7,104 results match your criteria periodontitis background

A systematic review and gap analysis of frailty and oral health characteristics in older adults: A call for clinical translation.

Gerodontology 2021 Jul 30. Epub 2021 Jul 30.

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

Objective: This systematic review updates the evidence for association between oral health characteristics and frailty status, identifying gaps in translational dental research and application of frailty assessment into clinical practice.

Background: Clinicians have little guidance on stage-appropriate dental treatment for medically complex older adults. Oral health characteristics have been associated with frailty status, determined through validated assessment tools representing a concise measure of health. Read More

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Periodontitis exacerbates the renal degenerative effects of obesity in rats.

J Periodontal Res 2021 Jul 30. Epub 2021 Jul 30.

Department of Biochemistry, School of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.

Background/objectives: Obesity and periodontitis are systemic subclinical inflammatory diseases with established negative renal effects. The aim of this animal study was to thoroughly investigate the possible effects of these two diseases on renal structure and function.

Methods: Thirty-two male Sprague Dawley rats were divided into four groups: control (C), obesity (Ob), experimental periodontitis (Ep), and Ob + Ep. Read More

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The level of fibroblast growth factor-2 prepared from Advanced Platelet Rich Fibrin (A-PRF) in obese Saudi subjects compared to healthy subjects.

J Prev Med Hyg 2021 Mar 29;62(1):E185-E191. Epub 2021 Apr 29.

College Of Pharmacy, Riyadh Elm University, Riyadh, Saudi Arabia.

Background: The prevalence of obesity has increased substantially in the last few decades. World Health Organization (2020) estimated that around 600 million obese adults worldwide were obese, and a further increase is expected in the future due to increased consumption of high-calorie diets and a sedentary lifestyle as per the evidence.

Aim: To evaluate and compare the level of fibroblast growth factor platelet rich fibrin (A-PRF) in obese subject compare to healthy weight subject. Read More

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The effect of adjunctive use of melatonin as a supplement on serum ferritin level in periodontal patients: A randomized, controlled trial.

Dent Res J (Isfahan) 2021 24;18:39. Epub 2021 May 24.

Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Ferritin is an acute-phase protein that is increased in inflammatory diseases. Melatonin has been studied due to its antioxidant effects and the elimination of free radicals. The aim of this study was to evaluate the effect of melatonin supplement as an adjunct to routine periodontal treatment on serum ferritin levels in patients with periodontitis. Read More

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Association of subgingival Epstein-Barr virus and periodontitis.

F1000Res 2021 24;10:414. Epub 2021 May 24.

Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia.

The Epstein-Barr virus (EBV) is gaining interest as a possible agent in the etiology of periodontitis. Previous studies have shown controversy on whether EBV DNA in the subgingival periodontal pockets is associated with periodontitis. The present study aimed to seek the potential relationship between EBV and periodontitis. Read More

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Optical profile: A key determinant of antibacterial efficacy of photodynamic therapy in dentistry.

Photodiagnosis Photodyn Ther 2021 Jul 24:102461. Epub 2021 Jul 24.

Department of Biomedical Engineering, Ming Chuan University, No. 5, Deming Road., Gweishan District, Taoyuan, Taiwan, 33348. Electronic address:

Background: Periodontal disease affects 20-50% of population worldwide, posing a global health challenge. It has been reported to be more prevalent among adults. Actinobacillus actinomycetemcomitans (A. Read More

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The prognostic performance of the 2017 world workshop classification on staging and grading of periodontitis compared to the british society of periodontology's implementation.

J Periodontol 2021 Jul 27. Epub 2021 Jul 27.

Department of Periodontology, The School of Dentistry, University of Birmingham, Birmingham, UK.

Background: The British Society of Periodontology (BSP) implemented a simplified version of the 2017 World Workshop Classification (WWC) on Staging and Grading of periodontitis, for use in UK clinical practice. The aim of this study was to assess the long-term (>10 years) prognostic capability of BSP's implementation (BSP-i) compared to the 2017 WWC, using periodontal-related tooth loss (TLP) as a disease outcome.

Methods: Data on medical history, smoking status, and clinical periodontal parameters were retrieved from 270 patients who received non-surgical and surgical periodontal therapy from 1966 to 2007. Read More

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The association between low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio cholesterol ratio and thickened carotid intima-media thickness: A case-control study.

