10,271 results match your criteria peripheral vasoconstrictors


Risk factor identification and predictive models for central line requirements for patients on vasopressors.

Anaesth Intensive Care 2021 Jul 14;49(4):275-283. Epub 2021 Aug 14.

Department of Emergency Medicine, Yale School of Medicine, New Haven, CT, USA.

Vasopressors are ubiquitous in intensive care units. While central venous catheters are the preferred route of infusion, recent evidence suggests peripheral administration may be safe for short, single-agent courses. Here, we identify risk factors and develop a predictive model for patient central venous catheter requirement using the Medical Information Mart for Intensive Care, a single-centre dataset of patients admitted to an intensive care unit between 2008 and 2019. Read More

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Central and peripheral release of oxytocin: Relevance of neuroendocrine and neurotransmitter actions for physiology and behavior.

Handb Clin Neurol 2021 ;180:25-44

Department of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address:

The hypothalamic neuropeptide oxytocin (OT) is critically involved in the modulation of socio-emotional behavior, sexual competence, and pain perception and anticipation. While intracellular signaling of OT and its receptor (OTR), as well as the functional connectivity of hypothalamic and extra-hypothalamic OT projections, have been recently explored, it remains elusive how one single molecule has pleotropic effects from cell proliferation all the way to modulation of complex cognitive processes. Moreover, there are astonishing species-dependent differences in the way OT regulates various sensory modalities such as touch, olfaction, and vision, which can be explained by differences in OTR expression in brain regions processing sensory information. Read More

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Role of Lateral Hypothalamus in Acupuncture Inhibition of Cocaine Psychomotor Activity.

Int J Mol Sci 2021 Jun 1;22(11). Epub 2021 Jun 1.

Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea.

Acupuncture modulates the mesolimbic dopamine (DA) system; an area implicated in drug abuse. However, the mechanism by which peripheral sensory afferents, during acupuncture stimulation, modulate this system needs further investigation. The lateral hypothalamus (LH) has been implicated in reward processing and addictive behaviors. Read More

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MAPKs Are Highly Abundant but Do Not Contribute to α-Adrenergic Contraction of Rat Saphenous Arteries in the Early Postnatal Period.

Int J Mol Sci 2021 Jun 3;22(11). Epub 2021 Jun 3.

Department of Human and Animal Physiology, Faculty of Biology, M.V. Lomonosov Moscow State University, 119234 Moscow, Russia.

Previously, the abundance of p42/44 and p38 MAPK proteins had been shown to be higher in arteries of 1- to 2-week-old compared to 2- to 3-month-old rats. However, the role of MAPKs in vascular tone regulation in early ontogenesis remains largely unexplored. We tested the hypothesis that the contribution of p42/44 and p38 MAPKs to the contraction of peripheral arteries is higher in the early postnatal period compared to adulthood. Read More

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Partial Agonist Activity of Neonicotinoids on Rat Nicotinic Receptors: Consequences over Epinephrine Secretion and In Vivo Blood Pressure.

Int J Mol Sci 2021 May 12;22(10). Epub 2021 May 12.

University of Angers, INSERM U1083, CNRS UMR 6015, MITOVASC, SFR ICAT, 49000 Angers, France.

Neonicotinoid insecticides are nicotine-derived molecules which exert acute neurotoxic effects over the insect central nervous system by activating nicotinic acetylcholine receptors (nAChRs). However, these receptors are also present in the mammalian central and peripheral nervous system, where the effects of neonicotinoids are faintly known. In mammals, cholinergic synapses are crucial for the control of vascular tone, blood pressure and skeletal muscle contraction. Read More

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Differential Effects of Angiotensin-II Compared to Phenylephrine on Arterial Stiffness and Hemodynamics: A Placebo-Controlled Study in Healthy Humans.

Cells 2021 05 5;10(5). Epub 2021 May 5.

Medizinische Klinik I, Universitätsklinikum Schleswig-Holstein, 23538 Lübeck, Germany.

