140 results match your criteria persisted multifactorial

Gestational Age and Neonatal Electrocardiograms.

Pediatrics 2021 Nov 24. Epub 2021 Nov 24.

Department of Cardiology, Herlev-Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.

Objectives: Interpretation of the neonatal electrocardiogram (ECG) is challenging due to the profound changes of the cardiovascular system in this period. We aimed to investigate the impact of gestational age (GA) on the neonatal ECG and create GA-specific reference values.

Methods: The Copenhagen Baby Heart Study is a prospective general population study that offered cardiac evaluation of neonates. Read More

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November 2021

Prevalence, Trends and Conditions for the DTP3 Vaccine: A 25-Year Historical Perspective.

Risk Manag Healthc Policy 2021 14;14:4301-4310. Epub 2021 Oct 14.

Programa de Pós-graduação em Medicina Integral, Instituto de Medicina Integral Professor Fernando Figueira, Recife, Pernambuco, Brazil.

Background: The aim was to verify the prevalence of vaccination coverage, tendency and factors of the third dose of the vaccine against diphtheria, tetanus and pertussis-DTP3 in surveys over the period of 25 years in a state of the Northeast of Brazil.

Methods: Cross-sectional and temporal series, utilizing ad hoc database, were extracted from the Health and Nutrition State Research 1991, 1997, 2006 and 2015/2016. Children from 12 to 23 months of age with proof in the vaccination card were included. Read More

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October 2021

Effects of Feeding a Hypoallergenic Diet with a Nutraceutical on Fecal Dysbiosis Index and Clinical Manifestations of Canine Atopic Dermatitis.

Animals (Basel) 2021 Oct 16;11(10). Epub 2021 Oct 16.

"S. Siro" Veterinary Clinic, 20151 Milan, Italy.

Background: an imbalance of the intestinal microbiota can cause health problems in the gastrointestinal tract and in other organs. Canine Atopic Dermatitis (CAD) is a genetically predisposed, inflammatory and pruritic allergic skin disease with multifactorial etiology and multimodal treatment. The aim of this study was to assess the effect of a nutraceutical product on Dysbiotic Index (DI) and the skin lesions of atopic dogs. Read More

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October 2021

IgM Deficiency in Autoimmune Blistering Mucocutaneous Diseases Following Various Treatments: Long Term Follow-Up and Relevant Observations.

Front Immunol 2021 27;12:727520. Epub 2021 Sep 27.

Department of Dermatology, The Center for Blistering Diseases, Tufts University School of Medicine, Boston, MA, United States.

IgM deficiency has been reported in patients with many autoimmune diseases treated with Rituximab (RTX). It has not been studied, in detail, in autoimmune mucocutaneous blistering diseases (AIMBD). Our objectives were: (i) Examine the dynamics of IgM levels in patients with and without RTX. Read More

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November 2021

Association between protoporphyrin IX and sarcopenia: a cross sectional study.

BMC Geriatr 2021 06 26;21(1):384. Epub 2021 Jun 26.

Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taiwan, Republic of China.

Background: According to the European Working Group on Sarcopenia in Older People (EWGSOP), the diagnosis of sarcopenia primarily focused on low muscle strength with the detection of low muscle quality and quantity as confirming index. Many studies had identified mitochondrial dysfunction as one of the multifactorial etiologies of sarcopenia. Yet, no study had investigated the role of biosynthetic pathway intermediate, which was found in mitochondria, in the development of sarcopenia. Read More

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A study of serum growth differentiation factor 15 in Indian women with and without gestational diabetes mellitus in the third trimester of pregnancy and its association with pro-inflammatory markers and glucose metabolism.

Diabetol Int 2021 Jul 21;12(3):254-259. Epub 2020 Nov 21.

Department of Endocrinology and Metabolism, IPGME&R and SSKM Hospital, 244 AJC Bose road, Kolkata, West Bengal India.

The pathogenesis of gestational diabetes mellitus (GDM) is multifactorial and it shares many features with type 2 diabetes mellitus. Growth differentiation factor 15 (GDF-15), a member of transforming growth factor-β superfamily, is expressed in a high amount in the placenta in addition to other organs. This cross-sectional study was performed to assess the difference of GDF-15 and pro-inflammatory cytokines between pregnant women with or without GDM, and to explore the possible association of GDF-15 with the parameters of dysglycemia (Serum insulin, HOMA-IR, fasting, 60 min, and 120 min post-75 gm oral glucose plasma glucose levels) and inflammation (IL-6 and TNF-α) in women with GDM at 24-28 weeks of gestation. Read More

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Virtual Therapeutic Garden: A Promising Method Supporting the Treatment of Depressive Symptoms in Late-Life: A Randomized Pilot Study.

