2,522 results match your criteria persisted spontaneous


Mechanical actions of dendritic-spine enlargement on presynaptic exocytosis.

Nature 2021 Nov 24. Epub 2021 Nov 24.

Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

Synaptic transmission involves cell-to-cell communication at the synaptic junction between two neurons, and chemical and electrical forms of this process have been extensively studied. In the brain, excitatory glutamatergic synapses are often made on dendritic spines that enlarge during learning. As dendritic spines and the presynaptic terminals are tightly connected with the synaptic cleft, the enlargement may have mechanical effects on presynaptic functions. Read More

View Article and Full-Text PDF
November 2021

Pediatric traumatic brain injury and a subsequent transient immune challenge independently influenced chronic outcomes in male mice.

Brain Behav Immun 2021 Nov 19;100:29-47. Epub 2021 Nov 19.

Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia; Department of Neurology, Alfred Health, Prahran, VIC, Australia; Department of Medicine (Royal Melbourne Hospital), The University of Melbourne, Parkville, VIC, Australia. Electronic address:

Traumatic brain injury (TBI) is a major contributor to death and disability worldwide. Children are at particularly high risk of both sustaining a TBI and experiencing serious long-term consequences, such as cognitive deficits, mental health problems and post-traumatic epilepsy. Severe TBI patients are highly susceptible to nosocomial infections, which are mostly acquired within the first week of hospitalization post-TBI. Read More

View Article and Full-Text PDF
November 2021

Hypothesis and Theory: Evaluating the Co-Evolution of the Melanocortin-2 Receptor and the Accessory Protein MRAP1.

Front Endocrinol (Lausanne) 2021 1;12:747843. Epub 2021 Nov 1.

Department of Biological Sciences, University of Denver, Denver, CO, United States.

The melanocortin receptors (MCRs) and the MRAP accessory proteins belong to distinct gene families that are unique to the chordates. During the radiation of the chordates, the melancortin-2 receptor paralog (MC2R) and the MRAP1 paralog (melanocortin-2 receptor accessory protein 1) have co-evolved to form a heterodimer interaction that can influence the ligand selectivity and trafficking properties of MC2R. This apparently spontaneous interaction may have begun with the ancestral gnathostomes and has persisted in both the cartilaginous fishes and the bony vertebrates. Read More

View Article and Full-Text PDF
November 2021

Breast cancer-associated opsoclonus-myoclonus syndrome: a case report.

World J Surg Oncol 2021 Nov 16;19(1):328. Epub 2021 Nov 16.

Department of Surgery, University College London, Royal Free London NHS Foundation Trust, London, UK.

Background: Paraneoplastic neurological syndromes constitute rare neurological complications of malignant disease, manifesting in <1% of patients with cancer. Opsoclonus-myoclonus syndrome (OMS) presents with chaotic ocular saccades (opsoclonus), spontaneous muscular jerking (myoclonus) that may be accompanied by ataxia, strabismus, aphasia, or mutism. Its paraneoplastic variant in the adult is most commonly associated with small-cell lung cancer, followed by breast cancer. Read More

View Article and Full-Text PDF
November 2021

Synaptic potentiation of anterior cingulate cortex contributes to chronic pain of Parkinson's disease.

Mol Brain 2021 Nov 6;14(1):161. Epub 2021 Nov 6.

Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.

Parkinson's disease (PD) is a multi-system neurodegenerative disorder. Patients with PD often suffer chronic pain. In the present study, we investigated motor, sensory and emotional changes in three different PD mice models. Read More

View Article and Full-Text PDF
November 2021

[Central control malfunction in Wolfram syndrome: Report of one case of difficult weaning].

Rev Mal Respir 2021 Nov 24;38(9):946-950. Epub 2021 Oct 24.

Service de pneumologie, L'institut du thorax, Hôpital G. et R. Laennec, CHU de Nantes, boulevard Jacques-Monod, 44093 Nantes cedex 1, France; Université de Nantes, 44000 Nantes, France.

Introduction: Wolfram syndrome is a rare autosomal recessive genetic disease characterized by diabetes insipidus, diabetes mellitus, optic atrophy and deafness. A neurodegenerative syndrome is usually associated, including cerebellar ataxia. A few cases of central apnea have been reported in the literature. Read More

View Article and Full-Text PDF
November 2021

Mycobacteria avium-related peritonitis in a patient undergoing peritoneal dialysis: case report and review of the literature.

