95,473 results match your criteria peripheral tissues

Mini Review: Biomaterials in Repair and Regeneration of Nerve in a Volumetric Muscle Loss.

Neurosci Lett 2021 Jul 28:136145. Epub 2021 Jul 28.

Bone Muscle Research Center, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX 76019; Materials Science and Engineering Department, College of Engineering, University of Texas at Arlington, Arlington, TX 76019. Electronic address:

Volumetric muscle loss (VML) following a severe trauma or injury is beyond the intrinsic regenerative capacity of muscle tissues, and hence interventional therapy is required. Extensive muscle loss concomitant with damage to neuromuscular components overwhelms the muscles' remarkable regenerative capacity. The loss of nervous and vascular tissue leads to further damage and atrophy, so a combined treatment for neuromuscular junction (NMJ) along with the volumetric muscle regeneration is important. Read More

View Article and Full-Text PDF

The crosstalk between brain and periphery: Implications for brain health and disease.

Neuropharmacology 2021 Jul 28:108728. Epub 2021 Jul 28.

Centre for Neuroscience Studies, Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada; Department of Psychiatry, Queen's University, Kingston, ON K7L 3N6, Canada; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, 22281-100, Brazil; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, 21941-902, Brazil. Electronic address:

Mounting evidence indicates that signaling molecules identified primarily in the peripheral circulation can affect cognitive function in physiological and pathological conditions, including in the development of several neurological diseases. However, considering the properties of the vascular blood-brain barrier (BBB), circulating lipophobic molecules would not be expected to cross this vascular structure. Thus, if and how peripheral lipophobic molecules, such as hormones and cytokines, reach the brain to exert their reported effects remains to be better established. Read More

View Article and Full-Text PDF

A comparative account of nesfatin-1 in vertebrates.

Gen Comp Endocrinol 2021 Jul 28:113874. Epub 2021 Jul 28.

Department of Zoology, University of Delhi, Delhi- 110007, India. Electronic address:

Nesfatin-1 was discovered as an anorexigenic peptide derived from proteolytic cleavage of the prepropeptide, nucleobindin 2 (NUCB2). It is widely expressed in central as well as peripheral tissues and is known to have pleiotropic effects such as regulation of feeding, reproduction, cardiovascular functions and maintenance of glucose homeostasis. In order to execute its multifaceted role, nesfatin-1 employs diverse signaling pathways though its receptor has not been identified till date. Read More

View Article and Full-Text PDF

Submicron particle docetaxel intratumoral injection in combination with anti-mCTLA-4 into 4T1-Luc orthotopic implants reduces primary tumor and metastatic pulmonary lesions.

Med Oncol 2021 Jul 31;38(9):106. Epub 2021 Jul 31.

US Biotest, Inc., 231 Bonetti Drive, Suite 240, San Luis Obispo, CA, USA.

We describe here characterization of the response of local and metastatic disease and immunomodulation following intratumoral (IT) injection of submicron particle docetaxel (SPD) administered alone or in combination with systemic antibody anti-mCTLA-4 (anti-mCTLA-4) in the metastatic 4T1-Luc2-1A4 (4T1) murine breast cancer model. In-life assessments of treatment tolerance, tumor volume (TV), and metastasis were performed (n = 10 animals/group). At study end, immune cell populations in tumor-site tissues and peripheral blood were analyzed using flow cytometry. Read More

View Article and Full-Text PDF

Intratumoral talimogene laherparepvec injection with concurrent preoperative radiation in patients with locally advanced soft-tissue sarcoma of the trunk and extremities: phase IB/II trial.

J Immunother Cancer 2021 Jul;9(7)

Internal Medicine, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

Background: Soft-tissue sarcomas (STS) in the extremities and trunk treated with standard-of-care preoperative external beam radiation therapy (EBRT) followed by surgical resection are associated with local and distant relapses. In preclinical studies, oncolytic virotherapy in sarcoma has demonstrated antitumor effects via direct intratumoral oncolysis and cytotoxic T-cell-mediated immune responses. Talimogene laherparepvec (TVEC) is a replication-competent, immune-enhanced, oncolytic herpes simplex virus type 1 engineered for intratumoral injection; it has been approved by the FDA for the treatment of locally advanced and metastatic melanoma. Read More

View Article and Full-Text PDF

MicroRNA profiles of human peripheral arteries and abdominal aorta in normal conditions: MicroRNAs-27a-5p, -139-5p and -155-5p emerge and in atheroma too.