The α-adrenoceptor agonist phenylephrine (PE) and Angiotensin II (Ang II) are both potent vasoconstrictors at peripheral resistance arteries. PE has pure vasoconstrictive properties. Ang II, additionally, modulates central nervous blood pressure (BP) control via sympathetic baroreflex resetting. Read More

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Adverse events associated with administration of vasopressor medications through a peripheral intravenous catheter: do not confound access route and specific drug complications!

Crit Care 2021 05 29;25(1):183. Epub 2021 May 29.

SAMU de Paris, Service d'Anesthésie Réanimation, Hôpital Universitaire Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris, Université de Paris, Paris, France.

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Augmented glucose production is not contingent on high catecholamines in fetal sheep with IUGR.

J Endocrinol 2021 05 13;249(3):195-207. Epub 2021 May 13.

School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona, USA.

Fetuses with intrauterine growth restriction (IUGR) have high concentrations of catecholamines, which lowers the insulin secretion and glucose uptake. Here, we studied the effect of hypercatecholaminemia on glucose metabolism in sheep fetuses with placental insufficiency-induced IUGR. Norepinephrine concentrations are elevated throughout late gestation in IUGR fetuses but not in IUGR fetuses with a bilateral adrenal demedullation (IAD) at 0. Read More

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Severe Hyponatremia and Seizure From Peripheral Infusion of Norepinephrine Diluted in Dextrose 5% in Water: A Case Report.

A A Pract 2021 May 14;15(5):e01479. Epub 2021 May 14.

Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.

Recent studies have demonstrated that vasopressors can be delivered safely through peripheral intravenous lines. While norepinephrine is usually delivered at a concentration of 16 to 32 μg/mL, out of concern for extravasation and interstitial necrosis, some patients receive more dilute norepinephrine solutions through peripheral intravenous catheters. We describe a case of severe hyponatremia and seizure resulting from administration of norepinephrine concentrated at 4 μg/mL in dextrose 5% in water. Read More

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Vitamin B6 deficiency hyperactivates the noradrenergic system, leading to social deficits and cognitive impairment.

Transl Psychiatry 2021 05 3;11(1):262. Epub 2021 May 3.

Project for Schizophrenia Research, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, 156-8506, Japan.

We have reported that a subpopulation of patients with schizophrenia have lower levels of vitamin B (VB6) in peripheral blood than do healthy controls. In a previous study, we found that VB6 level was inversely proportional to the patient's positive and negative symptom scale (PANSS) score for measuring symptom severity, suggesting that the loss of VB6 might contribute to the development of schizophrenia symptoms. In the present study, to clarify the relationship between VB6 deficiency and schizophrenia, we generated VB6-deficient (VB6(-)) mice through feeding with a VB6-lacking diet as a mouse model for the subpopulation of schizophrenia patients with VB6 deficiency. Read More

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Vasopressors in Trauma: A Never Event?

Anesth Analg 2021 07;133(1):68-79

Anesthesia and Critical Care-Réanimation, Hôpital Beaujon, Université de Paris, Paris, France.

Vasopressor use in severely injured trauma patients is discouraged due to concerns that vasoconstriction will worsen organ perfusion and result in increased mortality and organ failure in hypotensive trauma patients. Hypotensive resuscitation is advocated based on limited data that lower systolic blood pressure and mean arterial pressure will result in improved mortality. It is classically taught that hypotension and hypovolemia in trauma are associated with peripheral vasoconstriction. Read More

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Time to Use Peripheral Norepinephrine in the Operating Room.

Anesth Analg 2021 07;133(1):284-288

Department of Anesthesiology, Virginia Commonwealth University Health System, Richmond, Virginia.

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Adrenergic signaling promotes the expansion of cancer stem-like cells of malignant peripheral nerve sheath tumors.

Biochem Biophys Res Commun 2021 06 16;557:199-205. Epub 2021 Apr 16.

