2,353 results match your criteria peroxynitrite levels


Comparison of Three Different Cord Clamping Techniques Regarding Oxidative-antioxidative Capacity in Term Newborns.

Am J Perinatol 2022 Jan 13. Epub 2022 Jan 13.

Biochemistry, Gaziantep University, Gaziantep, Turkey.

Objective As newborns are exposed to oxidative stress during delivery, cord clamping techniques play significant role on antioxidant status. In this study, we aimed to show the relationship between early cord clamping (ECC), delayed cord clamping (DCC) and cut umblical cord milking (C-UCM) techniques with total oxidant capacity (TOC), total antioxidant capacity (TAC) and peroxynitrite levels. Study Design Sixty-nine term infants were selected with APGAR score of 7 and above in the first and fifth minutes. Read More

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January 2022

An Avocado Extract Enriched in Mannoheptulose Prevents the Negative Effects of a High-Fat Diet in Mice.

Nutrients 2021 Dec 29;14(1). Epub 2021 Dec 29.

Pennington Biomedical Research Center, Louisiana State University, 5600 Perkins Road, Baton Rouge, LA 70808, USA.

Beginning at 16 weeks of age and continuing for 44 weeks, male C57BL/6J were fed either a control (CON) diet; a high-fat (HF) diet (60% unsaturated); or the HF diet containing an extract of unripe avocados (AvX) enriched in the 7-carbon sugar mannoheptulose (MH), designed to act as a glycolytic inhibitor (HF + MH). Compared to the CON diet, mice on the HF diet exhibited higher body weights; body fat; blood lipids; and leptin with reduced adiponectin levels, insulin sensitivity, VO2max, and falls from a rotarod. Mice on the HF + MH diet were completely protected against these changes in the absence of significant diet effects on food intake. Read More

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December 2021

FeTMPyP a peroxynitrite decomposition catalyst ameliorated functional and behavioral deficits in chronic constriction injury induced neuropathic pain in rats.

Free Radic Res 2022 Jan 6:1-13. Epub 2022 Jan 6.

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Kolkata, India.

Neuropathic pain is a maladaptive pain phenotype that results from injury or damage to the somatosensory nervous system and is proposed to be linked to a cascade of events including excitotoxicity, oxidative stress, mitochondrial dysfunction, neuroinflammation and apoptosis. Oxidative/nitrosative stress is a critical link between neuroinflammation and neurodegeneration through poly (ADP) ribose polymerase (PARP) overactivation. Hence, the present study investigated the antioxidant and anti-inflammatory effects of peroxynitrite decomposition catalyst; FeTMPyP in chronic constriction injury (CCI) of sciatic nerve-induced neuropathy in rats. Read More

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January 2022

SIRT2 tyrosine nitration by peroxynitrite in response to renal ischemia/reperfusion injury.

Free Radic Res 2022 Jan 11:1-15. Epub 2022 Jan 11.

Emergency Center, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are the production of renal ischemia/reperfusion (I/R). The current study is to elucidate a mechanism of SIRT2 tyrosine nitration to accelerate the cell apoptosis induced by peroxynitrite (ONOO‾), the most reactive and deleterious RNS type in renal ischemia/reperfusion (I/R) injury. Our results demonstrate that there is a significant enhancement of the 3-nitrotyrosine levels in renal tissues of Acute Kidney Injury (AKI) patients and rats that underwent renal I/R, and a positive correlation between the 3-nitrotyrosine level and renal function impairment, indicative of an accumulation of peroxynitrite. Read More

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January 2022

Bioactivity Potential of L. Flower: Phytochemical Profile, Antiradical Capacity and Protective Effects on Human Plasma Components under Oxidative/Nitrative Stress In Vitro.

Pharmaceuticals (Basel) 2021 Dec 14;14(12). Epub 2021 Dec 14.

Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Lodz, 90-151 Lodz, Poland.

