11,641 results match your criteria pge2 levels

Phenolic Compounds of Red Wine Modulate the Functional Activity of Macrophages via Inhibition of and the Citrate Pathway.

Oxid Med Cell Longev 2021 25;2021:5533793. Epub 2021 May 25.

Department of Science, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.

Phenolic compounds of red wine powder (RWP) extracted from the Italian red wine have been investigated for the potential immunomodulatory and anti-inflammatory capacity on human macrophages. These compounds reduce the secretion of IL-1, IL-6, and TNF- proinflammatory cytokines and increase the release of IL-10 anti-inflammatory cytokine induced by lipopolysaccharide (LPS). In addition, RWP restores Annexin A1 levels, thus involving activation of proresolutive pathways. Read More

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D-dopachrome tautomerase activates COX2/PGE pathway of astrocytes to mediate inflammation following spinal cord injury.

J Neuroinflammation 2021 Jun 11;18(1):130. Epub 2021 Jun 11.

Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, People's Republic of China.

Background: Astrocytes are the predominant glial cell type in the central nervous system (CNS) that can secrete various cytokines and chemokines mediating neuropathology in response to danger signals. D-dopachrome tautomerase (D-DT), a newly described cytokine and a close homolog of macrophage migration inhibitory factor (MIF) protein, has been revealed to share an overlapping function with MIF in some ways. However, its cellular distribution pattern and mediated astrocyte neuropathological function in the CNS remain unclear. Read More

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Eicosanoid profiling in patients with complete form of pachydermoperiostosis carrying SLCO2A1 mutations.

J Dermatol 2021 Jun 11. Epub 2021 Jun 11.

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Pachydermoperiostosis (PDP) is a genetic disease characterized by digital clubbing, periostosis, and pachydermia caused by mutated HPGD or SLCO2A1. Plasma prostaglandin (PG)E levels are increased in these patients. However, other eicosanoids have not been quantitated. Read More

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Efficacy of horse oil on lipopolysaccharide-induced inflammation in human keratinocyte.

J Tradit Chin Med 2021 Jun;41(3):355-359

Department of Biochemistry, Chung-Ang University College of Medicine.

Objective: To investigate the efficacy of horse oil on lipopolysaccharide (LPS)-induced inflammation in human keratinocytes.

Methods: Western blot analysis was performed to measure the expression of cyclooxygenase-2 (COX-2) and IκBα. ELISA was used to analyze prostaglandin E2 (PGE2) levels. Read More

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Intersecting Mechanisms of Hypoxia and Prostaglandin E2-Mediated Inflammation in the Comparative Biology of Oral Squamous Cell Carcinoma.

Front Oncol 2021 21;11:539361. Epub 2021 May 21.

Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PEI, Canada.

The importance of inflammation in the pathogenesis of cancer was first proposed by Rudolph Virchow over 150 years ago, and our understanding of its significance has grown over decades of biomedical research. The arachidonic acid pathway of inflammation, including cyclooxygenase (COX) enzymes, PGE2 synthase enzymes, prostaglandin E2 (PGE2) and PGE2 receptors has been extensively studied and has been associated with different diseases and different types of cancers, including oral squamous cell carcinoma (OSCC). In addition to inflammation in the tumour microenvironment, low oxygen levels (hypoxia) within tumours have also been shown to contribute to tumour progression. Read More

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Naproxen inhibits spontaneous lung adenocarcinoma formation in Kras mice.

Neoplasia 2021 Jun 3;23(6):574-583. Epub 2021 Jun 3.

Center for Cancer Prevention and Drug Development, Hem-Onc, Department of Medicine, Stephenson Cancer Center, University of Oklahoma HSC, Oklahoma City, OK, USA; VA Medical Center, Oklahoma City, OK, USA. Electronic address:

Lung cancer is the leading cause of cancer related deaths worldwide. The present study investigated the effects of naproxen (NSAID) on lung adenocarcinoma in spontaneous lung cancer mouse model. Six-week-old transgenic Kras mice (n = 20; male + female) were fed modified AIN-76A diets containing naproxen (0/400 ppm) for 30 wk and euthanized at 36 wk of age. Read More

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Parecoxib alleviates the motor behavioral decline of aged rats by ameliorating mitochondrial dysfunction in the substantia nigra via COX-2/PGE2 pathway inhibition.

