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Preclinical and clinical study on [F]DRKXH1: a novel β-amyloid PET tracer for Alzheimer's disease.

Eur J Nucl Med Mol Imaging 2021 Jul 22. Epub 2021 Jul 22.

Department of Nuclear Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, No. 1665, Kongjiang Street, Yangpu District, Shanghai, 200092, China.

Background: The deposition of β-amyloid (Aβ) in the brain is a biomarker of Alzheimer's disease (AD). Highly sensitive Aβ positron emission tomography (PET) imaging plays an essential role in diagnosing and evaluating the therapeutic effects of AD.

Aim: To synthesize a new Aβ tracer [F]DRKXH1 (5-(4-(6-(2-[18]fluoroethoxy)ethoxy)imidazo[1,2-alpha]pyridin-2-yl)phenyl) and evaluate the tracer performance by biodistribution analysis, in vivo small-animal PET-CT dynamic scan, ex vivo and in vitro autoradiography, and PET in human subjects. Read More

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[Value of (18)F-FDG PET-CT imaging to predict epidermal growth factor receptor mutations in patients with lung squamous cell carcinoma].

Zhonghua Zhong Liu Za Zhi 2021 Jul;43(7):795-800

Department of Nuclear Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

To investigate the value of (18)F-fluorodeoxy glucose ((18)F-FDG) positron emission tomography/computed tomography (PET-CT) in predicting the epidermal growth factor receptor (EGFR) mutations in patients with lung squamous cell carcinoma. We retrospectively analyzed the clinical data and (18)F-FDG PET-CT imaging data of 206 patients with lung squamous cell carcinoma confirmed by pathology and underwent EGFR mutation test in the First Affiliated Hospital of Nanjing Medical University from June 2013 to October 2018. Receiver operating characteristic (ROC) curve analysis was performed to quantify the predictive value of maximum standard uptake value (SUV(max)), metabolic tumor volume (MTV), total lesion glycolysis (TLG). Read More

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Positron emission tomography/computed tomography in the management of Hodgkin and B-cell non-Hodgkin lymphoma: An update.

Cancer 2021 Jul 19. Epub 2021 Jul 19.

Department of Nuclear Medicine, University Hospital Rheinish-Westphalian Technical University, Aachen University, Aachen, Germany.

F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is now an integral part of lymphoma staging and management. Because of its greater accuracy compared with CT alone, PET/CT is currently routinely performed for staging and for response assessment at the end of treatment in the vast majority of FDG-avid lymphomas and is the cornerstone of response classification for these lymphomas according to the Lugano classification. Interim PET/CT, typically performed after 2 to 4 of 6 to 8 chemotherapy/chemoimmunotherapy cycles with or without radiation, is commonly performed for prognostication and potential treatment escalation or de-escalation early in the course of therapy, a concept known as response-adapted or risk-adapted treatment. Read More

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Correlation of 4'-[methyl-11C]-thiothymidine PET with Ki-67 immunohistochemistry separately in patients with newly diagnosed and recurrent gliomas.

Nucl Med Commun 2021 Jul 19. Epub 2021 Jul 19.

Department of Radiology Department of Neurological Surgery, Faculty of Medicine, Kagawa University, Kagawa Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

Objective: 4'-[methyl-11C]-thiothymidine (4DST) uptake on PET was correlated with proliferative activity separately in patients with newly diagnosed and recurrent gliomas.

Methods: A total of 29 patients, 18 with newly diagnosed gliomas and 11 with recurrent gliomas who underwent 4DST PET/computed tomography (CT) were available for a retrospective analysis of prospectively collected data. The maximum standardized uptake value (SUVmax) of tumor (T) and the mean SUV of normal contralateral hemisphere (N) were calculated, and the tumor-to-normal (T/N) ratio was determined. Read More

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Assessment of volumetric parameters derived from 68Ga-PSMA PET/CT in prostate cancer patients with biochemical recurrence: an institutional experience.

Nucl Med Commun 2021 Jul 19. Epub 2021 Jul 19.