Vascular 2021 Jul 27:17085381211035282. Epub 2021 Jul 27.

Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China.

Background: It is indicated that Low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C ratio) has greater predictive value for thickened carotid intima-media thickness (CIMT) comparing with classic lipid parameters. However, there have been few reports about their association in general Chinese population.

Method: We included a total of 1220 CIMT participants and 2440 matched controls, who had ultrasonography of carotid artery during 2009 and 2016. Read More

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Recommendations for treating stage I-III periodontitis in the Taiwanese population: A consensus report from the Taiwan Academy of Periodontology.

J Formos Med Assoc 2021 Jul 19. Epub 2021 Jul 19.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Background/purpose: Based on the fundamental of the S3-level clinical practice guideline (CPG) for treating stage I-III periodontitis developed by the European Federation of Periodontology (EFP), this consensus report aimed to develop treatment recommendations for treating periodontitis in the Taiwanese population.

Methods: The report was constructed by experts from the Taiwan Academy of Periodontology. The following topics were reviewed: (a) the prevalence of periodontitis in Asia and current status of treatment in Taiwan; (b) specific anatomical considerations for treating periodontitis in Asians; (d) educational and preventive interventions and supragingival plaque control; (d) subgingival instrumentation and adjunctive treatment; (e) surgical periodontal therapy; and (f) maintenance and supportive periodontal care. Read More

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A pilot study of red complex and three genera subgingival microbiome in periodontitis subjects with and without diabetes, evaluated by MinION platform.

F1000Res 2021 8;10:79. Epub 2021 Feb 8.

Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia.

: Subgingival niche is one biofilm habitat containing rich microbiota, which plays an active role in maintaining the health of periodontal tissue and determining host response. As such, a study of changing subgingival biofilms is important for understanding the effect of a systemic condition. In this study, we compared the occurrence of six bacteria cohabiting in the subgingival area of periodontitis subjects, with (DP, n = 8) and without (NDP, n = 4) diabetes. Read More

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Quercetin protects oral mucosal keratinocytes against lipopolysaccharide-induced inflammatory toxicity by suppressing the AKT/AMPK/mTOR pathway.

Immunopharmacol Immunotoxicol 2021 Jul 26:1-8. Epub 2021 Jul 26.

Department of Pharmacy, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.

Background: Cytokines can induce a chronic inflammatory response in the periodontium, leading to periodontitis. Quercetin, a naturally occuring flavonoid, has been shown to inhibit periodontitis, but how it works is poorly understood. In this study, we assessed the impact of quercetin on lipopolysaccharide (LPS)-induced inflammatory damage in oral mucosal keratinocytes (hOMK107) and explored its underlying mechanism. Read More

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Histologic, Radiographic, and Micro-Computed Tomography Evaluation of Experimentally Enlarged Root Apices in Dog Teeth with Apical Periodontitis after Regenerative Treatment.

Curr Ther Res Clin Exp 2021 16;94:100620. Epub 2020 Dec 16.

Division of Oral Diagnostic Sciences, Department of Oral and Maxillofacial Pathology, College of Dentistry, Riyadh Elm University, Riyadh, Kingdom of Saudi Arabia.

Background: Blood clot (BC) and platelet-rich fibrin (PRF) has been successfully used to biologically treat immature roots. It is nowadays considered the treatment of choice.

Objective: This study aimed to determine the ability of PRF and BC scaffolds to enhance regeneration of disinfected root canals and healing of apical periodontitis within experimentally enlarged canal apices of dog teeth. Read More

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December 2020

Polymorphism of CD14 Gene Is Associated with Adverse Outcome among Patients Suffering from Cardiovascular Disease.

Mediators Inflamm 2021 8;2021:3002439. Epub 2021 Jul 8.

Department of Operative Dentistry and Periodontology, Martin Luther University of Halle-Wittenberg, Germany.

Background: The biological link between severe periodontitis and cardiovascular disease is well established. Both complex inflammatory diseases are influenced by genetic background. Therefore, the impact of genetic variations of receptors of the innate immune system-(Toll-like receptors (TLRs)) TLR2, TLR4, cluster of differentiation 14 (CD14), and the transcription factor nuclear factor- (NF-B)-was investigated. Read More

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Prevalence of periodontitis in obese patients in Bahrain: a cross-sectional study.

BMC Oral Health 2021 Jul 24;21(1):376. Epub 2021 Jul 24.

