18,394 results match your criteria persisted compared


Botulinum toxin type A for the treatment of excessive gingival display - A systematic review.

J Stomatol Oral Maxillofac Surg 2022 May 13. Epub 2022 May 13.

University Institute of the Face and Neck, Côte d'Azur University, Nice University Hospital, 31 Avenue de Valombrose, 06100 Nice, France; Saint George Aesthetic Clinic, 2 Avenue de Rimiez, 06105 Nice, France.

Gummy smile has traditionally been treated with invasive or demanding surgical and orthodontic techniques. Several studies have shown that targeted injection of the upper lip elevator muscles with botulinum toxin is an effective treatment for this condition. However, no standardized injection protocol with reproducible results has yet been published. Read More

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Pregnancy and the Risk of In-Hospital Coronavirus Disease 2019 (COVID-19) Mortality.

Obstet Gynecol 2022 May 5;139(5):846-854. Epub 2022 Apr 5.

Department of Obstetrics, Gynecology & Reproductive Sciences, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, Texas; and the Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.

Objective: To evaluate whether pregnancy is an independent risk factor for in-hospital mortality among patients of reproductive age hospitalized with coronavirus disease 2019 (COVID-19) viral pneumonia.

Methods: We conducted a retrospective cohort study (April 2020-May 2021) of 23,574 female inpatients aged 15-45 years with an International Classification of Diseases, Tenth Revision, Clinical Modification diagnosis code for COVID-19 discharged from 749 U.S. Read More

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Sustainability of a Clinical Decision Support Intervention for Outpatient Care for Emergency Department Patients With Acute Pulmonary Embolism.

JAMA Netw Open 2022 May 2;5(5):e2212340. Epub 2022 May 2.

Kaiser Permanente Division of Research, Oakland, California.

Importance: Physicians commonly hospitalize patients presenting to the emergency department (ED) with acute pulmonary embolism (PE), despite eligibility for safe outpatient management. Risk stratification using electronic health record-embedded clinical decision support systems can aid physician site-of-care decision-making and increase safe outpatient management. The long-term sustainability of early improvements after the cessation of trial-based, champion-led promotion is uncertain. Read More

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Successful telehealth transformation of a pediatric outpatient obesity teaching program due to the COVID-19 pandemic - the "Video KiCK" program.

J Pediatr Endocrinol Metab 2022 May 16. Epub 2022 May 16.

KiCK - Initiative, Center for Diabetology and Endocrinology for Children and Adolescents, Children`s Hospital Auf Der Bult, Hannover, Germany.

Objectives: To investigate if digital approaches can ameliorate the known consequences of social-distancing restrictions in the context of the global COVID-19 pandemic for adolescent participants originally registered for a face-to-face outpatient weight regulation program and whether video-based multiprofessional outpatient obesity therapy is successful for a group of adolescents with preexisting obesity.

Methods: The certified KiCK outpatient training program for children and adolescents with overweight and obesity was remodeled as a consequence of the lockdown traditional face-to-face program to a completely digital and video-based format on short notice. The virtual approach was compared with the results of the conventional program regarding metabolic parameters, body mass index standard deviation score (BMI SDS), well-being, and physical fitness. Read More

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Enhanced Blood Clotting After Rewarming From Experimental Hypothermia in an Intact Porcine Model.

Front Physiol 2022 29;13:901908. Epub 2022 Apr 29.

Department of Clinical Medicine, Anaesthesia and Critical Care Research Group, UiT The Arctic University of Norway, Tromsø, Norway.

Due to functional alterations of blood platelets and coagulation enzymes at low temperatures, excessive bleeding is a well-recognized complication in victims of accidental hypothermia and may present a great clinical challenge. Still, it remains largely unknown if hemostatic function normalizes upon rewarming. The aim of this study was to investigate effects of hypothermia and rewarming on blood coagulation in an intact porcine model. Read More

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Arterial Blood Gases and Cardiorespiratory Parameters in Etorphine-Medetomidine-Midazolam Immobilized Free-Ranging and Game-Farmed Southern White Rhinoceroses () Undergoing Electro-Ejaculation.

Front Vet Sci 2022 27;9:862100. Epub 2022 Apr 27.

Cryovault, Hemmersbach Rhino Force NCP, Hoedspruit, South Africa.