Horse chestnut () flower is a traditional medicine applied to alleviate symptoms of chronic venous insufficiency (CVI). However, its flavonoid-based composition has not been sufficiently recognized, and the data supporting its traditional application are lacking. In the work, 43 constituents were detected by UHPLC-PDA-ESI-TQ-MS/MS (flavonoids, phenolic acids, flavanols, and coumarins), including 31 reported in the flower for the first time. Read More

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December 2021

Captopril alleviates oxidative damage in diabetic retinopathy.

Life Sci 2022 Feb 23;290:120246. Epub 2021 Dec 23.

Department of Ophthalmology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. Electronic address:

Aims: To primarily explore the mechanism of captopril in oxidative stress and investigate the link between captopril alleviated oxidative damage and diabetic retinopathy (DR).

Main Methods: Human retinal microvascular endothelial cells (HRMECs) were used for in vitro experiments and cultured in a 5.5 mM or 30 mM glucose medium. Read More

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February 2022

Structural and (Pseudo-)Enzymatic Properties of Neuroglobin: Its Possible Role in Neuroprotection.

Cells 2021 11 30;10(12). Epub 2021 Nov 30.

Dipartimento di Scienze, Università Roma Tre, Viale Marconi 446, 00146 Roma, Italy.

Neuroglobin (Ngb), the third member of the globin family, was discovered in human and murine brains in 2000. This monomeric globin is structurally similar to myoglobin (Mb) and hemoglobin (Hb) α and β subunits, but it hosts a bis-histidyl six-coordinated heme-Fe atom. Therefore, the heme-based reactivity of Ngb is modulated by the dissociation of the distal HisE7-heme-Fe bond, which reflects in turn the redox state of the cell. Read More

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November 2021

A Preliminary Study on the Effect of Hydrogen Gas on Alleviating Early CCl-Induced Chronic Liver Injury in Rats.

Antioxidants (Basel) 2021 Dec 1;10(12). Epub 2021 Dec 1.

Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.

As a small-molecule reductant substance, hydrogen gas has an obvious antioxidant function. It can selectively neutralize hydroxyl radicals (OH) and peroxynitrite (ONOO) in cells, reducing oxidative stress damage. The purpose of this study was to investigate the effect of hydrogen gas (3%) on early chronic liver injury (CLI) induced by CCl and to preliminarily explore the protective mechanism of hydrogen gas on hepatocytes by observing the expression of uncoupling protein 2 (UCP2) in liver tissue. Read More

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December 2021

Dual-Channel Fluorescent Probe for the Simultaneous Monitoring of Peroxynitrite and Adenosine-5'-triphosphate in Cellular Applications.

J Am Chem Soc 2022 Jan 21;144(1):174-183. Epub 2021 Dec 21.

Department of Chemistry, The University of Texas at Austin, 105 E 24th Street A5300, Austin, Texas 78712-1224, United States.

Changes in adenosine triphosphate (ATP) and peroxynitrite (ONOO) concentrations have been correlated in a number of diseases including ischemia-reperfusion injury and drug-induced liver injury. Herein, we report the development of a fluorescent probe ATP-LW, which enables the simultaneous detection of ONOO and ATP. ONOO selectively oxidizes the boronate pinacol ester of ATP-LW to afford the fluorescent 4-hydroxy-1,8-naphthalimide product NA-OH (λ = 450 nm, λ = 562 nm or λ = 488 nm, λ = 568 nm). Read More

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January 2022

TGF-β/Smad signaling pathway plays a crucial role in patulin-induced pro-fibrotic changes in rat kidney via modulation of slug and snail expression.

Toxicol Appl Pharmacol 2022 Jan 8;434:115819. Epub 2021 Dec 8.

Food Toxicology Laboratory, Food, Drug, and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India; Academy of Scientific and Innovative Research, CSIR-Indian Institute of Toxicology Research, Lucknow 226001, Uttar Pradesh, India. Electronic address:

Patulin (PAT) is a mycotoxin that contaminates a variety of food and foodstuffs. Earlier in vitro and in vivo findings have indicated that kidney is one of the target organs for PAT-induced toxicity. However, no study has evaluated the chronic effects of PAT exposure at environmentally relevant doses or elucidated the detailed mechanism(s) involved. Read More

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January 2022

Arterial stiffness is associated with oxidative stress and endothelial activation among persons with treated HIV in Zambia.