Department of Cellular Physiology, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Malignant peripheral nerve sheath tumor (MPNST), a highly malignant tumor that arises in peripheral nerve tissues, is known to be highly resistant to radiation and chemotherapy. Although there are several reports on genetic mutations and epigenetic changes that define the pathogenesis of MPNST, there is insufficient information regarding the microenvironment that contributes to the malignancy of MPNST. In the present study, we demonstrate that adrenaline increases the cancer stem cell population in MPNST. Read More

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Adverse events associated with administration of vasopressor medications through a peripheral intravenous catheter: a systematic review and meta-analysis.

Crit Care 2021 04 16;25(1):146. Epub 2021 Apr 16.

Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada.

Background: It is unclear whether vasopressors can be safely administered through a peripheral intravenous (PIV). Systematic review and meta-analysis methodology was used to examine the incidence of local anatomic adverse events associated with PIV vasopressor administration in patients of any age cared for in any acute care environment.

Methods: MEDLINE, EMBASE, CINAHL, the Cochrane Central Register of controlled trials, and the Database of Abstracts of Reviews of Effects were searched without restriction from inception to October 2019. Read More

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A prospective comparison of peripheral metaraminol versus dilute noradrenaline in the intensive care unit.

Anaesth Intensive Care 2021 Mar 14;49(2):144-146. Epub 2021 Apr 14.

Intensive Care Department, Sir Charles Gairdner Hospital, Perth, Australia.

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Clinical use of peripheral perfusion parameters in septic shock.

Authors:
Jan Bakker

Curr Opin Crit Care 2021 06;27(3):269-273

Department of Intensive Care, Erasmus MC - University Medical Center, Rotterdam, The Netherlands.

Purpose Of Review: Current goals of resuscitation in septic shock are mainly a fixed volume of fluids and vasopressors to correct hypotension and improve tissue perfusion indicated by decreasing lactate levels.

Recent Findings: Abnormal peripheral perfusion by objective and subjective parameters are associated with increased mortality in various phases of the treatment of critically ill patients including patients with septic shock. Ongoing resuscitation in septic shock patients with normal peripheral perfusion is not associated with improved outcome, rather with increased mortality. Read More

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Hyperinsulinemia blunts sympathetic vasoconstriction: a possible role of β-adrenergic activation.

Am J Physiol Regul Integr Comp Physiol 2021 06 14;320(6):R771-R779. Epub 2021 Apr 14.

Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri.

Herein we report in a sample of healthy young men ( = 14) and women ( = 12) that hyperinsulinemia induces time-dependent decreases in total peripheral resistance and its contribution to the maintenance of blood pressure. In the same participants, we observe profound vasodilatory effects of insulin in the lower limb despite concomitant activation of the sympathetic nervous system. We hypothesized that this prominent peripheral vasodilation is possibly due to the ability of the leg vasculature to escape sympathetic vasoconstriction during systemic insulin stimulation. Read More

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[Safety of administration of norepinephrine through peripheral vein line in patients with septic shock].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Mar;33(3):276-280

Department of 2nd Intensive Care Unit, Lanzhou University Second Hospital, Lanzhou 730000, Gansu, China.

Objective: To analysis the risk factors and safety of administration of norepinephrine (NE) via peripheral vein line (PVL) in patients with septic shock.

Methods: A single-center retrospective study was conducted. According to the Lanzhou University Second Hospital information system (HIS) and nursing adverse events report cards, patients with septic shock administrated with NE via PVL to correct the hypotension from January 1st 2015 to December 31st, 2019 were enrolled. Read More

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Advantages of imaging photoplethysmography for migraine modeling: new optical markers of trigemino-vascular activation in rats.

J Headache Pain 2021 Apr 1;22(1):18. Epub 2021 Apr 1.

Research Laboratory of Neuromodulation, Almazov National Medical Research Centre, Saint Petersburg, Russia.

Background: Existent animal models of migraine are not without drawbacks and limitations. The aim of our study was to evaluate imaging photoplethysmography (PPG) as a method of assessing intracranial blood flow in rats and its changes in response to electrical stimulation of dural trigeminal afferents.

