1,476 results match your criteria pfcs

Performance Characteristics of a Lumen-Apposing Metal Stent for Pancreatic Fluid Collections: A Prospective Cohort Study.

J Can Assoc Gastroenterol 2021 Aug 28;4(4):158-164. Epub 2020 Jul 28.

Division of Gastroenterology, University of Alberta Hospital, Edmonton, Alberta, Canada.

Background: Endoscopic ultrasound-guided transmural drainage is the preferred management of pancreatic fluid collections (PFCs). Optimizing drainage is important and there remains debate as to the choice of stent. A recent trend towards the use of lumen-apposing metal stents (LAMS) has emerged. Read More

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Coaxial Double-Pigtail Stent Placement: A Simple Solution to Decrease Bleeding Risk Associated With Lumen-Apposing Metal Stent?

Cureus 2021 Jun 28;13(6):e15981. Epub 2021 Jun 28.

Gastroenterology, Valleywise Health Medical Center, Phoenix, USA.

Endoscopic cystogastrostomy using lumen-apposing metal stent (LAMS) is considered the first-line therapy for symptomatic pancreatic fluid collections (PFCs). Routine coaxial placement of a double-pigtail stent (DPS) through LAMS is debated. We report the case of a patient with delayed massive gastrointestinal bleed eight weeks after LAMS placement due to splenic artery pseudoaneurysm leading to a complicated hospitalization. Read More

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Validation of the Orlando Protocol for endoscopic management of pancreatic fluid collections in the era of lumen-apposing metal stents.

Dig Endosc 2021 Jul 31. Epub 2021 Jul 31.

Digestive Health Institute, Orlando Health, Orlando, Florida, USA.

Objectives: Although lumen-apposing metal stents (LAMS) are being increasingly used in lieu of plastic stents, clinical approach to endoscopic management of pancreatic fluid collections (PFCs) is poorly standardized. We compared outcomes of approaches over two time intervals, initially using plastic stents and later integrating LAMS.

Methods: This was a retrospective, observational, before-after study of prospectively collected data on consecutive patients with symptomatic PFCs managed over two time periods. Read More

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Preparation of fluorinated covalent organic polymers at room temperature for removal and detection of perfluorinated compounds.

J Hazard Mater 2021 Jul 16;420:126659. Epub 2021 Jul 16.

Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, China. Electronic address:

Covalent organic polymers (COPs) are promising adsorbents for the removal and detection of various types of pollutants. However, the preparation of COPs that exhibit uniform dispersion and good appearance at room temperature is challenging. Herein, fluorinated covalent organic polymers (F-COPs) with different morphologies were synthesized through the Schiff base reaction of 4,4-diamino-p-terphenyl (DT) and 2,3,5,6-tetrafluoroterephthalaldehyde (TFA). Read More

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[Study on the Analytical Method of Solid Phase Extraction-Ultra Performance Liquid Chromatography Tandem Quadrupole Linear Ion Trap Mass Spectrometry for 12 Perfluorinated Compounds in Human Urine].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Jul;52(4):679-685

Department of Laboratory Technology and Science of Public Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.

Objective: To establish a method for simultaneous determination of 12 kinds of perfluorinated compounds (PFCs) in human urine based on ultra performance liquid chromatography tandem quadrupole linear ion trap mass spectrometry (UPLC-QTtrap-MS).

Methods: After pH adjustment with 2% formic acid, the urine samples were loaded on a WAX solid phase extraction (SPE) cartridge for extraction, purification and concentration. The eluates were collected, concentrated to dryness under nitrogen, and reconstituted with 10 mmol/L ammonium acetate aqueous solution-methanol ( ∶ = 70∶30) before injection. Read More

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Clinical Practice Guidelines for the Endoscopic Management of Peripancreatic Fluid Collections.

Clin Endosc 2021 Jul 27. Epub 2021 Jul 27.

Division of Gastroenterology, Department of Internal Medicine, Cha University Bundang Medical Center, Seongnam, Korea.

Endoscopic ultrasonography-guided intervention has gradually become a standard treatment for peripancreatic fluid collections (PFCs). However, it is difficult to popularize the procedure in Korea because of restrictions on insurance claims regarding the use of endoscopic accessories, as well as the lack of standardized Korean clinical practice guidelines. The Korean Society of Gastrointestinal Endoscopy (KSGE) appointed a Task Force to develope medical guidelines by referring to the manual for clinical practice guidelines development prepared by the National Evidence-Based Healthcare Collaborating Agency. Read More

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Clinical Practice Guidelines for the Endoscopic Management of Peripancreatic Fluid Collections.