South Afr J HIV Med 2021 28;22(1):1298. Epub 2021 Oct 28.

Division of Infectious Diseases, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, United States of America.

Background: Cardiovascular disease (CVD) prevalence is rising among persons with HIV (PLWH) in sub-Saharan Africa. Oxidative stress and endothelial activation, resulting in reduced vascular compliance, are contributors to CVD risk. However, there is a paucity of vascular health data in this population. Read More

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October 2021

GNP-CeO- polyaniline hybrid hydrogel for electrochemical detection of peroxynitrite anion and its integration in a microfluidic platform.

Mikrochim Acta 2021 11 27;188(12):436. Epub 2021 Nov 27.

Materials Science & Sensor Application Division, CSIR-Central Scientific Instruments Organization (CSIR-CSIO), Chandigarh, 160030, India.

Peroxynitrite anion (ONOO) is an important in vivo oxidative stress biomarker whose aberrant levels have pathophysiological implications. In this study, an electrochemical sensor for ONOO detection was developed based on graphene nanoplatelets-cerium oxide nanocomposite (GNP-CeO) incorporated polyaniline (PANI) conducting hydrogels. The nanocomposite-hydrogel platform exhibited distinct synergistic advantages in terms of large electroactive surface coverage and providing a conductive pathway for electron transfer. Read More

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November 2021

A bifunctional fluorescence probe for dual-channel detecting of mitochondrial viscosity and endogenous/exogenous peroxynitrite.

Bioorg Chem 2021 Nov 11:105484. Epub 2021 Nov 11.

Institute of Environmental Science, Shanxi University, Taiyuan 030006, PR China. Electronic address:

The irregular viscosity in the mitochondrial can induce mitochondrial dysfunction. The content of peroxynitrite (ONOO) is related to various physiological and pathological processes. However, many mitochondrial probes only realized the detection of viscosity or ONOO in single channel, thus it is necessary to explore single fluorescence probe for dual-detecting mitochondrial viscosity and ONOO. Read More

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November 2021

Lifetime exposure of ambient PM elevates intraocular pressure in young mice.

Ecotoxicol Environ Saf 2021 Nov 13;228:112963. Epub 2021 Nov 13.

Department of Ophthalmology & Visual Science, Eye Institute, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China; NHC Key Laboratory of Myopia, Chinese Academy of Medical Sciences, and Shanghai Key Laboratory of Visual Impairment and Restoration (Fudan University), Shanghai 200031, China. Electronic address:

Epidemiological studies suggest that ambient particulate matter exposure may be a new risk factor of glaucoma, but it lacks solid experimental evidence to establish a causal relationship. In this study, young mice (4 weeks old) were exposed concentrated ambient PM (CAP) for 9 months, which is throughout most of the life span of a mouse under heavy pollution. CAP was introduced using a versatile aerosol concentration enrichment system which mimics natural PM exposure. Read More

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November 2021

Naringin prevents cyclophosphamide-induced erythrocytotoxicity in rats by abrogating oxidative stress.

Toxicol Rep 2021 25;8:1803-1813. Epub 2021 Oct 25.

Department of Biochemistry, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria.

Earlier reports have shown that Cyclophosphamide (CYCP), an anti-malignant drug, elicited cytotoxicity; and that naringin has several beneficial potentials against oxidative stress and dyslipidaemias. We investigated the influence of naringin on free radical scavenging, cellular integrity, cellular ATP, antioxidants, oxidative stress, and lipid profiles in the CYCP-induced erythrocytotoxicity rat model. Rats were pretreated orally by gavage for fourteen consecutive days with three doses (50, 100, and 200 mg/kg) naringin before single CYCP (200 mg/kg, i. Read More

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October 2021

Osteoprotegerin regulates vascular function through syndecan-1 and NADPH oxidase-derived reactive oxygen species.