With the rapid loss of individuals in the wild, semen cryopreservation has gained importance to safeguard the genetic diversity of white rhinoceroses (). For semen collection electro-ejaculation, immobilization of free-ranging individuals requires the potent opioid etorphine, which is routinely combined with azaperone, but causes hypoxemia, hypercarbia, acidemia, muscle rigidity, tachycardia, and systemic hypertension. In this study, the suitability of two alternative immobilization protocols including etorphine, medetomidine, and midazolam at different doses (high vs. Read More

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Ethnicity and risk of SARS-CoV-2 infection among the healthcare workforce: Results of a retrospective cohort study in rural United Kingdom.

Int J Infect Dis 2022 May 12. Epub 2022 May 12.

Lincoln International Institute for Rural Health, University of Lincoln, Lincoln, UK; School of Nursing and Public Health, University of KwaZulu-Natal, Durban South Africa.

Background: The reason why Black and South Asian healthcare workers are at a higher risk of SARS-CoV-2 infection remain unclear. We aim to quantify risk of SARS-CoV-2 infection among ethnic minority healthcare staff and elucidate pathways of infection.

Methods: A one-year-follow-up retrospective cohort study has been conducted among NHS employees working at 123 facilities in Lincolnshire, UK. Read More

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Recovery of the medial gastrocnemius muscle after calcaneus fracture differs between contractile and elastic components.

Clin Biomech (Bristol, Avon) 2022 May 10;96:105664. Epub 2022 May 10.

Institute for Biomechanics, BG Klinikum Murnau, Murnau, Germany; Institute for Biomechanics, Paracelsus Medical Private University, Salzburg, Austria.

Background: Calcaneal fractures result in severe functional impairments and walking restrictions. Postoperative evaluation mainly focusses on the restoration of calcaneal anatomy while ankle plantar flexor insufficiency remains largely neglected. This study aims to investigate biomechanical and morphologic adaptions of elastic and contractile components of the gastrocnemius medialis after unilateral calcaneal fracture. Read More

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Dental anxiety treatment by a dentist in primary care: A 1-year follow-up study.

Eur J Oral Sci 2022 May 15:e12872. Epub 2022 May 15.

Faculty of Dentistry, University, of Oslo, Oslo, Norway.

In an earlier randomized controlled trial of dental anxiety treatments (n = 96) we compared the effects of dentist-administered cognitive behavioural therapy (D-CBT) and dental treatment supplemented with the Four Habits communication model plus midazolam sedation. Both treatments, applied in a general dental practice, were associated with a clinically relevant decrease in dental anxiety. In this follow-up study, 52 of the 82 treatment completers responded to an online questionnaire 1 year post-treatment. Read More

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Use of Prescription Medications With Cardiovascular Adverse Effects Among Older Adults in the United States.

Pharmacoepidemiol Drug Saf 2022 May 15. Epub 2022 May 15.

Program on Medicines and Public Health, Titus Family Department of Clinical Pharmacy, University of Southern California, Los Angeles, California.

Background: Many commonly used prescription medications have cardiovascular adverse effects, yet the cumulative risk of cardiovascular events associated with the concurrent use of these medications is unknown. We examined the association between the concurrent use of prescription medications with known risk of a major adverse cardiovascular event (MACE) ["MACE medications"] and the risk of such events among older adults.

Methods: A multi-center, population-based study from the Atherosclerosis Risk in Communities (ARIC) study of a cohort of 3,669 community-dwelling adults aged 61 to 86 years with no history of cardiovascular disease who reported the use of at least one medication between September 2006 and August 2013 were followed up until August 2015. Read More

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Mutations Impact Clinical Outcome in Metastatic Non-Small Cell Lung Cancer.

Cancers (Basel) 2022 Apr 20;14(9). Epub 2022 Apr 20.

Sahlgrenska Center for Cancer Research, Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, 40530 Gothenburg, Sweden.

There is an urgent need to identify new predictive biomarkers for treatment response to both platinum doublet chemotherapy (PT) and immune checkpoint blockade (ICB). Here, we evaluated whether treatment outcome could be affected by mutational status in patients with metastatic (Stage IV) non-small cell lung cancer (NSCLC). All consecutive patients molecularly assessed and diagnosed between 2016-2018 with Stage IV NSCLC in the region of West Sweden were included in this multi-center retrospective study. Read More

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Sex Differences in Skeletal Muscle Force Production, Fatiguability and Recovery in Slow and Fast Twitch Muscles.