Gut Liver 2021 Jul 27. Epub 2021 Jul 27.

Division of Gastroenterology, Department of Internal Medicine, CHA University Bundang Medical Center, Seongnam, Korea.

The Korean Society of Gastrointestinal Endoscopy developed medical guidelines by referring to the manual for clinical practice guidelines development prepared by the National Evidencebased Healthcare Collaborating Agency. Previous studies on peripancreatic fluid collections (PFCs) were searched, and certain studies were selected with the help of experts. Then, a set of key questions was selected, and treatment guidelines were systematically reviewed. Read More

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Neurochemical changes underlying cognitive impairment in olfactory bulbectomized rats and the impact of the mGlu-positive allosteric modulator CDPPB.

Brain Res 2021 Jul 1;1768:147577. Epub 2021 Jul 1.

Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Neurobiology, 12 Smętna Street, 31-343 Kraków, Poland. Electronic address:

The olfactory bulbectomized (OBX) rat model is a well-established model of depression in which antidepressant drugs reverse deficits in the passive avoidance test 14 days after administration. Recently, the olfactory bulbectomized rat model has been proposed to be a model of Alzheimer's disease (AD), and the available data indicate similarities between the changes that typically occur in AD and those observed in OBX animals. In the present study, the occurrence of neurochemical impairments related to AD were investigated 8 months after OB ablation. Read More

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Bioaccumulation, Biodistribution, Toxicology and Biomonitoring of Organofluorine Compounds in Aquatic Organisms.

Int J Mol Sci 2021 Jun 11;22(12). Epub 2021 Jun 11.

Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), Università Degli Studi di Palermo, 90100 Palermo, Italy.

This review is a survey of recent advances in studies concerning the impact of poly- and perfluorinated organic compounds in aquatic organisms. After a brief introduction on poly- and perfluorinated compounds (PFCs) features, an overview of recent monitoring studies is reported illustrating ranges of recorded concentrations in water, sediments, and species. Besides presenting general concepts defining bioaccumulative potential and its indicators, the biodistribution of PFCs is described taking in consideration different tissues/organs of the investigated species as well as differences between studies in the wild or under controlled laboratory conditions. Read More

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Comprehensive adsorption behavior and mechanism of PFOA and PFCs in various subsurface systems in China.

Sci Total Environ 2021 Jun 25;794:148463. Epub 2021 Jun 25.

State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, School of resource and environmental engineering, East China University of Science and Technology, Shanghai 200237, China. Electronic address:

The adsorption-desorption performance of perfluorooctanoic acid (PFOA), one of the environmentally persistent pollutants which is refractory to degrade in soil, was investigated and reported. The adsorption-desorption process of PFOA was firstly conducted using different fractions (sand, coarse silt and fine silt) of soil collected from Shanghai, China. More than 50% of PFOA (2. Read More

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Platelet and White Cell Reactivity to Top-Load Intravenous Perfluorocarbon Infusion in Healthy Sheep.

J Surg Res 2021 Jun 27;267:342-349. Epub 2021 Jun 27.

Department of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida 32610.

Background: Perfluorocarbon emulsions (PFCs) are intravenous artificial oxygen carriers with enhanced gas solubility. As lipid micelle nanoparticle emulsions, PFCs may have a class effect that causes degrees of thrombocytopenia. Understanding the extent of the platelet effects, including mechanism and potential inflammation after PFC infusion, is important for safe human trials. Read More

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A review of responses of terrestrial organisms to perfluorinated compounds.

Sci Total Environ 2021 Jun 22;793:148565. Epub 2021 Jun 22.

Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants, School of Energy and Environmental Engineering, University of Science and Technology Beijing, Beijing 100083, China. Electronic address:

Perfluorinated compounds (PFCs) are a class of persistent organic pollutants with widespread distribution in the environment. Since the soil environment has become a significant sink for PFCs, the toxicological assessment about their potential effects on terrestrial organisms is necessary. This review compiles the toxicity researches of regular and emerging PFCs on classical terrestrial biota i. Read More

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How could perfluorocarbon affect cytokine storm and angiogenesis in coronavirus disease 2019 (COVID-19): role of hypoxia-inducible factor 1α.

Inflamm Res 2021 Jul 26;70(7):749-752. Epub 2021 Jun 26.

