11,441 results match your criteria pharmaceutical companies

Interventions for treating leg ulcers in people with sickle cell disease.

Cochrane Database Syst Rev 2021 Jan 9;1:CD008394. Epub 2021 Jan 9.

Iberoamerican Cochrane Centre, Biomedical Research Institute Sant Pau (IIB Sant Pau), CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.

Background: The frequency of skin ulceration makes an important contributor to the morbidity burden in people with sickle cell disease. Many treatment options are available to the healthcare professional, although it is uncertain which treatments have been assessed for effectiveness in people with sickle cell disease. This is an update of a previously published Cochrane Review. Read More

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January 2021

Free of charge medicine schemes in the NHS. A local and regional Drug and Therapeutic Committees (DTC) experience.

Br J Clin Pharmacol 2021 Sep 23. Epub 2021 Sep 23.

Centre of Clinical Pharmacology and Therapeutics, Institute of Health Informatics, University College London.

Introduction: Free of charge (FoC) medicine schemes are increasingly available and allow access to investigational treatments outside clinical trials or in advance of licensing or NHS commissioning.

Methods: We retrospectively reviewed FoC medicine schemes evaluated between 2013 and 2019 by a single NHS trust and a regional drug and therapeutics committee (DTC). The details of each locally reviewed FoC scheme, and any nationally available MHRA Early Access to Medicines Scheme (MHRA EAMS) in the same period, were recorded and categorised. Read More

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September 2021

Learning From Failure at the CUTTING-EDGE of Transcatheter Mitral Valve Therapies.

JACC Cardiovasc Interv 2021 Sep;14(18):2022-2026

Department of Cardiology, Inselspital, University of Bern, Bern, Switzerland. Electronic address:

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September 2021

Dermatology COVID-19 Registries: Updates and Future Directions.

Dermatol Clin 2021 Oct 31;39(4):575-585. Epub 2021 May 31.

Department of Dermatology, University Hospital, Munich University of Ludwig Maximilian, Munich, Germany; Dr. Philip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.

During the COVID-19 pandemic, rapid, real-world evidence is essential for the development of knowledge and subsequent public health response. In dermatology, provider-facing and patient-facing registries focused on COVID-19 have been important sources of research and new information aimed at guiding optimal patient care. The 7 dermatology registries included in this update now include more than 8000 case reports sourced from physicians and patients from countries all over the world. Read More

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October 2021

Contemporary antiretrovirals and body-mass index: a prospective study of the RESPOND cohort consortium.

Lancet HIV 2021 Sep 20. Epub 2021 Sep 20.

ViiV Healthcare, Research Triangle, NC, USA.

Background: Weight gain effects of individual antiretroviral drugs are not fully understood. We investigated associations between a prespecified clinically significant increase (>7%) in body-mass index (BMI) and contemporary antiretroviral use.

Methods: The International Cohort Consortium of Infectious Diseases (RESPOND) is a prospective, multicohort collaboration, including data from 17 well established cohorts and over 29 000 people living with HIV. Read More

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September 2021

BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity.

J Exp Med 2021 Nov 23;218(11). Epub 2021 Sep 23.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA.

Activity of the NLRP3 inflammasome, a critical mediator of inflammation, is controlled by accessory proteins, posttranslational modifications, cellular localization, and oligomerization. How these factors relate is unclear. We show that a well-established drug target, Bruton's tyrosine kinase (BTK), affects several levels of NLRP3 regulation. Read More

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November 2021

Success stories of AI in drug discovery - where do things stand?

Expert Opin Drug Discov 2021 Sep 23. Epub 2021 Sep 23.

Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, 126 Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Malaysia.

Introduction: The use of Artificial intelligence (AI) in drug discovery and development (DDD) has gained more traction in the past few years. Many scientific reviews have already been made available in this area. Thus, in this review, the authors have focused on the success stories of AI-driven drug candidates and scientometric analysis of the literature in this field. Read More

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September 2021

Navigating the complex realm of drug access in paediatric care.

