2,657 results match your criteria peyronie's disease

The Association Between Hemoglobin A1c Levels and Inflatable Penile Prosthesis Infection: Analysis of US Insurance Claims Data.

J Sex Med 2021 Jun 6;18(6):1104-1109. Epub 2021 Jun 6.

Department of Urology, Stanford University School of Medicine, Stanford, CA, USA.

Background: The association between elevated hemoglobin A1c (HbA1c) levels and the risk of postoperative infection after penile prosthesis surgery remains controversial.

Aim: To examine the association between HbA1c levels and penile implant infections in men undergoing inflatable penile prosthesis (IPP) surgery for erectile dysfunction using a large insurance claims database.

Methods: This was a retrospective review using Optum's de-identified Clinformatics Data Mart Database. Read More

View Article and Full-Text PDF

Molecular Mechanisms and Current Pharmacotherapy of Peyronie's Disease: A Review.

Front Pharmacol 2021 20;12:643641. Epub 2021 May 20.

Andrology Laboratory, West China Hospital, Sichuan University, Chengdu, China.

Peyronie's disease (PD) is a localized fibrotic lesion of the penis that has adverse effects on men's health. In this review, we summarized the molecular mechanisms and pharmacotherapies of PD. A literature search was conducted using PubMed and Cochrane Library during 2001-2020. Read More

View Article and Full-Text PDF

Safety and Efficacy Study of Collagenase Clostridium Histolyticum Applied With an Intensive Protocol in the Treatment of Peyronie's Disease.

Sex Med 2021 Jun 3;9(3):100375. Epub 2021 Jun 3.

Department of Urology, University Hospital San Cecilio, Granada, Spain.

Introduction: Collagenase clostridium histolyticum (CCH) is a treatment for Peyronie's disease (PD) whose efficacy and safety has been demonstrated using a classic protocol and a shortened protocol.

Aim: To evaluate the efficacy and safety of an even more intense protocol in which a CCH injection is applied for 3 separate cycles of 1 week.

Methods: Prospective, nonrandomized, clinical study of a cohort of 13 patients with PD and non-ventral curvatures, between 30 and 90 degrees and with stable disease were included. Read More

View Article and Full-Text PDF

Management of Patients With Normal Physical Exams and Ultrasound Evidence of Isolated Septal and Punctate Penile Scarring.

Sex Med 2021 May 30;9(3):100346. Epub 2021 May 30.

Division of Urology, London Health Sciences Centre , London, Ontario, Canada; Division of Urology, Western University Ringgold Standard Institution, London, Ontario, Canada. Electronic address:

Introduction: Atypical penile tunical lesions including isolated septal (ISS) and punctate scarring (PS) are an under recognized and difficult to treat subset of Peyronie's disease (PD) that often present with normal physical exams. Current guidelines provide little direction in the treatment of these men.

Aim: To review the results of our treatment approach in men with ISS and PS. Read More

View Article and Full-Text PDF

Efficacy of a Novel Penile Traction Device in Improving Penile Length and Erectile Function Post Prostatectomy: Results from a Single-Center Randomized, Controlled Trial.

J Urol 2021 Jun 1:101097JU0000000000001792. Epub 2021 Jun 1.

Mayo Clinic, Rochester, Minnesota.

Purpose: RestoreX is a novel penile traction therapy device, with randomized, controlled data demonstrating improvements in penile length and erectile function after 30 to 90 minutes of daily use in men with Peyronie's disease. We sought to determine if similar improvements could be achieved post prostatectomy.

Materials And Methods: Men post prostatectomy were randomly assigned to control or one of 2 penile traction therapy protocols for 6 months, followed by a 3-month open-label phase. Read More

View Article and Full-Text PDF

Low-intensity extracorporeal shock wave therapy for Peyronie's disease: a single-center experience.

Asian J Androl 2021 May 21. Epub 2021 May 21.

APHP - Sorbonne University, Pitié Salpêtrière, Academic Urology Unit, 83 bvd Hôpital, Paris 75013, France.

The aim of this article is to assess the outcomes of a low-intensity extracorporeal shock wave therapy (LiESWT) protocol for the treatment of Peyronie's disease (PD). Patients treated for PD were prospectively recorded, and data were retrospectively reviewed. Age, characteristics of fibrous plaques, concomitant treatments, International Index of Erectile Function (IIEF-5), Lue score, and pain score on Likert scale were collected. Read More

View Article and Full-Text PDF

Mechanical characterization of fibrotic and mineralized tissue in Peyronie's disease.

