30,845 results match your criteria peripheral lung


Evaluation of chemotherapy-related peripheral neuropathy in lung cancer treatment.

Tumori 2021 Oct 1;107(5):392-399. Epub 2020 Dec 1.

Chest Diseases Clinic, Izmir Metropolitan Municipality Hospital, Izmir, Turkey.

Objective: Chemotherapy-related peripheral neuropathies are observed frequently in lung cancer treatment in clinical practice. The present study aimed to evaluate the electrophysiologic findings and clinical symptoms in patients treated for lung cancer with different chemotherapy regimens who had the findings of peripheral neuropathy.

Methods: Patients who had electromyography (EMG) examinations with the prediagnosis of peripheral neuropathy at two different centers between January 2011 and December 2019 were included. Read More

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October 2021

Cannabinoids: an Effective Treatment for Chemotherapy-Induced Peripheral Neurotoxicity?

Neurotherapeutics 2021 Oct 19. Epub 2021 Oct 19.

Experimental Neurology Unit, School of Medicine and Surgery, University of Milano Bicocca, via Cadore 48, Monza, Italy.

Chemotherapy-induced peripheral neurotoxicity (CIPN) is one of the most frequent side effects of antineoplastic treatment, particularly of lung, breast, prostate, gastrointestinal, and germinal cancers, as well as of different forms of leukemia, lymphoma, and multiple myeloma. Currently, no effective therapies are available for CIPN prevention, and symptomatic treatment is frequently ineffective; thus, several clinical trials are addressing this unmet clinical need. Among possible pharmacological treatments of CIPN, modulation of the endocannabinoid system might be particularly promising, especially in those CIPN types where analgesia and neuroinflammation modulation might be beneficial. Read More

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October 2021

Cell-Free Mitochondrial DNA as a Potential Biomarker for Astronauts' Health.

J Am Heart Assoc 2021 Oct 20:e022055. Epub 2021 Oct 20.

Cardiovascular Research Institute Icahn School of Medicine at Mount Sinai New York NY.

Background Space travel-associated stressors such as microgravity or radiation exposure have been reported in astronauts after short- and long-duration missions aboard the International Space Station. Despite risk mitigation strategies, adverse health effects remain a concern. Thus, there is a need to develop new diagnostic tools to facilitate early detection of physiological stress. Read More

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October 2021

A candidate gene study reveals association between a variant of the SRp55 splicing factor gene and systemic sclerosis.

Clin Exp Rheumatol 2021 Oct 19. Epub 2021 Oct 19.

Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Italy.

Objectives: To examine the possible implication of the mRNA-binding protein serine/arginine protein 55 (SRp55, also known as SRSF6) rs2235611 single nucleotide polymorphism (SNP) in the genetic predisposition to systemic sclerosis (SSc) susceptibility and clinical phenotype.

Methods: A total population of 872 white Italian individuals (414 SSc patients, 458 controls) was studied. SSc patients were assessed for limited and diffuse cutaneous subsets and the presence of autoantibodies, interstitial lung disease (ILD), and nailfold videocapillaroscopy (NVC) abnormalities. Read More

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October 2021

Do not forget the lungs: I/E mode physiotherapy for people recovering from COVID-19. Preliminary feasibility study.

Panminerva Med 2021 Oct 19. Epub 2021 Oct 19.

Division of Pulmonology, Cardiovascular and Thoracic Department, Azienda Ospedaliera Universitaria Città Della Salute e Della Scienza di Torino, Turin, Italy.

Background: Early chest physiotherapy is recommended for patients with post-COVID syndrome to improve dyspnea, relieve anxiety, minimize disability, preserve lung function and improve quality of life. However, there is still no consensus on the best treatments to manage respiratory symptoms. We aimed to test a method based on a guided in/expiratory (I/E) modulation to treat the lung inhomogeneity. Read More

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October 2021

Distinction of lymphoid and myeloid clonal hematopoiesis.

Nat Med 2021 Oct 18. Epub 2021 Oct 18.