FASEB J 2022 May;36 Suppl 1

University of Guelph, Cambridge, ON.

Sex differences in skeletal muscle fatiguability have been well documented during isometric contractions in humans but whether this sexual dimorphism occurs in skeletal muscle at the cellular level is not well understood. Therefore, we aimed to determine if sex differences persisted in skeletal muscle function in isolated tissue. We hypothesized that sexual dimorphisms would not be apparent in twitch and tetanic contraction characteristics or fatigue and recovery of slow and fast twitch muscles. Read More

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Loss of Chloride Transporter DRA Triggers Interleukin-33 Secretion from Colonocytes to drive Type 2 Lamina Propria Lymphocyte Expansion.

FASEB J 2022 May;36 Suppl 1

Medicine, University of Illinois at Chicago, Chicago, IL.

Down Regulated in Adenoma (DRA), the major chloride transporter in the mammalian intestine has recently emerged as a critical gene contributing to the pathogenesis of Ulcerative Colitis (UC). We have previously shown that DRA knockout (KO) mice display several features of UC including compromised barrier function and dysbiosis. Further, DRA KO mice show increased susceptibility to intestinal inflammation. Read More

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Chronic Circadian Disruption Contributes to Excess Aldosterone Production and Loss of Diurnal Electrolyte Excretion.

FASEB J 2022 May;36 Suppl 1

Med - Nephrology, University of Alabama at Birmingham, Birmingham, AL.

Disruptions in circadian rhythms contribute to a number of cardiometabolic health risks, including kidney disease. While chronic circadian disruption (CCD) has been recognized as a health risk in a number of other organ systems, we do not understand the effects of CCD on kidney function and sodium handling factors. Individuals with CCDs such as rotating shift workers, have an increased incidence of kidney and cardiovascular disease including impaired sodium excretion patterns. Read More

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Association between indices of cardiac repolarization, adiposity and metabolic syndrome. The Polish Norwegian Study (PONS).

FASEB J 2022 May;36 Suppl 1

Cancer Center and Institute of Oncology, Warsaw, Poland.

Background: Several cardiac repolarization indices have been associated with cardiovascular disease (CVD) mortality and arrhythmia risk, but little is known about their relation to adiposity in apparently healthy individuals.

Study Objective: To compare prevalence of T-wave inversion (TWI) and QT interval duration across levels of adiposity and metabolic health.

Hypothesis: We hypothesized that repolarization indices are associated with body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) and metabolic syndrome. Read More

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The use of choline supplementation for the prevention of chemotherapy-related cognitive impairments.

FASEB J 2022 May;36 Suppl 1

University of South Florida, Tampa, FL.

The majority of patients who report chemotherapy-related cognitive deficits are women. Many chemotherapeutic agents suppress ovarian function, decreasing circulating estrogen. Because estrogen regulates high affinity choline uptake (HACU) and HACU is the rate-limiting step for acetylcholine (ACh) synthesis, chemotherapeutic agents may indirectly impair cholinergic mediated cognitive processes. Read More

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Chronic Stress Accelerates the Progression of Cerebrovascular Dysfunction with Alzheimer's Disease.

FASEB J 2022 May;36 Suppl 1

West Virginia University, Morgantown, WV.

Vascular contributions to cognitive impairment and dementia are a key pathology associated with Alzheimer's disease (AD). Past work in our lab has shown that chronic stress induces cerebrovascular dysfunction due to a pro-oxidative environment while epidemiological studies suggest a link between chronic stress and dementia. With this in mind, we tested the hypothesis that chronic stress accelerates the vascular pathology associated with AD potentially via the xanthine oxidase pathway. Read More

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Pressure Only Wave Separation Pulsatile Hemodynamics in Adolescents: Accuracy and Associations with Left Ventricular Mass Index.

FASEB J 2022 May;36 Suppl 1

Department of Health and Human Physiology, University of Iowa, Iowa City, IA.