Mech Ageing Dev 2021 Jul 27:111547. Epub 2021 Jul 27.

DIMES-Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy; Subcellular Nephro-Vascular Diagnostic Program, Pathology Unit, IRCCS, Policlinico S. Orsola Hospital, Bologna, Italy.

Atherosclerosis may starts early in life and each artery has peculiar characteristics likely affecting atherogenesis. The primary objective of the work was to underpin the microRNA (miR)-profiling differences in human normal femoral, abdominal aortic, and carotid arteries. The secondary aim was to investigate if those identified miRs, differently expressed in normal conditions, may also have a role in atherosclerotic arteries at adult ages. Read More

View Article and Full-Text PDF

The Early Diagnostic Efficacy of Serum Histone H3 in Rabbit Urosepsis Model.

Biomed Res Int 2021 16;2021:9969344. Epub 2021 Jul 16.

Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.

Objective: We want to explore the changing law of circulating histones in the acute stage of urosepsis and to find more sensitive and specific biomarkers for diagnosing urosepsis as early as possible.

Methods: Twenty healthy male New Zealand rabbits were randomly divided into 4 groups ( = 5): the control group, sham group, model group of LPS 600 g/kg, and model group of LPS 1000 g/kg. Heart rate (HR), respiration rate (RR), rectal temperature (T), and mean arterial pressure (MAP) were examined at 1, 3, 6, 12, and 24 hours after operation. Read More

View Article and Full-Text PDF

CXCR5CD8 T Cells Shape Antibody Responses Following Protein Immunisation and Peripheral Viral Infection.

Front Immunol 2021 13;12:626199. Epub 2021 Jul 13.

Department of Molecular and Biomedical Science, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia.

Crosstalk between T and B cells is crucial for generating high-affinity, class-switched antibody responses. The roles of CD4 T cells in this process have been well-characterised. In contrast, regulation of antibody responses by CD8 T cells is significantly less defined. Read More

View Article and Full-Text PDF

Glutamic acid promotes hair growth in mice.

Sci Rep 2021 Jul 29;11(1):15453. Epub 2021 Jul 29.

Faculty of Nursing, University of Campinas, UNICAMP, Tessalia Vieira de Camargo St., 126, Campinas, SP, 13083-887, Brazil.

Glutamic acid is the main excitatory neurotransmitter acting both in the brain and in peripheral tissues. Abnormal distribution of glutamic acid receptors occurs in skin hyperproliferative conditions such as psoriasis and skin regeneration; however, the biological function of glutamic acid in the skin remains unclear. Using ex vivo, in vivo and in silico approaches, we showed that exogenous glutamic acid promotes hair growth and keratinocyte proliferation. Read More

View Article and Full-Text PDF

Neuroprotective Efficacy of Apple Cider Vinegar on Zinc-High Fat Diet-Induced Mono Amine Oxidase Alteration in Murine Model of AD.

J Am Coll Nutr 2021 Jul 29:1-10. Epub 2021 Jul 29.

Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Ranchi, Jharkhand, India.

Objective: Monoamine Oxidase (MAO), which catalyzes the oxidative deamination of amines present in the brain and peripheral tissues, is involved in the metabolism of monoamines and is vital for cognition. This study was designed to examine the protective effect of Apple Cider Vinegar (ACV) on MAO and amine neurotransmitters such as dopamine (DA), serotonin (5-HT), non-adrenaline (NA) levels.

Method: In this experiment, out of five groups, three groups of animals were pretreated with one of the test drugs each i. Read More

View Article and Full-Text PDF

Melatonin Adjusts the Phase of Mouse Circadian Clocks in the Cornea Both Ex Vivo and In Vivo.

J Biol Rhythms 2021 Jul 29:7487304211032385. Epub 2021 Jul 29.

Department of Ophthalmology, University of Washington School of Medicine, Seattle, Washington.

The presence of an endogenous circadian clock within most mammalian cells is associated with the amazing observation that within a given tissue, these clocks are largely in synchrony with each other. Different tissues use a variety of systemic or environmental cues to precisely coordinate the phase of these clocks. The cornea is a unique tissue in that it is largely isolated from the direct blood supply that most tissues experience, it is transparent to visible light, and it is exposed directly to environmental light and temperature. Read More

View Article and Full-Text PDF

Single Nucleotide Polymorphisms in Are Related to Breast Cancer Risk and Prognosis in the Northeastern Chinese Population.