Department of Nuclear Medicine, Ankara City Hospital, University of Health Sciences Department of Nuclear Medicine, Ankara City Hospital, Ankara Department of Nuclear Medicine, Sabuncuoğlu Şerefeddin Training and Research Hospital, University of Amasya, Amasya, Turkey.

Objective: The aim of this study was to evaluate the relationship between volumetric parameters calculated using semiautomatic quantification of lesions detected in 68Ga-labeled prostate-specific membrane antigen PET-computed tomography (68Ga-PSMA PET/CT) and clinical characteristics in prostate cancer (PCa) patients with biochemical recurrence.

Methods: A total of 85 consecutive PCa patients with biochemical recurrence who underwent 68Ga-PSMA PET/CT at our institution from January 2019 to March 2020 were retrospectively assessed. 68Ga-PSMA PET/CT-derived volumetric parameters, including whole-body PSMA tumor volume (wbPSMA-TV) and whole-body total lesion PSMA (wbTL-PSMA), as well as the established maximum and mean standardized uptake value (SUVmax and SUVmean), were calculated for each patient. Read More

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Characterization of point-spread function specification error on Geometric Transfer Matrix partial volume correction in [C]PiB amyloid imaging.

EJNMMI Phys 2021 Jul 20;8(1):54. Epub 2021 Jul 20.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Purpose: Partial-volume correction (PVC) using the Geometric Transfer Matrix (GTM) method is used in positron emission tomography (PET) to compensate for the effects of spatial resolution on quantitation. We evaluate the effect of misspecification of scanner point-spread function (PSF) on GTM results in amyloid imaging, including the effect on amyloid status classification (positive or negative).

Methods: Twenty-nine subjects with Pittsburgh Compound B ([C]PiB) PET and structural T1 MR imaging were analyzed. Read More

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68Ga-DOTATOC-PET/MRI-A Secure One-Stop Shop Imaging Tool for Robotic Radiosurgery Treatment Planning in Patients with Optic Nerve Sheath Meningioma.

Cancers (Basel) 2021 Jul 1;13(13). Epub 2021 Jul 1.

Department of Radiation Oncology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 13353 Berlin, Germany.

Optic nerve sheath meningiomas (ONSM) are rare but can lead to irreversible blindness. Hybrid imaging may enhance tumor delineation and diagnostic accuracy via receptor binding. However, relevant clinical data for ONSM are lacking. Read More

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The relationship between synaptic density marker SV2A, glutamate and N-acetyl aspartate levels in healthy volunteers and schizophrenia: a multimodal PET and magnetic resonance spectroscopy brain imaging study.

Transl Psychiatry 2021 Jul 17;11(1):393. Epub 2021 Jul 17.

MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, London, W12 0NN, UK.

Glutamatergic excitotoxicity is hypothesised to underlie synaptic loss in schizophrenia pathogenesis, but it is unknown whether synaptic markers are related to glutamatergic function in vivo. Additionally, it has been proposed that N-acetyl aspartate (NAA) levels reflect neuronal integrity. Here, we investigated whether synaptic vesicle glycoprotein 2 A (SV2A) levels are related to glutamatergic markers and NAA in healthy volunteers (HV) and schizophrenia patients (SCZ). Read More

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Diffusion-weighted MRI and F-FDG PET/CT in assessing the response to neoadjuvant chemoradiotherapy in locally advanced esophageal squamous cell carcinoma.

Radiat Oncol 2021 Jul 19;16(1):132. Epub 2021 Jul 19.

Department of Radiation Oncology, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University, 160 Pujian Road, Shanghai, 200127, China.

Background: Neoadjuvant chemoradiotherapy (nCRT) followed by surgery is a currently widely used strategy for locally advanced esophageal cancer (EC). However, the conventional imaging methods have certain deficiencies in the evaluation and prediction of the efficacy of nCRT. This study aimed to explore the value of functional imaging in predicting the response to neoadjuvant chemoradiotherapy (nCRT) in locally advanced esophageal squamous cell carcinoma (ESCC). Read More

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F-fluorodeoxyglucose positron emission tomography-based prediction for splenectomy in patients with suspected splenic lymphoma.