Neuropharmacology 2021 Jun 3;194:108627. Epub 2021 Jun 3.

Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China; Neuroscience Research Center, Hebei Medical University, Shijiazhuang, 050017, China; Hebei Key Laboratory of Forensic Medicine, Department of Forensic Medicine, Hebei Medical University, Shijiazhuang, 050017, China. Electronic address:

Mitochondrial dysfunction manifests as an early event in the substantia nigra (SN) in aging and Parkinson disease. Cyclooxygenase 2 (COX-2), the rate-limiting enzyme in the prostaglandin E2 (PGE2) synthesis pathway, is implicated in aging and age-related neurodegenerative diseases; moreover, inhibition of COX-2 expression has been shown to be neuroprotective for nigrostriatal dopaminergic neurons. However, it is not known whether the neuroprotective effect of COX-2 inhibition is related to improved mitochondrial function during the aging process. Read More

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Protective effects of calcium ions via L-type calcium channels and NMDA receptors on prostaglandin E-induced apoptosis in rat cortical cells.

Mol Biol Rep 2021 Jun 5. Epub 2021 Jun 5.

Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan.

Calcium ions mediate a variety of physiological responses of developing neurons including survival. The purpose of this study was to examine the effect of calcium influx through L-type calcium channels (LTCCs) or NMDA receptors on prostaglandin E (PGE)-induced apoptosis in rat cortical cells. Cultures of rat cortical cells were prepared from an embryonic day 18 rat neocortex. Read More

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Enhanced mPGES-1 Contributes to PD-Related Peritoneal Fibrosis via Activation of the NLRP3 Inflammasome.

Front Med (Lausanne) 2021 18;8:675363. Epub 2021 May 18.

Department of Nephrology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, China.

Microsomal prostaglandin E synthase-1 (mPGES-1)-derived prostaglandin E (PGE2) is a chief mediator of inflammation. However, the role and mechanism of mPGES-1 in peritoneal dialysis (PD)-associated peritoneal fibrosis have not been investigated. In PD patients, mPGES-1 expression in peritoneum tissues and the levels of PGE2, IL-1β, and IL-18 in the dialysate were examined. Read More

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Anti-inflammatory and immunoregulatory effects of pinolenic acid in rheumatoid arthritis.

Rheumatology (Oxford) 2021 Jun 3. Epub 2021 Jun 3.

Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.

Objectives: In pre-clinical studies, pinolenic acid (PNLA), an omega-6-polyunsaturated fatty acid from pine nuts has shown anti-inflammatory effects. We aimed to investigate the effect of PNLA in human cell lines and peripheral blood mononuclear cells (PBMCs) from rheumatoid arthritis (RA) patients and healthy controls (HCs).

Methods: Modified Boyden chamber was used to assess chemokine-induced migration of THP-1 monocytes. Read More

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Cardamonin Attenuates Inflammation and Oxidative Stress in Interleukin-1β-Stimulated Osteoarthritis Chondrocyte through the Nrf2 Pathway.

Antioxidants (Basel) 2021 May 27;10(6). Epub 2021 May 27.

Department of Orthopedics, National Defense Medical Center, Tri-Service General Hospital, Taipei 114, Taiwan.

Osteoarthritis (OA) is a chronic degenerative joint disease characterized by the deterioration of articular cartilage. The progression of OA leads to an increase in inflammatory mediators in the joints, thereby promoting the destruction of the cartilage matrix. Recent studies have reported on the anti-inflammatory and antioxidant properties of cardamonin, which also appears to interact with cellular targets, such as nuclear erythroid 2-related factor 2 (Nrf2), extracellular signal-regulated kinase (ERK), and mammalian target of rapamycin (mTOR) during the progression of tumors. Read More

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Novel Hydrogen Sulfide (HS)-Releasing BW-HS-101 and Its Non-HS Releasing Derivative in Modulation of Microscopic and Molecular Parameters of Gastric Mucosal Barrier.

Int J Mol Sci 2021 May 14;22(10). Epub 2021 May 14.

Department of Physiology, Jagiellonian University Medical College, 31531 Cracow, Poland.

