1,233 results match your criteria periodic leg

Multidimensional Pain Characteristics in Older Adults with Chronic Venous Leg Ulcers.

Adv Wound Care (New Rochelle) 2021 May 11. Epub 2021 May 11.

University of Florida, Geriatric Medicine, HPNP box 100187, Gainesville, Florida, United States, 32610;

Objective: Pain affects wound healing, treatment, and quality of life because it has significant impacts on physical, psychological, and social wellbeing. Despite the fact that more than half of chronic venous leg ulcer (CVLU) patients experience mild to moderate pain, the multidimensional characteristics of CVLU pain are not well documented. The objective of this study was to describe the multidimensional pain characteristics including the sensory, affective, cognitive, and behavioral dimensions of CVLU prior to debridement. Read More

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Clinical characteristics of periodic limb movements during sleep categorized by continuous positive airway pressure titration polysomnography in patients with obstructive sleep apnea.

Sleep Breath 2021 May 10. Epub 2021 May 10.

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Republic of Korea.

Purpose: The presence of periodic limb movements during sleep (PLMS) varies among patients with obstructive sleep apnea (OSA) undergoing treatment with continuous positive airway pressure (CPAP). The factors associated with this variation are unknown.

Methods: PLMS were defined as a periodic leg movements index of > 15/h. Read More

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Heart rate changes associated with the different types of leg movements during sleep in children, adolescents and adults with restless legs syndrome.

J Sleep Res 2021 May 6:e13379. Epub 2021 May 6.

Seattle Children's Hospital and University of Washington, Seattle, WA, USA.

The objective of this study was to describe in detail the heart rate changes accompanying short-interval leg movements during sleep, periodic leg movements during sleep, and isolated leg movements during sleep in children and adolescents with restless legs syndrome, and to compare them with the same findings in adults with restless legs syndrome. We analysed time series of R-R intervals synchronized to the onset of short-interval leg movements during sleep, periodic leg movements during sleep or isolated leg movements during sleep that entailed an arousal during non-rapid-eye-movement sleep. We assessed cardiac activation based on the heart rate changes with respect to baseline during non-rapid-eye-movement sleep without leg movements. Read More

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Association of Central Hypersomnia and Fatigue in Patients With Multiple Sclerosis: A Polysomnographic Study.

Neurology 2021 Apr 30. Epub 2021 Apr 30.

Neurology Department, Saint Antoine Hospital, AP-HP, Paris.

Objective: To evaluate sleepiness and central hypersomnia in multiple sclerosis (MS) associated fatigue, we performed long term polysomnography in MS patients and healthy controls.

Methods: Patients with MS and healthy controls completed questionnaires on sleep, fatigue, sleepiness, and depression. They underwent nocturnal polysomnography, multiple sleep latency tests and bed rest 24-hour polysomnography. Read More

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Restless Legs Syndrome: Contemporary Diagnosis and Treatment.

Neurotherapeutics 2021 Apr 20. Epub 2021 Apr 20.

Mayo Center for Sleep Medicine, 200 First Street SW, Rochester, MN, 55905, USA.

Restless legs syndrome (RLS) is characterized by an uncomfortable urge to move the legs while at rest, relief upon movement or getting up to walk, and worsened symptom severity at night. RLS may be primary (idiopathic) or secondary to pregnancy or a variety of systemic disorders, especially iron deficiency, and chronic renal insufficiency. Genetic predisposition with a family history is common. Read More

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An automatic sleep disorder detection model based on EEG cross-frequency coupling and Random Forest model.

J Neural Eng 2021 Apr 13. Epub 2021 Apr 13.

Research and Innovation Development, Brussels, Belgium, Intrasoft International S.A., Place du Champ de Mars 5/10 1050 Brussels, BRUSSELS, 1050, BELGIUM.