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Clonal hematopoiesis (CH) results from somatic genomic alterations that drive clonal expansion of blood cells. Somatic gene mutations associated with hematologic malignancies detected in hematopoietic cells of healthy individuals, referred to as CH of indeterminate potential (CHIP), have been associated with myeloid malignancies, while mosaic chromosomal alterations (mCAs) have been associated with lymphoid malignancies. Here, we analyzed CHIP in 55,383 individuals and autosomal mCAs in 420,969 individuals with no history of hematologic malignancies in the UK Biobank and Mass General Brigham Biobank. Read More

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October 2021

The therapeutic promises of Lianhuaqingke in the mice model of coronavirus pneumonia (HCoV-229E and SARS-CoV-2).

Chin Med 2021 Oct 18;16(1):104. Epub 2021 Oct 18.

Shijiazhuang Yiling Pharmaceutical Co., Ltd, No.238, The South of Tianshan Street, Shijiazhuang, 050035, Hebei, China.

Background: Lianhuaqingke (LHQK) has been approved for the treatment of acute tracheobronchitis and exerts a broad-spectrum antiviral effect in our previous study.

Methods: Acute pneumonia caused by HCoV-229E was modeled in BALB/c mice. The anti-viral effect of LHQK was assessed by measuring the lung index and virus titer of lung tissues. Read More

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October 2021

Neurocysticercosis in a Japanese woman with lung cancer who repeatedly visited endemic countries.

BMC Infect Dis 2021 Oct 18;21(1):1077. Epub 2021 Oct 18.

Department of Neurosurgery, Tokushima Municipal Hospital, 2-34, Kitajyosanjima-cho, Tokushima, 770-0812, Japan.

Background: Taenia solium, present in most developing countries, infects many individuals and may result in their death. Neurocysticercosis (NCC) develops after invasion of the brain by parasitic larvae. It is the most common parasitic disease of the human central nervous system. Read More

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October 2021

Percentage of residual B cells after 2 weeks of rituximab treatment predicts the improvement of systemic sclerosis-associated interstitial lung disease.

J Dermatol 2021 Oct 18. Epub 2021 Oct 18.

Department of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

The benefit of rituximab (RTX) for systemic sclerosis-associated interstitial lung disease (SSc-ILD) has been shown in previous clinical trials. However, predictors of RTX efficacy have not been clarified. We investigated whether B-cell responsiveness to RTX is related to therapeutic effect. Read More

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October 2021

Propofol decreases CD8+ T cells and sevoflurane increases regulatory T cells after lung cancer resection: a randomized controlled trial.

J Thorac Dis 2021 Sep;13(9):5430-5438

Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, Tokyo, Japan.

Background: Anaesthetics generally have an immunosuppressive effect, which may be related to prognosis. We conducted to clarify the relationship between peri-operative immunosuppression and anaesthetic agents in patients undergoing lung cancer surgery, resulting in better selection of intraoperative anaesthesia.

Methods: Prospective randomized controlled study was performed in single-University hospital. Read More

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September 2021

Primary Mediastinal Ewing sarcoma presenting as a massive lung lesion with a mediastinal shift.

Clin Case Rep 2021 Oct 10;9(10):e04857. Epub 2021 Oct 10.

Department of Internal Medicine Hamad Medical Corporation Doha Qatar.

Primary pulmonary Ewing sarcoma can present as a massive mass in the left hemithorax covering the entire lung and can press the pulmonary artery and cause a significant mediastinal shift. Read More

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October 2021

Sex-Differences in the Oxygenation Levels of Intercostal and Vastus Lateralis Muscles During Incremental Exercise.

Front Physiol 2021 1;12:738063. Epub 2021 Oct 1.

Laboratory of Exercise Physiology, Department of Health Science, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

This study aimed to examine sex differences in oxygen saturation in respiratory (SmO-) and locomotor muscles (SmO-) while performing physical exercise. Twenty-five (12 women) healthy and physically active participants were evaluated during an incremental test with a cycle ergometer, while ventilatory variables [lung ventilation ( E), tidal volume (Vt), and respiratory rate (RR)] were acquired through the breath-by-breath method. SmO was acquired using the MOXY devices on the and . Read More

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October 2021

Chronic AT blockade improves hyperglycemia by decreasing adipocyte inflammation and decreasing hepatic PCK1 and G6PC1 expression in obese rats.

Am J Physiol Endocrinol Metab 2021 Oct 18. Epub 2021 Oct 18.

Department of Molecular and Cellular Biology, grid.266096.dUniversity of California, Merced, CA, United States.

