J Biol Chem 2021 Mar 18:100565. Epub 2021 Mar 18.
Department of Chemistry, Biochemistry Division, Johannes Gutenberg-University, Mainz, Germany; Centre for Biomolecular Magnetic Resonance (BMRZ), Goethe University, Frankfurt, Germany; current address: Faculty of Chemistry and Earth Sciences, Institute of Organic and Macromolecular Chemistry, Friedrich-Schiller-University, Jena, Germany; Cluster of Excellence 'Balance of the Microverse', Friedrich-Schiller-University, Jena, Germany. Electronic address:
Rhodesain is the lysosomal cathepsin L-like cysteine protease of T. brucei rhodesiense, the causative agent of Human African Trypanosomiasis. The enzyme is essential for the proliferation and pathogenicity of the parasite as well as its ability to overcome the blood-brain barrier of the host. Read More