132 results match your criteria pew inflammation

Comparison of Simplified Creatinine Index and Systemic Inflammatory Markers for Nutritional Evaluation of Hemodialysis Patients.

Nutrients 2021 May 30;13(6). Epub 2021 May 30.

Department of Medicine, Division of Nephrology, Taipei Veterans General Hospital, Taipei 11217, Taiwan.

Protein-energy wasting (PEW) is associated with adverse outcomes in hemodialysis patients. This study compares the simplified creatinine index (SCI) and circulating inflammatory markers as nutritional screening tools for hemodialysis patients. Maintenance hemodialysis patients (230 total patients, 34. Read More

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Chronic Kidney Disease as a Systemic Inflammatory Syndrome: Update on Mechanisms Involved and Potential Treatment.

Life (Basel) 2021 May 5;11(5). Epub 2021 May 5.

Department of Systems Medicine, Nephrology and Dialysis Unit, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, Italy.

Chronic kidney disease (CKD) is characterized by manifestations and symptoms involving systemic organs and apparatus, associated with elevated cardiovascular morbidity and mortality, bone disease, and other tissue involvement. Arterial hypertension (AH), diabetes mellitus (DM), and dyslipidemia, with glomerular or congenital diseases, are the traditional risk factors recognized as the main causes of progressive kidney dysfunction evolving into uremia. Acute kidney injury (AKI) has recently been considered an additional risk factor for the worsening of CKD or the development of CKD de novo. Read More

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Optimal Protein Intake in Pre-Dialysis Chronic Kidney Disease Patients with Sarcopenia: An Overview.

Yoshitaka Isaka

Nutrients 2021 Apr 6;13(4). Epub 2021 Apr 6.

Department of Nephrology, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.

Multi-factors, such as anorexia, activation of renin-angiotensin system, inflammation, and metabolic acidosis, contribute to malnutrition in chronic kidney disease (CKD) patients. Most of these factors, contributing to the progression of malnutrition, worsen as CKD progresses. Protein restriction, used as a treatment for CKD, can reduce the risk of CKD progression, but may worsen the sarcopenia, a syndrome characterized by a progressive and systemic loss of muscle mass and strength. Read More

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Frequency of Intradialytic Hypotension Events Do Not Increase with Oral Nutritional Supplementation during Hemodialysis Treatment: A Randomized Controlled Trial.

J Ren Nutr 2021 Feb 26. Epub 2021 Feb 26.

Nephrology and Mineral Metabolism Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City. Electronic address:

Objective: This study aimed to compare the effect of the use of a renal-specific oral nutritional supplement (RS-ONS) during hemodialysis sessions and the use of RS-ONS at home on the incidence of intradialytic hypotension.

Methods: A single-center, 12-week, open-label, randomized controlled clinical trial was conducted. The intervention was a RN-ONS divided into two portions: 100 and 137 mL. Read More

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February 2021

Protein-Energy Wasting and Mortality Risk Prediction Among Peritoneal Dialysis Patients.

J Ren Nutr 2021 Feb 25. Epub 2021 Feb 25.

Department of Internal Medicine-Nephrology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand; Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Special Task Force for Activating Research in Renal Nutrition (Renal Nutrition Research Group), Office of Research Affairs, Chulalongkorn University, Bangkok, Thailand. Electronic address:

Objectives: Protein-energy wasting (PEW) is defined as the loss of body protein and energy reserves associated with kidney disease. However, the extent to which PEW contributes to increased mortality among peritoneal dialysis (PD) patients remains unclear.

Methods: This is a retrospective cohort study from 2012 to 2020. Read More

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February 2021

Ontogeny and heterogeneity of innate lymphoid cells and the noncoding genome.

Immunol Rev 2021 Mar 8;300(1):152-166. Epub 2021 Feb 8.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Since their discovery a decade ago, it has become evident that innate lymphoid cells (ILCs) play critical roles in protective immune responses against intracellular and extracellular pathogens but are also central regulators of epithelial barrier integrity and tissue homeostasis. ILCs populate almost every tissue in mammalian organisms; therefore, not surprisingly, dysregulation of their functions contributes to the development and progression of multiple inflammatory and metabolic diseases. Our knowledge of the transcriptional programs governing the development, differentiation, and functions of the different groups of ILCs has increased dramatically in the last ten years. Read More

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Association between the uremic toxins indoxyl-sulfate and p-cresyl-sulfate with sarcopenia and malnutrition in elderly patients with advanced chronic kidney disease.