Introduction: Early-life exposure to cardiovascular disease (CVD) risk factors, such as high blood pressure (BP), is associated with cardiovascular target organ damage in later life. However, not all BP-related risk is explained by higher systolic and diastolic BP alone. In adolescence, aortic wave separation (WS) pulsatile hemodynamic parameters are associated with adverse left ventricular (LV) structure but are limited by the requirement for measured aortic flow. Read More

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Sex Differences in Hydrogen Peroxide-Induced K Channel Activation in Arterioles of Ischemic Myocardium after Exercise Training.

FASEB J 2022 May;36 Suppl 1

Texas A&M University, College Station, TX.

The objective of this study was to determine sex differences in potassium (K ) channel contribution to H O -mediated dilation after exercise training in arterioles distal to chronic coronary artery occlusion. We tested the hypothesis that females would have enhanced H O -mediated vasodilation compared to males through enhanced coupling of H O with large-conductance, calcium-dependent K (BKCa; iberiotoxin 100 nM) channels and 4-aminopyridine (4-AP; 1 mM)-sensitive voltage-gated K (Kv). Adult Yucatan miniature swine were surgically instrumented with an Ameroid constrictor around the proximal left circumflex coronary artery, which gradually induced occlusion and created a collateral-dependent vascular bed. Read More

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Urinary Serpin-A3 is an Early Predictor of Clinical Response to Therapy in Patients with Proliferative Lupus Nephritis.

FASEB J 2022 May;36 Suppl 1

Molecular Physiology Unit, Universidad Nacional Autónoma de México, Mexico.

Background: Serpin-A3 is a regulator of different inflammatory processes, however its role in the kidney is unknown. We previously reported that urinary Serpin-A3 excretion (uSerpA3) is significantly elevated in patients with active lupus nephritis (LN) and rats with Chronic Kidney Disease (CKD).

Objective: Determine the association between uSerpA3 temporal course during the 1 -year of treatment and response to therapy in patients with proliferative LN. Read More

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Weekly Acute Intermittent Hypoxia as a Strategy to Restore Spontaneous Micturition Patterns in Awake Rats with Moderate Contusion SCI: Therapeutic Efficacy and Time Course.

FASEB J 2022 May;36 Suppl 1

Physiology and Biophysics, Stony Brook University, Stony Brook, NY.

Both daily and weekly exposures to neuroplasticity-inducing acute intermittent hypoxia (AIH) have been proposed as non-invasive therapeutic paradigms to improve respiratory and motor function following spinal cord injury (SCI). SCI can also lead to bladder dysfunction that results in inefficient voiding and urine retention that are associated with a high degree of morbidity and a poor quality of life. Our ongoing preclinical studies have been investigating the therapeutic potential of AIH as a strategy to promote restoration of lower urinary tract (LUT; bladder) function in SCI. Read More

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Addressing persistence and retention of chemistry and biochemistry majors with engagement seminars beyond the first year.

FASEB J 2022 May;36 Suppl 1

Chemistry and Biochemistry, University of the Incarnate Word, San Antonio, TX.

Undergraduate persistence and retention are two measures widely used by institutions to measure student success. In 2020, the national rate at which newly enrolled full-time students persisted decreased for the first time in 7 years with the largest decrease in persistence rates for Hispanic students. The recent declines in both persistence and retention are attributed to the global pandemic. Read More

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Household Air Pollution Concentrations after Liquefied Petroleum Gas Interventions in Rural Peru: Findings from a One-Year Randomized Controlled Trial Followed by a One-Year Pragmatic Crossover Trial.

Environ Health Perspect 2022 May 12;130(5):57007. Epub 2022 May 12.

Center for Global Non-Communicable Disease Research and Training, Johns Hopkins University, Baltimore, Maryland, USA.

Background: Household air pollution (HAP) from biomass fuel combustion remains a leading environmental risk factor for morbidity worldwide.

Objective: Measure the effect of liquefied petroleum gas (LPG) interventions on HAP exposures in Puno, Peru.

Methods: We conducted a 1-y randomized controlled trial followed by a 1-y pragmatic crossover trial in 180 women age 25-64 y. Read More

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Changes in Acoustic Absorbance Pre- and Post-Cochlear Implantation.

Am J Audiol 2022 May 12:1-12. Epub 2022 May 12.

Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN.