Medical Biology Research Center, Health Technology Institute, Kermanshah, University of Medical Sciences, Kermanshah, Iran.

Coronavirus disease 2019 (COVID-19) pandemic is still a world-class challenge. Inflammation, especially its severe form with excess release of pro-inflammatory cytokines (cytokine storm) which is a life-threatening condition, is among the most important suspects involved in COVID-19 pathogenesis. It has been shown that cytokine storm could cause notable morbidities such as acute respiratory distress syndrome (ARDS) which leads to hypoxia which is significantly associated with mortality of patients with COVID-19. Read More

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Can PET/CT be used more effectively in pleural effusion evaluation?

Jpn J Radiol 2021 Jun 24. Epub 2021 Jun 24.

Pulmonology Department, Faculty of Medicine, Pamukkale University, Denizli, Turkey.

Purpose: Sometimes, characterization of pleural effusion (PE) can be challenging especially in patients whom invasive procedures/recurrent invasive procedures cannot be performed. The main purpose of the study is to answer this question, Can F-FDG-PET/CT contribute to reduction in the number of invasive procedures or patients undergoing to invasive procedures? Results may increase the effectiveness of patient management by facilitating clinical decision-making, especially in patients who cannot undergo invasive/recurrent invasive procedures.

Methods: Sixty-seven patients' F-FDG-PET/CT, pleural fluid cytologies (PFCs) and, if any, pleural biopsies were re-assessed. Read More

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Synthesis of magnetic chitosan biopolymeric spheres and their adsorption performances for PFOA and PFOS from aqueous environment.

Carbohydr Polym 2021 Sep 7;267:118165. Epub 2021 May 7.

Department of Environmental Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, Republic of Korea. Electronic address:

Due to numerous applications and excellent environmental stability, long-chain perfluorinated chemicals (PFCs) are ubiquitous in water across the world and adversely affect the living organisms. Thus, this study focused on the mitigation of the most frequently used long-chain PFCs namely perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) from water using reduced graphene oxide modified zinc ferrite immobilized chitosan beads ([email protected]) as an adsorbent. The results from the adsorption isotherm and kinetic studies revealed that the adsorption data fitted well to the Langmuir and the pseudo-second-order models. Read More

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September 2021

Head-to-head comparison between endoscopic ultrasound guided lumen apposing metal stent and plastic stents for the treatment of pancreatic fluid collections: A systematic review and meta-analysis.

J Hepatobiliary Pancreat Sci 2021 Jun 9. Epub 2021 Jun 9.

Gastroenterology Unit of Hospital General Universitario de Alicante, Alicante, Spain.

Background/aims: Peripancreatic fluid collections (PFCs) result from acute or chronic pancreatic inflammation that suffers a rupture of its ducts. Currently, there exists three options for drainage or debridement of pancreatic pseudocysts and walled-off necrosis (WON). The traditional procedure is drainage by placing double pigtail plastic stents (DPPS); lumen-apposing metal stent (LAMS) has a biflanged design with a wide lumen that avoids occlusion with necrotic tissue, which is more common with DPPS and reduces the possibility of migration. Read More

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Inactivation of common airborne antigens by perfluoroalkyl chemicals modulates early life allergic asthma.

Proc Natl Acad Sci U S A 2021 Jun;118(24)

School of Civil and Environmental Engineering, Nanyang Technological University, 639798 Singapore, Singapore;

Allergic asthma, driven by T helper 2 cell-mediated immune responses to common environmental antigens, remains the most common respiratory disease in children. Perfluorinated chemicals (PFCs) are environmental contaminants of great concern, because of their wide application, persistence in the environment, and bioaccumulation. PFCs associate with immunological disorders including asthma and attenuate immune responses to vaccines. Read More

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Planktonic microbial responses to perfluorinated compound (PFC) pollution: Integrating PFC distributions with community coalescence and metabolism.

Sci Total Environ 2021 Sep 15;788:147743. Epub 2021 May 15.

Key Laboratory of Integrated Regulation and Resource Development on Shallow Lake of Ministry of Education, College of Environment, Hohai University, Nanjing 210098, China; Yangtze Institute for Conservation and Development, Hohai University, Jiangsu 210098, China. Electronic address:

The presence of perfluorinated compound (PFC) contamination in riverine ecosystems represents a novel challenge for environmental remediation. However, little attention has been paid to how PFCs affect planktonic microbial community coalescence. Here, the spatial profiles of fourteen PFCs and their contributions to community assembly were determined using field sampling in a natural river confluence. Read More

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September 2021

Maternal exposure of mice to sodium p-perfluorous nonenoxybenzene sulfonate causes endocrine disruption in both dams and offspring.