Hydrogen sulfide (HS) is an endogenously produced molecule with anti-inflammatory and cytoprotective properties. We aimed to investigate for the first time if a novel, esterase-sensitive HS-prodrug, BW-HS-101 with the ability to release HS in a controllable manner, prevents gastric mucosa against acetylsalicylic acid-induced gastropathy on microscopic and molecular levels. Wistar rats were pretreated intragastrically with vehicle, BW-HS-101 (0. Read More

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Fatty Acid-Binding Proteins Aggravate Cerebral Ischemia-Reperfusion Injury in Mice.

Biomedicines 2021 May 10;9(5). Epub 2021 May 10.

Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-Ku, Sendai 980-8578, Japan.

Fatty acid-binding proteins (FABPs) regulate the intracellular dynamics of fatty acids, mediate lipid metabolism and participate in signaling processes. However, the therapeutic efficacy of targeting FABPs as novel therapeutic targets for cerebral ischemia is not well established. Previously, we synthesized a novel FABP inhibitor, i. Read More

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Humulene Inhibits Acute Gastric Mucosal Injury by Enhancing Mucosal Integrity.

Antioxidants (Basel) 2021 May 11;10(5). Epub 2021 May 11.

Institute of Pharmaceutical Sciences and Research, College of Pharmacy and Inje, Inje University, 607 Obang-dong, Gimhae 621749, Korea.

This study was designed to determine whether α-humulene, a major constituent in many plants used in fragrances, has a protective role against gastric injury in vivo and in vitro. A rat model of hydrochloric acid (HCl)/ethanol-induced gastritis and human mast cells (HMC-1) were used to investigate the mucosal protective effect of α-humulene. α-Humulene significantly inhibited gastric lesions in HCl/ethanol-induced acute gastritis and decreased gastric acid secretion pyloric ligation-induced gastric ulcers in vivo. Read More

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2-Arachidonyl-lysophosphatidylethanolamine Induces Anti-Inflammatory Effects on Macrophages and in Carrageenan-Induced Paw Edema.

Int J Mol Sci 2021 May 4;22(9). Epub 2021 May 4.

College of Pharmacy, Pusan National University, Busan 46241, Korea.

2-Arachidonyl-lysophosphatidylethanolamine, shortly 2-ARA-LPE, is a polyunsaturated lysophosphatidylethanolamine. 2-ARA-LPE has a very long chain arachidonic acid, formed by an ester bond at the -2 position. It has been reported that 2-ARA-LPE has anti-inflammatory effects in a zymosan-induced peritonitis model. Read More

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Xenocoumacin 2 reduces protein biosynthesis and inhibits inflammatory and angiogenesis-related processes in endothelial cells.

Biomed Pharmacother 2021 May 28;140:111765. Epub 2021 May 28.

Institute of Pharmaceutical Biology, Faculty of Biochemistry, Chemistry and Pharmacy, Goethe University Frankfurt, Frankfurt, Germany; LOEWE Center for Translational Biodiversity Genomics (LOEWE-TBG), Frankfurt, Germany. Electronic address:

Xenocoumacin (Xcn) 1 and 2 are the major antibiotics produced by the insect-pathogenic bacterium Xenorhabdus nematophila. Although the antimicrobial activity of Xcns has been explored, research regarding their action on mammalian cells is lacking. We aimed to investigate the action of Xcns in the context of inflammation and angiogenesis. Read More

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CircARL8B Contributes to the Development of Breast Cancer Via Regulating miR-653-5p/HMGA2 Axis.

Biochem Genet 2021 May 28. Epub 2021 May 28.

Department of Pathology, Chaonan Minsheng Hospital of Shantou, Shantou, Guangdong, China.

Circular RNAs (circRNAs) act as essential regulators in breast cancer (BC) progression. In this paper, we aimed to investigate the functions of circARL8B in BC. The levels of circARL8B, ADP Ribosylation Factor Like GTPase 8B (ARL8B), miR-653-5p and high-mobility group AT-hook 2 (HMGA2) mRNA were examined by qRT-PCR. Read More

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Berberine modulates hyper-inflammation in mouse macrophages stimulated with polyinosinic-polycytidylic acid via calcium-CHOP/STAT pathway.

Sci Rep 2021 May 28;11(1):11298. Epub 2021 May 28.

Department of Pathology, College of Korean Medicine, Gachon University, Seong-nam, 13120, Republic of Korea.