Dental Postgraduate Training Department, Ministry of Health, Manama, Bahrain.

Background: Adult obesity has been associated with various systemic diseases and is an increasing problem in Bahrain. Recent evidence indicates a correlation between adult obesity and periodontitis. Hence the aim of this study was to assess the prevalence of periodontitis in overweight/obese adults in Bahrain and to determine the factors associated with periodontitis in these obese adults. Read More

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Effects of multiple sessions of antimicrobial photodynamic therapy (aPDT) in the treatment of periodontitis in patients with uncompensated type 2 diabetes: a randomized controlled clinical study.

Photodiagnosis Photodyn Ther 2021 Jul 21:102451. Epub 2021 Jul 21.

Department of Diagnostic and Surgery, Periodontics Division, São Paulo State University - UNESP, Dentistry School of Araçatuba, Araçatuba, SP, Brazil.. Electronic address:

Background: The aim of this study was to compare, through clinical and microbiological analysis, the use of multiple applications of aPDT as an adjuvant therapy to non-surgical periodontal treatment of stage III and IV grade C periodontitis in type 2 diabetic (DM2) patients.

Methods: Thirty-four patients with non-compensated DM2 and periodontitis were randomly divided into two groups: SRP Group (n=17): scaling and root planning (SRP); and SRP+aPDT Group (n=17): SRP followed by 3 consecutive aPDT applications, immediately, 48 and 96 hours after in pockets with probing depth (PD) ≥5mm. In SRP+aPDT, after 1 minute of irrigation with methylene blue (10mg/ml), the sites were irradiated with a 660 nm diode laser for 50 seconds (157 J/cm, 4. Read More

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Swedish quality registry for caries and periodontal diseases (SKaPa): validation of data on dental caries in 6- and 12-year-old children.

BMC Oral Health 2021 Jul 24;21(1):373. Epub 2021 Jul 24.

Department of Pediatric Dentistry, Faculty of Odontology, Malmö University, 205 06, Malmö, Sweden.

Background: The Swedish Quality Registry for caries and periodontal disease (SKaPa) automatically collects data on caries and periodontitis from patients' electronic dental records. Provided the data entries are reliable and accurate, the registry has potential value as a data source for registry-based research. The aim of this study was to evaluate the reliability and accuracy of the SKaPa registry information on dental caries in 6- and 12-year-old children. Read More

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Tooth Loss Is Associated with Disease-Related Parameters in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis-A Cross-Sectional Study.

J Clin Med 2021 Jul 9;10(14). Epub 2021 Jul 9.

Department of Cariology, Endodontology and Periodontology, University of Leipzig, 04103 Leipzig, Germany.

Background: The aim of this cross-sectional study was to investigate potential associations between periodontal inflamed surface area (PISA) and tooth loss with disease-related parameters in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS).

Methods: Patients who attended the Department of Nephrology and Rheumatology, University Medical Centre Goettingen, Germany, were included. The oral examination comprised the detection of the number of remaining teeth and periodontal condition based on staging and grading matrix. Read More

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Salivary Pro-Inflammatory Markers and Smoking Status Influences the Treatment Effectiveness of Periodontal Disease Patients with Hypertension.

Int J Environ Res Public Health 2021 Jul 9;18(14). Epub 2021 Jul 9.

Department of Oral Hygiene, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Background: Hypertension and periodontal diseases share several risk factors. Inflammation biomarkers in saliva are related to hypertension and periodontal disease. The aim of this study was to explore the role of the salivary inflammatory biomarkers in the treatment effectiveness of patients with hypertension and periodontal disease. Read More

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The Effect of Periodontal Disease on Metabolic Control in Patients With Diabetes Mellitus in South Africa: Protocol for a Systematic Review.

JMIR Res Protoc 2021 Jul 22;10(7):e27471. Epub 2021 Jul 22.

Research Support Unit, University of the Western Cape, Cape Town, South Africa.

Background: The increase in the prevalence of type 2 diabetes mellitus (T2DM) and its associated complications is burdensome to the South African health system. Understanding the role of comorbid diseases, such as periodontal disease (PD), and their effect on metabolic control in patients with DM in South Africa will raise awareness about the importance of periodontal interventions among patients with DM in South Africa.

