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Reproductive performance, expression of TRAP6 and TGF-β4 genes in utero-vaginal junction mucosa, and indicators of liver function in female Chukar partridge (Alectoris chukar) breeders fed with fish oil and calcitriol during the egg-laying period.

Theriogenology 2021 Mar 30;168:50-58. Epub 2021 Mar 30.

Department of Animal Science, Sari Agricultural Science and Natural Resources University, Sari, 48177- 36781, Iran.

Reproductive attributes, expression of TRAP6 and TGF-β mRNA in the mucosa of the utero-vaginal junction (UVJ) of oviduct, and liver function were evaluated in Chukar partridge (Alectoris chukar) breeders subjected to long-term oral administration of fish oil (FO) and/or calcitriol (CT). A total of forty-eight 1.5-year-old laying Chukar partridges and 16 age-matched males (female:male ratio of 3:1) were randomly allocated to four groups (4 replicates of 3 female birds and one male bird each). Read More

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Healthcare Resource Utilization in Inguinal Hernia Repair: A Three-Year Cost Evaluation of Truven Health Marketscan Research Databases.

J Surg Res 2021 Apr 10;264:408-417. Epub 2021 Apr 10.

Department of Surgery, University of Wisconsin, 600 Highland Avenue MC 7375, Madison, WI 53792.

Background: Inguinal hernia repair is the most commonly performed elective operation in the United States, with over 800,000 cases annually. While clinical outcomes comparing laparoscopic versus open techniques have been well documented, there is little data comparing costs associated with these techniques. This study evaluates the cost of healthcare resources during the 90-d postoperative period following inguinal hernia repair. Read More

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Preoperative brain µ-opioid receptor availability predicts weight development following bariatric surgery in women.

JCI Insight 2021 Apr 13. Epub 2021 Apr 13.

Turku PET Centre, University Of Turku and Turku University Hospital, Turku, Finland.

Bariatric surgery is the most effective method for weight loss in morbid obesity. There is significant individual variability in the weight loss outcomes, yet factors leading to postoperative weight loss or weight regain remain elusive. Alterations in the µ-opioid receptor (MOR) and dopamine D2 receptor (D2R) systems are associated with obesity and appetite control, and the magnitude of initial brain receptor system perturbation may predict long-term surgical weight loss outcomes. Read More

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Telemedicine Medical Screening Evaluation Expedites the Initiation of Emergency Care for Children.

Pediatr Emerg Care 2021 Apr 9. Epub 2021 Apr 9.

From the *Division of Pediatric Emergency Medicine, Department of Pediatrics, New York City Health and Hospitals, Jacobi Medical Center; Division of Pediatric Emergency Medicine Departments of †Emergency Medicine ‡Pediatrics §Department of Emergency Medicine, NewYork-Presbyterian, Weill Cornell Medicine, New York, NY.

Objective: Prior studies show that staffing a physician at triage expedites care in the emergency department. Our objective was to describe the novel application and effect of a telemedicine medical screening evaluation (Tele-MSE) at triage on quality metrics in the pediatric emergency department (PED).

Methods: We conducted a retrospective quasi-experimental pre-post intervention study of patients presenting to an urban PED from December 2017 to November 2019 who received a Tele-MSE at triage. Read More

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Malnutrition risk prior to hematopoietic stem cell transplantation predicts mortality in adults.

Bone Marrow Transplant 2021 Apr 12. Epub 2021 Apr 12.

Division of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Patients with hematological malignancies have a high risk of developing malnutrition. Few data are currently available that illustrate the impact of the patients' nutritional status prior to HSCT on their outcome. The aim of this study was to investigate the association between the patients' malnutrition status prior to receiving autologous or allogeneic HSCT and mortality in adults with hematological malignancies. Read More

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When lockdown policies amplify social inequalities in COVID-19 infections: evidence from a cross-sectional population-based survey in France.

BMC Public Health 2021 Apr 12;21(1):705. Epub 2021 Apr 12.

Sorbonne University, Paris, France.

Background: Significant differences in COVID-19 incidence by gender, class and race/ethnicity are recorded in many countries in the world. Lockdown measures, shown to be effective in reducing the number of new cases, may not have been effective in the same way for all, failing to protect the most vulnerable populations. This survey aims to assess social inequalities in the trends in COVID-19 infections following lockdown. Read More

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Pre-deployment personality traits predict prescription opioid receipt over 2-year post-deployment period in a longitudinal cohort of deployed National Guard soldiers.

Addict Behav 2021 Mar 22;119:106919. Epub 2021 Mar 22.