Int J Impot Res 2021 May 25. Epub 2021 May 25.

VA RR&D Center for Limb Loss and MoBility (CLiMB), VA Puget Sound Health Care System, Seattle, WA, USA.

Peyronie's disease affects penile mechanics, but published research lacks biomechanical characterization of affected tunica albuginea. This work aims to establish mechanical testing methodology and characterize pathological tissue mechanics of Peyronie's disease. Tunica albuginea was obtained from patients (n = 5) undergoing reconstructive surgery for Peyronie's disease, sectioned into test specimens (n = 12), stored frozen at -20 °C, and imaged with micro-computed tomography (µCT). Read More

View Article and Full-Text PDF

Continuing Collagenase Clostridium Histolyticum Injections Among Initial Nonresponders Results in Significant Curvature Improvements in the Majority of Peyronie's Disease Men.

J Sex Med 2021 Jun 19;18(6):1092-1098. Epub 2021 May 19.

Male Fertility and Peyronie's Clinic, Orem, UT, United States. Electronic address:

Background: It is currently unclear if men with Peyronie's Disease (PD) who achieve minimal benefits with the first 2 series of Collagenase Clostridium Histolyticum (CCH) injections should continue with additional injections.

Aim: To analyze curvature improvements from the final two series of CCH injections based on amount of improvement during the first 2 series.

Methods: A prospective registry was analyzed of all men undergoing CCH injections for PD at a single institution. Read More

View Article and Full-Text PDF

Erectile dysfunction and prostate diseases are the predominant Google search terms amongst men's health topics.

Int J Impot Res 2021 May 20. Epub 2021 May 20.

Albany Medical College, Albany, NY, USA.

Patients are becoming increasingly active consumers of health information on the internet with urologic concerns being no exception. Our objective was to explore online search trends for topics related to men's health and identify information-seeking patterns related to news and media coverage of these topics. We used Google Trends ( http://google. Read More

View Article and Full-Text PDF

Low-intensity shockwave therapy in Peyronie's disease: long-term results from a prospective, randomized, sham-controlled trial.

Int J Impot Res 2021 May 18. Epub 2021 May 18.

Department of Urology, 'Martha-Maria' Hospital Nuremberg, Nuremberg, Germany.

Low-intensity shockwave therapy (LiST) is an effective treatment for pain reduction in patients with Peyronie's disease (PD). We aimed to report the long-term results of a previously published randomized, sham-controlled trial on LiST for PD management. For the initial study, 102 patients with stable PD were randomly assigned to six sessions of LiST (n = 51) or sham (n = 51) therapy. Read More

View Article and Full-Text PDF

Long-Term Functional Outcomes After Surgical Correction of Congenital Penile Curvature.

Urology 2021 May 12. Epub 2021 May 12.

Department of Urology, Hospices Civils de Lyon, Pierre-Bénite. Electronic address:

Objectives: To present the surgical results and the functional outcomes after surgical correction of congenital penile curvature (CPC) by different plication techniques.

Methods: All consecutive patients operated for CPC from 2010 to 2019 in a university hospital of Lyon, France, were retrospectively identified and included for analyzing surgical results. They were proposed to answer a questionnaire (between January 2020 and May 2020) that included questions of the Peyronie's Disease Questionnaire (PDQ), the Erection Hardness Score (EHS), and the Internal Index of Erectile Function (IIEF5), along with non-validated specific questionnaires. Read More

View Article and Full-Text PDF

Discordant erectile function assessment between validated questionnaire scores and penile Doppler ultrasound in Peyronie's disease.

Int J Impot Res 2021 May 12. Epub 2021 May 12.

Department of Urology, University of Miami Miller School of Medicine, Miami, FL, USA.

Peyronie's disease results in curvature of the penis which may cause difficulty with penetrative intercourse. The diagnosis of Peyronie's disease is easily obtained through history and physical examination alone, but the severity of erectile dysfunction relies on patient history and use of validated questionnaires. However, erectile dysfunction questionnaires were not validated in the Peyronie's disease population and may not be a reliable assessment. Read More

View Article and Full-Text PDF

Effects of patients' understanding and choice of surgical types on postoperative outcomes of Peyronie's disease: a single-center retrospective study of 108 patients.

Asian J Androl 2021 May 11. Epub 2021 May 11.

Department of Urology and Andrology, Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200011, China.

