7,924 results match your criteria periodic acid-schiff

Rheumatological features of Whipple disease.

Sci Rep 2021 Jun 10;11(1):12278. Epub 2021 Jun 10.

UMR1227, Lymphocytes B et Autoimmunité, Université de Brest, INSERM, CHU Brest, LabEx IGO, Brest, France.

Whipple disease (WD) is a rare infectious systemic disease. Rheumatologists are at the frontline of WD diagnosis due to the early rheumatological manifestations. An early diagnosis is crucial, as usual anti-rheumatic drugs, especially TNF inhibitors, may worsen the disease course. Read More

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Effect of fulvic acid on gastric mucosa damage caused by chronic water avoidance stress.

Biotech Histochem 2021 Jun 8:1-8. Epub 2021 Jun 8.

Hamidiye Medical School, Department of Histology and Embryology, University of Health Science, Istanbul, Turkey.

We investigated the antioxidant and anti-ulcerogenic effects of fulvic acid (FA) on oxidative damage caused by water avoidance stress (WAS) in rat gastrointestinal mucosa. Three experimental groups were established: control (C), chronic stress (CS), and chronic stress + FA (CS + FA). After WAS, a single dose of FA was administered for 10 days to the CS + FA group. Read More

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Ameliorative effects of eosinophil deficiency on immune response, endoplasmic reticulum stress, apoptosis, and autophagy in fungus-induced allergic lung inflammation.

Respir Res 2021 Jun 7;22(1):173. Epub 2021 Jun 7.

Department of Pulmonary Medicine, Shanghai Respiratory Research Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

Background: Respiratory fungal exposure is known to be associated with various allergic pulmonary disorders. Eosinophils have been implicated in tissue homeostasis of allergic inflammation as both destructive effector cells and immune regulators. What contributions eosinophils have in Aspergillus fumigatus (Af)-induced allergic lung inflammation is worthy of investigating. Read More

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The Ovariol Morphology and Ultrastructure of Ünal, 1999 (Orthoptera, Tettigoniidae) and the Histochemical Features of the Yolk Granules.

Microsc Microanal 2021 Jun 7:1-8. Epub 2021 Jun 7.

Faculty of Science, Department of Biology, Gazi University, Ankara06500, Turkey.

This study presents the oocyte development of Poecilimon ataturki Ünal, 1999 (Orthoptera, Tettigoniidae) with histology, morphology, and histochemistry by using a stereomicroscope, a light microscope, a scanning electron microscope, and a transmission electron microscope. The ovary in this species is a panoistic type which contains many ovarioles which consist of terminal filament, germarium, and vitellarium. Germarium is the region that has undifferentiated cells which generate the oocytes and follicular cells. Read More

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Hyalinization as a histomorphological risk predictor in oral pathological lesions.

J Oral Biol Craniofac Res 2021 Jul-Sep;11(3):415-422. Epub 2021 May 20.

Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.

Background: Hyalinization is a process of conversion of stromal connective tissue into a homogeneous, acellular translucent material. Nevertheless, hyalinization could provide insights into the biologic behaviour and prognosis of pathological lesions. Few studies with limited sample size have intended to assess the correlation of hyalinization and biologic behaviour in oral lesions. Read More

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Mucoacinar Carcinoma: A Rare Variant of Mucoepidermoid Carcinoma.

Am J Surg Pathol 2021 Jun 7. Epub 2021 Jun 7.

Tang Tock Seng Hospital, Tang Tock Seng, Singapore Department of Laboratory Medicine & Pathobiology, University Health Network, Toronto, ON Department of Pathology and Laboratory Medicine, University of Calgary, Arnie Charbonneau Cancer Institute, Calgary, AB, Canada Memorial Sloan Kettering Cancer Center, New York, NY Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA Massachussetts General Hospital, Boston, MA Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL.