Inappropriate activation of the renin-angiotensin system decreases glucose uptake in peripheral tissues. Chronic angiotensin receptor type 1 (AT) blockade increases glucose uptake in skeletal muscle, decreases the abundance of large adipocytes, and macrophage infiltration in adipose. However, the contributions of each tissue to the improvement in hyperglycemia in response to AT blockade are not known. Read More

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October 2021

Shape-sensing robotic-assisted bronchoscopy for pulmonary nodules: initial multicenter experience using the Ion™ Endoluminal System.

BMC Pulm Med 2021 Oct 16;21(1):322. Epub 2021 Oct 16.

Department of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Background: Traditional bronchoscopy provides limited approach to peripheral nodules. Shape-sensing robotic-assisted bronchoscopy (SSRAB, Ion™ Endoluminal System) is a new tool for minimally invasive peripheral nodule biopsy. We sought to answer the research question: Does SSRAB facilitate sampling of pulmonary nodules during bronchoscopists' initial experience?

Methods: The lead-in stage of a multicenter, single-arm, prospective evaluation of the Ion Endoluminal System (PRECIsE) is described. Read More

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October 2021

Pathophysiology of Takotsubo Syndrome - a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology - Part 2: vascular pathophysiology, gender and sex hormones, genetics, chronic cardiovascular problems and clinical implications.

Eur J Heart Fail 2021 Oct 16. Epub 2021 Oct 16.

National Heart and Lung Institute, Imperial College, London, UK.

While the first part of the scientific statement on the pathophysiology of Takotsubo syndrome was focused the catecholamines and sympathetic nervous system, in the second part we focus on the vascular pathophysiology including coronary and systemic vascular responses, the role of the central and peripheral nervous systems during the acute phase and abnormalities in the subacute phase, the gender differences and integrated effects of sex hormones, genetics of Takotsubo syndrome including insights from microRNA studies and inducible pluripotent stem cell models of Takotsubo syndrome. We then discuss the chronic abnormalities of cardiovascular physiology in survivors, the limitations of current clinical and preclinical studies, the implications of the knowledge of pathophysiology for clinical management and future perspectives and directions of research. This article is protected by copyright. Read More

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October 2021

Angiogenic effects of cell therapy within a biomaterial scaffold in a rat hind limb ischemia model.

Sci Rep 2021 Oct 15;11(1):20545. Epub 2021 Oct 15.

Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Critical limb ischemia (CLI) is a life- and limb-threatening condition affecting 1-10% of humans worldwide with peripheral arterial disease. Cellular therapies, such as bone marrow-derived mesenchymal stem cells (MSCs) have been used for the treatment of CLI. However, little information is available regarding the angiogenic potency of MSCs and mast cells (MC) in angiogenesis. Read More

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October 2021

Cancer-associated fibroblasts-derived exosomes promote lung cancer progression by OIP5-AS1/ miR-142-5p/ PD-L1 axis.

Mol Immunol 2021 Oct 13;140:47-58. Epub 2021 Oct 13.

Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, 226000, Jiangsu, China. Electronic address:

Cancer-associated fibroblasts (CAFs) are the most important stromal cells in the tumor microenvironment (TEM) and have been reported to regulate various cancer development. Exosomes are considered important elements involved in intercellular communication and TME regulation, while the potential function of CAFs in lung cancer immunosuppressive microenvironments remains unknown. CAFs-derived exosomes (CAFs-exo) and normal fibroblasts (NFs)-derived exosomes (NFs-exo) were isolated by ultra-centrifugation and characterized by transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA) and western blot analysis. Read More

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October 2021

PLAC8 promotes EV71 infected inflammatory lesion by disturbing Th-cell-related cytokines release in neonatal mouse.

Virology 2021 Oct 8;564:39-45. Epub 2021 Oct 8.

School of Basic Medicine, Hubei University of Arts and Science, Xiangyang, 441053, China. Electronic address:

Enterovirus 71 can cause severe hand, foot, and mouth disease (HFMD) in children. However, little is known about the mechanism of inflammatory disorders caused by EV71 infection and why severe cases are mainly children aged under-three. In current study, using mRNA microarray assay, the differential expression of Placenta-specific 8 (PLAC8) was identified in mice brain. Read More

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October 2021

Acute Hyperglycemia does not affect Central Respiratory Chemoreflex Responsiveness to CO in Healthy Humans.