J Clin Med 2021 May 1;10(9). Epub 2021 May 1.

Polish Milton H. Erickson Institute, 94-036 Lodz, Poland.

The multifactorial genesis of old-age depression requires multi-professional therapy combining physical activity and psychosocial interventions; however, there is still a percentage of older people who do not exhibit satisfactory improvements. The aim of this study was to evaluate the effectiveness of virtual therapy in the elderly for whom the previous multimodal, biopsychosocial therapeutic programme had not brought the expected results. Twenty-five elderly women with depressive symptoms were randomly divided into a virtual reality group (VR, = 13) and a control group (Control, = 12). Read More

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Vascular Acrosyndromes Associated With Prolonged Tumor Response in Advanced Lung Cancer Patients During Treatment With Antimetabolites: A Report of Two Cases.

Front Oncol 2021 1;11:644282. Epub 2021 Apr 1.

Department of Oncology, Centre Hospitalier Regional Universitaire (CHRU) Morvan, University Hospital of Brest, Brest, France.

Background: Pemetrexed and gemcitabine are both antimetabolites drugs approved in advanced non-small cell lung cancer (NSCLC). Their toxicity profile is well known. However, rare vascular side effects can occur such as vascular acrosyndromes and especially digital ischemia. Read More

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No support for the hereditarian hypothesis of the Black-White achievement gap using polygenic scores and tests for divergent selection.

Kevin A Bird

Am J Phys Anthropol 2021 06 2;175(2):465-476. Epub 2021 Feb 2.

Department of Horticulture, Michigan State University, East Lansing, Michigan, USA.

Objectives: Debate about the cause of IQ score gaps between Black and White populations has persisted within genetics, anthropology, and psychology. Recently, authors claimed polygenic scores provide evidence that a significant portion of differences in cognitive performance between Black and White populations are caused by genetic differences due to natural selection, the "hereditarian hypothesis." This study aims to show conceptual and methodological flaws of past studies supporting the hereditarian hypothesis. Read More

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Progressive survival improvement of incident dialysis patients in a tertiary center, Ireland.

Ir J Med Sci 2021 Nov 14;190(4):1597-1603. Epub 2021 Jan 14.

Department of Nephrology & Transplantation, Beaumont Hospital, Dublin, Ireland.

Background: The survival of incident dialysis patients' end-stage kidney disease in some European and American has been reported to improve in modern era compared to earlier periods. However, in Ireland, this has not been well documented.

Aim: To investigate the survival outcomes of incident end-stage kidney failure dialysis patients in a tertiary center over a 24-year period, 1993-2017. Read More

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November 2021

Correction of serum chloride concentration in dogs with congestive heart failure.

J Vet Intern Med 2021 Jan 11;35(1):51-57. Epub 2020 Dec 11.

University of Florida, College of Veterinary Medicine, Gainesville, Florida, USA.

Background: Hypochloremia associated with congestive heart failure (CHF) in dogs is likely multifactorial. Loop diuretics cause 1:2 sodium [Na ]:chloride [Cl ] loss, whereas water retention causes a 1:1 [Na ]:[Cl ] dilution. Mathematical [Cl ] correction separates these effects on [Cl ]. Read More

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January 2021

Polygenic risk for autism spectrum disorder associates with anger recognition in a neurodevelopment-focused phenome-wide scan of unaffected youths from a population-based cohort.

PLoS Genet 2020 09 17;16(9):e1009036. Epub 2020 Sep 17.

Department of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, United States of America.

The polygenic nature and the contribution of common genetic variation to autism spectrum disorder (ASD) allude to a high degree of pleiotropy between ASD and other psychiatric and behavioral traits. In a pleiotropic system, a single genetic variant contributes small effects to several phenotypes or disorders. While analyzed broadly, there is a paucity of research studies investigating the shared genetic information between specific neurodevelopmental domains and ASD. Read More

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September 2020

Decreased cerebrospinal fluid neuronal pentraxin receptor is associated with PET-Aβ load and cerebrospinal fluid Aβ in a pilot study of Alzheimer's disease.