Ann Transl Med 2021 Jun;9(12):1009

Department of Hematology, Huadong Hospital, Fudan University, Shanghai, China.

Background: Diagnostic splenectomy is often performed on patients with suspected splenic lymphoma. However, unnecessary splenectomy entails more harm than benefit for patients. Therefore, a preliminary screening method for patients with suspected splenic lymphoma that has high sensitivity and specificity is urgently needed. Read More

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FDG-PET/CT in the Radiotherapy Treatment Planning of Locally Advanced Anal Cancer: A Monoinstitutional Experience.

Front Oncol 2021 1;11:655322. Epub 2021 Jul 1.

Department of Radiation Oncology, Ospedali Riuniti Umberto I°, GM Lancisi, G Salesi, Ancona, Italy.

Aims: Radiotherapy with concurrent 5-fluorouracil/mitomycin-C based chemotherapy has been established as definitive standard therapy approach for anal cancer. Intensity Modulated Radiotherapy (IMRT) leads to a precise treatment of the tumor, allowing dose escalation on Gross Tumor Volume (GTV), with a surrounding healthy tissues sparing. Our study assessed the impact of 18-Fluorodeoxyglucose positron emission tomography (18FDG-PET/CT) on the radiotherapy contouring process and its contribution to lymphatic spread detection, resulting to a personalization of Clinical Target Volume (CTV) and dose prescription. Read More

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Challenges and opportunities for more efficient water use and circular wastewater management. The case of Campania Region, Italy.

J Environ Manage 2021 Jul 15;297:113171. Epub 2021 Jul 15.

Department of Science and Technology, Parthenope University of Naples, Naples, Italy; School of Environment, Beijing Normal University, Beijing, China.

By 2050, global demand for water is expected to increase by some 55% due to population growth and urbanization. The utilization of large amounts of freshwater in the world, generate huge volumes of wastewater of which, globally, more than 80% is discharged without treatment, thus causing impacts on aquatic ecosystems, human health and economic productivity. More sustainable practices of wastewater management are expected as a way towards circular bioeconomy (CBE) processes, whose goal is to implement closed systems promoting the systematic use of recycling, reuse and recovery of bioproducts and by-products and the reduction of waste generation. Read More

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Striatal acetylcholine-dopamine imbalance in Parkinson's disease: in vivo neuroimaging study with dual-tracer PET and dopaminergic PET-informed correlational tractography.

J Nucl Med 2021 Jul 16. Epub 2021 Jul 16.

University of Michigan, United States.

Previous studies of animal models of Parkinson's disease (PD) suggest an imbalance between striatal acetylcholine (ACh) and dopamine (DA), although other studies have questioned this. To our knowledge, there are no previous in vivo neuroimaging studies examining striatal ACh-DA imbalance in PD patients. Using cholinergic and dopaminergic PET (F-FEOBV and C-DTBZ, respectively) and correlational tractography, our aim was to investigate the ACh-DA interaction at two levels of dopaminergic loss in PD subjects: integrity loss of the nigrostriatal dopaminergic white matter tract; and loss at the presynaptic-terminal level. Read More

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Quantitative radiomics features in diffuse large B-cell lymphoma: does segmentation method matter?

J Nucl Med 2021 Jul 16. Epub 2021 Jul 16.

Amsterdam UMC, Vrije Universiteit Amsterdam, department of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Netherlands.

Introduction: Radiomics features may predict outcome in diffuse large B-cell lymphoma (DLBCL). Currently, multiple segmentation methods are used to calculate metabolic tumor volume (MTV). We assessed the influence of segmentation method on the discriminative power of radiomics features in DLBCL for patient level and for the largest lesion. Read More

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The diagnostic value of metabolic, morphological and heterogeneous parameters of 18F-FDG PET/CT in mediastinal lymph node metastasis of non-small cell lung cancer.

Nucl Med Commun 2021 Jul 15. Epub 2021 Jul 15.

Department of Nuclear Medicine Department of Radiology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing 400030, P.R. China.