Minneapolis VA Health Care System, Minneapolis, MN, USA; Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN, USA; Department of Psychology, University of Minnesota, Minneapolis, MN, USA. Electronic address:

Background: While military service members are at risk forpain conditions, receipt of prescribed opioids is associated with a range of serious adverse outcomes. The goal of this study is to examine the association between pre-deployment personality traits and receipt of prescription opioids after return from deployment.

Method: Data were drawn from the Readiness and Resilience in National Guard Soldiers (RINGS) cohort study, an ongoing study of post-deployment health. Read More

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Cognitive decline heralds onset of symptomatic inherited prion disease.

Brain 2021 Apr;144(3):989-998

Department of Neuropsychology, NHNN, University College London Hospitals NHS Foundation Trust, London, UK.

The clinical effectiveness of any disease-modifying treatment for prion disease, as for other neurodegenerative disorders, will depend on early treatment before damage to neural tissue is irrevocable. Thus, there is a need to identify markers that predict disease onset in healthy at-risk individuals. Whilst imaging and neurophysiological biomarkers have shown limited use in this regard, we recently reported progressive neurophysiological changes in individuals with the inherited prion disease mutation P102L. Read More

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[Retention of procedural competences in medicine students after training using a simulation model].

Rev Med Chil 2020 Oct;148(10):1427-1434

Departamento de Educación Médica, Facultad de Medicina, Universidad de Concepción, Concepción, Chile.

Background: Boot camps are used to acquire skills in simple surgical procedures, such as sutures, in a short period of time.

Aim: To assess the retention of the procedural skills of medical students who participated in a simulation-based suture workshop.

Material And Methods: One hundred five medical students were trained using the EPROBA methodology (Entrenamiento PROcedimental BAsico), with prior informed consent. Read More

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October 2020

Erosive Hand Osteoarthritis: Incidence and Predictive Characteristics among Participants in the Osteoarthritis Initiative.

Arthritis Rheumatol 2021 Apr 12. Epub 2021 Apr 12.

Care New England Medical Group/Primary Care and Specialty Services, Pawtucket, RI, USA.

Objective: To evaluate age, sex, race, osteoarthritis severity, metabolic factors, and bone health as risk factors for incident erosive hand osteoarthritis (EHOA) at baseline and over 48-month period.

Methods: This study was a longitudinal cohort design including participants from the Osteoarthritis Initiative with complete hand radiographs from baseline and 48-month visits who were eligible at baseline for incident EHOA. Individuals were classified as having EHOA if they had Kellgren-Lawrence (KL) grade≥2 in at least one interphalangeal joint on two different fingers and central erosion in at least one joint. Read More

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Impact of maternal medication for opioid use disorder on neurodevelopmental outcomes of infants treated for neonatal opioid withdrawal syndrome.

J Neonatal Perinatal Med 2021 Apr 2. Epub 2021 Apr 2.

Department of Pediatrics, University of Massachusetts Medical School-Baystate, Springfield, MA, USA.

Background: Increasing rates of maternal opioid use disorder has led to greater number of opioid exposed newborns (OENs). Maternal enrollment in medication for opioid use disorder (MOUD) program improves short term neonatal outcomes. This study aimed at assessing neurobehavioral outcomes for OENs. Read More

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Helping us grow generations of GPs (HUGG): a pilot study evaluating Longitudinal Support Networks (LSNs) on recruitment, retention and resilience of GPs in Derbyshire.

Educ Prim Care 2021 Apr 10:1-3. Epub 2021 Apr 10.

Division of Primary Care, University of Nottingham School of Medicine, Nottingham, UK.

: To understand if longitudinal support networks (LSNs), including all career stages in General Practice (GP) from medical school to retirement, provide informal cross-generational support impacting on recruitment, retention and resilience of GPs in Derbyshire.: Through open invitation, 39 participants interested in GP from medical school, through foundation, GP training and all stages of the GP career (including retired GPs) were joined together in small teams (LSNs). LSNs were encouraged to meet virtually to create an informal network, giving an opportunity to discuss all aspects of primary care as a group. Read More

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Pregnancy outcome in women with prior placenta accreta spectrum disorders treated with conservative-reconstructive surgery: analysis of 202 cases.

J Matern Fetal Neonatal Med 2021 Apr 11:1-5. Epub 2021 Apr 11.

CYMSA Clínica y Maternidad Suizo Argentina, Buenos Aires, Argentina.

Aim: To report the outcome of pregnant women with a prior pregnancy complicated by placenta accreta spectrum (PAS) disorders treated with resective-conservative surgery at the time of cesarean section.

Materials And Methods: Retrospective analysis of pregnant women treated with conservative surgery in the prior pregnancy complicated by PAS disorders. The primary outcome was spontaneous preterm birth with intact membranes or following a preterm labor rupture of the membranes before 37 weeks of gestation. Read More

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Patient Self-Assessment and Acoustic Voice Analysis in Screening of Postoperative Vocal Fold Paresis and Paralysis.