Clin Sci (Lond) 2021 10;135(20):2429-2444

Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, U.K.

Osteogenic factors, such as osteoprotegerin (OPG), are protective against vascular calcification. However, OPG is also positively associated with cardiovascular damage, particularly in pulmonary hypertension, possibly through processes beyond effects on calcification. In the present study, we focused on calcification-independent vascular effects of OPG through activation of syndecan-1 and NADPH oxidases (Noxs) 1 and 4. Read More

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October 2021

Intramyocardial injection of human adipose-derived stem cells ameliorates cognitive deficit by regulating oxidative stress-mediated hippocampal damage after myocardial infarction.

J Mol Med (Berl) 2021 12 11;99(12):1815-1827. Epub 2021 Oct 11.

Bioinnovation Center, Tzu Chi Foundation, Department of Neurosurgery, Buddhist Tzu Chi General Hospital, Tzu Chi University, No.707, Sec. 3, Chung Yang Rd. 970, Hualien, Taiwan.

Cognitive impairment is a serious side effect of post-myocardial infarction (MI) course. We have recently demonstrated that human adipose-derived stem cells (hADSCs) ameliorated myocardial injury after MI by attenuating reactive oxygen species (ROS) levels. Here, we studied whether the beneficial effects of intramyocardial hADSC transplantation can extend to the brain and how they may attenuate cognitive dysfunction via modulating ROS after MI. Read More

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December 2021

Endocan alters nitric oxide production in endothelial cells by targeting AKT/eNOS and NFkB/iNOS signaling.

Nitric Oxide 2021 12 27;117:26-33. Epub 2021 Sep 27.

Vascular Research Laboratory, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, 613 401, Tamil Nadu, India. Electronic address:

Endocan, a secretary proteoglycan, known to induce vascular inflammation. Nitric oxide (NO) produced by endothelial cells is an important signaling molecule in maintaining the vascular homeostasis. However, the precise effect of endocan in regulating NO pathway is not known. Read More

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December 2021

A novel fast-response and highly selective AIEgen fluorescent probe for visualizing peroxynitrite in living cells, and inflammatory mice.

Analyst 2021 Oct 25;146(21):6556-6565. Epub 2021 Oct 25.

State Key Laboratory of Pharmaceutical Biotechnology, Institute of Artificial Intelligence Biomedicine, Engineering Research Center of Protein and Peptide Medicine, Nanjing University, Nanjing, 210023, PR China.

Most of the ONOO fluorescent probes have restricted applications because of their aggregation-caused quenching (ACQ) effect, long response time and low fluorescence enhancement. Herein, we developed a novel AIEgen fluorescent probe (PE-XY) based on a benzothiazole and quinolin scaffold with high sensitivity and selectivity for imaging of ONOO. The results indicated that probe PE-XY exhibited fast response towards ONOO with 2000-fold enhancement of fluorescence intensity ratio . Read More

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October 2021

Peroxisomal PEX7 Receptor Affects Cadmium-Induced ROS and Auxin Homeostasis in Arabidopsis Root System.

Antioxidants (Basel) 2021 Sep 20;10(9). Epub 2021 Sep 20.

Department of Environmental Biology, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.

Peroxisomes are important in plant physiological functions and stress responses. Through the production of reactive oxygen and nitrogen species (ROS and RNS), and antioxidant defense enzymes, peroxisomes control cellular redox homeostasis. Peroxin (PEX) proteins, such as PEX7 and PEX5, recognize peroxisome targeting signals (PTS1/PTS2) important for transporting proteins from cytosol to peroxisomal matrix. Read More

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September 2021

The Role of Thioredoxin/Peroxiredoxin in the β-Cell Defense Against Oxidative Damage.

Front Endocrinol (Lausanne) 2021 7;12:718235. Epub 2021 Sep 7.

Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, United States.

Oxidative stress is hypothesized to play a role in pancreatic β-cell damage, potentially contributing to β-cell dysfunction and death in both type 1 and type 2 diabetes. Oxidative stress arises when naturally occurring reactive oxygen species (ROS) are produced at levels that overwhelm the antioxidant capacity of the cell. ROS, including superoxide and hydrogen peroxide, are primarily produced by electron leak during mitochondrial oxidative metabolism. Read More

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September 2021

A highly selective ratiometric molecular probe for imaging peroxynitrite during drug-induced acute liver injury.

J Mater Chem B 2021 10 13;9(39):8246-8252. Epub 2021 Oct 13.

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China.

Drug-induced acute liver injury (DIALI) is a common liver disease, affecting a number of people worldwide with increasing morbidity each year. Thus, it is vital to develop new tools for intervention and diagnosis. Peroxynitrite (ONOO), a highly reactive species, plays an important role in the DIALI process. Read More

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October 2021

The correlation of antioxidant levels of breast cancer: A case controlled study.

Medicine (Baltimore) 2021 Sep;100(35):e26878

Department of Chemistry, College of Science, University of Duhok, Kurdistan Region, Iraq.

Abstract: Many free radicles are implicated to activate a number of oncogenic signaling, cause damage to deoxyribonucleic acid and tumor suppressor genes, or promote expression of proto-oncogenes. Reduced level of antioxidants and increases oxidative stress markers are associated with the development of various types of cancer.This prospective study included 60 women who were grouped into equal groups. Read More

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September 2021

Omega-3 and omega-6 fatty acids have distinct effects on endothelial fatty acid content and nitric oxide bioavailability.

Prostaglandins Leukot Essent Fatty Acids 2021 10 24;173:102337. Epub 2021 Aug 24.

Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115-6110, United States; Elucida Research LLC, Beverly, MA 01915-0091, United States. Electronic address:

Treatment with high dose icosapent ethyl (IPE), an ethyl ester of the omega-3 fatty acid eicosapentaenoic acid (EPA), significantly reduced ischemic events in patients with either cardiovascular disease (CV) or diabetes plus other risk factors (REDUCE-IT) but the mechanism is not well understood.  We compared the effects of EPA, docosahexaenoic acid (DHA), and the omega-6 fatty acid arachidonic acid (AA) on bioavailability of nitric oxide (NO) and fatty acid composition. Human umbilical vein endothelial cells (HUVECs) were pretreated with EPA, DHA, or AA (10 µM). Read More

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October 2021

Dietary supplementation of β-conglycinin, with or without sodium butyrate on the growth, immune response and intestinal health of hybrid grouper.

Sci Rep 2021 08 27;11(1):17298. Epub 2021 Aug 27.

Laboratory of Aquatic Animal Nutrition and Feed, Fisheries College, Guangdong Ocean University, Zhanjiang, 524025, People's Republic of China.

We investigated the effects of low and high doses of β-conglycinin and the ameliorative effects of sodium butyrate (based on high-dose β-conglycinin) on the growth performance, serum immunity, distal intestinal histopathology, and gene, protein expression related to intestinal health in hybrid grouper (Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂). The results revealed that the instantaneous growth rate (IGR) of grouper significantly increased, decreased, and increased in the low-dose β-conglycinin (bL), high-level β-conglycinin (bH) and high-level β-conglycinin plus sodium butyrate (bH-NaB), respectively. Read More

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Nutraceutical Strategy to Counteract Eye Neurodegeneration and Oxidative Stress in Fed with High-Sugar Diet.

Antioxidants (Basel) 2021 Jul 27;10(8). Epub 2021 Jul 27.

Department for Innovation in Biological, Agro-Food and Forest Systems (DIBAF), Università degli Studi della Tuscia, largo dell'Università snc, 01100 Viterbo, Italy.