BMC Nephrol 2021 Oct 19;22(1):345. Epub 2021 Oct 19.

Department of Nephrology, Ningbo Hangzhou Bay Hospital, Ningbo, Zhejiang, China.

Background: Mycobacteria avium (M. avium) is a species of ubiquitous slowly growing nontuberculous mycobacteria. It causes opportunistic infections. Read More

View Article and Full-Text PDF
October 2021

Spontaneous Recovery of Hemophagocytic Lymphohistiocytosis Due to Primary Epstein-Barr Virus Infection in an Adult Patient.

Am J Case Rep 2021 Oct 17;22:e933272. Epub 2021 Oct 17.

Department of Infectious Diseases, Tokyo Bay Urayasu Ichikawa Medical Center, Urayasu, Chiba, Japan.

BACKGROUND Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening systemic hyperinflammatory condition. Most adult HLH cases are secondary to infection, malignancy, and rheumatic diseases. Epstein-Barr virus (EBV) infection is the most frequent cause of infection-induced HLH. Read More

View Article and Full-Text PDF
October 2021

Case Report: Successful Therapy of Spontaneously Occurring Canine Degenerative Lumbosacral Stenosis Using Autologous Adipose Tissue-Derived Mesenchymal Stem Cells.

Front Vet Sci 2021 23;8:732073. Epub 2021 Sep 23.

Laboratory for Molecular Biomedicine, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia.

The management of degenerative lumbosacral stenosis (DLSS) in dogs usually requires aggressive, costly surgical treatments that may themselves present complications, while do not fully resolve the symptoms of the disease. In this study, the dog diagnosed with severe DLSS, with hind limb paresis, was treated using a new and least invasive treatment. Cultured autologous adipose tissue-derived mesenchymal stem cells (AT-MSCs) were injected bilaterally at the level of L7-S1, in the vicinity of the external aperture of the intervertebral foramen of DLSS patient. Read More

View Article and Full-Text PDF
September 2021

Hemorrhagic disseminated intravascular coagulation after 177Lu-Dotatate in metastatic midgut neuroendocrine tumor: A case report.

Medicine (Baltimore) 2021 Oct;100(40):e27455

UNICANCER, Comprehensive Cancer Centre F. Baclesse, Department of Nuclear Medicine, Caen, France.

Rationale: Peptide receptor radionuclide therapy with 177Lu-Dotatate represents a major breakthrough in the treatment of metastatic well differentiated neuroendocrine tumors. This treatment is generally well tolerated. Reported severe long-term hematological side effects are rare and include hematopoietic neoplasms and bone marrow failure. Read More

View Article and Full-Text PDF
October 2021

Uterine artery chemoembolization followed by hysteroscopic resection for management of retained placenta accreta with marked vascularity after evacuation of first-trimester miscarriage in angular pregnancy: A case report.

Case Rep Womens Health 2021 Oct 23;32:e00360. Epub 2021 Sep 23.

Department of Obstetrics and Gynecology, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu, Japan.

Background: Angular pregnancy is a rare form of eccentric intrauterine gestation. To determine the management strategy, angular pregnancy should be differentiated from interstitial pregnancy and cornual pregnancy.

Case: A 37-year-old woman (gravida 5, para 4) with no previous disease history was referred because of a retained placenta with hemorrhage 20 days following the manual vacuum aspiration of an intrauterine pregnancy performed after the diagnosis of miscarriage at 8 weeks of gestation. Read More

View Article and Full-Text PDF
October 2021

Congenital pulmonary airway malformation (cpam) mimicking an spontaneous pneumothorax in a newborn.

Cir Pediatr 2021 Oct 1;34(4):207-210. Epub 2021 Oct 1.

Pediatric Surgery Department. La Paz Children's University Hospital. Madrid.

Introduction: Patients with congenital pulmonary airway malformation (CPAM) are usually asymptomatic, but some may present with respiratory distress. We report a rare presentation of a CPAM as an image compatible with persistent and localized spontaneous pneumothorax.