Sleep disorders are medical disorders of a subject's sleep architecture and based on their severity, they can interfere with mental, emotional and physical functioning. The most common ones are insomnia, narcolepsy, sleep apnea, bruxism, etc. There is an increased risk of developing sleep disorders in elderly like insomnia, periodic leg movements, rapid eye movement (REM) behaviour disorders, sleep disorder breathing, etc. Read More

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Automatic Sleep-Stage Scoring in Healthy and Sleep Disorder Patients Using Optimal Wavelet Filter Bank Technique with EEG Signals.

Int J Environ Res Public Health 2021 03 17;18(6). Epub 2021 Mar 17.

School of Engineering, Ngee Ann Polytechnic, Singapore 599489, Singapore.

Sleep stage classification plays a pivotal role in effective diagnosis and treatment of sleep related disorders. Traditionally, sleep scoring is done manually by trained sleep scorers. The analysis of electroencephalogram (EEG) signals recorded during sleep by clinicians is tedious, time-consuming and prone to human errors. Read More

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Accuracy of Actigraphy Compared to Concomitant Ambulatory Polysomnography in Narcolepsy and Other Sleep Disorders.

Front Neurol 2021 4;12:629709. Epub 2021 Mar 4.

Department of Neurology, Helsinki Sleep Clinic, Vitalmed Research Center, Helsinki, Finland.

Actigraphy provides longitudinal sleep data over multiple nights. It is a less expensive and less cumbersome method for measuring sleep than polysomnography. Studies assessing accuracy of actigraphy compared to ambulatory polysomnography in different sleep-disordered patients are rare. Read More

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Respiratory-related leg movements vs periodic limb movements in sleep: a scoring conundrum. an editorial.

Sleep Med 2021 May 21;81:98-100. Epub 2020 Nov 21.

Hackensack-Meridian Health-JFK University Medical Center, 65 James Street, Edison NJ 08820, USA.

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Accelerometer-measured physical activity and its impact on sleep quality in patients suffering from restless legs syndrome.

BMC Neurol 2021 Feb 26;21(1):90. Epub 2021 Feb 26.

Practice for Neurology, Paracelsus-Klinik, In der Vahr 65, 28329, Bremen, Germany.

Background: The primary symptoms of restless legs syndrome (RLS) are sleep onset insomnia and difficulty to maintain sleep. Previous studies have shown that regular physical activity can reduce the risk of developing RLS. However, the relationship between physical activity and sleep quality parameters in individuals suffering from RLS has not yet been investigated by applying accelerometry. Read More

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February 2021

Trajectory Planning of Flexible Walking for Biped Robots Using Linear Inverted Pendulum Model and Linear Pendulum Model.

Sensors (Basel) 2021 Feb 4;21(4). Epub 2021 Feb 4.

School of Mechanical-Electrical Engineering, North China Institute of Science and Technology, Beijing 065201, China.

Linear inverted pendulum model (LIPM) is an effective and widely used simplified model for biped robots. However, LIPM includes only the single support phase (SSP) and ignores the double support phase (DSP). In this situation, the acceleration of the center of mass (CoM) is discontinuous at the moment of leg exchange, leading to a negative impact on walking stability. Read More

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February 2021

Systematic assessment of autonomic symptoms in restless legs syndrome.

Sleep Med 2021 Apr 18;80:30-38. Epub 2021 Jan 18.

Sleep-Wake Disorders Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, France; National Reference Network for Narcolepsy, CHU Montpellier, France; Institute for Neurosciences of Montpellier INM, Univ Montpellier, INSERM, Montpellier, France. Electronic address:

Objectives: To compare the clinical features of autonomic dysfunction using the SCOPA-AUT questionnaire in untreated patients with restless legs syndrome (RLS) with controls, to identify factors associated with more severe autonomic symptoms, and to assess the effect of medication in patients.

Methods: The SCOPA-AUT questionnaire that evaluates cardiovascular, gastrointestinal, urinary, thermoregulatory, pupillomotor, and sexual dysfunctions was completed by 409 consecutive untreated patients with RLS (54.1 ± 14. Read More

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Limb and trunk accelerometer data collected with wearable sensors from subjects with Parkinson's disease.

