16,482 results match your criteria periodontitis patients

Application value of combination therapy of periodontal curettage and root planing on moderate-to-severe chronic periodontitis in patients with type 2 diabetes.

Head Face Med 2021 Apr 8;17(1):12. Epub 2021 Apr 8.

Department of Periodontology, Qingdao Stomatological Hospital, No. 17 Dexian Road, Qingdao, 266000, Shandong, China.

Background: Our study attempted to observe the value of periodontal curettage combined with root planing on moderate-to-severe chronic periodontitis in patients with type 2 diabetes.

Methods: There involved 72 patients with type 2 diabetes mellitus complicated with moderate-to-severe chronic periodontitis who were diagnosed and treated in our hospital from January 2019 to December 2019. The patients enrolled were randomly divided into four groups using a computer-generated table: root planing and periodontal curettage combined group (n = 18), root planning group (n = 18), periodontal curettage group (n = 18) and cleansing group (n = 18). Read More

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The Oral Microbiome in Periodontal Health.

Front Cell Infect Microbiol 2021 22;11:629723. Epub 2021 Mar 22.

Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czechia.

The estimation of oral microbiome (OM) taxonomic composition in periodontally healthy individuals can often be biased because the clinically periodontally healthy subjects for evaluation can already experience dysbiosis. Usually, they are included just based on the absence of clinical signs of periodontitis. Additionally, the age of subjects is used to be higher to correspond well with tested groups of patients with chronic periodontitis, a disorder typically associated with aging. Read More

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Molecular subgroup of periodontitis revealed by integrated analysis of the microbiome and metabolome in a cross-sectional observational study.

J Oral Microbiol 2021 Mar 25;13(1):1902707. Epub 2021 Mar 25.

Department of Oral Microbiology, School of Dentistry, Pusan National University, Busan, South Korea.

: Periodontitis (PT) is a multifactorial, chronic inflammatory disease that can have heterogeneous clinical presentations. The oral microbiome and its metabolites have been implicated as the causes and regulators of PT pathogenesis. In this study, we assessed the oral microbiome and its metabolome in PT patients to clarify the interactions between the microbiome and its metabolites. Read More

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Tobacco Use and Oral Health.

Addiction 2021 Apr 6. Epub 2021 Apr 6.

Faculty of Dentistry, University of Otago, Dunedin, New Zealand.

This review outlines the important oral implications of tobacco use. The lining of the mouth (oral mucosa), if exposed to tobacco and its products in a susceptible individual, can develop benign, potentially malignant, and malignant tumours. Treatment and prognosis depend on tumour type, how early it is detected, its size and site in the oral cavity and whether it has spread. Read More

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No Benefit of an Adjunctive Phototherapy Protocol in Treatment of Periodontitis: a Split-Mouth Randomised Controlled Trial.

J Clin Periodontol 2021 Apr 4. Epub 2021 Apr 4.

Research Centre for the Study of Periodontal and Peri-implant Diseases, University of Ferrara, Italy.

Aim: To assess the efficacy of a commercially-available adjunctive phototherapy protocol ('Perio-1') in treatment of periodontitis.

Materials And Methods: In an examiner-blind, randomised, controlled, split-mouth, multi-centre study, 60 periodontitis patients received root surface debridement (RSD) in sextants either alone (control sextants) or with the adjunctive phototherapy protocol (test sextants). Re-evaluation was performed at 6, 12 and 24 weeks. Read More

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A Allele of Rs5498 and Rs3181092 is Correlated with Increased Risk for Periodontal Disease.

Open Life Sci 2019 Jan 31;14:638-646. Epub 2019 Dec 31.

Stomatology Therapeutic Center, Huzhou Central Hospital, Affiliated Cent Hosp Huzhou University, Huzhou 313000, P.R. China.

Objective: Periodontal disease (PD) is viewed today as multifactorial problems initiated and sustained by bacteria but significantly modified by the body's response to bacterial plaque. Recent studies have suggested that gene polymorphisms could be involved in the pathophysiology of periodontitis. This study aimed to investigate a possible correlation of the polymorphisms of intercellular adhesion molecule-1 () and vascular cell adhesion molecule-1 () with PD. Read More

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January 2019

Outcome of Root Canal Treatment of Necrotic Teeth with Apical Periodontitis Filled with a Bioceramic-Based Sealer.

Int J Dent 2021 18;2021:8816628. Epub 2021 Mar 18.