Paediatr Child Health 2021 Oct 20;26(6):334-336. Epub 2021 Mar 20.

Faculty of Medicine, University of British Columbia, Vancouver, British Columbia.

A Drug Access Navigator (DAN) is a role that has been established in patient care settings with the goal of expediting the process by which patients obtain drugs through the Health Canada Special Access Program (SAP), individual drug companies' patient access programs (PAP), and public and private drug plans. In the paediatric setting, the process of accessing many drugs has grown increasingly complex. The majority of paediatric prescriptions involve 'off-label' drug use. Read More

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October 2021

Establishing the Bioequivalence Safe Space for Immediate-Release Oral Dosage Forms Using Physiologically Based Biopharmaceutics Modeling (PBBM): Case Studies.

J Pharm Sci 2021 Sep 19. Epub 2021 Sep 19.

Regulatory Affairs, Simulations Plus, Inc., Lancaster, CA, USA.

For oral drug products, in vitro dissolution is the most used surrogate of in vivo dissolution and absorption. In the context of drug product quality, safe space is defined as the boundaries of in vitro dissolution, and relevant quality attributes, within which drug product variants are expected to be bioequivalent to each other. It would be highly desirable if the safe space could be established via a direct link between available in vitro data and in vivo pharmacokinetics. Read More

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September 2021

Monoclonal Antibodies in Myeloma: Optimizing Targeted Therapy.

Cancer J 2021 May-Jun 01;27(3):222-230

From the Monter Cancer Center, Division of Hematology/Medical Oncology, Department of Medicine, Northwell Health Cancer Institute, New Hyde Park, NY.

Abstract: In the past several years, there have been significant advances in the therapeutic arsenal of agents used to treat multiple myeloma (MM). Despite these advances, MM remains incurable. One of the most recent therapeutic advances is the development of targeted monoclonal antibodies (MoAbs). Read More

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September 2021

Risky business: COVAX and the financialization of global vaccine equity.

Felix Stein

Global Health 2021 09 20;17(1):112. Epub 2021 Sep 20.

Postdoctoral Researcher, Centre for Development and the Environment (SUM), University of Oslo, Sandakerveien 130, 0484, Oslo, Norway.

Background: During the first year and a half of the COVID-19 pandemic, COVAX has been the world's most prominent effort to ensure equitable access to SARS-CoV-2 vaccines. Launched as part of the Access to COVID-19 Tools Accelerator (Act-A) in June 2020, COVAX suggested to serve as a vaccine buyers' and distribution club for countries around the world. It also aimed to support the pharmaceutical industry in speeding up and broadening vaccine development. Read More

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September 2021

Early intravenous nitroglycerin use in prehospital setting and in the emergency department to treat patients with acute heart failure: Insights from the EAHFE Spanish registry.

Int J Cardiol 2021 Sep 17. Epub 2021 Sep 17.

Momentum Research, Inc., Durham, NC, USA; INSERM U-942 (Biotherapy in the critically ill), Paris, France.

Background And Objective: Although recommended for the treatment of acute heart failure (AHF), the use of intravenous (IV) nitroglycerin (NTG) is supported by scarce and contradicting evidence. In the current analysis, we have assessed the impact of IV NTG administration by EMS or in emergency department (ED) on outcomes of AHF patients.

Methods: We analyze AHF patients included by 45 hospitals that were delivered to ED by EMS. Read More

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September 2021

Changing lives, dynamic plans: Prospective assessment of 12-month changes in pregnancy timing intentions and personal circumstances using data from HER Salt Lake.

PLoS One 2021 20;16(9):e0257411. Epub 2021 Sep 20.

Department of Obstetrics & Gynecology, University of Utah, Salt Lake City, Utah.

Objectives: To explore the association between changes in personal circumstances and shifts in pregnancy intentions.