Exp Gerontol 2021 05 30;147:111266. Epub 2021 Jan 30.

Unit of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy. Electronic address:

Background: in patients with chronic kidney disease (CKD) indoxyl sulfate (IS) and p-cresyl sulfate (PCs) may induce sarcopenia either directly or via systemic inflammation. We evaluated whether IS and PCs were associated with: sarcopenia, systemic inflammation and nutritional status.

Methods: we examined cross sectionally 93 patients with advanced CKD. Read More

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Comparison of nutritional and hydration status in patients undergoing twice and thrice-weekly hemodialysis: a silent drama in developing countries.

Int Urol Nephrol 2021 Mar 4;53(3):571-581. Epub 2021 Jan 4.

Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No. 15, Col. Sección XVI, Delegación Tlalpan, Ciudad de México, 14000, México.

Purpose: In low and middle- income countries, due to lack of financial resources, the number of patients receiving one or two hemodialysis (HD) sessions a week has increased, leading to a large number of complications. Protein-energy wasting (PEW) and overhydration (OH) are common complications; nevertheless, the evidence regarding the nutritional status of patients receiving 2 and 3 weekly dialysis sessions is scarce. Thus, our objective was to compare the nutritional and hydration status of patients with two and three HD sessions. Read More

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Assessment of nutritional status in maintenance hemodialysis patients: A multicenter cross-sectional study in Iran.

Semin Dial 2021 01 14;34(1):77-82. Epub 2020 Oct 14.

Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: Protein-energy wasting (PEW) is common in hemodialysis patients and is linked with a high rate of morbidity and mortality. Regarding importance of nutrition in these patients, a recent study was administered to evaluate the nutritional status of hemodialysis patients.

Materials: In this cross-sectional study 540 HD patients from 15 dialysis centers were evaluated. Read More

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January 2021

Frailty phenotype and multi-domain impairments in older patients with chronic kidney disease.

BMC Geriatr 2020 09 29;20(1):371. Epub 2020 Sep 29.

Unit of Nephrology, Dialysis and Kidney Transplantation Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Via della Commenda 15, 20122, Milan, Italy.

Background: Older subjects with chronic kidney disease (CKD) are often affected by multiple geriatric impairments that may benefit from a comprehensive geriatric assessment (CGA). However, ordinary execution of CGA in all these individuals would be unaffordable. We evaluated if Frailty Phenotype (FP) could identify older CKD-patients that may benefit the most from a CGA. Read More

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September 2020

Impact of malnutrition on health-related quality of life in patients on maintenance hemodialysis.

Ther Apher Dial 2020 Sep 25. Epub 2020 Sep 25.

Mansoura Nephrology and Dialysis Unit (MNDU), Mansoura University, Mansoura, Egypt.

Malnutrition is considered as one of the most important risk factors that adversely affect the quality of life (QOL) in maintenance hemodialysis (MHD) patients. Many clinically useful nutrition assessment techniques are now available, but the usefulness of such techniques in predicting QOL in MHD patients had not been sufficiently tested. The aim of this study was to explore the relation between different nutritional assessment methods, and QOL and identify nutritional parameter that can best predict physical and mental domains of QOL in MHD patients. Read More

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September 2020

Protein Energy Wasting in Children With Chronic Kidney Disease and End-Stage Kidney Disease: An Observational Study.

J Ren Nutr 2021 05 18;31(3):270-277. Epub 2020 Sep 18.

Department of Pediatric Nephrology, St John's National Academy of Health Sciences, Bangalore, Karnataka, India.

Objectives: Protein energy wasting (PEW), a specific nutritional comorbidity associated with increased mortality, is underrecognized in children with chronic kidney disease (CKD). The aim of this study was to determine the burden and factors associated with PEW and assess the utility of parameters used to diagnose PEW in children with CKD and End stage kidney disease (ESKD).

Methods: Children between 2 and 18 years of age with CKD stages 2-5 were recruited over 30 months. Read More

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Relationship of dietary and serum zinc and leptin levels with protein energy wasting in haemodialysis patients.