Aberrant production of reactive oxygen species (ROS) is a common feature of damaged retinal neurons in diabetic retinopathy, and antioxidants may exert both preventive and therapeutic action. To evaluate the beneficial and antioxidant properties of food supplementation with Lisosan G, a powder of bran and germ of grain () obtained by fermentation with selected lactobacillus and natural yeast strains, we used an in vivo model of hyperglycemia-induced retinal damage, the fruit fly fed with high-sucrose diet. Lisosan G positively affected the visual system of hyperglycemic flies at structural/functional level, decreased apoptosis, and reactivated protective autophagy at the retina internal network. Read More

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Association of Tumour Microenvironment with Protein Glycooxidation, DNA Damage, and Nitrosative Stress in Colorectal Cancer.

Cancer Manag Res 2021 12;13:6329-6348. Epub 2021 Aug 12.

Department of Hygiene, Epidemiology and Ergonomics, Medical University of Bialystok, Białystok, 15-222, Poland.

Purpose: In this study, we evaluated the total antioxidant capacity, nitrosative stress, and protein/DNA oxidation and glycoxidation products in patients with colorectal cancer regarding histopathological parameters associated with the tumour microenvironment, such as inflammatory infiltration and tumour budding and compare all determined parameters between tumours located in the right and left side of the colon and normal mucosa.

Patients And Methods: Ferric reducing antioxidant power (FRAP), nitrosative stress (myeloperoxidase (MPO), nitrogen oxide (NO), peroxynitrite, and nitrotyrosine), protein oxidation products (protein carbonyls (PC), total thiols, and ischemia modified albumin (IMA)), protein glycooxidation products (tryptophan, kynurenine, N-formylkynurenine, dityrosine, Amadori product, advanced glycation end products (AGE)) and 8-hydroxydeoxyguanosine (8-OHdG) were measured in homogenates from normal and cancerous tissue of 30 patients with colorectal cancer.

Results: Levels of FRAP (p=0. Read More

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Reactive Species from Two-Signal Activated Macrophages Interfere with Their Oxygen Consumption Measurements.

Antioxidants (Basel) 2021 Jul 20;10(7). Epub 2021 Jul 20.

Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, 0379 Oslo, Norway.

Metabolic modulation of macrophage activation has emerged as a promising strategy lately in immunotherapeutics. However, macrophages have a broad spectrum of functions and thus, understanding the exact metabolic changes that drive a particular immune response, is of major importance. In our previous work, we have reported a key role of nitric oxide (NO) in two(2)-signal activated macrophages [M(2-signals)]. Read More

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Construction of a near-infrared fluorescent probe for ratiometric imaging of peroxynitrite during tumor progression.

Analyst 2021 Aug;146(16):5204-5211

Key Laboratory of Life-Organic Analysis of Shandong Province, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, P.R. China.

Malignant tumors are one of the main causes for human death and are tightly associated with overexpression of reactive oxygen species (ROS) in pathological processes. Therefore, in vivo monitoring of ROS, especially ONOO-, remains of great significance for diagnosis and therapy of tumors to improve the survival rate. Herein, we designed and constructed a reliable near-infrared (NIR) ratiometric fluorescent biosensor CDMS for monitoring the fluctuations of ONOO- in the process of tumor progression. Read More

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Oligomerization and Nitration of the Grass Pollen Allergen Phl p 5 by Ozone, Nitrogen Dioxide, and Peroxynitrite: Reaction Products, Kinetics, and Health Effects.

Int J Mol Sci 2021 Jul 16;22(14). Epub 2021 Jul 16.

Multiphase Chemistry Department, Max Planck Institute for Chemistry, 55128 Mainz, Germany.

The allergenic and inflammatory potential of proteins can be enhanced by chemical modification upon exposure to atmospheric or physiological oxidants. The molecular mechanisms and kinetics of such modifications, however, have not yet been fully resolved. We investigated the oligomerization and nitration of the grass pollen allergen Phl p 5 by ozone (O), nitrogen dioxide (NO), and peroxynitrite (ONOO). Read More

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