Department of Conservative Odontology, Laboratory of Dento-Facial Clinical and Biological Approach (ABCDF) LR12ES10, Faculty of Dental Medicine, University of Monastir, Avicenne Avenue, Monastir 5019, Tunisia.

Introduction: Apical periodontitis is among the most common pathologies in endodontics. The treatment of apical periodontitis has always been an important occupation in the modern practice of endodontics, and the failure has been associated with nonhermetic root canal filling. With that in mind, bioceramic-based sealers have been incorporated into endodontic practice. Read More

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Georgian Med News 2021 Feb(311):54-57

1Saint Petersburg State University, Department of Clinical Dentistry SPbU; Russian Federation.

Chronic generalized parodontitis is one of the most prevalent disorders among diseases of oral cavity, making the search for optimal treatment modalities of this disorder one of the mostressing matters to this day.  The purpose of this study was to assess outcomes of conventional therapy and secondary prevention of chronic generalized parodontitis with in combination with use of laser therapy and antioxidant drug treatment.   The study is presented as a joint multi-site investigation conducted by the group of authors from St. Read More

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February 2021


Georgian Med News 2021 Feb(311):50-54

Ivane Javakhishvili Tbilisi State University, Georgia.

Periodontitis is the most common oral disease worldwide and is the leading cause of tooth loss. It is considered to be a major burden in terms of costs of treatment and preventive measures. According to the systematic reviews, there is a link between periodontitis and cancer. Read More

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February 2021

Serum proteins associated with periodontitis relapse post-surgery: A pilot study.

J Periodontol 2021 Apr 4. Epub 2021 Apr 4.

Umeå University, Department of Molecular Periodontology, Umeå, Sweden.

Background: The knowledge of which genes and proteins that are connected to the susceptibility to gingivitis with subsequent local tissue degradation seen in periodontitis is insufficient. Changes of serum proteins associated with recurrence of bleeding on probing (BOP) and increased periodontal pocket depths (PPD) after surgical treatment of periodontitis could reveal molecules that could be early signals of tissue destruction and/or of importance for systemic effects in other tissues or organs.

Methods:  We performed a longitudinal pilot study and followed 96 inflammation-related proteins over time in serum from patients who underwent surgical treatment of periodontitis (n = 21). Read More

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Periodontal disease and risk of mortality and kidney function decline in advanced chronic kidney disease: a nationwide population-based cohort study.

Clin Oral Investig 2021 Apr 4. Epub 2021 Apr 4.

Department of Anesthesiology, Shuang Ho Hospital, Taipei Medical University, No. 291, Zhongzheng Rd., Zhonghe District, New Taipei City, 23561, Taiwan.

Objectives: Periodontal disease is prevalent in patients with chronic kidney disease (CKD) and potentially associated with kidney function decline. However, it is uncertain whether periodontal disease affects the risk of mortality and morbidity in patients with advanced CKD.

Materials And Methods: Taiwan's National Health Insurance Research Database was used to conduct a nationwide population-based cohort study. Read More

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Wiad Lek 2021 ;74(3 cz 1):504-507


Objective: The aim: Is to develop and test questionnaires allowing systematization of the main dental complaints and knowledge on hygienic oral care in patients with non-alcoholic fatty liver disease (NAFLD) given their individual characteristics.

Patients And Methods: Materials and methods: The developed questionnaires and database have been tested on 36 patients with NAFLD and 10 patients of the control group.

Results: Results: As a result of the study, it appears that the main dental complaints in patients with NAFLD are dry mouth and the associated need for frequent mouth rinsing with water, bleeding gums, mainly during teeth brushing, distortion of taste and bad breath. Read More

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Changes in the characteristics of dental emergencies under the influence of SARS-CoV-2 pandemic: a retrospective study.

BMC Oral Health 2021 04 3;21(1):174. Epub 2021 Apr 3.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Dental Emergency and General Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Background: Further understanding of the distribution and changing characteristics of dental diseases is of great significance for all dental emergency centers for strengthening the medical staff's treatment knowledge abilities and effective use of emergency resources in the face of public health emergencies involving highly infectious respiratory diseases.

