9 results match your criteria permeation mlx

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Enhanced transdermal delivery of meloxicam by nanocrystals: Preparation, and evaluation.

Asian J Pharm Sci 2018 Nov 7;13(6):518-526. Epub 2017 Dec 7.

Shanghai Dermatology Hospital, Shanghai 200443, China.

Meloxicam (MLX) is efficient in relieving pain and inflammatory symptoms, which, however, is limited by the poor solubility and gastrointestinal side effects. The objective of this study is to develop a nanocrystal formulation to enhance transdermal delivery of MLX. MLX nanocrystals were successfully prepared by the nanoprecipitation technique based on acid-base neutralization. Read More

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November 2018

Cocrystallization as a novel approach to enhance the transdermal administration of meloxicam.

Eur J Pharm Sci 2018 Oct 20;123:184-190. Epub 2018 Jul 20.

Programa de Pós-Graduação em Farmácia, Universidade Federal de Santa Catarina, Florianópolis, SC 88040-970, Brazil. Electronic address:

Despite its large effectiveness, the long-term oral administration of high doses of meloxicam (MLX) may lead to gastrointestinal events such as abdominal pain, diarrhea, dyspepsia, ulceration, hemorrhage, and gastrointestinal perforation. Moreover, the pH-dependent solubility of MLX makes the development of new oral formulations even more challenging. As an alternative to overcome these limitations, the transdermal delivery of this drug has been purposed. Read More

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October 2018

Development of Tizanidine HCl-Meloxicam loaded mucoadhesive buccal films: In-vitro and in-vivo evaluation.

PLoS One 2018 22;13(3):e0194410. Epub 2018 Mar 22.

Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan.

The purpose of the study was to develop Tizanidine HCl (TZN) and Meloxicam (MLX) loaded bilayer mucoadhesive films intended for buccal administration, aiming to enhance the bioavailability. Bilayer films were prepared by solvent evaporation technique selecting arabinoxylan (ARX) as a sustained release (SR) layer forming polymer and hydroxypropyl methylcellulose (HPMC) E-15 as an immediate release (IR) layer-forming polymer. Prepared films were subjected to in-vitro drug release, surface morphology, mechanical strength, compatibility of the ingredients, drug contents, ex-vivo mucoadhesion strength and drug permeation. Read More

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Ion-pair formation combined with a penetration enhancer as a dual strategy to improve the transdermal delivery of meloxicam.

Drug Deliv Transl Res 2018 02;8(1):64-72

Department of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Mailbox 59#, No. 103 Wenhua Road, Shenyang, 110016, China.

The aim of the study was to develop a novel drug-in-adhesive patch for transdermal delivery of meloxicam (MLX). The formulation involved a strategy to combine a chemical enhancer with an ion-pair agent. Diethylamine (DETA) was selected as the counter ion to form the ion-pair agent MLX-DETA. Read More

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February 2018

Flexosomes for transdermal delivery of meloxicam: characterization and antiinflammatory activity.

Artif Cells Nanomed Biotechnol 2017 Mar 28;45(2):305-312. Epub 2016 Feb 28.

a Department of Pharmaceutics, College of Pharmacy , King Saud University , Riyadh , Saudi Arabia.

The study aims to investigate the impact of flexosomes (FLs) on transdermal delivery of meloxicam (MLX). FLs are composed of phospholipid, Tween 80, and ethanol which were prepared by film hydration method. The prepared FLs were characterized for particle size, zeta potential, and entrapment efficiency (EE). Read More

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Development and characterization of a novel controlled release drug delivery system based on nanostructured lipid carriers gel for meloxicam.

Life Sci 2013 Nov 7;93(21):763-72. Epub 2013 Oct 7.

Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar 143104, India.

Aim: The main objective of the current investigation was to develop nanostructured lipid carriers (NLC) based gel for the enhancement of transdermal absorption of meloxicam (MLX) to achieve local as well as systemic drug action without concurrent gastrointestinal toxicity.

Main Methods: NLC gel containing MLX was prepared and characterized for particle size, polydispersity, zeta potential, pH, rheology, entrapment efficiency, occlusion factor, and thermal behavior. In vitro drug release, in vitro skin permeation and deposition studies were carried out using Franz diffusion cells. Read More

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November 2013

Preparation and evaluation of solid lipid nanoparticles based nanogel for dermal delivery of meloxicam.

Chem Phys Lipids 2013 Oct-Nov;175-176:65-72. Epub 2013 Aug 28.

Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar 143104, India. Electronic address:

The aim of the current investigation was to prepare and investigate the potential of solid lipid nanoparticles based gel (SLN-gel) for the dermal delivery of meloxicam (MLX). The meloxicam loaded SLN (MLX-SLN) gel was developed and characterized by means of photon correlation spectroscopy, rheometry, and differential scanning calorimetry to determine the physicochemical properties. The behavior of SLN gel on rat skin was evaluated in vitro using Franz diffusion cells to determine the skin permeation and penetration characteristics, in vivo on mice to determine the skin tolerance by histopathological examinations. Read More

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Nanoemulsion based gel for transdermal delivery of meloxicam: physico-chemical, mechanistic investigation.

Life Sci 2013 Mar 23;92(6-7):383-92. Epub 2013 Jan 23.

Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar - 143104, India.

Aims: The aim of the present investigation was to develop a nanoemulsion (NE) gel formulation for the transdermal delivery of meloxicam (MLX) in order to ensure maximum controlled and sustained drug release capacity.

Main Methods: The MLX containing NE gel was prepared and characterized for particle size, zeta potential, pH, rheology, in vitro drug release, in vitro skin permeation, and in vitro hemolysis. Differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) of MLX-NE gel treated rat skin was performed to investigate the skin permeation mechanism of meloxicam from NE gel. Read More

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Formulation of meloxicam gel for topical application: In vitro and in vivo evaluation.

Acta Pharm 2010 Jun;60(2):153-63

Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai-400019, India.

Skin delivery of NSAIDs offers several advantages over the oral route associated with potential side effects. In the present investigation, topical gel of meloxicam (MLX) was formulated using N-methyl pyrrolidone (NMP) as a solubilizer and Carbopol Ultrez 10® as a gelling polymer. MLX gel was evaluated with respect to different physicochemical parameters such as pH, viscosity and spreadability. Read More

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