Respir Physiol Neurobiol 2021 Oct 12:103803. Epub 2021 Oct 12.

Department of Biology, Faculty of Science and Technology, Mount Royal University, Calgary, Alberta, Canada. Electronic address:

The central respiratory chemoreceptor complex (CCRC) is comprised of brainstem neurons and surrounding interoceptors, which collectively increase ventilation in response to elevated brainstem tissue CO/[H] (i.e., central chemoreflex; CCR). Read More

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October 2021

Effect of a day-trip to altitude (2500 m) on exercise performance in pulmonary hypertension: randomised crossover trial.

ERJ Open Res 2021 Oct 11;7(4). Epub 2021 Oct 11.

Clinic of Pulmonology, University Hospital of Zurich, Zurich, Switzerland.

Question Addressed By The Study: To investigate exercise performance and hypoxia-related health effects in patients with pulmonary hypertension (PH) during a high-altitude sojourn.

Patients And Methods: In a randomised crossover trial in stable (same therapy for >4 weeks) patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) with resting arterial oxygen tension ( ) ≥7.3 kPa, we compared symptom-limited constant work-rate exercise test (CWRET) cycling time during a day-trip to 2500 m 470 m. Read More

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October 2021

Peripheral Hybrid CBR and iNOS Antagonist MRI-1867 Displays Anti-Fibrotic Efficacy in Bleomycin-Induced Skin Fibrosis.

Front Endocrinol (Lausanne) 2021 28;12:744857. Epub 2021 Sep 28.

Section on Fibrotic Disorders, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, United States.

Scleroderma, or systemic sclerosis, is a multi-organ connective tissue disease resulting in fibrosis of the skin, heart, and lungs with no effective treatment. Endocannabinoids acting cannabinoid-1 receptors (CBR) and increased activity of inducible NO synthase (iNOS) promote tissue fibrosis including skin fibrosis, and joint targeting of these pathways may improve therapeutic efficacy. Recently, we showed that in mouse models of liver, lung and kidney fibrosis, treatment with a peripherally restricted hybrid CBR/iNOS inhibitor (MRI-1867) yields greater anti-fibrotic efficacy than inhibiting either target alone. Read More

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September 2021

An interferon inducible signature of airway disease from blood gene expression profiling.

Eur Respir J 2021 Oct 14. Epub 2021 Oct 14.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Background: The molecular basis of airway remodeling in chronic obstructive pulmonary disease remains poorly understood. We identified gene expression signatures associated with chest CT scan airway measures to understand molecular pathways associated with airway disease.

Methods: In 2,396 subjects in the COPDGene Study, we examined the relationship between quantitative CT airway phenotypes and blood transcriptomes to identify airway disease-specific genes and to define an airway wall thickness (AWT) gene set score. Read More

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October 2021

Bronchus-blocked ultrasound-guided percutaneous transthoracic needle biopsy (BUS-PTNB) for intubated patients with severe lung diseases.

Crit Care 2021 Oct 14;25(1):359. Epub 2021 Oct 14.

Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, No. 37, Guo Xue Alley, Chengdu, 610041, Sichuan, China.

Background: Examinations based on lung tissue specimen can play a significant role in the diagnosis for critically ill and intubated patients with lung infiltration. However, severe complications including tension pneumothorax and intrabronchial hemorrhage limit the application of needle biopsy.

Methods: A refined needle biopsy technique, named bronchus-blocked ultrasound-guided percutaneous transthoracic needle biopsy (BUS-PTNB), was performed on four intubated patients between August 2020 and April 2021. Read More

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October 2021

One year of COVID-19 pandemic: what we Radiologists have learned about imaging.

Rofo 2021 Oct 14. Epub 2021 Oct 14.

Radiology and Interventional Therapy, Vivantes-Klinikum Neukölln, Berlin, Germany.

Background:  Since its outbreak in December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has infected more than 151 million people worldwide. More than 3.1 million have died from Coronavirus Disease 2019 (COVID-19), the illness caused by SARS-CoV-2. Read More

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October 2021

Lung cancer-associated T cell repertoire as potential biomarker for early detection of stage I lung cancer.

Lung Cancer 2021 Sep 28;162:16-22. Epub 2021 Sep 28.

Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, China; Xiangya Lung Cancer Center, Xiangya Hospital, Central South University, Changsha, China; Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Changsha, China. Electronic address:

Background: Early detection of lung cancer in asymptomatic patients remains challenging, especially for stage I. Considering the substantial interaction with tumor immunogenicity, we hypothesized that lung cancer-associated TCR (LC-aTCR) may serve as potential biomarker in early detection of stage I lung cancer.

Methods: Individuals who received low-dose computed tomography (LDCT) screening were enrolled in the study. Read More

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September 2021

Peripheral blood RNA biomarkers for cardiovascular disease from bench to bedside: A Position Paper from the EU-CardioRNA COST Action CA17129.

Cardiovasc Res 2021 Oct 14. Epub 2021 Oct 14.

Cardiovascular Research Unit, Luxembourg Institute of Health, Strassen, Luxembourg.

Despite significant advances in the diagnosis and treatment of cardiovascular diseases, recent calls have emphasized the unmet need to improve precision-based approaches in cardiovascular disease. Although some studies provide preliminary evidence of the diagnostic and prognostic potential of circulating coding and non-coding RNAs, the complex RNA biology and lack of standardization have hampered the translation of these markers into clinical practice. In this position paper of the CardioRNA COST action CA17129, we provide recommendations to standardize the RNA development process in order to catalyze efforts to investigate novel RNAs for clinical use. Read More

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October 2021

Positive Expiratory Pressure: A Potential Therapy to Mitigate Acute Bronchoconstriction in the Asthma of Obesity.

J Appl Physiol (1985) 2021 Oct 14. Epub 2021 Oct 14.

Pulmonary Disease and Critical Care Medicine, University of Vermont College of Medicine, Burlington, Vermont, United States.

Late-onset non-allergic (LONA) asthma in obesity is characterized by increased peripheral airway closure secondary to abnormally collapsible airways. We hypothesized that positive expiratory pressure (PEP) would mitigate the tendency to airway closure during bronchoconstriction, potentially serving as rescue therapy for LONA asthma of obesity. The PC dose of methacholine was determined in 18 obese participants with LONA asthma. Read More

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October 2021

Effect of life stage and target tissue on dose-response assessment of ethyl methane sulfonate-induced genotoxicity.

Environ Mol Mutagen 2021 Oct 14. Epub 2021 Oct 14.

Division of Genetic and Molecular Toxicology, National Center for Toxicological Research U.S. Food and Drug Administration, Jefferson, Arkansas.

In order to investigate the possibility that treatment age affects the genotoxic response to ethyl methane sulfonate (EMS) exposure, we dosed gpt-delta neonatal mice on postnatal days 1-28 with 5 to 100 mg/kg/day of EMS and measured micronucleus (MN) induction in peripheral blood and gpt gene mutation in liver, lung, bone marrow, small intestine, spleen, and kidney. The data were compared to measurements from similarly exposed adult gpt-delta mice (Cao et al., 2014, Environ Mol Mutagenesis 55: 385-399). Read More

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October 2021

Infliximab-induced interstitial lung disease.

BMJ Case Rep 2021 Oct 13;14(10). Epub 2021 Oct 13.

Department of Respiratory Medicine, University Hospital of Patras, Patras, Greece.

A 70-year-old man was referred to our respiratory department with non-productive cough over the past 6 months. High-resolution CT revealed reticular pattern with basal and peripheral predominance, centrilobular nodules and mild ground glass opacities. Serology tests were normal and bronchoalveolar lavage revealed lymphocytosis. Read More

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October 2021

Brain-lung interactions and mechanical ventilation in patients with isolated brain injury.

Crit Care 2021 Oct 13;25(1):358. Epub 2021 Oct 13.

Department of Emergency Medicine, Inselspital, University Hospital, University of Bern, Bern, Switzerland.

During the last decade, experimental and clinical studies have demonstrated that isolated acute brain injury (ABI) may cause severe dysfunction of peripheral extracranial organs and systems. Of all potential target organs and systems, the lung appears to be the most vulnerable to damage after brain injury (BI). The pathophysiology of these brain-lung interactions are complex and involve neurogenic pulmonary oedema, inflammation, neurodegeneration, neurotransmitters, immune suppression and dysfunction of the autonomic system. Read More

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October 2021