Methods: The medical records of 4158 dental emergency patients in 2019 and 2020 were retrospectively analyzed and divided into pre-SARS-COV-2 group and SARS-COV-2 group according to time. The demographic data, date and time, diagnosis, and treatment methods of the two groups were statistically described, and the chi-squared test was used to analyze the differences. Read More

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Periodontitis Prevalence, Severity, and Risk Factors: A Comparison of the AAP/CDC Case Definition and the EFP/AAP Classification.

Int J Environ Res Public Health 2021 Mar 26;18(7). Epub 2021 Mar 26.

Periodontology Department, Faculty of Dentistry, University of Istanbul, 34134 Istanbul, Turkey.

Background: This cross-sectional study evaluated the utility of the 2018 European Federation of Periodontology/American Academy of Periodontology (EFP/AAP) classifications of epidemiological studies in terms of periodontitis severity, prevalence and associated risk factors and the 2012 American Academy of Periodontology/Centers for Disease Control and Prevention (AAP/CDC) case definitions.

Methods: We included 488 participants aged 35-74 years. Measurements were recorded at six sites per tooth by two qualified examiners. Read More

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Oral Diagnostic Methods for the Detection of Periodontal Disease.

Diagnostics (Basel) 2021 Mar 22;11(3). Epub 2021 Mar 22.

Clinic of Conservative and Preventive Dentistry, Center of Dental Medicine, University of Zurich, 8032 Zurich, Switzerland.

Periodontitis is a common immune-inflammatory oral disease. Early detection plays an important role in its prevention and progression. Saliva is a reliable medium that mirrors periodontal health and is easily obtainable for identifying periodontal biomarkers in point-of-care diagnostics. Read More

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Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases.

Molecules 2021 Mar 22;26(6). Epub 2021 Mar 22.

Department of General Surgery and Surgical-Medical Specialties, School of Dentistry, University of Catania, 95124 Catania, Italy.

Matrix metalloproteinase-9 (MMP-9) has been shown to play a key role in endothelial function and perhaps pivotal in the correlation between periodontal disease and cardiovascular disease (CVD). For the study, the impact of MMP-9 of periodontitis and CVD on serum and saliva concentrations was analyzed. For the study patients with periodontitis (n = 31), CVD (n = 31), periodontitis + CVD (n = 31), and healthy patients (n = 31) were enrolled. Read More

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The Role of Inflammatory Diet and Vitamin D on the Link between Periodontitis and Cognitive Function: A Mediation Analysis in Older Adults.

Nutrients 2021 Mar 12;13(3). Epub 2021 Mar 12.

Evidence-Based Hub, Clinical Research Unit, Centro de Investigação Interdisciplinar Egas Moniz, 2829-511 Almada, Portugal.

Patients suffering from periodontitis are at a higher risk of developing cognitive dysfunction. However, the mediation effect of an inflammatory diet and serum vitamin D levels in this link is unclear. In total, 2062 participants aged 60 years or older with complete periodontal diagnosis and cognitive tests from the National Health and Nutrition Examination Survey (NHANES) 2011-2012 and 2013-2014 were enrolled. Read More

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Microbiologic Profiles of Patients with Dental Prosthetic Treatment and Periodontitis before and after Photoactivation Therapy-Randomized Clinical Trial.

Microorganisms 2021 Mar 30;9(4). Epub 2021 Mar 30.

Department of Dental Technology, "Grigore T. Popa" University of Medicine and Pharmacy, 16 Universitatii Str., 700115 Iasi, Romania.

Fixed prosthodontic dental restorations can potentially affect the periodontal tissues and vice versa, the periodontium can influence the longevity and esthetic appearance of dental restorations. We proposed an investigation on total bacterial load, specific periodontal pathogens, and periodontal clinical parameters in patients with dental fixed prosthesis and different degrees of periodontal tissue loss that followed photoactivation therapy (PDT) adjunctive to scaling and root planing. The study was conducted on 160 subjects, which were randomly assigned to scaling and root planing (SRP) alone (52 subjects, 256 sites), SRP and chlorhexidine rinsing (58 subjects, 276 sites), and SRP plus PDT (50 subjects, 318 sites). Read More

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IL-8 as a Potential Therapeutic Target for Periodontitis and Its Inhibition by Caffeic Acid Phenethyl Ester In Vitro.

Int J Mol Sci 2021 Mar 31;22(7). Epub 2021 Mar 31.

Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung 40402, Taiwan.