Front Oncol 2021 12;11:706428. Epub 2021 Jul 12.

Cancer Center, The First Hospital of Jilin University, Changchun, China.

Background: The long noncoding RNA HOX transcript antisense RNA () is highly expressed in breast cancer (BC) tissues and is associated with the recurrence and metastasis of BC. Until now, the results of studies on associations between several functional single nucleotide polymorphisms(SNPs) (rs920778, rs1899663, and rs4759314) in with BC susceptibility carried out in different regions of China are still inconsistent. There is no study on correlation between SNPs and prognosis of Chinese population. Read More

View Article and Full-Text PDF

An Integrated View on Neuronal Subsets in the Peripheral Nervous System and Their Role in Immunoregulation.

Front Immunol 2021 12;12:679055. Epub 2021 Jul 12.

Department of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

The peripheral nervous system consists of sensory circuits that respond to external and internal stimuli and effector circuits that adapt physiologic functions to environmental challenges. Identifying neurotransmitters and neuropeptides and the corresponding receptors on immune cells implies an essential role for the nervous system in regulating immune reactions. Vice versa, neurons express functional cytokine receptors to respond to inflammatory signals directly. Read More

View Article and Full-Text PDF

Regulated control of gene therapies by drug-induced splicing.

Nature 2021 Jul 28. Epub 2021 Jul 28.

Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

So far, gene therapies have relied on complex constructs that cannot be finely controlled. Here we report a universal switch element that enables precise control of gene replacement or gene editing after exposure to a small molecule. The small-molecule inducers are currently in human use, are orally bioavailable when given to animals or humans and can reach both peripheral tissues and the brain. Read More

View Article and Full-Text PDF

Tissue Cytokine Adenoid Experssion in Hypertrophic Adenoid Gland in Children with Allergic Rhinitis.

J Coll Physicians Surg Pak 2021 Aug;31(8):903-909

Department of Otolaryngology - Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China.

Objective: To investigate the inflammatory pattern in terms of inflammatory cells and cytokines expression in children with adenoid hypertrophy (AH) and coexistent allergic rhinitis (AR).

Study Design: A cross-sectional analytical study.

Place And Duration Of Study: Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong P. Read More

View Article and Full-Text PDF

4-Methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy for chronic prostatitis.

Prostate 2021 Jul 28. Epub 2021 Jul 28.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Institute of Urology, and Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, Anhui, China.

Background: Hyaluronan (HA), an extracellular matrix component, accumulates in most chronic inflammatory tissues. Here, we studied the impact of HA on the pathogenesis of chronic prostatitis.

Materials And Methods: First, we sorted demographic characteristics and peripheral blood serum samples from patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) to assess the relationship between the levels of HA in peripheral blood serum and the severity of inflammation in patients. Read More

View Article and Full-Text PDF

Positron Emission Tomography Imaging of Autotaxin in Thyroid and Breast Cancer Models Using [F]PRIMATX.

Mol Pharm 2021 Jul 28. Epub 2021 Jul 28.

Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton T6G 1Z2, Alberta, Canada.

Autotaxin (ATX) is a secreted enzyme responsible for producing lysophosphatidic acid (LPA). The ATX/LPA signaling axis is typically activated in wound healing and tissue repair processes. The ATX/LPA axis is highjacked and upregulated in the progression and persistence of several chronic inflammatory diseases, including cancer. Read More

View Article and Full-Text PDF

Neurodegenerative movement disorders: an epigenetics perspective and promise for the future.

Neuropathol Appl Neurobiol 2021 Jul 27. Epub 2021 Jul 27.

Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.

Neurodegenerative movement disorders (NMDs) are age dependent disorders that are characterised by the degeneration and loss of neurons, typically accompanied by pathological accumulation of different protein aggregates in the brain, which lead to motor symptoms. NMDs include Parkinson's disease, multiple system atrophy, progressive supranuclear palsy, and Huntington's disease, among others. Epigenetic modifications are responsible for functional gene regulation during development, adult life, and ageing, and have progressively been implicated in complex diseases such as cancer, and more recently in neurodegenerative diseases, such as NMDs. Read More

View Article and Full-Text PDF

Antixenosis in Glycine max (L.) Merr against Acyrthosiphon pisum (Harris).

Sci Rep 2021 Jul 27;11(1):15289. Epub 2021 Jul 27.