Mucoepidermoid carcinoma (MEC) is generally characterized by an admixture of mucous, epidermoid and intermediate type cells. Numerous variants morphologies are described and defined by stromal and/or cytoplasmic tinctorial characteristics. We now report 11 cases of MEC with serous acinar differentiation, reflecting a distal intercalated duct/acinar phenotype, which we designate as mucoacinar carcinomas. Read More

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Anticoccidial effect of toltrazuril and Radix Sophorae Flavescentis combination: Reduced inflammation and promoted mucosal immunity.

Vet Parasitol 2021 May 27;296:109477. Epub 2021 May 27.

College of Animal Science and Technology, Henan University of Science and Technology, 263 Kaiyuan Avenue, Luoyang, Henan, 471023, People's Republic of China.

An anticoccidial model of chicken infected with Eimeria tenella was established to investigate the effect of toltrazuril (Tol) combined with the Radix Sophorae Flavescentis (RSF) on coccidiosis. The anticoccidial index (ACI) was evaluated, and the cecal developmental parameters (i.e. Read More

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Transitional cell carcinoma matrix stiffness regulates the osteopontin and YAP expression in recurrent patients.

Mol Biol Rep 2021 Jun 4. Epub 2021 Jun 4.

Urology & Nephrology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Cells translate the mechanosensing of extracellular matrix component dysregulation and stiffness into the signal transduction including Osteopontin (OPN) through the Hippo pathway. But how extracellular matrix (ECM) component dysregulation and stiffness are ultimately linked to transitional cell carcinoma (TCC) development remains poorly understood. This study was aimed to evaluate the possible links between ECM component alteration after cancer surgery and OPN and Yes-associated protein (YAP) expression in TCC and adjacent tissues. Read More

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Ameliorative Role of Diallyl Disulfide Against Glycerol-induced Nephrotoxicity in Rats.

J Pharm Bioallied Sci 2021 Jan-Mar;13(1):129-135. Epub 2020 Dec 21.

Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.

Introduction: This study investigated the role of diallyl disulfide (DADS) against glycerol-induced nephrotoxicity in rats. Moreover, the role of peroxisome proliferator activated receptor-γ (PPAR-γ) in DADS-mediated renoprotection has been explored.

Materials And Methods: Male Wistar albino rats were challenged with glycerol (50% w/v, 8 mL/kg intramuscular) to induce nephrotoxicity. Read More

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December 2020

"Migratory Kerato osteomyelitis" - A refractory lesion of the mandible: A pathologist's and surgeon's dilemma!!

J Oral Maxillofac Pathol 2021 Mar 19;25(Suppl 1):S61-S67. Epub 2021 Mar 19.

Army Dental Centre (R&R), New Delhi, India.

A 62 year old female patient presented with a chief complaint of non healing extraction socket in the lower left back teeth region. She underwent extraction of 37 at a private clinic following which an ulceroinfiltrative lesion developed at operated side. Multiple biopsies from the lesion were inconclusive. Read More

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Clear-cell variant of oral squamous cell carcinoma: A rare entity.

J Oral Maxillofac Pathol 2021 Mar 19;25(Suppl 1):S22-S26. Epub 2021 Mar 19.

Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospital, SIMATS University, Chennai, Tamil Nadu, India.

Clear-cell variant of oral squamous cell carcinoma is an extremely rare entity in the maxillofacial region. We report a case of 42-year-old female who presented with a soft-tissue growth with erythematous and nonscrapable irregular white patches on the left alveolar mucosa for the past 3 months. Histopathologic examination showed lobules and sheets of clear cells with features of malignancy extending from the surface epithelium. Read More

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Morphological and Histological Features of the Vomeronasal Organ in African Pygmy Hedgehog ().

Animals (Basel) 2021 May 19;11(5). Epub 2021 May 19.

Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-11 Inada-cho, Obihiro 080-8555, Japan.

The vomeronasal organ (VNO) detects specific chemicals such as pheromones and kairomones. Hedgehogs (Eulipotyphla: Erinaceidae) have a well-developed accessory olfactory bulb that receives projections from the VNO, but little is known about the hedgehog VNO. Here, we studied the histological features of the VNO in five individual African pygmy hedgehogs by hematoxylin-eosin, periodic acid-Schiff, and Alcian blue stains. Read More

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NLRP3 Deletion Attenuated Angiotensin II-Induced Renal Fibrosis by Improving Mitochondrial Dysfunction and Endoplasmic Reticulum Stress.