Surgical correction can be considered for treating patients with a chronic phase of Peyronie's disease (PD) and persistent penile curvature. In clinical practice, some patients pay too much attention to surgical complications and refuse the recommended feasible surgical types. Meanwhile, they require operations according to their preferences. Read More

View Article and Full-Text PDF

Single-cell Transcriptomics Uncover a Novel Role of Myeloid Cells and T-lymphocytes in the Fibrotic Microenvironment in Peyronie's Disease.

Eur Urol Focus 2021 May 4. Epub 2021 May 4.

Laboratory of Experimental Urology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium; Department of Urology, University Hospitals Leuven, Leuven, Belgium.

Background: Peyronie's disease (PD) is an acquired fibrotic disease affecting the penile tunica albuginea that can lead to curvature and deformities, shortening, and erectile dysfunction. Although immunological mechanisms have been suggested for the pathophysiology of PD, these have not been investigated using single-cell transcriptomics.

Objective: To investigate the immunological signature of plaques from PD patients using immunohistochemistry (IHC) and single-cell RNA sequencing (scRNA-Seq). Read More

View Article and Full-Text PDF

The penile duplex ultrasound: How and when to perform it?

Andrology 2021 May 6. Epub 2021 May 6.

Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

Background: Because it is a superficial structure, the penis is ideally suited to ultrasound imaging. A number of disease processes, including Peyronie's disease, penile fractures and tumors, are clearly visualized with ultrasound. Baseline and dynamic assessment of cavernosal arterial changes after pharmaco-stimulation with alprostadil allows standardized diagnosis of arterial and venogenic causes of erectile dysfunction (ED). Read More

View Article and Full-Text PDF

[Recommendations of the Committee of Andrology and Sexual Medicine of the AFU concerning the management of andrological and sexual medicine pathologies during the COVID-19 crisis].

Prog Urol 2021 Jun-Jul;31(8-9):495-502. Epub 2020 Aug 18.

265, avenue des États-du-Languedoc, Montpellier, 34000, France.

Objective: To assist urologists in the management of andrological and sexual medicine pathologies during the COVID-19 crisis.

Material And Method: Use of the formalized consensus method.

Results: The medical and surgical management of patients in andrology and sexual medicine must be adapted. Read More

View Article and Full-Text PDF

[French Urological Association (AFU) guidelines for Peyronie's disease assessment and treatment].

Prog Urol 2021 Jun-Jul;31(8-9):477-494. Epub 2021 Apr 30.

Centre d'urologie du Polygone, Montpellier.

Introduction: Peyronie's disease is a common cause for consultation in urology. Many controversies surround its treatment. No French Guidelines have been published so far. Read More

View Article and Full-Text PDF

Sexual Dysfunction in Men Who Have Sex With Men.

Philip J Cheng

Sex Med Rev 2021 Apr 27. Epub 2021 Apr 27.

Reproductive Medicine Associates of New Jersey, Department of Urology, Basking Ridge, NJ, USA. Electronic address:

Introduction: Historically, sexual health research has focused on men who have sex with women (MSW) and most research examining the sexual health of men who have sex with men (MSM) has focused on HIV transmission. Despite a high prevalence of sexual health disorders among MSM, there is limited research that has evaluated the diversity of sexual issues in these patients.

Objectives: The purpose of this review is to describe the unique sexual behaviors, concerns, and dysfunctions of MSM by evaluating the literature on sexual health in this specific patient population. Read More

View Article and Full-Text PDF

[A rare tumor of the penis occurring in context of Peyronie's disease].

Ann Pathol 2021 Apr 22. Epub 2021 Apr 22.

Service de pathologie, centre, université de Paris, hôpital européen Georges-Pompidou, AP-HP, 20, rue Leblanc, 75015 Paris, France. Electronic address:

View Article and Full-Text PDF

Fibroproliferative disorders and diabetes: Understanding the pathophysiologic relationship between Peyronie's disease, Dupuytren disease and diabetes.

Endocrinol Diabetes Metab 2021 04 31;4(2):e00195. Epub 2020 Oct 31.

Department of Dermatology and Cutaneous Biology The Joan and Joel Rosenbloom Research Center for Fibrotic Diseases Sidney Kimmel Medical College Thomas Jefferson University Philadelphia PA USA.

Introduction: Fibrosis is characterized by dysregulation and accumulation of extracellular matrix. Peyronie's disease and Dupuytren disease are fibroproliferative disorders of the tunica albuginea of the penis and fascia of the hand, respectively. Chronic hyperglycaemia due to diabetes mellitus can also lead to tissue injury and fibrosis. Read More

View Article and Full-Text PDF

Trends in treatment of Peyronie's disease in adult men in the United States from 2008 to 2017-results from an encounter and claims database.