Methods: Experiments were carried out with 32 anesthetized adult male Wistar rats. Read More

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Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients From 29 Countries.

JAMA 2021 03;325(12):1164-1172

School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

Importance: Tracheal intubation is one of the most commonly performed and high-risk interventions in critically ill patients. Limited information is available on adverse peri-intubation events.

Objective: To evaluate the incidence and nature of adverse peri-intubation events and to assess current practice of intubation in critically ill patients. Read More

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Determination of the optimal dose of ephedrine in the treatment of arterial hypotension due to general anesthesia in neonates and infants below 6 months old: the ephedrine study protocol for a randomized, open-label, controlled, dose escalation trial.

Trials 2021 Mar 12;22(1):208. Epub 2021 Mar 12.

Hospices Civils de Lyon, EPICIME-CIC 1407 de Lyon, Inserm, Département d'épidémiologie clinique, Bron, CHU-Lyon, F-69677, France.

Background: Arterial hypotension induced by general anesthesia is commonly identified as a risk factor of morbidity, especially neurological, after cardiac or noncardiac surgery in adults and children. Intraoperative hypotension is observed with sevoflurane anesthesia in children, in particular in neonates, infants younger than 6 months, and preterm babies. Ephedrine is commonly used to treat intraoperative hypotension. Read More

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Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.

Front Immunol 2021 22;12:616583. Epub 2021 Feb 22.

Center of Autoimmune and Hematopoietic and Musculoskeletal diseases, The Feinstein Institute for Medical Research, Manhasset, NY, United States.

Epinephrine is a hormone secreted primarily by medullary cells of the adrenal glands which regulates permeability of blood-brain barrier (BBB). Recent studies showed signaling by epinephrine/epinephrine receptor in T cells is involved in autoimmune diseases. Nevertheless, the production of epinephrine by T cells and its pathogenic function in T cells are not well investigated. Read More

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Association of working memory and elevated overnight urinary norepinephrine in patients with schizophrenia.

J Psychiatr Res 2021 05 13;137:89-95. Epub 2021 Feb 13.

Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address:

Introduction: Norepinephrine has both central and peripheral origins and is known to influence cognitive processes in attention, learning, and working memory, but the research regarding the impact of norepinephrine on cognition in schizophrenia remains sparse, and mainly focuses on centrally regulated noradrenergic effects. This study examined the relationship between cumulative overnight norepinephrine levels in the urine and working memory in patients with schizophrenia and healthy controls.

Methods: Urinary catecholamines were collected overnight in patients with schizophrenia (n = 75) and healthy controls (n = 33). Read More

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Kidney and epigenetic mechanisms of salt-sensitive hypertension.

Nat Rev Nephrol 2021 05 24;17(5):350-363. Epub 2021 Feb 24.

Division of Clinical Epigenetics, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.

Dietary salt intake increases blood pressure (BP) but the salt sensitivity of BP differs between individuals. The interplay of ageing, genetics and environmental factors, including malnutrition and stress, contributes to BP salt sensitivity. In adults, obesity is often associated with salt-sensitive hypertension. Read More

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Intraoperative periarticular injection can alleviate the inflammatory response and enhance joint function recovery after hip arthroplasty in elderly patients with osteoporotic femoral neck fractures.

Medicine (Baltimore) 2021 Feb;100(7):e24596

Department of Orthopaedics, Second Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China.

Purpose: This study aimed to investigate the potential beneficial effects of periarticular injection (PAI) of multimodal drugs on the inflammatory response and joint function after hip arthroplasty in elderly patients with osteoporotic femoral neck fractures.