Int Urol Nephrol 2020 Oct 28;52(10):1969-1977. Epub 2020 Jul 28.

RFM Dialysis Units, Ankara, Turkey.

Objective: This study was carried out to evaluate the relationship between dietary and serum zinc and leptin levels with protein-energy wasting (PEW) in haemodialysis patients.

Methods: The study was conducted on 80 volunteer patients aged 19-65 years who received haemodialysis treatment three times a week for at least 1 year. Anthropometric measurements and body composition analyses were performed. Read More

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October 2020

Relation of protein energy wasting to carotid intima media thickness in hemodialysis patients.

J Hum Hypertens 2020 Jul 13. Epub 2020 Jul 13.

Mansoura Nephrology and Dialysis Unit (MNDU), Mansoura Faculty of Medicine, Mansoura, Egypt.

Carotid intima media thickness (CIMT) can reflect the degree of atherosclerosis and cardiovascular risk in hemodialysis patients. Factors such as advanced age, male gender, family history, and smoking can increase the risk of CIMT. In hemodialysis (HD) patients, lower serum albumin level was found to be correlated with higher CIMT. Read More

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Ultrasonography of Quadriceps Femoris Muscle and Subcutaneous Fat Tissue and Body Composition by BIVA in Chronic Dialysis Patients.

Nutrients 2020 May 12;12(5). Epub 2020 May 12.

Division of Nephrology, San Giovanni di Dio Hospital, 92100 Agrigento, Italy.

Protein Energy Wasting (PEW) in hemodialysis (HD) patients is a multifactorial condition due to specific pathology-related pathogenetic mechanisms, leading to loss of skeletal muscle mass in HD patients. Computed Tomography and Magnetic Resonance Imaging still represent the gold standard techniques for body composition assessment. However, their widespread application in clinical practice is difficult and body composition evaluation in HD patients is mainly based on conventional anthropometric nutritional indexes and bioelectrical impedance vector analysis (BIVA). Read More

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Polysaccharide extracted from reduces high-fat diet-induced obesity in mice by regulating the composition of intestinal microbiota.

Nutr Metab (Lond) 2020 30;17:27. Epub 2020 Mar 30.

1Department of Orthopedic Surgery, The First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Dalian, China.

Background: Obesity is a severe public health threat worldwide. Emerging evidence suggests that gut microbiota dysbiosis is closely associated with obesity and its related metabolic complications. The aim of the present study is to investigate the effects of polysaccharide extracted from (PEW) on high-fat diet (HFD)-induced obesity, and the potential mechanisms involving modulation of the gut microbiota composition. Read More

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N-terminal Pro-B-Type Natriuretic Peptide and Malnutrition in Patients on Hemodialysis.

Int J Nephrol 2020 5;2020:9528014. Epub 2020 Mar 5.

Service de Cardiologie, Centre Hospitalier Universitaire, Guadeloupe, France.

Natriuretic peptides, brain natriuretic peptide (BNP), and N-terminal probrain natriuretic peptide (NT-proBNP) are mainly known as diagnostic markers for heart failure with high diagnostic and prognostic values in the general population. In patients who are undergoing hemodialysis (HD), changes in NT-proBNP can be related to noncardiac problems such as fluid overload, inflammation, or malnutrition and can also be influenced by the dialysis characteristics. The current review aimed to summarize findings from studies on the association between NT-proBNP and malnutrition in HD patients. Read More

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A Practical Approach to Nutrition, Protein-Energy Wasting, Sarcopenia, and Cachexia in Patients with Chronic Kidney Disease.

Blood Purif 2020 18;49(1-2):202-211. Epub 2019 Dec 18.

Division of Nephrology and Hypertension and Kidney Transplantation, Orange, California, USA,

Objectives of Review: Protein-energy wasting (PEW) is a state of disordered catabolism resulting from metabolic and nutritional derangements in chronic disease states. Patients with chronic kidney disease (CKD), and end-stage renal disease (ESRD) in particular, have muscle wasting, sarcopenia, and cachexia that contribute to frailty and morbidity. Moreover, reverse epidemiology findings have strongly linked PEW with mortality in CKD and ESRD. Read More

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December 2020

Protein energy wasting; what is it and what can we do to prevent it?