Neurosci Lett 2020 07 23;731:135078. Epub 2020 May 23.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada; Department of Clinical Biochemistry, University Health Network, Toronto, Canada. Electronic address:

Multifactorial pathological processes of Alzheimer's disease (AD) begin decades prior to clinical onset. Early identification of patients at risk of developing AD using biomarkers reflecting various aspects of pathogenesis is necessary for prevention and early intervention. Cortical β-amyloid (Aβ) burden assessed by positron emission tomography (PET) or cerebrospinal fluid (CSF) levels of Aβ42 are validated biomarkers for early identification. Read More

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Ultrastructural, transcriptional, and functional differences between human reticulated and non-reticulated platelets.

J Thromb Haemost 2020 08 13;18(8):2034-2046. Epub 2020 Jul 13.

Department of Cardiology and Angiology II, Clinical Pharmacology, University Heart Center Freiburg-Bad Krozingen, Bad Krozingen, Germany.

Background: Reticulated platelets (RP) are the youngest circulating platelets in blood. An increased amount of this subpopulation is associated with higher cardiovascular risk and mortality.

Objectives: It is unknown to what extent intrinsic properties of RP contribute to their hyperreactive features. Read More

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The impaired diaphragmatic function after bilateral lung transplantation: A multifactorial longitudinal study.

J Heart Lung Transplant 2020 Aug 21;39(8):795-804. Epub 2020 Apr 21.

Thoracic Surgery and Lung Transplantation Unit, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico of Milan, Milan, Italy.

Background: Lung transplantation is a complex but effective treatment of end-stage pulmonary disease. Among the post-operative complications, phrenic nerve injury, and consequent diaphragmatic dysfunction are known to occur but are hitherto poorly described. We aimed to investigate the effect of lung transplantation on diaphragmatic function with a multimodal approach. Read More

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Factors affecting readmission rates after pancreatectomy.

J Hepatobiliary Pancreat Sci 2020 Apr 16;27(4):182-190. Epub 2020 Feb 16.

Department of Surgery, University Hospitals Seidman Cancer Center and Case Comprehensive Cancer Center, Cleveland, OH, USA.

Background: Pancreatectomy is a complex operation with a historic readmission rate of approximately 20%. Hospital readmissions lead to increased patient and health system costs, morbidity, and mortality making them a topic of great interest. The objective of this study was to identify factors associated with readmission after pancreatectomy in order to target areas for improvement. Read More

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Genetic risk for dengue hemorrhagic fever and dengue fever in multiple ancestries.

EBioMedicine 2020 Jan 2;51:102584. Epub 2020 Jan 2.

Department of Immunogenetics, Institute of Tropical Medicine, Nagasaki University, Nagaski, Japan; Department of Immunology and Microbiology, Pasteur Institute, Ho Chi Minh City, Vietnam.

Background: Genetic risk factors for dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) and dengue fever (DF) are limited, in particular there are sparse data on genetic risk across diverse populations.

Methods: We conducted a genome-wide association study (GWAS) in a derivation and validation sample of 7, 460 participants of Latin American, South Asian, and South East Asian ancestries. We then developed a weighted polygenic risk score (PRS) for each participant in each of the validation cohorts of the three ancestries to predict the risk of DHF/DSS compared to DF, DHF/DSS compared to controls, and, DF compared to controls. Read More

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January 2020

Guinea pig seborrheic dermatitis model of Malassezia restricta and the utility of luliconazole.

Med Mycol 2020 Aug;58(6):820-826

Department of Dermatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

Seborrheic dermatitis (SD) is a multifactorial disease in which Malassezia restricta has been proposed as the predominant pathogenic factor. However, experimental evidence supporting this hypothesis is limited. A guinea pig SD model using a clinical isolate of M. Read More

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A Specific Mutation in Muc2 Determines Early Dysbiosis in Colitis-Prone Winnie Mice.

Inflamm Bowel Dis 2020 03;26(4):546-556

National Institute of Gastroenterology "S. de Bellis," Institute of Research, Castellana Grotte (BA), Italy.