Methods: Fifty six elderly patients with unilateral osteoporotic femoral neck fractures were randomly allocated to 2 groups: the PAI group, which received the multimodal drug PAI intraoperatively before incision closure, and the control group, which received an injection of saline at the same time as placebo. The C-reactive protein (CRP), interleukin-1β (IL-1β), and IL-6 levels as well as the erythrocyte sedimentation rate (ESR) in peripheral venous blood samples were measured, along with the Visual Analogue Scale (VAS) score with activity and Harris hip score preoperation at 1, 2, 4, 7, and 14 days as well as 1 and 3 months post-operation. Read More

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February 2021

Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors.

Transl Psychiatry 2021 02 16;11(1):59. Epub 2021 Feb 16.

Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Dopamine (DA) and norepinephrine (NE) are catecholamines primarily studied in the central nervous system that also act in the pancreas as peripheral regulators of metabolism. Pancreatic catecholamine signaling has also been increasingly implicated as a mechanism responsible for the metabolic disturbances produced by antipsychotic drugs (APDs). Critically, however, the mechanisms by which catecholamines modulate pancreatic hormone release are not completely understood. Read More

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February 2021

Influence of anxiety and anesthetic vasoconstrictors upon hemodynamic parameters during dental procedures in controlled hypertensive and non-hypertensive patients.

J Clin Exp Dent 2021 Feb 1;13(2):e156-e164. Epub 2021 Feb 1.

Department of Stomatology, Valencia University Medical and Dental School, C/ Gascó Oliag 1, 46010 - Valencia, Spain.

Background: To determine the influence of dental anxiety and the vasoconstrictor used in local anesthesia upon different hemodynamic parameters - systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR) and peripheral oxygen saturation (SatO2) - during dental extraction and oral hygiene. The safety of local anesthesia with vasoconstrictor in patients with medically controlled hypertension was also assessed.

Material And Methods: A total of 159 patients were divided into two groups according to the dental treatment received: tooth extraction (n = 106) and oral hygiene (n = 53). Read More

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February 2021

TNF-α, CXCL-1 and IL-1 β as activators of the opioid system involved in peripheral analgesic control in mice.

Eur J Pharmacol 2021 Apr 2;896:173900. Epub 2021 Feb 2.

Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Av. Antônio Carlos, 6627, 31.270-100, Belo Horizonte, Brazil. Electronic address:

Tissue injury results in the release of inflammatory mediators, including a cascade of nociceptive substances, which contribute to development of hyperalgesia. In addition, during this process endogenous analgesic substances are also peripherally released with the aim of controlling the hyperalgesia. Thus, the present study aimed to investigate whether inflammatory mediators TNF-α, IL-1β, CXCL1, norepinephrine (NE) and prostaglandin E2 (PGE2) may be involved in the deflagration of peripheral endogenous modulation of inflammatory pain by activation of the opioid system. Read More

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Vasomotor action of androgens in the mesenteric artery of hypertensive rats. Role of perivascular innervation.

PLoS One 2021 2;16(2):e0246254. Epub 2021 Feb 2.

Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, Spain.

Androgens may exert cardiovascular protective actions by regulating the release and function of different vascular factors. In addition, testosterone (TES) and its 5-reduced metabolites, 5α- and 5β-dihydrotestosterone (5α- and 5β-DHT) induce vasorelaxant and hypotensive effects. Furthermore, hypertension has been reported to alter the release and function of the neurotransmitters nitric oxide (NO), calcitonin gene-related peptide (CGRP) and noradrenaline (NA). Read More

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September 2021

Acute physical and mental stress resulted in an increase in fatty acids, norepinephrine, and hemodynamic changes in normal individuals: A possible pathophysiological mechanism for hypertension-Pilot study.

J Clin Hypertens (Greenwich) 2021 04 29;23(4):888-894. Epub 2021 Jan 29.

Heart Institute (InCor) Medical School, Universidade de Sao Paulo, Sao Paulo, Brazil.

Hypertension is often associated with metabolic changes. The sustained increase in sympathetic activity is related to increased blood pressure and metabolic changes. Environmental stimuli may be related to increased sympathetic activity, blood pressure, and metabolic changes, especially in genetically predisposed individuals. Read More

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