Lesley Rees

Pediatr Nephrol 2021 02 13;36(2):287-294. Epub 2019 Dec 13.

Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, WC1N 3JH, London, UK.

Some children with declining height and BMI SDS fail to respond to optimisation of nutritional intake. As well as poor growth, they have muscle wasting and relative preservation of body fat. This is termed protein energy wasting (PEW). Read More

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February 2021

Relationship between protein-energy wasting in adults with chronic hemodialysis and the response to treatment with erythropoietin.

BMC Nephrol 2019 08 14;20(1):316. Epub 2019 Aug 14.

Nephrology and Mineral Metabolism Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No. 15, Col. Belisario Dominguez Sección XVI, Deleg. Tlalpan, 14080, Mexico City, CP, Mexico.

Background: It is known that one of the leading causes of morbidity in chronic kidney disease (CKD) is the anemic syndrome. Although the pathogenic mechanisms of anemia are multiple, erythropoietin deficiency appears as the dominant factor. Patients in hemodialysis (HD) have a high prevalence of protein energy wasting (PEW) that may explains the poor response to Erythropoietin (EPO). Read More

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Sarcopenia is Associated with Malnutrition but Not with Systemic Inflammation in Older Persons with Advanced CKD.

Nutrients 2019 Jun 19;11(6). Epub 2019 Jun 19.

Unit of Nephrology, Dialysis and Renal Transplantation-Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico di Milano, 20122 Milan, Italy.

Background: In patients with chronic kidney disease (CKD), sarcopenia can be determined by a wide spectrum of risk factors. We evaluated the association of sarcopenia with nutritional, behavioral and inflammatory patterns in older patients with advanced CKD.

Methods: we cross-sectionally evaluated 113 patients with CKD stages 3b-5. Read More

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Association of serum IL-18 with protein-energy wasting in end-stage renal disease patients on haemodialysis.

Int Urol Nephrol 2019 Jul 22;51(7):1271-1278. Epub 2019 May 22.

Division of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, 639 Zhizaoju Road, Shanghai, 200011, China.

Purpose: Protein-energy wasting (PEW) is highly prevalent in end-stage renal disease (ESRD) patients with inflammation who are on haemodialysis treatment. Interleukin-18 (IL-18) is an important pro-inflammatory cytokine that is significantly elevated in ESRD patients. However, the relationship between PEW and IL-18 is unclear. Read More

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Nutritional status of older patients on hemodialysis: Which nutritional markers can best predict clinical outcomes?

Nutrition 2019 09 20;65:113-119. Epub 2019 Mar 20.

Nutrition Institute, Rio de Janeiro State University, Rio de Janeiro, Brazil; Renal Medicine and Baxter Novum, CLINTEC, Karolinska Institutet, Stockholm, Sweden.

Objective: The aim of this study was to investigate nutritional status in older patients undergoing maintenance hemodialysis (MHD) to determine the prevalence of nutritional markers indicating protein-energy wasting (PEW) as assessed by subjective global assessment (SGA) and other methods, and to explore which nutritional markers can best predict clinical outcomes.

Methods: The study included 173 patients (median age 69 y; 65% men; 38% diabetes) undergoing MHD for >3 mo. Nutritional markers included SGA, malnutrition-inflammation score (MIS), geriatric nutritional risk index (GNRI), handgrip strength (HGS), midarm muscle circumference (MAMC), triceps skinfold thickness (SKF), calf circumference, and albumin. Read More

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September 2019

Assessment of nutritional status in the maintenance of haemodialysis patients: a cross-sectional study from Palestine.

BMC Nephrol 2019 03 15;20(1):92. Epub 2019 Mar 15.

Poison Control and Drug Information Center (PCDIC), College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine.

Background: Protein-energy wasting (PEW) is a relatively prevalent problem among adult haemodialysis patients (HDP). PEW is an important determinant of morbidity and mortality in HDP, therefore it is essential for dietitians to accurately assess malnutrition (MN) in these patients. HDP appear to be more susceptible to developing MN; however, this is not well documented. Read More

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Assessment of Malnutrition Inflammation Score in Different Stages of Chronic Kidney Disease.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):51-61

Ex Resident,Department of Medicine Pt. B.D. Sharma University of Health Sciences, Rohtak(Haryana).