Background: Inflammatory bowel disease (IBD), including Crohn disease (CD) and ulcerative colitis (UC), is a multifactorial disorder characterized by chronic inflammation and altered gut barrier function. Dysbiosis, a condition defined by dysregulation of the gut microbiome, has been reported in patients with IBD and in experimental models of colitis. Although several factors have been implicated in directly affecting gut microbial composition, the genetic determinants impacting intestinal dysbiosis in IBD remain relatively unknown. Read More

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Lesion Network Mapping Analysis Identifies Potential Cause of Postoperative Depression in a Case of Cingulate Low-Grade Glioma.

World Neurosurg 2020 Jan 10;133:278-282. Epub 2019 Oct 10.

Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada; Joint Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada; Krembil Research Institute, Toronto, Ontario, Canada.

Background: Depression following resection of diffuse low-grade glioma has rarely been described. Location of the tumor and surgical route are potential causes. Lesion network mapping (LNM), leveraging high-quality resting-state functional magnetic resonance imaging data from large samples of healthy adults, has been used to explore the broader network connectivity for given lesions. Read More

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January 2020

Accidental Pediatric Paliperidone Ingestion Resulting in Delayed Profound Tachycardia.

J Emerg Med 2019 Oct 4;57(4):e109-e111. Epub 2019 Oct 4.

Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia School of Medicine, Charlottesville, Virginia.

Background: Paliperidone is an atypical antipsychotic that is approved to treat schizophrenia in patients 12 years of age and older. There are minimal data on the clinical effects of exposure in the < 12-year-old age group.

Case Report: We report the case of a 7-year-old girl who was accidentally dosed with paliperidone for 3 days. Read More

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October 2019

Stellate Ganglion Nerve Block by Point-of-Care Ultrasonography for Treatment of Refractory Infarction-Induced Ventricular Fibrillation.

Ann Emerg Med 2020 02 26;75(2):257-260. Epub 2019 Sep 26.

Department of Emergency Medicine, Mount Sinai St. Luke's and Mount Sinai West, Icahn School of Medicine, New York, NY.

Stellate ganglion blockade has been previously suggested as a treatment option for intractable ventricular arrhythmia; however, its use in emergency department management of pulseless arrest with shockable rhythm has not been described. We report the case of a 65-year-old man brought in by ambulance who complained of chest pain and received an out-of-hospital ECG suggestive of anterior-wall ST-segment elevation myocardial infarction. Shortly after arrival, the patient became unresponsive, with no palpable pulse, and was found to be in ventricular fibrillation. Read More

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February 2020

Lipid Peroxidation, Protein Oxidation, Gelatinases, and Their Inhibitors in a Group of Adults with Obesity.

Horm Metab Res 2019 Jun 10;51(6):389-395. Epub 2019 May 10.

Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Palermo, Italy.

The association between obesity and cardiovascular diseases has a multifactorial pathogenesis, including the synthesis of inflammatory molecules, the increase in oxidative stress and the dysregulation of the matrix metalloprotease (MMP) concentration and activity. In a group of adults with obesity, divided in 2 subgroups according to the body mass index (BMI), we examined lipid peroxidation, expressed as thiobarbituric acid-reactive substances (TBARS), protein oxidation, expressed as protein carbonyl groups (PCs), plasma gelatinases (MMP-2 and MMP-9), and their tissue inhibitors (TIMP-1 and TIMP-2). In the whole group, as well as in the 2 subgroups (with BMI 30-35 or BMI>35) of obese subjects, we observed an increase in TBARS, PCs, MMP-2, and MMP-9, and also TIMP-1 and TIMP-2 in comparison with the control group. Read More

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Prospective study of polygenic risk, protective factors, and incident depression following combat deployment in US Army soldiers.

Psychol Med 2020 04 15;50(5):737-745. Epub 2019 Apr 15.

Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.

Background: Whereas genetic susceptibility increases the risk for major depressive disorder (MDD), non-genetic protective factors may mitigate this risk. In a large-scale prospective study of US Army soldiers, we examined whether trait resilience and/or unit cohesion could protect against the onset of MDD following combat deployment, even in soldiers at high polygenic risk.

Methods: Data were analyzed from 3079 soldiers of European ancestry assessed before and after their deployment to Afghanistan. Read More

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Effect of a multifactorial intervention on the increase in physical activity in subjects with type 2 diabetes mellitus: a randomized clinical trial (EMID Study).