Purpose: Until recently, there has been little investigation on the effects of cochlear implantation on the transmission of acoustic stimuli through the middle-ear system. Recent studies have shown that cochlear implantation decreases low-frequency acoustic absorbance, consistent with a stiffer middle-ear system postsurgery. The objectives of this study are (a) to investigate the time course of changes in acoustic absorbance post-cochlear implantation in the implanted ear and (b) to compare changes in acoustic absorbance between implanted and nonimplanted ears over time. Read More

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Sex-Related Differences in Outcomes for Oropharyngeal Squamous Cell Carcinoma by HPV Status.

Int J Otolaryngol 2022 2;2022:4220434. Epub 2022 May 2.

Division of General Internal Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: Overall survival for HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) has differed by sex, but little is known regarding cancer-specific outcomes. We assessed the independent association of sex with cancer-specific survival in patients with HPV-associated oropharyngeal squamous cell carcinoma (OPSCC).

Methods: We identified 14,183 patients from the Surveillance, Epidemiology, and End Results (SEER) program with OPSCC and tumor HPV status. Read More

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The antidepressant effect and safety of non-intranasal esketamine: A systematic review.

J Psychopharmacol 2022 May 12;36(5):531-544. Epub 2022 May 12.

Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background: The introduction of esketamine into the field of psychiatry comes on the heels of excitement from studies on racemic ketamine. While the intranasal route has been the most studied to date, other modes of administration of esketamine may also be of interest in the management of depression.

Aims: To systematically review the literature on non-intranasal esketamine for depression in terms of its antidepressant effect and safety. Read More

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Partial hepatectomy vs. transcatheter arterial chemoembolization for multiple hepatocellular carcinomas of BCLC-B stage: A meta-analysis of high-quality studies.

Eur J Surg Oncol 2022 Apr 29. Epub 2022 Apr 29.

Department of General Surgery (Hepatobiliary Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China; Academician (Expert) Workstation of Sichuan Province, Luzhou, 646000, China; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, 646000, China. Electronic address:

Background/aim: The Barcelona Clinic Liver Cancer (BCLC) recommends that transcatheter arterial chemoembolization (TACE) are indicated in patients with multiple hepatocellular carcinomas (HCCs) of BCLC-B stage. However, partial hepatectomy (PH) has increasely performed in these patients. The purpose of this meta-analyses is to illustrate the comparative survival benefits of PH and TACE for patients with multiple HCCs of BCLC-B stage. Read More

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Acute inflammatory response via neutrophil activation protects against the development of chronic pain.

Sci Transl Med 2022 May 11;14(644):eabj9954. Epub 2022 May 11.

Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthesia, Faculty of Medicine, Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec H3A 1G1, Canada.

The transition from acute to chronic pain is critically important but not well understood. Here, we investigated the pathophysiological mechanisms underlying the transition from acute to chronic low back pain (LBP) and performed transcriptome-wide analysis in peripheral immune cells of 98 participants with acute LBP, followed for 3 months. Transcriptomic changes were compared between patients whose LBP was resolved at 3 months with those whose LBP persisted. Read More

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Sex Differences in Outcomes Following Ruptured Abdominal Aortic Aneurysm Repair.

JAMA Netw Open 2022 May 2;5(5):e2211336. Epub 2022 May 2.

University Health Network, Peter Munk Cardiac Centre, Division of Vascular Surgery, University of Toronto, Toronto, Ontario, Canada.

Importance: Sex differences in aortic surgery outcomes are commonly reported. However, data on ruptured abdominal aortic aneurysm (rAAA) repair outcomes in women vs men are limited.

Objective: To assess differences in perioperative and long-term mortality following rAAA repair in women vs men. Read More

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Does hormonal therapy improve sperm retrieval rates in men with non-obstructive azoospermia: a systematic review and meta-analysis.

Hum Reprod Update 2022 May 8. Epub 2022 May 8.

Department of Urology, Imperial Healthcare NHS Trust, Charing Cross Hospital, London, UK.

Background: The beneficial effects of hormonal therapy in stimulating spermatogenesis in patients with non-obstructive azoospermia (NOA) and either normal gonadotrophins or hypergonadotropic hypogonadism prior to surgical sperm retrieval (SSR) is controversial. Although the European Association of Urology guidelines state that hormone stimulation is not recommended in routine clinical practice, a significant number of patients undergo empiric therapy prior to SSR. The success rate for SSR from microdissection testicular sperm extraction is only 40-60%, thus hormonal therapy could prove to be an effective adjunctive therapy to increase SSR rates. Read More

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