Sci Data 2021 02 5;8(1):47. Epub 2021 Feb 5.

Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, Massachusetts, USA.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms. Dyskinesia and motor fluctuations are complications of PD medications. An objective measure of on/off time with/without dyskinesia has been sought for some time because it would facilitate the titration of medications. Read More

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February 2021

Video electroencephalogram combined with electromyography in the diagnosis of hyperkinetic movement disorders with an unknown cause.

Neurol Sci 2021 Jan 18. Epub 2021 Jan 18.

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, 100730, China.

Objectives: Diagnosis of hyperkinetic movement disorders with an unknown cause is usually challenging. The objective of this study is to learn about video electroencephalogram (VEEG) combined with electromyography (EMG) in the diagnosis of hyperkinetic movement disorders with an unknown cause.

Methods: We performed an observational cohort study by recruiting consecutive patients with hyperkinetic movements as the main manifestation with an unknown cause for VEEG combined with EMG evaluations. Read More

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January 2021

Analysis of the characteristics of sleep in patients with patent foramen ovale complicated with obstructive sleep apnea.

Sleep Breath 2021 Jan 13. Epub 2021 Jan 13.

Department of Neurology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou City, 450014, Henan Province, China.

Purpose: Analyzing sleep quality and sleep structure in patients with patent foramen ovale (PFO) complicated with obstructive sleep apnea (OSA) and the interaction between OSA and PFO in sleep.

Methods: We compared patients with PFO complicated with OSA, patients with simple PFO, and controls. Pittsburgh Sleep Quality Index was used to compare sleep quality and polysomnography was used to compare sleep structure of the three groups. Read More

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January 2021

Dynamic Prevalence of Sleep Disorders Following Stroke or Transient Ischemic Attack: Systematic Review and Meta-Analysis.

Stroke 2021 Jan 7;52(2):655-663. Epub 2021 Jan 7.

School of Nursing, College of Nursing (F.H., H.-C.H., O.F.D.M., H.-Y.C.), Taipei Medical University, Taiwan.

Background And Purpose: The exact prevalence of sleep disorders following stroke or transient ischemic attack (TIA) remains unclear. We aimed to determine the prevalence of sleep-disordered breathing, insomnia, periodic leg movement during sleep, and restless leg syndrome following stroke or TIA in acute, subacute, and chronic phases and examine the moderating effects of patient characteristics (eg, age) and methodological features (eg, study quality) on the prevalence.

Methods: We performed a systematic review and meta-analysis. Read More

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January 2021

Tibialis anterior electromyographic bursts during sleep in histamine-deficient mice.

J Sleep Res 2020 Dec 13:e13255. Epub 2020 Dec 13.

PRISM Lab, Dipartimento di Scienze Biomediche e Neuromotorie, Alma Mater Studiorum, Università di Bologna, Bologna, Italy.

Antihistamine medications have been suggested to elicit clinical features of restless legs syndrome. The available data are limited, particularly concerning periodic leg movements during sleep, which are common in restless legs syndrome and involve bursts of tibialis anterior electromyogram. Here, we tested whether the occurrence of tibialis anterior electromyogram bursts during non-rapid eye movement sleep is altered in histidine decarboxylase knockout mice with congenital histamine deficiency compared with that in wild-type control mice. Read More

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December 2020

Non-Hermitian Floquet Phases with Even-Integer Topological Invariants in a Periodically Quenched Two-Leg Ladder.

Longwen Zhou

Entropy (Basel) 2020 Jul 7;22(7). Epub 2020 Jul 7.

Department of Physics, College of Information Science and Engineering, Ocean University of China, Qingdao 266100, China.