Eur J Cardiovasc Nurs 2019 06 26;18(5):399-409. Epub 2019 Feb 26.

1 Institute of Biomedical Research of Salamanca (IBSAL), Primary Health Care Research Unit, Spain.

Background: Regular physical activity is essential for metabolic control in type 2 diabetes mellitus.

Aims: The aim of this study was to assess the short and long-term impact of a multifactorial intervention on physical activity and clinically relevant biochemical parameters in patients with type 2 diabetes mellitus.

Methods: This randomised, controlled clinical trial (NCT02991079) included two parallel groups aged 25-70 years from a primary care health centre in Salamanca, Spain. Read More

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The presence of eosinophil aggregates correlates with increased postoperative prednisone requirement.

Laryngoscope 2019 04 28;129(4):794-799. Epub 2018 Dec 28.

Department of Otorhinolaryngology-Head and Neck Surgery, Chicago, Illinois.

Objectives/hypothesis: Failure after sinus surgery is multifactorial, but often due to recurrence of inflammatory mucosal disease. Postoperative steroid requirements for controlling mucosal inflammation may provide insight into predicting which patients require more aggressive medical therapy to prevent disease relapse.

Study Design: Retrospective chart review. Read More

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The IASP classification of chronic pain for ICD-11: chronic primary pain.

Pain 2019 Jan;160(1):28-37

Department of Neurophysiology, CBTM, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

This article describes a proposal for the new diagnosis of chronic primary pain (CPP) in ICD-11. Chronic primary pain is chosen when pain has persisted for more than 3 months and is associated with significant emotional distress and/or functional disability, and the pain is not better accounted for by another condition. As with all pain, the article assumes a biopsychosocial framework for understanding CPP, which means all subtypes of the diagnosis are considered to be multifactorial in nature, with biological, psychological, and social factors contributing to each. Read More

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January 2019

Aluminum Ingestion Promotes Colorectal Hypersensitivity in Rodents.

Cell Mol Gastroenterol Hepatol 2019 20;7(1):185-196. Epub 2018 Sep 20.

Université Lille, INSERM, CHR Lille, Lille Inflammation Research International Center, U995, Lille, France.

Background & Aims: Irritable bowel syndrome (IBS) is a multifactorial disease arising from a complex interplay between genetic predisposition and environmental influences. To date, environmental triggers are not well known. Aluminum is commonly present in food, notably by its use as food additive. Read More

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Cystine-thiamin-containing hair-growth formulation modulates the response to UV radiation in an in vitro model for growth-limiting conditions of human keratinocytes.

J Photochem Photobiol B 2018 Dec 17;189:318-325. Epub 2018 Sep 17.

Merz Pharmaceuticals GmbH, Alfred-Wegener-Straße 2, 60438 Frankfurt, Germany. Electronic address:

Background: Ultraviolet radiation (UVR) is known to be harmful to normal human epidermal keratinocytes (NHEKs) of the epidermal skin layer, as well as to hair-follicle-associated keratinocytes. An oral formulation containing l-cystine, thiamin, calcium d-pantothenate, medicinal yeast, keratin and p-aminobenzoic acid (Panto[vi]gar®) has demonstrated clinical efficacy for the treatment of diffuse telogen effluvium; however, its mode of action at the cellular level, and in particular whether protective mechanisms are involved, has yet to be elucidated.

Objectives: To assess the capacity of ingredients of this oral formulation, both separately and in combination, to modulate the effects of UVR in growth-limited NHEKs in vitro. Read More

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December 2018

Outcome disparities in colorectal cancer: a SEER-based comparative analysis of racial subgroups.

Int J Colorectal Dis 2019 Feb 15;34(2):285-292. Epub 2018 Nov 15.

Division of Hematology/Oncology, Mayo Clinic Cancer Center, 5881 E. Mayo Blvd, Phoenix, AZ, 85054, USA.

Purpose: Previous studies of ethnic disparities in colorectal cancer (CRC) have focused mainly on patients of Caucasian and African-American descent. We aimed to evaluate outcomes for a range of races, representing a broader demographic of the US population.

Methods: The Surveillance, Epidemiology, and End Results database was queried to identify patients with CRC diagnosed between 1994 and 2014. Read More

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February 2019