Objective: The review will aim to determine the effect of PD on the metabolic control of T2DM in a South African population. Read More

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IL-13 gene polymorphisms (-1112 C/T and -1512 A/C) in patients with chronic and aggressive periodontitis: Effects on GCF and outcome of periodontal therapy.

Niger J Clin Pract 2021 Jul;24(7):965-972

Department of Biochemistry, Cumhuriyet University, Faculty of Medicine, Sivas, Turkey.

Background: IL-13 is the key cytokine in the regulation of inflammatory with an autoimmune disease and has an anti-inflammatory effect.

Aims: This study aimed to compare IL-13 (-1112 C/T and -1512 A/C) gene polymorphisms in patients with aggressive periodontitis (AgP), chronic periodontitis (CP), and periodontally healthy group (C) and evaluate the effect of nonsurgical periodontal therapy on gingival crevicular fluid (GCF) IL-13 levels in patients.

Materials And Methods: One hundred thirty patients with AgP, 120 patients with CP, and 70 periodontally healthy subjects were included in this study. Read More

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Er:YAG versus Scaling and Root Planing for the Treatment of Periodontal Disease: A Single-Blinded Split-Mouth Randomized Clinical Trial.

J Periodontol 2021 Jul 19. Epub 2021 Jul 19.

Division of Periodontics, Section of Oral, Diagnostic and Rehabilitation Sciences, Columbia University College of Dental Medicine, New York, NY.

Background: This randomized, controlled clinical trial aimed to compare the differences in periodontal clinical outcomes, duration of the procedure, and patient's experience between conventional scaling and root planing and Erbium-doped:Yttrium-Aluminum-Garnet (Er:YAG) in the treatment of generalized moderate to severe chronic periodontitis or generalized stages II or III, and grade B periodontitis based on the Centers for Disease Control (CDC), American Academy of Periodontology (AAP), and European Federation of Periodontology (EFP) definitions.

Methods: 30 subjects were initially recruited. In a split-mouth fashion, right and left sides were randomly allocated into the two treatment arms: conventional scaling and root planing (C-SRP) vs. Read More

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Application of the inverted classroom model in the teaching module "new classification of periodontal and peri-implant diseases and conditions" during the COVID-19 pandemic.

GMS J Med Educ 2021;38(5):Doc89. Epub 2021 Jun 15.

Hannover Medical School, Department of Conservative Dentistry, Periodontology and Preventive Dentistry, Hannover, Germany.

Due to the need for patient-free dental education during the COVID-19 pandemic, Hannover Medical School (MHH) implemented a new periodontology module. Its didactic structure was based on the "inverted classroom model" (ICM) in combination with elements of case-based learning. The educational objective was to increase the diagnostic confidence of dental students in the classification of periodontal patients (staging & grading), based on 33 digitized patient cases. Read More

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Antibodies against citrullinated proteins in relation to periodontitis with or without rheumatoid arthritis: a cross-sectional study.

BMC Oral Health 2021 Jul 20;21(1):360. Epub 2021 Jul 20.

Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia.

Background: Previous studies have reported conflicting findings between serum anti-citrullinated protein antibodies (ACPA) levels in rheumatoid arthritis (RA) participants with and without periodontitis (Pd). This study aimed to analyse possible correlations between serum ACPA levels and clinical parameters in Pd and RA participants.

Methods: Full mouth periodontal examination (probing pocket depth, clinical attachment levels, gingival bleeding index, visual plaque index) was conducted and serum samples obtained from 80 participants comprising RA, Pd, both RA and Pd (RAPd) and healthy individuals (HC). Read More

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Prognostic validity of the Periapical and Endodontic Status Scale for the radiographically assessed 2-year treatment outcomes in teeth with apical periodontitis: a prospective clinical study.

BMC Oral Health 2021 Jul 19;21(1):354. Epub 2021 Jul 19.

Clinic of Dental and Oral Pathology, Lithuanian University of Health Sciences, Eiveniu str. 2, 50161, Kaunas, Lithuania.

Background: Endodontic treatment planning and treatment success evaluation are largely based on radiographic assessment of anatomical and treatment-related parameters of teeth with apical periodontitis (AP). This prospective clinical study aimed to assess radiographically the 2-year endodontic treatment outcomes for teeth with AP, and to evaluate prognostic validity of Periapical and Endodontic Status Scale (PESS).