Periodically driven non-Hermitian systems could possess exotic nonequilibrium phases with unique topological, dynamical, and transport properties. In this work, we introduce an experimentally realizable two-leg ladder model subjecting to both time-periodic quenches and non-Hermitian effects, which belongs to an extended CII symmetry class. Due to the interplay between drivings and nonreciprocity, rich non-Hermitian Floquet topological phases emerge in the system, with each of them characterized by a pair of even-integer topological invariants ( w 0 , w π ) ∈ 2 Z × 2 Z . Read More

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Cortical Arousal Frequency is Increased in Narcolepsy Type 1.

Sleep 2020 Nov 29. Epub 2020 Nov 29.

Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Rigshospitalet, Denmark.

Study Objectives: Hypocretin deficient narcolepsy (type 1, NT1) presents with multiple sleep abnormalities including sleep onset rapid eye movement (REM) periods (SOREMPs) and sleep fragmentation. We hypothesized that cortical arousals, as scored by an automatic detector, are elevated in NT1 and narcolepsy type 2 (NT2) patients as compared to control subjects.

Methods: We analyzed nocturnal polysomnography (PSG) recordings from 25 NT1 patients, 20 NT2 patients, 18 clinical control subjects (CC, suspected central hypersomnia but with normal cerebrospinal (CSF) fluid hypocretin-1 (hcrt-1) levels and normal results on the multiple sleep latency test), and 37 healthy control (HC) subjects. Read More

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November 2020

REM Sleep Behavior Disorder and other sleep abnormalities in p. A53T SNCA mutation carriers.

Sleep 2020 Nov 24. Epub 2020 Nov 24.

1st Department of Neurology, Eginition University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Study Objectives: Τo assess whether REM Sleep Behavior Disorder (RBD) and other sleep abnormalities occur in carriers of the p.A53T alpha-synuclein gene (SNCA) mutation, using both subjective and objective measures.

Methods: We have assessed 15 p. Read More

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November 2020

[Restless legs syndrome in Parkinson's disease].

Zh Nevrol Psikhiatr Im S S Korsakova 2020 ;120(10. Vyp. 2):80-88

Sechenov First Moscow Medical University, Moscow, Russia.

Disturbances in sleep and wakefulness are important symptoms of Parkinson's disease (PD) and are associated with negative effects on patients' quality of life. The analysis of literature on the relationship between RLS and PD revealed three main hypotheses explaining the relatively high incidence of RLS in PD: (1) RLS can be considered as an early (prodromal) manifestation or a predictor of PD that can outpace its main symptoms by several years (by analogy with conduct disorder during sleep with REM); (2) the high incidence of RLS in the advanced stage of PD may be associated with augmentation of previously latent RLS symptoms during prolonged dopaminergic therapy of PD; (3) a significant proportion of RLS cases in PD patients are not «classical» RLS, but represent, for example, manifestations of motor or non-motor fluctuations or a special form of stereotypy in the legs. Further research is needed to determine if any of these statements are true. Read More

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November 2020

The musculoskeletal system manifestations in children with familial Mediterranean fever.

North Clin Istanb 2020 4;7(5):438-442. Epub 2020 Sep 4.

Department of Pediatric Rheumatology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey.

Objective: Familial Mediterranean fever (FMF) is a monogenic inherited periodic fever syndrome presenting with episodes of self-limiting fever and inflammation of serosal membranes. Besides the findings in the diagnostic criteria, musculoskeletal findings can also be seen in FMF patients attacks. In this study, we aim to reveal the frequency and genotype association of musculoskeletal manifestations in children with FMF. Read More

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September 2020

[Sleep-related movement and behavioural disorders in adults].

Rev Neurol 2020 Nov;71(10):377-386

Hospital Clinic de Barcelona, Barcelona, España.

Sleep-related movement and behaviour disorders may have an impact on sleep quality and lead to daytime symptoms. These groups of conditions include diseases such as restless legs syndrome, periodic leg movements, and REM and NREM parasomnias. The knowledge of their clinical features and management is of utmost importance for the neurologist and sleep specialist. Read More

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November 2020

Migraine and sleep disorders: a systematic review.

