), low detection limit (0.29 μM), and a rapid response (<1 min). Read More

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October 2021

International Dermatology Outcome Measures (IDEOM): Report from the 2020 Annual Meeting.

Dermatology 2021 Sep 17:1-8. Epub 2021 Sep 17.

Department of Dermatology, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Background: The International Dermatology Outcome Measures (IDEOM) initiative is a non-profit organization that aims to develop evidence-based outcome measurements to evaluate the impact of treatments for patients with dermatological disease. IDEOM includes all key stakeholders in dermatology (patient, physician, industry, insurer, and government) during the process of developing such outcome measurements.

Summary: Here, we provide an update of IDEOM activities that were presented at the 2020 IDEOM Virtual Annual Meeting (October 23-24, 2020). Read More

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September 2021

Towards Pharma 4.0 in clinical trials: a future-orientated perspective.

Drug Discov Today 2021 Sep 16. Epub 2021 Sep 16.

Centre for Pharmaceutical Engineering Science, University of Bradford, Bradford, UK.

Pharma 4.0, a technology ecosystem in drug development analogous to Industry 4.0 in healthcare, is transforming the traditional approach to drug discovery and development, aligning product quality with less time to market, and creating intelligent stakeholder networks through effective collaborations. Read More

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September 2021

Oxygen vacancy-rich N-doped carbon encapsulated BiOCl-CNTs heterostructures as robust electrocatalyst synergistically promote oxygen reduction and Zn-air batteries.

J Colloid Interface Sci 2021 Sep 2;607(Pt 1):826-835. Epub 2021 Sep 2.

Guangxi Key Laboratory of Low Carbon Energy Materials, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China. Electronic address:

The development of non-precious metal catalysts for oxygen reduction reactions (ORR) is vital for promising clean energy technologies such as fuel cells, and zinc-air batteries. Herein, we present a stepwise synthesis of N-doped and carbon encapsulated BiOCl-CNTs heterostructures. Electrocatalytic ORR studies show that the optimized catalyst has a high half-wave potential (E) of 0. Read More

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September 2021

When microbial electrochemistry meets UV: The applicability to high-strength real pharmaceutical industry wastewater.

J Hazard Mater 2021 Sep 9;423(Pt B):127151. Epub 2021 Sep 9.

Department of Environmental Engineering, Technical University of Denmark, DK-2800 Lyngby, Denmark. Electronic address:

Wastewater from pharmaceutical and related industries contains many residual pharmaceutical components rich in color and high COD contents, which cannot be removed through the traditional wastewater treatment processes. Recently, microbial electrolysis ultraviolet cell (MEUC) process has shown its promising potential to remove recalcitrant organics because of its merits of wide pH range, iron-free, and without complications of iron sludge production. However, its application to the real pharmaceutical-rich industrial wastewater is still unknown. Read More

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September 2021

Discovery of potent and selective Bcl-2 inhibitors with acyl sulfonamide skeleton.

Bioorg Med Chem 2021 Aug 8;47:116350. Epub 2021 Aug 8.

State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 201203 Shanghai, China. Electronic address:

The antiapoptotic protein B-cell lymphoma 2 (Bcl-2), overexpressed in many tumor cells, is an attractive target for potential small molecule anticancer drug discovery. Herein, a series of novel derivatives with acyl sulfonamide skeleton was designed, synthesized, and evaluated as Bcl-2 inhibitors by means of bioisosteric replacement. Among them, compound 24g demonstrated equal efficient inhibition activity against RS4;11 cell line compared to positive control ABT-199. Read More

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Recent advancements in modification of membrane materials over membrane separation for biomedical applications.

Environ Res 2021 Sep 15:112045. Epub 2021 Sep 15.

Advanced Membrane Technology Research Centre (AMTEC), Universiti Teknologi Malaysia, Johor, Malaysia.

A comprehensive overview of various modifications carried out on polymeric membranes for biomedical applications has been presented in this review paper. In particular, different methods of carrying out these modifications have been discussed. The uniqueness of the review lies in the sense that it discusses the surface modification techniques traversing the timeline from traditionally well-established technologies to emerging new techniques, thus giving an intuitive understanding of the evolution of surface modification techniques over time. Read More

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September 2021

Polyhydroxyalkanoates, bacterially synthesized polymers, as a source of chemical compounds for the synthesis of advanced materials and bioactive molecules.

Authors:
Maciej W Guzik

Appl Microbiol Biotechnol 2021 Sep 18. Epub 2021 Sep 18.

Jerzy Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences, Niezapominajek 8, 30-239, Kraków, Poland.

Research into polyhydroxyalkanoates (PHAs) is growing exponentially. These bacterially derived polyesters offer a spectrum of possible applications, such as in manufacturing of daily-use objects, production of medical devices and implantable objects, or as synthons in chemical and pharmaceutical industries. Thanks to their broad physicochemical features, PHAs can be seen as polymers of the future, which can replace traditional petrochemical equivalents. Read More

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September 2021

Polybrominated diphenyl ethers BDE-47 and BDE-99 modulate murine melanoma cell phenotype in vitro.

Environ Sci Pollut Res Int 2021 Sep 17. Epub 2021 Sep 17.

Departamento de Biologia Celular, Universidade Federal do Paraná, PO Box: 19031, CEP, Curitiba, PR, 81531-980, Brazil.

Cancer is one of the leading causes of mortality worldwide. Even with the advances of pharmaceutical industry and treatments, the mortality rate for various types of cancer remains high. In particular, phenotypic alterations of tumor cells concerning drug efflux, migratory and invasive capabilities may represent a hurdle for cancer treatment and contribute to poor prognosis. Read More

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September 2021

The United Kingdom Research study into Ethnicity And COVID-19 outcomes in Healthcare workers (UK-REACH): protocol for a prospective longitudinal cohort study of healthcare and ancillary workers in UK healthcare settings.

BMJ Open 2021 09 17;11(9):e050647. Epub 2021 Sep 17.

Department of Respiratory Sciences, University of Leicester, Leicester, UK

Introduction: The COVID-19 pandemic has resulted in significant morbidity and mortality and devastated economies globally. Among groups at increased risk are healthcare workers (HCWs) and ethnic minority groups. Emerging evidence suggests that HCWs from ethnic minority groups are at increased risk of adverse COVID-19-related outcomes. Read More

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September 2021