Case Report: A 2-month-old male infant without prenatal diagnosis, postnatal distress or barotrauma, was admitted with acute respiratory symptoms and a right tension pneumothorax on chest X-ray. Read More

View Article and Full-Text PDF
October 2021

Spontaneous emergence of leadership patterns drives synchronization in complex human networks.

Sci Rep 2021 09 15;11(1):18379. Epub 2021 Sep 15.

Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, 80125, Italy.

Synchronization of human networks is fundamental in many aspects of human endeavour. Recently, much research effort has been spent on analyzing how motor coordination emerges in human groups (from rocking chairs to violin players) and how it is affected by coupling structure and strength. Here we uncover the spontaneous emergence of leadership (based on physical signaling during group interaction) as a crucial factor steering the occurrence of synchronization in complex human networks where individuals perform a joint motor task. Read More

View Article and Full-Text PDF
September 2021

Predicting the different progressions of early pressure injury by ultraviolet photography in rat models.

Int Wound J 2021 Sep 1. Epub 2021 Sep 1.

Device Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.

Early pressure injury (PI) can result in either spontaneous healing (SH) or deterioration into ulcer (DU). However, determining whether PI will progress into SH or DU on the basis of non-blanchable erythema only is difficult. In this study, we constructed two animal PI models to mimic SH and DU injuries and observed haemorrhage by using ultraviolet (UV) photography to develop potential clinical indicators for predicting the progression of early PI. Read More

View Article and Full-Text PDF
September 2021

Risk factors for treatment failure in women with uncomplicated lower urinary tract infection.

PLoS One 2021 31;16(8):e0256464. Epub 2021 Aug 31.

Infection Control Program and WHO Collaborating Centre on Patient Safety, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland.

Given rising antibiotic resistance and increasing use of delayed prescription for uncomplicated lower urinary tract infections (UTI), patients at risk for treatment failure should be identified early. We assessed risk factors for clinical and microbiological failure in women with lower UTI. This case-control study nested within a randomized clinical trial included all women in the per-protocol population (PPP), those in the PPP with microbiologically confirmed UTI, and those in the PPP with UTI due to Escherichia coli. Read More

View Article and Full-Text PDF

Successful Treatment of a Patient with Cardiac Arrest Due to Hyperkalemia by Prolonged Cardiopulmonary Resuscitation along with Hemodialysis: A Case Report and Review of the Literature.

Medicina (Kaunas) 2021 Aug 7;57(8). Epub 2021 Aug 7.

Department of Anesthesiology and Reanimation, Yucelen Hospital, Mugla 48000, Turkey.

Severe hyperkalemia is a potentially life threatening cardiac emergency, especially in patients with renal failure, and can lead to fatal arrhythmias such as ventricular fibrillation or asystole, leading to cardiac arrest. We report a case of a 39-year-old woman who developed sudden cardiac arrest secondary to hyperkalemia (9.95 mEq/L) with renal insufficiency. Read More

View Article and Full-Text PDF

Age-related differences of γ-aminobutyric acid (GABA)ergic transmission in human colonic smooth muscle.

Neurogastroenterol Motil 2021 Aug 25:e14248. Epub 2021 Aug 25.

Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze,ed 16, Palermo, 90128, Italy.

Background: Enteric neurons undergo to functional changes during aging. We investigated the possible age-associated differences in enteric γ-aminobutyric acid (GABA)ergic transmission evaluating function and distribution of GABAergic receptors in human colon.

Methods: Mechanical responses to GABA and GABA receptor agonists on slow phasic contractions were examined in vitro as changes in isometric tension in colonic muscle strips from young (<65 years old) and aged patients (>65 years old). Read More

View Article and Full-Text PDF

Spontaneous attachment of complex Descemet's membrane detachment following multiple failed interventions.

BMJ Case Rep 2021 Aug 13;14(8). Epub 2021 Aug 13.

Department of Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India.

We describe a case with complex Descemet membrane detachment (DMD) which persisted despite initial two failed surgical attempts to appose the ocular tissues. However, over time, tissue alignment was obtained spontaneously. A 60-year-old woman, operated trabeculectomy, had a total DMD intraoperatively during a complicated cataract surgery. Read More

View Article and Full-Text PDF

Inactivation of Native K Channels.