Berberine is a well-known quaternary ammonium salt that is usually found in the roots of such plants as Phellodendron amurense and Coptis chinensis. However, the effects of berberine on double-stranded RNA (dsRNA)-induced macrophages have not been fully reported. In this study, we examined the anti-inflammatory effects of berberine on dsRNA [polyinosinic-polycytidylic acid; poly I:C]-induced macrophages. Read More

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Integrin α4β1 is required for IL-1α- and Nrf2-dependent, Cox-2 induction in fibroblasts, supporting a mechanism that suppresses α-SMA expression.

Wound Repair Regen 2021 May 28. Epub 2021 May 28.

Department of Surgery, Albany Medical College, Albany, New York, USA.

Growth and repair processes, both normal and pathological, require reciprocal interactions between cells and their microenvironment. Integrins are bidirectional, cell surface receptors that transduce mechanical and chemical signals to and from the extracellular matrix. We recently reported that keratinocyte α3β1 is required for interleukin (IL)-1α secretion. Read More

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Zerumbone Suppresses the LPS-Induced Inflammatory Response and Represses Activation of the NLRP3 Inflammasome in Macrophages.

Front Pharmacol 2021 11;12:652860. Epub 2021 May 11.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Zerumbone is a natural product isolated from the pinecone or shampoo ginger, (L.) Smith, which has a wide range of pharmacological activities, including anti-inflammatory effects. However, the effects of zerumbone on activation of the NLRP3 inflammasome in macrophages have not been examined. Read More

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Sex-dependent Effects of Nephron Ift88 Disruption on Blood Pressure, Renal Function and Cystogenesis.

J Am Soc Nephrol 2021 May 27. Epub 2021 May 27.

D Kohan, Division of Nephrology, University of Utah, Salt Lake City, United States

Background: Primary cilia regulation of renal function and blood pressure (BP) in health and disease is incompletely understood. The current study investigated the effect of nephron ciliary loss on renal physiology, blood pressure and ensuing cystogenesis.

Methods: Mice underwent doxycycline (DOX)-inducible nephron-specific knockout (KO) of the gene at 2 months of age using a Cre-LoxP strategy. Read More

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Ethyl ferulate contributes to the inhibition of the inflammatory responses in murine RAW 264.7 macrophage cells and acute lung injury in mice.

PLoS One 2021 26;16(5):e0251578. Epub 2021 May 26.

Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P.R. China.

Background: Ethyl ferulate (EF) is a derivative of ferulic acid (FA), which is a monomeric component purified from the traditional medicinal herb Ferula, but its effects have not been clear yet. The purpose of this study was to evaluate whether EF can reduce inflammation levels in macrophages by regulating the Nrf2-HO-1 and NF-кB pathway.

Methods: The LPS-induced raw 264. Read More

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Roles of eicosanoids in regulating inflammation and neutrophil migration as an innate host response to bacterial infections.

Infect Immun 2021 May 24. Epub 2021 May 24.

Department of Microbiology and Cell Science, College of Agricultural and Life Sciences, University of Florida, Gainesville, USA

Eicosanoids are lipid-based signaling molecules that play a unique role in innate immune responses. The multiple types of eicosanoids, such as prostaglandins (PGs) and leukotrienes (LTs), allow the innate immune cells to respond rapidly to bacterial invaders. Bacterial pathogens alter cyclooxygenase (COX)-derived prostaglandins (PG) in macrophages, such as PGE2 15d-PGJ, lipoxygenase (LOX)-derived leukotriene LTB which has chemotactic functions. Read More

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Protective effect of teprenone on gastric mucosal injury induced by dual antiplatelet therapy in rats.

Am J Transl Res 2021 15;13(4):2702-2709. Epub 2021 Apr 15.

Department of Pharmacy, Quanzhou First Hospital Affiliated to Fujian Medical University Quanzhou, Fujian Province, China.

Objective: To investigate the protective effect of teprenone on gastric mucosal injury induced by dual antiplatelet therapy in rats.