Study Design: New start contraceptive clients, who desired to prevent pregnancy for at least one year enrolled in the survey arm of the HER Salt Lake Contraceptive Initiative (September 2015 -March 2017) and responded to the question "What are your future pregnancy plans?" at enrollment and 12-month follow-up. We estimated multivariable binary logistic fixed-effects regressions to examine the association between changes in personal circumstances and a change from never desiring a pregnancy at enrollment to considering one in the future at 12-month follow-up. Read More

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September 2021

Bariatric Metabolic Surgery Reduced Liver Enzyme Levels in Patients with Non-Alcohol Fatty Liver Disease.

Kans J Med 2021 1;14:209-214. Epub 2021 Sep 1.

University of Kansas School of Medicine-Wichita, Wichita, KS.

Introduction: Approximately 93.3 million Americans are obese (BMI > 30 kg/m) and 51% have non-alcoholic fatty liver disease (NAFLD). Progression of NAFLD can lead to non-alcoholic steatohepatitis (NASH), which is the leading cause of liver transplant in the United States. Read More

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September 2021

Immune Recovery Following Autologous Hematopoietic Stem Cell Transplantation in HIV-Related Lymphoma Patients on the BMT CTN 0803/AMC 071 Trial.

Front Immunol 2021 3;12:700045. Epub 2021 Sep 3.

Department of Hematology & Hematopoietic Cell Transplantation, City of Hope Comprehensive Cancer Center, Duarte, CA, United States.

We report a first in-depth comparison of immune reconstitution in patients with HIV-related lymphoma following autologous hematopoietic cell transplant (AHCT) recipients (n=37, lymphoma, BEAM conditioning), HIV(-) AHCT recipients (n=30, myeloma, melphalan conditioning) at 56, 180, and 365 days post-AHCT, and 71 healthy control subjects. Principal component analysis showed that immune cell composition in HIV(+) and HIV(-) AHCT recipients clustered away from healthy controls and from each other at each time point, but approached healthy controls over time. Unsupervised feature importance score analysis identified activated T cells, cytotoxic memory and effector T cells [higher in HIV(+)], and naïve and memory T helper cells [lower HIV(+)] as a having a significant impact on differences between HIV(+) AHCT recipient and healthy control lymphocyte composition (p<0. Read More

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September 2021

SARS-CoV-2 vaccination in patients with inflammatory bowel disease.

GastroHep 2021 Jul 23;3(4):212-228. Epub 2021 Jul 23.

Department of Gastroenterology The Royal Melbourne Hospital Melbourne VIC Australia.

Background: The current COVID-19 pandemic, caused by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2), has drastically impacted societies worldwide. Vaccination against SARS-CoV-2 is expected to play a key role in the management of this pandemic. Inflammatory conditions such as inflammatory bowel disease (IBD) often require chronic immunosuppression, which can influence vaccination decisions. Read More

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Expected Impact of Biosimilars on the Pharmaceutical Companies.

Iran J Med Sci 2021 Sep;46(5):399-401

Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

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September 2021

The putative role of the relaxin-3/RXFP3 system in clinical depression and anxiety: a systematic literature review.

Neurosci Biobehav Rev 2021 Sep 16. Epub 2021 Sep 16.

Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom; South London & Maudsley NHS Foundation Trust, Bethlem Royal Hospital, Monks Orchard Road, London, United Kingdom.

The relaxin-3/RXFP3 system is one of several neuropeptidergic systems putatively implicated in regulating the behavioural alterations that characterise clinical depression and anxiety, making it a potential target for clinical translation. Accordingly, this systematic review identified published reports on the role of relaxin-3/RXFP3 signalling in these neuropsychiatric disorders and their behavioural endophenotypes, evaluating evidence from animal and human studies to ascertain any relationship. We searched PubMed, EMBASE, PsycINFO and Google Scholar databases up to February 2021, finding 609 relevant records. Read More

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September 2021

Transition of Care from Pediatric to Adult Care in Eosinophilic Esophagitis: Insights from a Patient Perspective Survey.