Objectives: To investigate the value of PET/CT metabolic, morphological and heterogeneous parameters in the diagnosis of 18F-FDG positive mediastinal lymph node metastasis in non-small cell lung cancer (NSCLC).

Patients And Methods: A total of 156 patients with pathologically diagnosed NSCLC and underwent 18F-FDG PET/CT scans were enrolled in this study. Mediastinal lymph nodes with 18F-FDG uptake greater than the mediastinum were analyzed. Read More

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Acceleration of ligamentization and osseointegration processes after anterior cruciate ligament reconstruction with autologous tissue-engineered polyethylene terephthalate graft.

Ann Transl Med 2021 May;9(9):770

Department of Sports Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Background: Despite the advantages of excellent mechanical properties for rapid return to sports and early rehabilitation after anterior cruciate ligament (ACL) reconstruction with polyethylene terephthalate (PET) artificial ligament, the graft failure rate during long-term follow-up is relatively high due to poor graft-host incorporation. The purpose of the present study was to investigate the effect of autologous tissue-engineered PET (ATE-PET) grafts on osseointegration and ligamentization after ACL reconstruction.

Methods: Forty-eight New Zealand white rabbits were randomly divided into PET group (n=24) and ATE-PET group (n=24). Read More

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Use of Multiple-Tube Phantom: A Method to Globally Correct Native T1 Relaxation Time Inhomogeneity in Dedicated Molecular Magnetic Resonance Breast Coil.

J Med Phys 2021 Jan-Mar;46(1):41-46. Epub 2021 May 5.

Department of Molecular Imaging and Nuclear Medicine, PET SUITE, Indraprastha Apollo Hospitals, New Delhi, India.

Background: Native T1 relaxation time (T1) presents an important prerequisite to reliably quantify pharmacokinetic parameter like K (volume transfer constant). Native T1 value can be varied because of the inhomogeneity in the breast coil, thus influencing the K measurement.

Purpose: The current study aims to design and use a phantom with multiple tubes for both breast cuffs to assess native T1 inhomogeneity across the dedicated molecular magnetic resonance (mMR) breast coil and adopt corrective method to spatially normalize T1 values to improve homogeneity. Read More

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Prognostic value of baseline total metabolic tumour volume of F-FDG PET/CT imaging in patients with angioimmunoblastic T-cell lymphoma.

EJNMMI Res 2021 Jul 15;11(1):64. Epub 2021 Jul 15.

The Department of Nuclear Medicine, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital , Nanjing, China.

Purpose: The aim of this study was to explore the prognostic value of baseline metabolic parameters of F-FDG PET/CT imaging in patients with angioimmunoblastic T-cell lymphoma (AITL).

Materials And Methods: Fifty-six AITL patients (average age 64.0 ± 1. Read More

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Internal dosimetry in F-18 FDG PET examinations based on long-time-measured organ activities using total-body PET/CT: does it make any difference from a short-time measurement?

EJNMMI Phys 2021 Jul 15;8(1):51. Epub 2021 Jul 15.

Institute of Radiation Medicine, Fudan University, 2094 Xietu Road, Shanghai, 200032, China.

Purpose: A 2-m axial field-of-view, total-body PET/CT scanner (uEXPLORER) has been recently developed to provide total-body coverage and ultra-high sensitivity, which together, enables opportunities for in vivo time-activity curve (TAC) measurement of all investigated organs simultaneously with high temporal resolution. This study aims at quantifying the cumulated activity and patient dose of 2-[F-18]fluoro-2-deoxy-D-glucose (F-18 FDG ) imaging by using delayed time-activity curves (TACs), measured out to 8-h post-injection, for different organs so that the comparison between quantifying approaches using short-time method (up to 75 min post-injection) or long-time method (up to 8 h post-injection) could be performed.

Methods: Organ TACs of 10 healthy volunteers were collected using total-body PET/CT in 4 periods after the intravenous injection of F-18 FDG. Read More

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Comparing different CT, PET and MRI multi-modality image combinations for deep learning-based head and neck tumor segmentation.