J Headache Pain 2020 Oct 27;21(1):126. Epub 2020 Oct 27.

Department of Applied Clinical Sciences and Biotechnology, University of L'Aquila, L'Aquila, Italy.

Migraine and sleep disorders are common and often burdensome chronic conditions with a high prevalence in the general population, and with considerable socio-economic impact and costs.The existence of a relationship between migraine and sleep disorders has been recognized from centuries by clinicians and epidemiological studies. Nevertheless, the exact nature of this association, the underlying mechanisms and interactions are complex and not completely understood. Read More

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October 2020

Accelerometer-Based Automated Counting of Ten Exercises without Exercise-Specific Training or Tuning.

J Healthc Eng 2020 10;2020:8869134. Epub 2020 Oct 10.

Department of Computer Science and Engineering, University of North Texas, Denton, TX 76203, USA.

Measuring physical activity using wearable sensors is essential for quantifying adherence to exercise regiments in clinical research and motivating individuals to continue exercising. An important aspect of wearable activity tracking is counting particular movements. One limitation of many previous models is the need to design the counting for a specific exercise. Read More

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October 2020

Frequency of Obstructive Sleep Apnea in Stage I and II Sarcoidosis Subjects Who Had No Corticosteroid Therapy.

Turk Thorac J 2020 Sep 1;21(5):296-302. Epub 2020 Sep 1.

Department of Pulmonary Medicine, İstanbul University, İstanbul School of Medicine, İstanbul, Turkey.

Objectives: The number of studies on the frequency of obstructive sleep apnea (OSA) in subjects with sarcoidosis is low. Therefore, we aimed to investigate the frequency and predictors of OSA in subjects with clinically stable stage I and II sarcoidosis who were not taking corticosteroid and/or immunosuppressive drugs. We also evaluated restless legs syndrome (RLS) and periodic leg movements in sleep (PLMS). Read More

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September 2020

Possible Assessment of Calf Venous Pump Efficiency by Computational Fluid Dynamics Approach.

Front Physiol 2020 8;11:1003. Epub 2020 Sep 8.

2C Technologies Ltd., Academic Spin-Off, University of Cagliari, Cagliari, Italy.

Three-dimensional simulations of peripheral, deep venous flow during muscular exercise in limbs of healthy subjects and in those with venous dysfunction were carried out by a computational fluid-dynamics (CFD) approach using the STAR CCM + platform. The aim was to assess the effects of valvular incompetence on the venous calf pump efficiency. The model idealizes the lower limb circulation by a single artery, a capillary bed represented by a porous region and a single vein. Read More

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September 2020

Self-reported sleepiness and not the apnoea hypopnoea index is the best predictor of sleepiness-related accidents in obstructive sleep apnoea.

Sci Rep 2020 10 1;10(1):16267. Epub 2020 Oct 1.

HP2 Laboratory, INSERM U1042, Grenoble Alpes University, Grenoble, France.

To evaluate the value of apnoea + hypopnoea index versus self-reported sleepiness at the wheel in anticipating the risk of sleepiness-related accidents in patients referred for obstructive sleep apnoea. A cross-sectional analysis of the French national obstructive sleep apnoea registry. 58,815 subjects referred for a suspicion of obstructive sleep apnoea were investigated by specific items addressing sleepiness at the wheel and sleepiness-related accidents. Read More

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October 2020

Strongly confined atomic localization by Rydberg coherent population trapping.

Opt Lett 2020 Oct;45(19):5440-5443

We investigate the possibility to attain strongly confined atomic localization using interacting Rydberg atoms in a coherent population trapping ladder configuration, where a standing-wave is used as a coupling field in the second leg of the ladder. Depending on the degree of compensation for the Rydberg level energy shift induced by the van der Waals interaction, by the coupling field detuning, we distinguish between two antiblockade regimes, i.e. Read More

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October 2020