Department of Botany and Ecology, University of Zielona Góra, Szafrana 1, 65-516, Zielona Góra, Poland.

To reveal the antixenosis potential against the pea aphid Acyrthosiphon pisum (Harris) (Hemiptera: Aphididae) we analyzed the pea aphid survival and probing behavior, and the quantitative and qualitative variation of flavonoids in the leaves of selected soybean Glycine max (L.) Merr (Fabaceae) cultivars 'Aldana', 'Annushka', 'Augusta', 'Madlen', 'Mavka', 'Simona', 'Violetta', and 'Viorica'. Aphid survival was drastically impeded on all cultivars. Read More

View Article and Full-Text PDF

Mammalian Digit Tip Regeneration: Moving from Phenomenon to Molecular Mechanism.

Cold Spring Harb Perspect Biol 2021 Jul 26. Epub 2021 Jul 26.

Department of Orthopedics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

In this review, we present the current state of knowledge surrounding mammalian digit tip regeneration. We discuss the origin and formation of the blastema, a structure integral to digit tip regeneration, as well as recent insights driven by single-cell RNA sequencing into the molecular markers and cellular composition of the blastema. The digit tip is a composite of many different tissue types and we address what is known about the role of these separate tissues in regeneration of the whole digit tip. Read More

View Article and Full-Text PDF

Aspergillus fumigatus Acetate Utilization Impacts Virulence Traits and Pathogenicity.

mBio 2021 Jul 27:e0168221. Epub 2021 Jul 27.

Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Departamento de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brazil.

Aspergillus fumigatus is a major opportunistic fungal pathogen of immunocompromised and immunocompetent hosts. To successfully establish an infection, A. fumigatus needs to use host carbon sources, such as acetate, present in the body fluids and peripheral tissues. Read More

View Article and Full-Text PDF

Prognostic value of inflammatory response biomarkers using peripheral blood and [18F]-FDG PET/CT in advanced NSCLC patients treated with first-line chemo- or immunotherapy.

Lung Cancer 2021 Jul 20;159:45-55. Epub 2021 Jul 20.

Department of Nuclear Medicine, Institut Curie, 92210 Saint-Cloud, France; Laboratoire d'Imagerie Translationnelle en Oncologie, Inserm, Institut Curie, 91401, Orsay, France.

Objectives: We aimed to compare the prognostic value of inflammatory biomarkers extracted from pretreatment peripheral blood and [18F]-FDG PET for estimating outcomes in non-small cell lung cancer (NSCLC) patients treated with first-line immunotherapy (IT) or chemotherapy (CT).

Materials And Methods: In this retrospective multicenter study, we evaluated 111 patients with advanced NSCLC who underwent baseline [18F]-FDG PET/CT before IT or CT between 2016 and 2019. Several blood inflammatory indices were evaluated: derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein (CRP) and systemic immune-inflammation index (SII). Read More

View Article and Full-Text PDF

LDLR expression in the cochlea suggests a role in endolymph homeostasis and cochlear amplification.

Hear Res 2021 Jul 15;409:108311. Epub 2021 Jul 15.

GIGA-Neurosciences, Unit of Cell and Tissue Biology, University of Liège, C.H.U. B36, B-4000 Liège, Belgium. Electronic address:

There is now growing evidence that hypercholesterolemia and high serum levels of low-density lipoproteins (LDL) predispose to sensorineural hearing loss. Circulating LDL-cholesterol is delivered to peripheral tissues via LDL receptor (LDLR) -mediated endocytosis. Recently, it has been shown that LDLR gene polymorphisms are associated with higher susceptibility to sudden deafness. Read More

View Article and Full-Text PDF

Adaptive selection of a prion strain conformer corresponding to established North American CWD during propagation of novel emergent Norwegian strains in mice expressing elk or deer prion protein.

PLoS Pathog 2021 Jul 26;17(7):e1009748. Epub 2021 Jul 26.

Prion Research Center (PRC), the Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America.

Prions are infectious proteins causing fatal, transmissible neurodegenerative diseases of animals and humans. Replication involves template-directed refolding of host encoded prion protein, PrPC, by its infectious conformation, PrPSc. Following its discovery in captive Colorado deer in 1967, uncontrollable contagious transmission of chronic wasting disease (CWD) led to an expanded geographic range in increasing numbers of free-ranging and captive North American (NA) cervids. Read More

View Article and Full-Text PDF

DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junction.