Salivary levels of interleukin-8 (IL-8) are elevated in patients with periodontitis. Caffeic acid phenethyl ester (CAPE) improves the periodontal status in subjects. However, whether CAPE can reduce IL-8 expression is unclear. Read More

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Effect of Anti-Rheumatic Treatment on the Periodontal Condition of Rheumatoid Arthritis Patients.

Int J Environ Res Public Health 2021 Mar 4;18(5). Epub 2021 Mar 4.

Department of Internal Medicine and Rheumatology, Martini Hospital Groningen, Van Swietenplein 1, 9728 NT Groningen, The Netherlands.

Periodontitis, a bacterial-induced infection of the supporting soft and hard tissues of the teeth (the periodontium), is common in patients with rheumatoid arthritis (RA). As RA and periodontitis underlie common inflammatory pathways, targeting the progression of RA might mediate both periodontitis and RA. On the other hand, patients with RA on immunosuppressive medication have an increased risk of infection. Read More

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Effect of Enamel Matrix Derivatives on Osteoclast Formation from PBMC of Periodontitis Patients and Healthy Individuals after Interaction with Activated Endothelial Cells.

Medicina (Kaunas) 2021 Mar 15;57(3). Epub 2021 Mar 15.

Competence Center for Periodontal Research, University Clinic of Dentistry, Medical University of Vienna, 1090 Vienna, Austria.

Enamel matrix derivative (EMD) is produced from developing porcine tooth buds and represents a complex of low-molecular-weight hydrophobic enamel proteins. EMD is widely applied in periodontal regeneration. Osteoclasts are multinuclear cells, which are responsible for bone resorption. Read More

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Inflammatory Status and Glycemic Control Level of Patients with Type 2 Diabetes and Periodontitis: A Randomized Clinical Trial.

Int J Environ Res Public Health 2021 Mar 15;18(6). Epub 2021 Mar 15.

Department of Oral Science, Nano and Biotechnology and CeSi-Met University of Chieti-Pescara, 66100 Chieti, Italy.

Background: Based on the holistic approach to prevention diabetic disease, the role of periodontal inflammation in type 2 diabetes mellitus (T2DM) is under intensive scrutiny. Data from clinical trials have shown benefit from a periodontal therapy in providing patients with type 2 diabetes improvement despite relatively disappointing long-terms response rates. The aim of this study was to investigate the short-term glycemic control level and systemic inflammatory status after periodontal therapy. Read More

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Evaluation of Microcirculation, Cytokine Profile, and Local Antioxidant Protection Indices in Periodontal Health, and Stage II, Stage III Periodontitis.

J Clin Med 2021 Mar 18;10(6). Epub 2021 Mar 18.

Laboratory "Health Systemic Process", University Lyon 1, EA4129, 69008 Lyon, France.

Periodontitis, initiated by the subgingival biofilm and modified by the individual's inflammatory/immune response, has been associated with vascular dysfunction. To analyze microcirculation indices in periodontal tissues and determine the activity of the enzymatic component of antioxidant defense and humoral immunity factors, a single-blind non-invasive clinical trial was realized. Forty subjects, aged from 30 to 65 years, with moderate to severe chronic periodontitis (chronic generalized periodontitis, CGP) vs. Read More

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Adjuvant Transgingival Therapy with Visible Light Plus Water-Filtered Infrared-A (VIS + wIRA) in Periodontal Therapy-A Randomized, Controlled, Stratified, Double-Blinded Clinical Trial.

Antibiotics (Basel) 2021 Mar 3;10(3). Epub 2021 Mar 3.

Department of Operative Dentistry and Periodontology, Faculty of Medicine, University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany.

The aim of this randomized, controlled, double-blinded clinical trial was to examine the additional healing effect of transgingival visible light and water-filtered infrared-A (VIS + wIRA) in the treatment of periodontitis patients compared with the standard therapy by subgingival instrumentation (SI). Therefore, forty patients with untreated periodontitis received a non-surgical periodontal treatment. Using a split-mouth study design, one quadrant of the upper jaw was randomly either exposed to VIS + wIRA four times for 20 min within two weeks in addition to SI or received only SI. Read More

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Non-Incised Papilla Surgical Approach and Leukocyte Platelet-Rich Fibrin in Periodontal Reconstruction of Deep Intrabony Defects: A Case Series.

Int J Environ Res Public Health 2021 Mar 3;18(5). Epub 2021 Mar 3.

Department of General Dentistry and Implants, Faculty of Medicine and Dentistry, University of Murcia, 30008 Murcia, Spain.