Nephron 2021 Jun 1:1-10. Epub 2021 Jun 1.

Division of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Background: Increasing evidence suggests that angiotensin II (Ang II), the bioactive pro-oxidant in the renin-angiotensin system, aggravates fibrosis, and the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is involved in multiple diseases, such as renal fibrosis. However, the role and underlying mechanism of Ang II in renal fibrosis remain unclear. Here, we investigated whether the NLRP3 inflammasome mediated Ang II-induced renal fibrosis, as well as the downstream pathways involved in this process. Read More

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[Chronic venous disease increases placental villous angiogenesis and lymphangiogenesis and villous cell apoptosis].

Haiyan Wu

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2021 Jun;37(6):538-545

Department of Obstetrics, Northwest Women's and Children's Hospital, Xi'an 710003, China. *Corresponding author, E-mail:

Objective To investigate the changes of key factors such as placental villi and lymph vessels in chronic venous disease (CVD) during pregnancy. Methods According to the CEAP classification criteria, tissues of CVD patients were collected, and was divided into control group and CVD group. Real-time quantitative PCR was used to detect mRNA level of CD31, D2-4, fms-related tyrosine kinase 1 (FLT-1), placental growth factor (PlGF) and hypoxia-inducible factor-1 (HIF-1α) in placental tissues. Read More

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Expression of STAT3 and vasculogenic mimicry in gallbladder carcinoma promotes invasion and metastasis.

Exp Ther Med 2021 Jul 9;22(1):738. Epub 2021 May 9.

Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.

Surgical treatment of gallbladder carcinoma remains challenging, while targeted therapy has been demonstrated to have potential. In the present study, the effect of signal transducer and activator of transcription 3 (STAT3) expression and vasculogenic mimicry (VM) on the occurrence and development of gallbladder carcinoma was evaluated. A total of 72 patients with gallbladder carcinoma and 10 patients with chronic cholecystitis were examined. Read More

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Performance of Nano-Hydroxyapatite/Beta-Tricalcium Phosphate and Xenogenic Hydroxyapatite on Bone Regeneration in Rat Calvarial Defects: Histomorphometric, Immunohistochemical and Ultrastructural Analysis.

Int J Nanomedicine 2021 18;16:3473-3485. Epub 2021 May 18.

Biology Department, School of Medicine, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.

Background: Synthetic biomaterials have played an increasingly prominent role in the substitution of naturally derived biomaterials in current surgery practice. In vitro and in vivo characterization studies of new synthetic biomaterials are essential to analyze their physicochemical properties and the underlying mechanisms associated with the modulation of the inflammatory process and bone healing.

Purpose: This study compares the in vivo tissue behavior of a synthetic biomaterial nano-hydroxyapatite/beta-tricalcium phosphate (nano-HA/ß-TCP mixture) and deproteinized bovine bone mineral (DBBM) in a rat calvarial defect model. Read More

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Development of allergic conjunctivitis induced by excretory-secretory protein and the effect of resolvin D1 on treatment.

Curr Eye Res 2021 May 24. Epub 2021 May 24.

Department of Ophthalmology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, South Korea.

Purpose: To evaluate whether allergic conjunctivitis (AC) could be induced by excretory-secretory protein (ESP) and analyze the therapeutic effect of resolvin (Rv) D1 and antiallergic agents.

Methods: Human conjunctival epithelial cells (HCVCs) were treated with 10 µg/well of ESP, and Th2 cytokines were measured using real-time PCR. C57BL/6 mice were treated with 10 µg/5 µL of ESP after sensitization, and conjunctivas isolated from the mice were stained with hematoxylin and eosin (H&E) for the analysis of eosinophils and periodic acid-Schiff (PAS) for the analysis of goblet cells. Read More

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Aspects of transition cow metabolomics-Part II: Histomorphologic changes in the liver parenchyma throughout the transition period, in cows with different liver metabotypes and effects of a metaphylactic butaphosphan and cyanocobalamin treatment.