Background: Protein-energy wasting (PEW) is common in patients with chronic kidney disease (CKD), and is associated with high morbidity and mortality. Malnutrition-Inflammation Score (MIS) has significant correlations with prospective hospitalization and mortality, as well as measures of anemia, inflammation, and nutrition in dialysis patients.

Material And Methods: The study was conducted on 100 adult patients of CKD selected from K&D clinic PGIMS, Rohtak. Read More

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December 2018

Hypoproteinemia as a factor in assessing malnutrition and predicting survival on hemodialysis.

J Artif Organs 2019 Sep 9;22(3):230-236. Epub 2019 Mar 9.

Department of Nephrology, Hypertension, Dialysis and Transplantation, University Hospital Centre Zagreb, Kispaticeva 12, 10 000, Zagreb, Croatia.

Series of studies have described malnutrition as one of the main non-traditional risk factors associated with poor prognosis and treatment outcome in patients on hemodialysis (HD). The aims of this study were to evaluate the link between HD treatment quality and the nutritional status and to additionally investigate the association of malnutrition and overall survival. A total of 134 adult out-patients (56. Read More

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September 2019

Association between malnutrition-inflammation score and risk of subsequent self-reported bone fractures in prevalent kidney transplant recipients.

Osteoporos Int 2019 Mar 19;30(3):611-620. Epub 2018 Nov 19.

Department of Medicine, Division of Nephrology, University of Tennessee Health Science Center, Memphis, TN, USA.

Chronic inflammation and protein energy wasting (PEW) syndrome are common in kidney transplant recipients (KTR). The presence of inflammation and PEW syndrome can directly affect bone resorption and bone formation, leading to bone loss and fractures. We showed PEW is independently associated with new clinically detected bone fractures in prevalent KTR. Read More

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Evaluating haemodialysis patient's nutritional status: Body mass index or body cell mass index?

Nephrology (Carlton) 2019 Sep 29;24(9):967-974. Epub 2019 Apr 29.

Nutrition Department, Nephrocare, Portugal.

Objective: Evaluate which of two combinations of parameters based on International Society of Renal Nutrition and Metabolism recommendations could better identify patients with protein-energy wasting (PEW) and to compare the relationship of these two combinations with other clinical and body composition parameters.

Methods: This was a multicentre longitudinal study with 24 months of follow-up. The PEW patients were characterized by: Group A (G ) - normalized protein catabolic rate (nPCR) < 1. Read More

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September 2019

Global Prevalence of Protein-Energy Wasting in Kidney Disease: A Meta-analysis of Contemporary Observational Studies From the International Society of Renal Nutrition and Metabolism.

J Ren Nutr 2018 11;28(6):380-392

Department of Medical Epidemiology and Biostatistics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Sweden.

Objective: To better define the prevalence of protein-energy wasting (PEW) in kidney disease is poorly defined.

Methods: We performed a meta-analysis of PEW prevalence from contemporary studies including more than 50 subjects with kidney disease, published during 2000-2014 and reporting on PEW prevalence by subjective global assessment or malnutrition-inflammation score. Data were reviewed throughout different strata: (1) acute kidney injury (AKI), (2) pediatric chronic kidney disease (CKD), (3) nondialyzed CKD 3-5, (4) maintenance dialysis, and (5) subjects undergoing kidney transplantation (Tx). Read More

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November 2018

Isolation and identification of peptides from simulated gastrointestinal digestion of preserved egg white and their anti-inflammatory activity in TNF-α-induced Caco-2 cells.

J Nutr Biochem 2019 01 27;63:44-53. Epub 2018 Sep 27.

Jiangxi Key Laboratory of Natural Products and Functional Food, Jiangxi Agricultural University, Nanchang 330045, China. Electronic address:

Simulated gastrointestinal digestion of preserved egg white (SGD-PEW) exerts anti-inflammatory effects on Caco-2 cells and a mouse model of DSS-induced colitis. Here, we aimed to separate peptides derived from SGD-PEW and evaluate their anti-inflammatory effects using an in vitro inflammatory model. Six peptides were isolated and identified. Read More

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January 2019