Methods: Healthy, specifically pathogen free SD, rats were selected and divided into 4 groups: Normal group (normal rats, without any treatment), Model group (rats received dual antiplatelet therapy: aspirin and clopidogrel), Teprenone group (rats received dual antiplatelet therapy and teprenone) and Pantoprazole group (rats received dual antiplatelet therapy and pantoprazole). The gastric mucosal blood flow, ulcer index, gastric gel mucus thickness, the levels of gastrin (Gas), prostaglandin (PG), prostaglandin E (PGE), endothelin-1 (ET-1) tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and IL-10 in serum, the levels of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD) and myeloperoxidase (MPO) in the gastric mucosa, as well as the expression of vascular endothelial growth factor (VEGF) in the rat's stomach were measured. Read More

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Chrysoeriol ameliorates COX-2 expression through NF-κB, AP-1 and MAPK regulation via the TLR4/MyD88 signaling pathway in LPS-stimulated murine macrophages.

Exp Ther Med 2021 Jul 3;22(1):718. Epub 2021 May 3.

The Research Institute for Health Functional Materials, Dong-Eui University, Busanjin-gu, Busan 47340, Republic of Korea.

Chrysoeriol is a flavonoid that has diverse biological properties, including antioxidation, anti-inflammation, chemoprevention and immunomodulation. Despite its reported anti-inflammatory activity, the exact underlying molecular mechanism has not yet been elucidated. In the current study, the anti-inflammatory mechanism of chrysoeriol involving lipopolysaccharide (LPS)-induced cyclooxygenase-2 (COX-2) and its upstream signaling molecules was investigated in RAW 264. Read More

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Change in prostaglandin signaling during sickness syndrome hyperalgesia after ovariectomy in female rats.

Behav Brain Res 2021 Jul 14;410:113368. Epub 2021 May 14.

Department of Pharmacology, Biological Sciences Section, Federal University of Paraná, Curitiba, PR, Brazil. Electronic address:

The present study investigated hyperalgesia during sickness syndrome in female rats. Hyperalgesia was induced by an intraperitoneal injection of lipopolysaccharide (LPS) or an intracerebroventricular injection of prostaglandin E (PGE). No differences were found in basal mechanical and thermal thresholds or in LPS-induced hyperalgesia in sham-operated animals in the diestrus or proestrus phase or in ovariectomized (OVX) animals. Read More

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The anti-inflammatory effects of an ethanolic extract of the rhizome of Atractylodes lancea, involves Akt/NF-κB signaling pathway inhibition.

J Ethnopharmacol 2021 May 13;277:114183. Epub 2021 May 13.

Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China; Research and Development Center for Natural Health Products, HKBU Institute of Research and Continuing Education, Shenzhen, China. Electronic address:

Ethnopharmacological Relevance: The dried rhizome of Atractylodes lancea (Thumb.) DC. (Compositae) has been prescribed in folk medicine for the management of various inflammatory conditions such as rheumatic diseases, gastritis and hepatitis. Read More

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Modulatory effects of carvacrol against cadmium-induced hepatotoxicity and nephrotoxicity by molecular targeting regulation.

Life Sci 2021 Jul 11;277:119610. Epub 2021 May 11.

Erzurum Veterinary Control Institute, 25070 Erzurum, Turkey.

Aim: Cadmium (Cd) is a toxic heavy metal that causes severe toxic effects on different tissues including liver and kidney. Therefore the research for alternatives to reduce the damage caused by Cd has substantial importance. This study was performed to examine the possible modulatory effects of carvacrol (CRV) against Cd-induced hepatorenal toxicities and the possible mechanisms underlying these effects. Read More

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Oleuropein attenuates the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-perturbing effects on pancreatic β-cells.

J Environ Sci Health A Tox Hazard Subst Environ Eng 2021 May 13:1-10. Epub 2021 May 13.

Department of Endocrinology & Metabolism, Kyung Hee University Hospital, Seoul, Republic of Korea.

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an endocrine disrupting compound and persistent organic pollutant that has been associated with diabetes in several epidemiological studies. Oleuropein, a major phenolic compound in olive fruit, is a superior antioxidant and radical scavenger. This study aimed to examine the effects of oleuropein against TCDD-induced stress response in a pancreatic beta cell line, INS-1 cells. Read More

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Gut microbiota modulation and anti-inflammatory properties of mixed lactobacilli in dextran sodium sulfate-induced colitis in mice.

Food Funct 2021 Jun;12(11):5130-5143

Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China. and Food College, Northeast Agricultural University, Harbin 150030, China.

Correlations between gut microbiota activities and inflammatory bowel disease (IBD) treatment are gaining research interest. In our previous study, Lactobacillus acidophilus KLDS 1.0901, Lactobacillus helveticus KLDS 1. Read More

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