J Dairy Sci 2021 May 20. Epub 2021 May 20.

Clinic for Ruminants and Swine, Faculty of Veterinary Medicine, Leipzig University, An den Tierkliniken 11, 04103 Leipzig, Germany.

The aims of this study were to evaluate histopathologic changes during the transition period, describe the histopathological features of the metabotypes identified in Part I (Schären et al., 2021b), and investigate effects of a metaphylactic treatment with butaphosphan and cyanocobalamin (BCC) on the liver parenchyma. Eighty German Holstein cows (mean 305-d production: 10,957 kg, range: 6,480-15,193 kg; mean lactation number: 3. Read More

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An efficient protocol for decellularization of the human endometrial fragments for clinical usage.

Prog Biomater 2021 May 21. Epub 2021 May 21.

Anatomy Department, Faculty of Medical Sciences, Tarbiat Modares University, 14115-111, Tehran, Iran.

The present study was aimed to compare different decellularization protocols for human endometrial fragments. The freeze-thaw cycles in combination with treatment by Triton X-100 and four concentrations of sodium dodecyl sulfate (SDS; 0.1, 0. Read More

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Development of osmotic vacuolization of proximal tubular epithelial cells following treatment with sodium-glucose transport protein 2 inhibitors in type II diabetes mellitus patients-3 case reports.

CEN Case Rep 2021 May 22. Epub 2021 May 22.

Nephrology Center, Toranomon Hospital Kanagawa, 1-3-1, Takatsu, Kawasaki, Kanagawa, 212-0015, Japan.

We encountered 3 cases of acute kidney injury that occurred after treatment with a SGLT2 inhibitor. In case 1, serum creatinine increased from 1.65 to 3. Read More

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sRAGE Inhibits the Mucus Hypersecretion in a Mouse Model with Neutrophilic Asthma.

Immunol Invest 2021 May 21:1-14. Epub 2021 May 21.

Pediatric Department, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, P.R. China.

: Neutrophilic asthma (NA) may result in irreversible airflow limitations. Soluble advanced glycosylation receptor (sRAGE) has been shown to be associated with neutrophilic airway inflammation. However, the association between sRAGE and mucus hypersecretion in NA remains unknown. Read More

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Long Non-coding RNA Promotes Renal Tubular Epithelial Cell Pyroptosis by Regulating the miR-18a-3p/GSDMD Pathway in Lipopolysaccharide-Induced Acute Kidney Injury.

Front Physiol 2021 29;12:663216. Epub 2021 Apr 29.

The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Acute kidney injury (AKI) is a complication of sepsis. Pyroptosis of gasdermin D (GSDMD)-mediated tubular epithelial cells (TECs) play important roles in pathogenesis of sepsis-associated AKI. Long non-coding RNA (lncRNA) maternally expressed gene 3 (), an imprinted gene involved in tumorigenesis, is implicated in pyroptosis occurring in multiple organs. Read More

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Short-term whole body cigarette smoke exposure induces regional differences in cellular response in the mouse larynx.

Toxicol Rep 2021 19;8:920-937. Epub 2021 Apr 19.

Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.

The larynx is an essential organ in the respiratory tract and necessary for airway protection, respiration, and phonation. Cigarette smoking is a significant risk factor associated with benign and malignant laryngeal diseases. Despite this association, the underlying mechanisms by which cigarette smoke (CS) drives disease development are not well elucidated. Read More

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Natural flavonol fisetin attenuated hyperuricemic nephropathy via inhibiting IL-6/JAK2/STAT3 and TGF-β/SMAD3 signaling.

Phytomedicine 2021 Mar 22:153552. Epub 2021 Mar 22.

Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu 610041, China.