Acta Oncol 2021 Jul 15:1-8. Epub 2021 Jul 15.

Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Background: Manual delineation of gross tumor volume (GTV) is essential for radiotherapy treatment planning, but it is time-consuming and suffers inter-observer variability (IOV). In clinics, CT, PET, and MRI are used to inform delineation accuracy due to their different complementary characteristics. This study aimed to investigate deep learning to assist GTV delineation in head and neck squamous cell carcinoma (HNSCC) by comparing various modality combinations. Read More

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Tzila Zwas

Harefuah 2021 Jul;160(7):468-473

Institute of Nuclear Medicine, The Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel.

Introduction: Nuclear medicine (NM) in Israel started in 1952 with the use of isotopes in medicine, using I-131 for thyroid disorders, initiated by Prof. Czerniak, founder of the profession. The first institute opened in 1954. Read More

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Harefuah 2021 Jul;160(7):448-454

Institute of Nuclear Medicine and Molecular Imaging, Soroka University Medical Center, Beer-Sheva, Israel, Affiliated to Ben Gurion University of the Negev, Faculty of Health Sciences.

Introduction: In recent years, nuclear medicine has become a diverse and central profession that influences the diagnosis and treatment of patients with diseases from all fields of medicine. Imaging through nuclear medicine is a significant step in the process of making therapeutic decisions and evaluating patients with malignancy, infectious or inflammatory process, heart problems, neurological disorders and more. The advantages of diagnostic methods from the field of nuclear medicine arise from their non-invasiveness and from the possibility of providing functional and metabolic information at a very early stage during the course of the disease. Read More

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The additional diagnostic impact of positron emission tomography-computed tomography for lymph node metastasis from colorectal cancer: A prospective lymph node level analysis.

J Surg Oncol 2021 Jul 14. Epub 2021 Jul 14.

Department of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Fukushima, Japan.

Background: We conducted a prospective study to determine the diagnostic performance of positron emission tomography-computed tomography (PET-CT) for lymph node metastasis in colorectal cancer patients.

Methods: We enrolled patients scheduled to receive curative surgery with lymph node dissection for colorectal adenocarcinoma who underwent contrast-enhanced abdominopelvic CT and PET-CT before surgery and who had primary lesions of cT2 or deeper. A radiologist determined the fluorodeoxyglucose uptake and the standardized uptake value (SUV) and metabolic volume (MV) to diagnose metastasis in cases with enlarged lymph nodes (≥7 mm long in minor diameter) on contrast-enhanced CT. Read More

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Evaluation of Hybrid PET/MRI for Gross Tumor Volume (GTV) Delineation in Colorectal Cancer Liver Metastases Radiotherapy.

Cancer Manag Res 2021 6;13:5383-5389. Epub 2021 Jul 6.

Department of Radiation Oncology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.

Purpose: Hybrid PET/MRI has been increasingly incorporated into the practice of radiation oncologists since it contains both anatomical and biological data and may bring about personalized radiation plans for each patient. The objective of this study was to evaluate the feasibility of GTV delineation from hybrid PET/MRI compared with that from current-practice MRI during radiotherapy planning in patients with colorectal liver metastases.

Patients And Methods: Twenty-four patients (thirty lesions) with colorectal liver metastases were prospectively enrolled in this study. Read More

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Synthesis and performance evaluation of plastic waste aerogel as sustainable and reusable oil absorbent.

Environ Pollut 2021 Jul 7;288:117717. Epub 2021 Jul 7.

Department of Energy Science and Technology, Environmental Waste Recycle Institute, Myongji University, Yongin, Gyeonggi-do, 17058, Republic of Korea. Electronic address:

Direct utilization of waste polyethylene terephthalate (PET) from the environment to form highly porous aerogel technology for oil absorption is an attractive approach from the view point of green chemistry. However, the oil absorption reaction is limited by low oil absorption capacity and less stability. For now, silica aerogel are used to solve these problem. Read More

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Physical Exercise and Immune System: Perspectives on the COVID-19 pandemic.