J Pediatr Gastroenterol Nutr 2021 Sep 17. Epub 2021 Sep 17.

Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Digestive Health Institute, Children's Hospital of Colorado Aurora, CO Trinity Partners, LLC, Waltham, MA Shire Human Genetic Therapies, Inc., a Takeda company, Cambridge, MA Takeda Pharmaceuticals USA, Inc., Lexington, MA The Department of Internal Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA.

Abstract: Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease. Patients with a childhood diagnosis require ongoing disease management in adulthood. However, knowledge of the patient experience during pediatric to adult healthcare transition is lacking. Read More

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September 2021

Venomics of the poorly studied hognosed pitvipers Porthidium arcosae and Porthidium volcanicum.

J Proteomics 2021 Sep 14:104379. Epub 2021 Sep 14.

College of Biochemistry and Pharmacy, Faculty of Chemical Sciences, University of Cuenca, Cuenca, Ecuador. Electronic address:

We report the first proteomics analyses of the venoms of two poorly studied snakes, the Manabi hognosed pitviper Porthidium arcosae endemic to the western coastal province of Manabí (Ecuador), and the Costa Rican hognosed pitviper P. volcanicum with distribution restricted to South Pacific Costa Rica and western Panamá. These venom proteomes share a conserved compositional pattern reported in four other congeneric species within the clade of South American Porthidium species, P. Read More

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September 2021

Cost-effectiveness of the adherence with recommendations for clinical monitoring of patients with diabetes.

Nutr Metab Cardiovasc Dis 2021 Jul 28. Epub 2021 Jul 28.

National Centre for Healthcare Research and Pharmacoepidemiology, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy; Center of Epidemiology and Biostatistics, Polytechnic University of Marche, Ancona, Italy.

Background And Aims: To validate a set of indicators for monitoring the quality of care of patients with diabetes in 'real-life' practice through its relationship with measurable clinical outcomes and healthcare costs.

Methods And Results: A population-based cohort study was carried out by including the 20,635 patients, residents in the Lombardy Region (Italy), who in the year 2012 were newly taken-in-care for diabetes. Adherence with clinical recommendations (i. Read More

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Safety and immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in children in Sierra Leone: a randomised, double-blind, controlled trial.

Lancet Infect Dis 2021 Sep 13. Epub 2021 Sep 13.

London School of Hygiene & Tropical Medicine, London, UK.

Background: Children account for a substantial proportion of cases and deaths from Ebola virus disease. We aimed to assess the safety and immunogenicity of a two-dose heterologous vaccine regimen, comprising the adenovirus type 26 vector-based vaccine encoding the Ebola virus glycoprotein (Ad26.ZEBOV) and the modified vaccinia Ankara vector-based vaccine, encoding glycoproteins from the Ebola virus, Sudan virus, and Marburg virus, and the nucleoprotein from the Tai Forest virus (MVA-BN-Filo), in a paediatric population in Sierra Leone. Read More

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September 2021

Pro-inflammatory and proliferative microglia drive progression of glioblastoma.

Cell Rep 2021 Sep;36(11):109718

Department of Neurosurgery, The First Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China. Electronic address:

Scant understanding of the glioblastoma microenvironment and molecular bases hampers development of efficient treatment strategies. Analyses of gene signatures of human gliomas demonstrate that the SETD2 mutation is correlated with poor prognosis of IDH1/2 wild-type (IDH-WT) adult glioblastoma patients. To better understand the crosstalk between SETD2 mutant (SETD2-mut) glioblastoma cells and the tumor microenvironment, we leverage single-cell transcriptomics to comprehensively map cellular populations in glioblastoma. Read More

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September 2021

Thrombin generation assays are versatile tools in blood coagulation analysis: a review of technical features, and applications from research to laboratory routine.

J Thromb Haemost 2021 Sep 15. Epub 2021 Sep 15.

Baxalta Innovations GmbH, part of the Takeda group of companies.