Background: The naturally occurring flavonol fisetin (3,3',4',7-tetrahydroxyflavone), widely dispersed in fruits, vegetables and nuts, has been reported to exert anti-inflammatory, antioxidant and anti-angiogenic effects. Our previous study indicated fisetin ameliorated inflammation and apoptosis in septic kidneys. However, the potential nephroprotective effect of fisetin in hyperuricemic mice remains unknown. Read More

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Spermatogenesis in the Roborovski hamster (Phodopus roborovskii) and the Chinese hamster (Cricetulus griseus).

Andrology 2021 May 13. Epub 2021 May 13.

Department of Life Sciences and Chemistry, Jacobs University, Bremen, Germany.

Background: Spermatogenesis is an elaborately organized and tightly regulated differentiation process. The spermatogenesis duration is stable within a certain species but highly variable between species of the same family.

Objectives: In this study, the spermatogenesis duration of the Roborovski hamster was measured for the first time, and the spermatogenesis duration of the Chinese hamster was re-assessed. Read More

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Hematological and cytochemical characteristics of peripheral blood cells in the argus snakehead ( Cantor).

PeerJ 2021 26;9:e11234. Epub 2021 Apr 26.

College of Life Sciences, Anhui Normal University, Wuhu, China.

Background: The argus snakehead ( Cantor) is a highly nutritious, freshwater, cultured bony fish with a high economic value. The health of the fish is closely related to its blood cells, which are critical for oxygen transport, natural defense, and immunity. We investigated the morphometry, microstructure, and cytochemical characteristics of the peripheral blood cells of . Read More

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Pulmonary alveolar proteinosis complicated with nocardiosis: A case report and review of the literature.

World J Clin Cases 2021 Apr;9(12):2874-2883

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, Zhejiang Province, China.

Background: Pulmonary alveolar proteinosis (PAP) is a pulmonary syndrome wherein large volumes of phospholipid and protein-rich surfactants accumulate within the alveoli. PAP forms include primary (auto-immune PAP), secondary, and congenital. Nocardiosis is a form of suppurative disease induced upon infection with bacteria of the genus. Read More

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Amelioration of diabetic retinopathy in db/db mice by treatment with different proportional three active ingredients from Tibetan medicine Berberis dictyophylla F.

J Ethnopharmacol 2021 Aug 6;276:114190. Epub 2021 May 6.

Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China. Electronic address:

Ethnopharmacological Relevance: Berberis dictyophylla F., a famous Tibetan medicine, has been used to prevent and treat diabetic retinopathy (DR) for thousands of years in clinic. However, its underlying mechanisms remain unclear. Read More

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Cryocrystalglobulinemia-An Uncommon Cutaneous Presentation of Multiple Myeloma and Novel Finding of Transepidermal Elimination of Crystals.

Am J Dermatopathol 2021 May 5. Epub 2021 May 5.

Department of Dermatology, National Skin Centre, Singapore, Singapore.

Abstract: Cryocrystalglobulinemia (CCG) is a rare subset of type 1 cryoglobulinemia that is classically associated with an underlying paraproteinemia. The cryocrystalglobulins are characterized by extracellular crystals, which are eosinophilic, periodic acid-Schiff positive, and exhibit nonbirefringence under polarized light. This archetypal appearance renders CCG readily diagnosable histologically. Read More

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Improved preservation of ovarian tissue morphology that is compatible with antigen detection using a fixative mixture of formalin and acetic acid.

Hum Reprod 2021 May 6. Epub 2021 May 6.

Nuffield Department of Women's and Reproductive Health, Women's Centre, John Radcliffe Hospital, University of Oxford, Oxford, UK.

Study Question: Can ovarian tissue morphology be better preserved whilst enabling histological molecular analyses following fixation with a novel fixative, neutral buffered formalin (NBF) with 5% acetic acid (referred to hereafter as Form-Acetic)?

Summary Answer: Fixation with Form-Acetic improved ovarian tissue histology compared to NBF in multiple species while still enabling histological molecular analyses.

What Is Known Already: NBF fixation results in tissue shrinkage in various tissue types including the ovary. Components of ovarian tissue, notably follicles, are particularly susceptible to NBF-induced morphological alterations and can lead to data misrepresentation. Read More

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