Endocr J 2021 May 11. Epub 2021 May 11.

Department of Biotechnology, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.

The toxicity of certain novel perfluoroalkyl substances (PFCs) has attracted increasing attention. However, the toxic effects of sodium p-perfluorous nonenoxybenzene sulfonate (OBS) on the endocrine system have not been elucidated. In this study, OBS was added to the drinking water during the pregnancy and lactation of the healthy female mice at dietary levels of 0. Read More

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Predicting the Need for Step-Up Therapy After EUS-Guided Drainage of Pancreatic Fluid Collections With Lumen-Apposing Metal Stents.

Clin Gastroenterol Hepatol 2021 Jun 2. Epub 2021 Jun 2.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.

Background & Aims: A significant proportion of individuals with pancreatic fluid collections (PFCs) require step-up therapy after endoscopic drainage with lumen-apposing metal stents. The aim of this study is to identify factors associated with PFCs that require step-up therapy.

Methods: A retrospective cohort study of patients undergoing endoscopic ultrasound-guided drainage of PFCs with lumen-apposing metal stents from April 2014 to October 2019 at a single center was performed. Read More

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Prenatal Exposure to Endocrine-Disrupting Chemicals and Subsequent Brain Structure Changes Revealed by Voxel-Based Morphometry and Generalized Q-Sampling MRI.

Int J Environ Res Public Health 2021 04 30;18(9). Epub 2021 Apr 30.

National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli 350, Taiwan.

Previous studies have indicated that prenatal exposure to endocrine-disrupting chemicals (EDCs) can cause adverse neuropsychiatric disorders in children and adolescents. This study aimed to determine the association between the concentrations of prenatal EDCs and brain structure changes in teenagers by using MRI. We recruited 49 mother-child pairs during the third trimester of pregnancy, and collected and examined the concentration of EDCs-including phthalate esters, perfluorochemicals (PFCs), and heavy metals (lead, arsenic, cadmium, and mercury)-in maternal urine and/or serum. Read More

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Electrocautery-enhanced Lumen-apposing Metal Stents in the Management of Symptomatic Pancreatic Fluid Collections: Results From the Multicenter Prospective Pivotal Trial.

J Clin Gastroenterol 2021 Apr 23. Epub 2021 Apr 23.

Borland-Groover Clinic, Jacksonville, FL Emory University School of Medicine, Atlanta, GA University of Colorado School of Medicine, Aurora, CO Johns Hopkins University School of Medicine, Baltimore, MD Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA University of Chicago Pritzker School of Medicine, Chicago, IL Department of Medicine, Division of Gastroenterology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross, Bangkok, Thailand.

Background And Aims: Endoscopic decompression is considered a first-line treatment for symptomatic pancreatic fluid collections (PFCs). A lumen-apposing metal stent (LAMS) with an electrocautery-enhanced delivery system [electrocautery-enhanced lumen-apposing metal stent (ELAMS)] may facilitate this procedure. This study evaluated the safety and efficacy of ELAMS in the management of symptomatic PFCs. Read More

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Metal Versus Plastic Stents for Pancreatic Fluid Collection Drainage: A Systematic Review and Meta-analysis.

J Clin Gastroenterol 2021 Apr 23. Epub 2021 Apr 23.

Department of Gastroenterology, Changhai Hospital Outpatient Department of Changhai Hospital, Naval Medical University, Shanghai, China.

Objectives: The therapeutic efficacy of metal stents (MSs) for pancreatic fluid collections (PFCs) is invariably controversial. Here, we conducted a meta-analysis to summarize the results of efficacy of MSs and plastic stents (PSs) in PFC drainage.

Subjects And Methods: We performed a literature search of PubMed/MEDLINE, EMBASE, and COCHRANE for all of the published studies regarding the use of MSs and PSs for endoscopic transmural drainage of PFCs from January, 1 2015 to June 1, 2020. Read More

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Safety issues in endoscopy ultrasound-guided interventions using lumen apposing metal stents: a review of the literature.

Minerva Gastroenterol (Torino) 2021 Apr 19. Epub 2021 Apr 19.

Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy -

Lumen-apposing metal stents (LAMS) are recently introduced devices that allow to create anastomoses. The indications for LAMS placement are increasing and currently these stents can be used in multiple clinical situations such as endoscopic drainage of pancreatic fluid collections (PFCs), endoscopic ultrasound-guided choledocho-duodenostomy (EUS-CDS), endoscopic ultrasound gallbladder drainage (EUS-GBD), endoscopic ultrasound gastrojejunostomy (EUS-GJ). Since their introduction, they have revealed to allow a higher rate of technical and clinical success, and potentially lower risk of adverse events (AEs) compared with previously available devices. Read More

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Per- and polyfluoroalkyl substances (PFAS) as contaminants of emerging concern in Asia's freshwater resources.

Environ Res 2021 06 3;197:111122. Epub 2021 Apr 3.

Institute of Biology, College of Science, University of the Philippines Diliman, Quezon City, 1101, Philippines. Electronic address:

The occurrence of per- and polyfluoroalkyl substances (PFAS) in water resources is an emerging concern because of their environmental persistence and bioaccumulation in humans. In Western countries, health advisories regarding PFAS exposure have been released to warn the public of its potential adverse effects. However, awareness regarding PFAS exposure in Asia is still at its infancy as reflected by the minimal safeguards imposed to protect the population from exposure. Read More

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On the Use of EBSD and Microhardness to Study the Microstructure Properties of Tungsten Samples Prepared by Selective Laser Melting.

Materials (Basel) 2021 Mar 4;14(5). Epub 2021 Mar 4.

Laser College of Engineering, Beijing University of Technology, Beijing 100124, China.

Additively manufactured tungsten and its alloys have been widely used for plasma facing components (PFCs) in future nuclear fusion reactors. Under the fusion process, PFCs experience a high-temperature exposure, which will ultimately affect the microstructural features, keeping in mind the importance of microstructures. In this study, microhardness and electron backscatter diffraction (EBSD) techniques were used to study the specimens. Read More

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Novel multidisciplinary hub-and-spoke tertiary service for the management of severe acute pancreatitis.

BMJ Open Gastroenterol 2021 03;8(1)

HPB Surgical Unit, Freeman Hospital, Newcastle upon Tyne, UK.

Objective: Severe acute pancreatitis (SAP) is associated with high mortality (15%-30%). Current guidelines recommend these patients are best managed in a multidisciplinary team setting. This study reports experience in the management of SAP within the UK's first reported hub-and-spoke pancreatitis network. Read More

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Where there is pancreatic juice, there is a way: Spontaneous fistulization of severe acute pancreatitis-associated collection into urinary bladder.

Indian J Radiol Imaging 2020 Oct-Dec;30(4):529-532. Epub 2021 Jan 13.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Pancreatic fluid collections (PFC) are notorious for their extension beyond the normal confines of the pancreatic bed. This distribution is explained by dissection along the fascial planes in retroperitoneum due to the digestive enzymes within the PFC. In genitourinary track, PFCs have been described to involve the kidneys and the ureters. Read More

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January 2021

Quality by design approach identifies critical parameters driving oxygen delivery performance in vitro for perfluorocarbon based artificial oxygen carriers.

Sci Rep 2021 Mar 10;11(1):5569. Epub 2021 Mar 10.

Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA, 15282, USA.

Perfluorocarbons (PFCs) exhibiting high solubility for oxygen are attractive materials as artificial oxygen carriers (AOC), an alternative to whole blood or Haemoglobin-based oxygen carriers (HBOCs). PFC-based AOCs, however, met clinical translation roadblocks due to product quality control challenges. To overcome these issues, we present an adaptation of Quality by Design (QbD) practices to optimization of PFC nanoemulsions (PFC-NEs) as AOCs. Read More

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The Role of Endoscopic Transpapillary Stenting of the Main Pancreatic Duct during the Endoscopic Treatment of Pancreatic Fluid Collections.

J Clin Med 2021 Feb 14;10(4). Epub 2021 Feb 14.

Department of General, Gastroenterological and Oncological Surgery, Collegium Medicum Nicolaus Copernicus University, 87-100 Torun, Poland.

Endotherapy is a recognized, widely available, and minimally invasive treatment method for pancreatic fluid collections (PFCs) formed in the course of acute pancreatitis (AP). The use of endoscopic techniques in the treatment of main pancreatic duct (MPD) disruption due to AP remains unclear. In this article, a comprehensive review of current literature referencing our observations was performed to identify publications on the role of MPD stenting in patients undergoing endoscopic drainage of PFCs resulting from AP. Read More

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February 2021