We present the preliminary results of the treatment of teeth with a deep, non-contained periodontal residual defect, vestibular bone dehiscence, and soft tissue recession, by combining an apical non-incised papilla surgical approach (NIPSA) to the defect and leukocyte platelet-rich fibrin (L-PRF) in the vestibular aspect. Four patients (upper left first premolar, upper left central incisor, upper right central incisor and upper right lateral incisor) have been treated. At one year of follow up, all cases showed a considerable reduction in the periodontal pocket depth, a gain in clinical attachment and no bleeding on probing, as well as an improvement in the marginal soft tissue minimizing soft tissue contraction (recession and/or loss of papilla) and improving soft tissue architecture. Read More

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Prospective Longitudinal Changes in the Periodontal Inflamed Surface Area Following Active Periodontal Treatment for Chronic Periodontitis.

J Clin Med 2021 Mar 10;10(6). Epub 2021 Mar 10.

Department of Dentistry and Oral Surgery, School of Medicine, Keio University, Tokyo 160-8582, Japan.

Periodontal disease is a chronic inflammatory disease of the periodontal tissue. The periodontal inflamed surface area (PISA) is a proposed index for quantifying the inflammatory burden resulting from periodontitis lesions. This study aimed to investigate longitudinal changes in the periodontal status as evaluated by the PISA following the active periodontal treatment. Read More

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Characteristics of Periodontal Tissues in Prosthetic Treatment with Fixed Dental Prostheses.

Molecules 2021 Mar 2;26(5). Epub 2021 Mar 2.

Department of Prosthodontics, Faculty of Stomatology, Yerevan State Medical University, Street Koryun 2, Yerevan 0025, Armenia.

The objective of the present study was to investigate the effects of various types of fixed prostheses on periodontal tissues and explore the association of gingival biotype and gum recession in relation to prosthesis types. The study participants (N = 95) were divided into three groups based on the type of dental prosthesis: Group-I: cobalt-chrome (Co-Cr) ceramic prosthesis fabricated by the conventional method (n = 35); Group-II: consisted of patients with Co-Cr ceramic prostheses fabricated by a computer-aided design and computer aided manufacturing (CAD/CAM) technique (n = 30); and Group-III: zirconia-based prostheses fabricated by the CAD/CAM technique (n = 30). Following the use of prostheses, periodontal examinations were performed using the Community Periodontal Index (CPI) and Modified Approximal Plaque Index (MAPI). Read More

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Evaluation of the effect of periodontitis on quality of life using Oral-Dental Health-Related Quality of Life-United Kingdom scale.

Int J Dent Hyg 2021 Apr 2. Epub 2021 Apr 2.

Department of Periodontology, Faculty of Dentistry, Baskent University, Ankara, Turkey.

Objective: The aim of this study was to investigate the impact of periodontitis on oral health-related quality of life (OHQoL) using Oral-Dental Health-Related Quality of Life-United Kingdom (OHRQoL-UK) scale and evaluate the contributing factors.

Methods: 50 patients with untreated periodontitis and 50 individuals without periodontitis were enrolled in the study. All subjects received detailed periodontal examination. Read More

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Influence of physical activity on periodontal health in patients with type 2 diabetes mellitus. A blinded, randomized, controlled trial.

Clin Oral Investig 2021 Apr 1. Epub 2021 Apr 1.

The University of Sydney School of Dentistry and the Charles Perkins Centre, Faculty of Health and Medicine, The University of Sydney, Sydney, Australia.

Objectives: The aim was to investigate the effect of physical activity on periodontal health and HbA1c levels in patients with type 2 diabetes mellitus (T2DM) over a period of 6 months.

Materials And Methods: Thirty-seven patients with non-insulin-dependent T2DM were included in the study. The intervention group (n=20) performed physical activity over a period of 6 months. Read More

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Clonal evolution of and at oral niche level in health and disease.

J Oral Microbiol 2021 Mar 15;13(1):1894047. Epub 2021 Mar 15.

Institute of Medical Sciences, School of Medicine Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen, UK.

species have long been recognised as aetiological agents of opportunistic infections of the oral mucosa, and more recently, as players of polymicrobial interactions driving caries, periodontitis and oral carcinogenesis. We studied the clonal structure of spp. at oral niche resolution in patients (n = 20) with a range of oral health profiles over 22 months. Read More

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