Methods: A total of 128 patients, representing 176 teeth with AP were examined by cone-beam computed tomography at baseline and at 24 months after endodontic treatment. Read More

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Down-regulated IL36RN expression based on peripheral blood mononuclear cells and plasma of periodontitis patients and its clinical significance.

Yue Zhou Yufu Liang

J Clin Lab Anal 2021 Jul 17:e23899. Epub 2021 Jul 17.

Department of Stomatology, Affiliated Hospital of Beihua University, Jilin, China.

Background: The role of IL-36 receptor antagonist (IL36RN), a mutated gene expression of IL-36 in periodontitis patients with peripheral blood mononuclear cells (PBMC) and plasma remains to be undetermined.

Materials And Methods: Our study discovered the IL36RN expression through GEO public databases and further validated by PBMC and plasma of periodontitis patients and healthy participants. A total of 194 participants of public datasets, consisting of 97 cases of periodontitis and 97 cases of healthy control were retrospectively evaluated and explored the gene enrichment pathways and clinical significance of IL36RN expression accompanied by three different cytokines. Read More

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The 2018 classification of periodontal diseases. Its predictive value for tooth loss.

J Periodontol 2021 Jul 16. Epub 2021 Jul 16.

Section of Periodontology, Department of Conservative Dentistry, Clinic for Oral, Dental and Maxillofacial Diseases, University Hospital Heidelberg, Heidelberg, 69120, Germany.

Background: Predictive models and assessment tools for disease susceptibility and progression are necessary to enhance personalized medicine. The aim of this study is to assess the predictive accuracy of using the 2018 classification to predict likelihood of tooth loss.

Material And Methods: 134 patients were screened 10 years after periodontal therapy. Read More

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Assessment of salivary thiocyanate levels and pH in the saliva of smokers and nonsmokers with chronic periodontitis - A comparative study.

Indian J Dent Res 2021 Jan-Feb;32(1):74-78

Department of Oral Pathology and Microbiology, Swargiya Dadasaheb Kalmegh Smruti Dental College & Hospital, Nagpur, Maharashtra, India.

Background: It has been speculated that the pathogenesis of diseases prompted by cigarette smoking includes oxidative damage by free radicals. Though, definitive evidence that smoking may cause the oxidative modification of target molecules in vivo is lacking. Therefore, the purpose of this study was to estimate and compare the levels of salivary Thiocyanate (SCN) and power of hydrogen (pH) in the saliva of smokers and nonsmokers with chronic periodontitis (ChP). Read More

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Obstructive sleep apnea and periodontitis: A cross-sectional study.

Indian J Dent Res 2021 Jan-Feb;32(1):44-50

Department of Periodontics, Vokkaligara Sangha Dental College & Hospital, Bangalore, Karnataka, India.

Objectives: (1) To assess the risk of Obstructive Sleep Apnea (OSA) using a pre-designed questionnaire; (2) To assess the periodontal parameters like pocket probing depth (PPD) and clinical attachment loss (CAL) in the study subjects and (3) To determine the association between the shared risk factors of OSA and periodontitis.

Background Of The Study: Periodontitis is a microbially associated, host-mediated inflammatory disease that results in the loss of periodontal attachment. It has multifactorial etiology and has been linked to an array of systemic diseases. Read More

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Comparative evaluation of periodontal inflammatory conditions among gutka-chewers with and without prediabetes.

Indian J Dent Res 2021 Jan-Feb;32(1):15-22

Department of Oral Medicine and Radiology, Daswani Dental College and Research Centre, Kota, Rajasthan, India.

Background: The metabolic syndrome has become one of the major public-health challenges worldwide which include diabetes, prediabetes (raised blood glucose level), abdominal obesity, high cholesterol level, and high blood pressure. Periodontitis is described as a multi-factorial irreversible and cumulative condition and, is also the sixth complication of diabetes. Areca nut chewing has already been linked with the development of various cancers, and more recently with metabolic syndrome. Read More

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PRMT5 inhibition modulates murine dendritic cells activation by inhibiting the metabolism switch: a new therapeutic target in periodontitis.

Ann Transl Med 2021 May;9(9):755

Department of Implant Dentistry, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.

Background: Protein arginine methyltransferase 5 (PRMT5) catalyzes the methylation of arginine residues in multiple proteins. Recent reports have highlighted the anti-inflammatory role of PRMT5. Dendritic cells (DCs) are well-known professional antigen-presenting cells that are crucial for immune response initiation. Read More

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