J Membr Biol 2021 Aug 12. Epub 2021 Aug 12.

Department of Cardiology, Medical University Hospital Heidelberg, 69120, Heidelberg, Germany.

We have experimented with isolated cardiomyocytes of mollusks Helix. During the whole-cell patch-clamp recordings of K currents a considerable decrease in amplitude was observed upon repeated voltage steps at 0.96 Hz. Read More

View Article and Full-Text PDF

A new technique in surgical treatment of congenital and spontaneous extensor tendon snapping: Dorsalization-ulnarization of the metacarpal head.

Authors:
I B Ozcelik A Sari

Hand Surg Rehabil 2021 Dec 4;40(6):782-786. Epub 2021 Aug 4.

Department of Orthopaedics and Traumatology, Faculty of Medicine, Namık Kemal University, Kampus Street, No.1, 59030, Suleymanpasa, Tekirdag, Turkey. Electronic address:

The present study reports results of a metacarpal transposition technique we have developed for congenital and spontaneous extensor tendon snapping. Six patients with a mean age of 14 years (range: 12-19 years) were included and evaluated retrospectively. They had Rayan-Murray type-3 atraumatic chronic extensor tendon instability: 2 on the middle finger, 3 on the ring finger, and 1 on the index and middle fingers. Read More

View Article and Full-Text PDF
December 2021

Knock-in models related to Alzheimer's disease: synaptic transmission, plaques and the role of microglia.

Mol Neurodegener 2021 07 15;16(1):47. Epub 2021 Jul 15.

Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK.

Background: Microglia are active modulators of Alzheimer's disease but their role in relation to amyloid plaques and synaptic changes due to rising amyloid beta is unclear. We add novel findings concerning these relationships and investigate which of our previously reported results from transgenic mice can be validated in knock-in mice, in which overexpression and other artefacts of transgenic technology are avoided.

Methods: App and App knock-in mice expressing humanised amyloid beta with mutations in App that cause familial Alzheimer's disease were compared to wild type mice throughout life. Read More

View Article and Full-Text PDF

Exploring Relationships Among Risk Factors for Persistence in Early Childhood Stuttering.

J Speech Lang Hear Res 2021 08 14;64(8):2909-2927. Epub 2021 Jul 14.

Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN.

Purpose The purpose of this study is to investigate how epidemiological and clinical factors collectively predict whether a preschooler who is stuttering will persist or recover and to provide guidance on how clinicians can use these factors to evaluate a child's risk for stuttering persistence. Method We collected epidemiological and clinical measures from 52 preschoolers ( = 54.4 months, = 6. Read More

View Article and Full-Text PDF

[Efficacy and safety of position selection combined with intra-pleural thrombin injection in the treatment of postoperative persistent air leakage in bullous pulmonary-pleural diseases].

Zhonghua Jie He He Hu Xi Za Zhi 2021 Jul;44(7):619-623

Department of Respiratory and Critical Care Medicine, Rizhao Hospital of Traditional Chinese Medicine, Shandong Province 276800, China.

To explore the efficacy and safety of position selection in combination with intra-pleural thrombin injection in the treatment of persistent air leakage (PAL) after medical thoracoscopic treatment of bullous pulmonary-pleural diseases (e.g. spontaneous pneumothorax or giant emphysematous bulla). Read More

View Article and Full-Text PDF

Glucose-Like Peptide-1 Receptor Agonists and Hepatic Decompensation Events in Patients With Cirrhosis and Diabetes.

Clin Gastroenterol Hepatol 2021 Jul 10. Epub 2021 Jul 10.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Background & Aims: The study sought to compare the effectiveness of glucose-like peptide-1 receptor agonists (GLP-1RAs) with dipeptidyl peptidase-4 (DPP-4) inhibitors, sulfonylureas, or sodium-glucose cotransporter-2 (SGLT-2) inhibitors in reducing decompensation events, among patients with cirrhosis and type 2 diabetes.