Rev Assoc Med Bras (1992) 2021 Jul 9. Epub 2021 Jul 9.

Fundação Oswaldo Cruz, Instituto Gonçalo Moniz - Salvador (BA), Brazil.

Physical exercise training (PET) has been considered an excellent non-pharmacological strategy to prevent and treat several diseases. There are various benefits offered by PET, especially on the immune system, promoting changes in the morphology and function of cells, inducing changes in the expression pattern of pro and anti-inflammatory cytokines. However, these changes depend on the type, volume and intensity of PET and whether it is being evaluated acutely or chronically. Read More

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Evaluation of [F]-JNJ-64326067-AAA tau PET tracer in humans.

J Cereb Blood Flow Metab 2021 Jul 14:271678X211031035. Epub 2021 Jul 14.

Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.

The [F]-JNJ-64326067-AAA ([F]-JNJ-067) tau tracer was evaluated in healthy older controls (HCs), mild cognitive impairment (MCI), Alzheimer's disease (AD), and progressive supranuclear palsy (PSP) participants. Seventeen subjects (4 HCs, 5 MCIs, 5 ADs, and 3 PSPs) received a [C]-PIB amyloid PET scan, and a tau [F]-JNJ-067 PET scan 0-90 minutes post-injection. Only MCIs and ADs were amyloid positive. Read More

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Predisposing Anatomical Factors of Humeral Fractures in Birds of Prey: A Preliminary Tomographic Comparative Study.

J Avian Med Surg 2021 Jul;35(2):123-134

Department of Veterinary Sciences, Veterinary Teaching Hospital, University of Messina, Polo Universitario dell'Annunziata, 98168 Messina, Italy.

The aim of this study was to identify possible predisposing anatomical factors associated with humeral fractures in birds of prey through comparison of specific anatomical features in different raptor species. An anatomical study of bone features in birds of prey was performed on 3 male subjects from 5 different species. The selected species included in this investigation were 3 diurnal species (the common buzzard [], the peregrine falcon [], and the European honey-buzzard []) and 2 nocturnal species (the barn owl [] and the tawny owl []). Read More

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Fibroblast activation protein inhibitor (FAPi) positive tumour fraction on PET/CT correlates with Ki-67 in liver metastases of neuroendocrine tumours.

Nuklearmedizin 2021 Jul 13. Epub 2021 Jul 13.

Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany.

Aim: Gallium-68-labelled inhibitors of the fibroblast activation protein (FAPi) enable positron emission tomography/computed tomography (PET/CT) imaging of fibroblast activation. We evaluated if [Ga]Ga-DATA5 m.SA. Read More

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Choroid Plexus Enlargement in Inflammatory Multiple Sclerosis: 3.0-T MRI and Translocator Protein PET Evaluation.

Radiology 2021 Jul 13:204426. Epub 2021 Jul 13.

From the Sorbonne Université, Paris Brain Institute, Institut du Cerveau, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Paris, France (V.A.G.R., E.M., A.C., M.T., M.H., E.P., C.L., B.B., B.S.); Université Paris-Saclay, Commissariat à l'énergie atomique et aux énergies alternatives, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, BioMaps, Service Hospitalier Frédéric Joliot, Orsay, France (M.T., M.B., P.G.); Service d'Imagerie Médicale, Hôpital Fondation Adolphe de Rothschild, Paris, France (E.P.); Department of Neurology, Pitié-Salpêtrière Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France (C.L.); and Department of Neurology, St Antoine Hospital, 184, rue du Faubourg St Antoine, Assistance Publique des Hôpitaux de Paris, 75571 Paris, France (B.B., B.S.).

Background Choroid plexuses (CPs) have been suggested as a key gateway for inflammation in experimental autoimmune encephalitis, but in vivo evidence of their involvement in multiple sclerosis (MS) is lacking. Purpose To assess CP volumetric and inflammatory changes in patients with MS versus healthy control participants. Materials and Methods This was a secondary analysis of 97 patients (61 with relapsing-remitting MS [RRMS] and 36 with progressive MS) and 44 healthy control participants who participated in three prospective 3. Read More

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