Thrombin is the pivotal enzyme in the biochemistry of secondary haemostasis crucial to maintaining homeostasis of haemostasis. In contrast to routine coagulation tests (PT or aPTT) or procoagulant or anticoagulant factor assays (e.g. Read More

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September 2021

3'untranslated regions (3'UTR) of mRNA displays anticancer effects in non-small cell lung cancer (NSCLC) cells.

Am J Cancer Res 2021 15;11(8):3857-3876. Epub 2021 Aug 15.

Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes and MOE Key Laboratory of Tumor Molecular Biology, Institute of Life and Health Engineering, Jinan University Guangzhou 510632, China.

RNA-based therapeutics has attracted substantial interest from both academics and pharmaceutical companies. In this study, we investigated the function and the underlying mechanism of 3'UTR in NSCLC H1299 and A549 cells. We found that transfected plasmids significantly increased the proliferation, migration and invasion of NSCLC cells, whereas 3'UTR could suppress the promotional effect of GSN protein on the development of NSCLC . Read More

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Vaccine complacency and dose distribution inequities limit the benefits of seasonal influenza vaccination, despite a positive trend in use.

Vaccine 2021 Sep 11. Epub 2021 Sep 11.

International Federation of Pharmaceutical Manufacturers and Associations, Ch. des Mines 9, P.O. Box 195, 1211 Geneva 20, Switzerland. Electronic address:

Sustainable demand for seasonal influenza vaccines is a component of national security strategies for pandemic preparedness. However, the ongoing COVID-19 pandemic has revealed many weaknesses in the capacity of countries to design and execute sustainable vaccination programs. An influenza pandemic remains a global threat and yet there is no global monitoring system for assessing progress towards influenza vaccination coverage targets. Read More

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September 2021

[Guidelines for Clinical Practice of the French College of Obstetricians and Gynecologists 2021 : Prophylactic procedures associated with gynecologic surgery].

Gynecol Obstet Fertil Senol 2021 Sep 11. Epub 2021 Sep 11.

Service de Gynécologie Obstétrique et Médecine de la Reproduction de l'hôpital Lyon Sud, 165 Chemin du Grand Revoyet, 69495 Pierre-Bénite, France.

Objective: To draw up recommendations on the use of prophylactic gynecologic procedures during surgery for other indications.

Design: A consensus panel of 19 experts was convened. A formal conflict of interest policy was established at the onset of the process and applied throughout. Read More

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September 2021

Cytochrome P450 enzymes: a review on drug metabolizing enzyme inhibition studies in drug discovery and development.

Bioanalysis 2021 Sep 14. Epub 2021 Sep 14.

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad, Balanagar, Telangana, 50003, India.

Assessment of drug candidate's potential to inhibit cytochrome P450 (CYP) enzymes remains crucial in pharmaceutical drug discovery and development. Both direct and time-dependent inhibition of drug metabolizing CYP enzymes by the concomitant administered drug is the leading cause of drug-drug interactions (DDIs), resulting in the increased toxicity of the victim drug. In this context, pharmaceutical companies have grown increasingly diligent in limiting CYP inhibition liabilities of drug candidates in the early stages and examining risk assessments throughout the drug development process. Read More

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September 2021

Peptide-Based Inhibitors for SARS-CoV-2 and SARS-CoV.

Adv Ther (Weinh) 2021 Aug 6:2100104. Epub 2021 Aug 6.

Department of Biomedical Engineering New Jersey Institute of Technology Newark NJ 07102 USA.

The COVID-19 (coronavirus disease) global pandemic, caused by the spread of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) virus, currently has limited treatment options which include vaccines, anti-virals, and repurposed therapeutics. With their high specificity, tunability, and biocompatibility, small molecules like peptides are positioned to act as key players in combating SARS-CoV-2, and can be readily modified to match viral mutation rate. A recent expansion of the understanding of the viral structure and entry mechanisms has led to the proliferation of therapeutic viral entry inhibitors. Read More

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