Methods: This population-based, retrospective cohort study included patients with type 2 diabetes and cirrhosis, in a commercial healthcare database (IBM MarketScan). We constructed 3 pairwise, 1:1 propensity score (PS)-matched cohorts of adults initiating GLP-1RAs or a comparator medication (ie, DPP-4 inhibitors [2006-2020], sulfonylurea [2005-2020], or SGLT-2 inhibitors [2013-2020]). Read More

View Article and Full-Text PDF

Follicle-Stimulating Hormone-Secreting Pituitary Adenoma Inducing Spontaneous Ovarian Hyperstimulation Syndrome, Treatment Using Fertilization and Embryo Transfer: A Case Report.

Front Endocrinol (Lausanne) 2021 24;12:621456. Epub 2021 Jun 24.

Reproductive Medicine Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Objective: To describe the management of a patient with a pituitary adenoma secreting follicle-stimulating hormone (FSH) associated with spontaneous ovarian hyperstimulation syndrome (sOHSS) who was treated with fertilization and embryo transfer (IVF-ET).

Methods: We report a clinical case of a woman of reproductive age with menstrual irregularity, infertility and ovarian hyperstimulation due to recurrent pituitary adenoma secreting FSH, which persisted after transsphenoidal surgery.She underwent the diagnosis by magnetic resonance imaging (MRI) and laboratory tests,and finally she was treated with IVF-ET. Read More

View Article and Full-Text PDF

Complex Long-term Effects of Radiation on Adult Mouse Behavior.

Radiat Res 2021 Jul 8. Epub 2021 Jul 8.

Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Developmental Genetics, Neuherberg, Germany.

We have shown previously that a single radiation event (0.063, 0.125 or 0. Read More

View Article and Full-Text PDF

Spontaneous Spinal Epidural Hematoma in an Adult Patient with Complex Congenital Heart Disease.

Int Heart J 2021 Jul 6;62(4):935-937. Epub 2021 Jul 6.

Department of Pediatrics, Miyazaki Prefectural Miyazaki Hospital.

Spontaneous spinal epidural hematoma (SSEH) is considered to be a relatively rare disease that can result in serious neurological sequelae. The pathogenesis and risk factors of SSEH are still unknown, and its differential diagnosis varies widely. Misdiagnosis with more common conditions such as stroke or aortic syndromes can occur. Read More

View Article and Full-Text PDF

Presentation of unpaired unconditional stimuli during extinction reduces renewal of conditional fear and slows re-acquisition.

Psychophysiology 2021 10 6;58(10):e13899. Epub 2021 Jul 6.

School of Applied Psychology, Griffith University, Brisbane, QLD, Australia.

Past research has shown that presenting unconditional stimuli (US) during extinction training, either paired with the conditional stimulus (CS) or explicitly unpaired, can reduce spontaneous recovery and slow the re-acquisition of conditional fear. Whether contextual renewal of conditioned fear as indexed by electrodermal responses and self-report measures of anxiety and CS evaluations is also reduced after presentation of paired or unpaired USs during extinction training is currently unclear. Three groups of participants (Paired, Unpaired, Standard Extinction) completed a sequence of habituation, acquisition, extinction, renewal, and re-acquisition phases. Read More

View Article and Full-Text PDF
October 2021

-infected chronic subdural hematoma mimicking an expanding hematoma: A case report.

Surg Neurol Int 2021 14;12:288. Epub 2021 Jun 14.

Department of Neurosurgery, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan.

Background: We present the rare case of a spontaneous intracranial subdural empyema caused by in a preexisting chronic subdural hematoma (CSDH).

Case Description: A 72-year-old man with a history of the right CSDH that remained radiologically unchanged for the past 2 years with conservative management was transferred to our hospital because of fever and convulsive seizure. Systemic sources of infection were not identified. Read More

View Article and Full-Text PDF

Tramadol-induced hiccups: a case-noncase study in the European pharmacovigilance database.

Ther Adv Drug Saf 2021 17;12:20420986211021230. Epub 2021 Jun 17.

Osakidetza Basque Health Service, Galdakao-Usansolo Hospital, Basque Country Pharmacovigilance Unit, Biocruces Bizkaia Health Research Institute, Galdakao, Spain.

Background: Hiccups are usually benign and self-limiting, but can sometimes be persistent. If left untreated, they can provoke severe discomfort, and even death. Hiccups can be idiopathic, organic, psychogenic, and caused by drugs. Read More

View Article and Full-Text PDF