PLoS Pathog 2021 Jul 26;17(7):e1008603. Epub 2021 Jul 26.

Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China.

Dengue virus (DENV) is a mosquito-borne pathogen that causes a spectrum of diseases including life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Vascular leakage is a common clinical crisis in DHF/DSS patients and highly associated with increased endothelial permeability. The presence of vascular leakage causes hypotension, circulatory failure, and disseminated intravascular coagulation as the disease progresses of DHF/DSS patients, which can lead to the death of patients. Read More

View Article and Full-Text PDF

Tissue-Specific Hydrogels for 3D Printing and Potential Application in Peripheral Nerve Regeneration.

Tissue Eng Part A 2021 Jul 26. Epub 2021 Jul 26.

Sun Yat-sen University First Affiliated Hospital, 71068, Department of Orthopedic and Microsurgery, Guangzhou, Guangdong, China;

Decellularized extracellular matrix hydrogel (dECM-G) has demonstrated its significant tissue-specificity, high biocompatibility, and versatile utilities in tissue engineering. However, the low mechanical stability and fast degradation are major drawbacks for its application in 3D printing. Herein, we report a hybrid hydrogel system consisting of dECM-Gs and photocrosslinkable gelatin methacrylate (GelMA), which resulted in significantly improved printability and structural fidelity. Read More

View Article and Full-Text PDF

Neuropeptide Y and Metabolism Syndrome: An Update on Perspectives of Clinical Therapeutic Intervention Strategies.

Front Cell Dev Biol 2021 9;9:695623. Epub 2021 Jul 9.

Centre of Neurological and Metabolic Research, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.

Through the past decade of research, the pathogenic mechanisms underlying metabolic syndrome have been suggested to involve not only the peripheral tissues, but also central metabolic regulation imbalances. The hypothalamus, and the arcuate nucleus in particular, is the control center for metabolic homeostasis and energy balance. Neuropeptide Y neurons are particularly abundantly expressed in the arcuate of the hypothalamus, where the blood-brain barrier is weak, such as to critically integrate peripheral metabolic signals with the brain center. Read More

View Article and Full-Text PDF

miR-122 and miR-197 expressions in hepatic carcinoma patients before and after chemotherapy and their effect on patient prognosis.

Am J Transl Res 2021 15;13(6):6731-6737. Epub 2021 Jun 15.

Department of General Surgery, Central Theater General Hospital (Hankou Hospital) Wuhan 430010, Hubei, China.

Objective: To quantify the miR-122 and miR-197 expression levels in liver cancer (LC) patients before and after chemotherapy and to determine their prognostic implications.

Methods: The present study included 169 patients with LC who were admitted to our hospital from January 2005 to December 2010. The miR-122 and miR-197 expression levels in the patients' cancerous and adjacent tissues were quantified, and their peripheral blood levels before and after chemotherapy were analyzed, as well as their prognostic implications. Read More

View Article and Full-Text PDF

Relationship between miRNA-433 and SPP1 in the presence of fracture and traumatic brain injury.

Exp Ther Med 2021 Sep 30;22(3):928. Epub 2021 Jun 30.

First Aid Center, Jinan Zhangqiu District People's Hospital, Jinan, Shandong 250200, P.R. China.

Limb fracture combined with traumatic brain injury (TBI) is one of the most common multiple injuries and patients often suffer from severe craniocerebral injury combined with long bone fracture of the limbs. The present study examined the expression of osteopontin (SPP1) in the tibial fracture callus and heterotopic ossification tissues in craniocerebral injury and investigated its relationship with miR-433. A total of 26 patients with tibial fracture combined with brain injury were included in the TBI group, and 26 patients with simple tibial fracture were included in the control group. Read More

View Article and Full-Text PDF
September 2021

GGC Repeat Expansion in the Gene Is Associated With a Phenotype of Predominant Motor-Sensory and Autonomic Neuropathy.

Front Genet 2021 7;12:694790. Epub 2021 Jul 7.

Department of Neurology, Peking University First Hospital, Beijing, China.

There is still a considerable proportion of patients with inherited peripheral neuropathy (IPN) whose pathogenic genes are unknown. This study was intended to investigate whether the GGC repeat expansion in the is presented in some patients with IPN. A total of 142 unrelated mainland Chinese patients with highly suspected diagnosis of IPN without any known causative gene were recruited. Read More

View Article and Full-Text PDF