Int J Impot Res 2021 Apr 7. Epub 2021 Apr 7.

Department of Surgery, Division of Urology, University of Utah Health Science Center, Salt Lake City, Utah, United States of America.

Treatments for Peyronie's Disease (PD) include oral medications, intralesional injections, and surgery. Collagenase Clostridium histolyticum (CCh) is the only FDA-approved treatment for PD. We sought to examine current trends in treatment of PD across the United States. Read More

View Article and Full-Text PDF


Wiad Lek 2021 ;74(3 cz 1):539-545


This review article focuses on conservative treatment options, topical, intralesional therapy, traction and vacuum therapy. A PubMed database search was performed for studies that were published between 1948 and 2019. Search keywords included "Peyronie's disease," "conservative therapy," "traction treatment," "extracorporeal shock wave therapy," "topical and oral therapies," and "vaccum therapy. Read More

View Article and Full-Text PDF

Biomechanical Simulation of Peyronie's Disease.

Appl Bionics Biomech 2021 13;2021:6669822. Epub 2021 Mar 13.

Cervenka Consulting s.r.o., Prague, Czech Republic.

A pathological disorder of human penile function, known as Peyronie's disease, is characterized by the formation of plaque particles within the tunica albuginea. The plagues in the shape of rigid plate form in the scars as a result of the imperfect healing process. Due to high stiffness, plagues are the source of pain and anomalous deformations during erectile penis function. Read More

View Article and Full-Text PDF

The evolution in the surgical management of Peyronie's disease.

Urologia 2021 May 30;88(2):79-89. Epub 2021 Mar 30.

Department of Urology, ASST Fatebenefratelli-Sacco, Luigi Sacco University Hospital, Milan, Italy.

Peyronie's disease (PD) is due to a fibrotic alteration of the tunica albuginea of the penis. It is responsible of penile pain, angulation, and possible erectile dysfunction (ED). Despite almost three centuries have passed since the first description of the disease, etiology still remains uncertain. Read More

View Article and Full-Text PDF

Buccal mucosa graft in surgical management of Peyronie's disease: Ultrasound features and clinical outcomes.

Arch Ital Urol Androl 2021 Mar 22;93(1):107-110. Epub 2021 Mar 22.

Urology Unit, Surgical Department, ASUR Marche Area Vasta 3, Macerata.

Introduction: Plaque incision and grafting represent the best surgical approach to the Peyronie's Disease (PD). The grafting procedures must be restricted to patients with normal preoperative status, excessive curvature and/or deformities. However, the ideal graft has not been identified yet. Read More

View Article and Full-Text PDF

Evaluation of alternative diluents for clinical use of collagenase clostridium histolyticum (CCH-aaes).

J Cosmet Dermatol 2021 Jun 5;20(6):1643-1647. Epub 2021 May 5.

Endo Pharmaceuticals, Inc, Horsham, PA, USA.

Background: Collagenase clostridium histolyticum (CCH-aesthetic formulation [CCH-aaes]; QWO™ [Endo Aesthetics, Malvern PA, USA] is approved as a subcutaneous injection for treatment of cellulite. In the aesthetic practice, dilution of marketed products is commonly employed to tailor treatments to individual patients or off-label locations. Dilution beyond the 0. Read More

View Article and Full-Text PDF

Peyronie's disease: pharmacological treatments and limitations.

Expert Rev Clin Pharmacol 2021 Jun 25;14(6):703-713. Epub 2021 Mar 25.

Division of Urology, Rush University Medical Center, Chicago, Illinois, USA.

: Peyronie's disease (PD) is a disorder of the tunica albuginea from disordered and excessive deposition of collagen resulting in a palpable scar, pain, erect penile deformity and erectile dysfunction that significantly impacts patients both physically and emotionally.: Several treatment options have been described for PD, including shockwave therapy, traction therapy, both oral and intralesional pharmacological options, and surgery. This review seeks to examine the data for different types of non-surgical treatments for PD. Read More

View Article and Full-Text PDF

Peyronie's disease may negatively impact the sexual experience of a couple and female sexual function: a single center study.

Transl Androl Urol 2021 Feb;10(2):555-562

Andrology and Urogynecology Clinic, Santa Maria Terni Hospital, University of Perugia, Terni, Italy.

Background: Peyonie's disease (PD) mostly affects males in the fifth decade of life, with a prevalence in the general population ranging between 0.5% and 20.3%. Read More

View Article and Full-Text PDF
February 2021