Scand J Surg 2021 Apr 12:14574969211007036. Epub 2021 Apr 12.

Heart Center, Kuopio University Hospital, Kuopio, Finland.

Background And Aims: The aim of this study was to evaluate the utility of two items in vocal fold paresis and paralysis screening after thyroid and parathyroid surgery: patient self-assessment of voice using the Voice Handicap Index and computer-based acoustic voice analysis using the Multi-Dimensional Voice Program.

Materials And Methods: This was a prospective study of 181 patients who underwent thyroid or parathyroid surgery over a 1-year study period (2017). Preoperatively, all patients underwent laryngoscopic vocal fold inspection and acoustic voice analysis, and they completed the Voice Handicap Index questionnaire. Read More

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Age and Inoculation Route Differentially Alter Metabolic Potential and Immune Cell Populations in Laying Hens.

Front Vet Sci 2021 26;8:653129. Epub 2021 Mar 26.

Department of Animal Science, Iowa State University, Ames, IA, United States.

In 2018 and 2019, was isolated from multiple post-molt commercial laying hens with unusually high mortality. A challenge study was conducted to elucidate the role of in this disease outbreak and the work herein represents the assessment of immunological responses in laying hens experimentally infected with isolates from these cases. A total of 200 laying hens at 22 or 96 weeks of age (100/ age group) were assigned to 1 of 4 experimental inoculation groups (negative control, oral gavage, subcutaneous injection, or intravenous injection) after a 72 h acclimation period. Read More

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Safety and Pharmacokinetics of FMX103 (1.5% Minocycline Topical Foam) in Subjects with Moderate-to-Severe Papulopustular Rosacea under Maximum-use Treatment Conditions.

J Clin Aesthet Dermatol 2021 Mar 1;14(3):E53-E57. Epub 2021 Mar 1.

Dr. Jones is with J&S Studies Inc., in College Station, Texas.

FMX103 1.5% is the first and only topical minocycline foam that is approved for the treatment of papulopustular rosacea in adults. We sought to characterize the safety and pharmacokinetics of minocycline under maximal-use conditions of FMX103 1. Read More

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Single-Arm, Multicenter Phase I/II Clinical Trial for the Treatment of Envenomings by Massive Africanized Honey Bee Stings Using the Unique Apilic Antivenom.

Front Immunol 2021 23;12:653151. Epub 2021 Mar 23.

Department of Infectology, Dermatology, Imaging Diagnosis and Radiotherapy, Botucatu Medical School (FMB), São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, Brazil.

We evaluated the safety, optimal dose, and preliminary effectiveness of a new-approach Africanized honeybee () Antivenom (AAV) in a phase I/II, multicenter, non-randomized, single-arm clinical trial involving 20 participants with multiple stings. Participants received 2 to 10 vials of AAV depending on the number of stings they suffered, or a predefined adjuvant, symptomatic, and complementary treatment. The primary safety endpoint was the occurrence of early adverse reactions within the first 24 h of treatment. Read More

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Changes in the Control of the Hypothalamic-Pituitary Gonadal Axis Across Three Differentially Selected Strains of Laying Hens ().

Front Physiol 2021 25;12:651491. Epub 2021 Mar 25.

Department of Animal Biosciences, University of Guelph, Guelph, ON, Canada.

Genetic selection for earlier sexual maturation and extended production cycles in laying hens has significantly improved reproductive efficiency. While limited emphasis has been placed on the underlying physiological changes, we hypothesize that modifications in the control of the hypothalamic-pituitary gonadal (HPG) axis have occurred. Thus, three strains of White leghorn derivatives were followed from hatch to 100 weeks of age (woa), including Lohmann LSL-lite ( = 120) as current commercial hens, heritage Shaver White leghorns ( = 100) as 2000s commercial equivalents, and Smoky Joe hens ( = 68) as 1960s commercial equivalents. Read More

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Exiting the COVID-19 pandemic: after-shock risks and avoidance of disruption tails in supply chains.

Dmitry Ivanov

Ann Oper Res 2021 Apr 5:1-18. Epub 2021 Apr 5.

Berlin School of Economics and Law, Department of Business and Economics, Professor of Supply Chain and Operations Management, 10825 Berlin, Germany.

Entering the COVID-19 pandemic wreaked havoc on supply chains. Reacting to the pandemic and adaptation in the "new normal" have been challenging tasks. Exiting the pandemic can lead to some after-shock effects such as "disruption tails. Read More

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Depression in patients with epilepsy during the COVID-19 pandemic based on longitudinal self-reporting.

Epileptic Disord 2021 Apr 9. Epub 2021 Apr 9.

Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Department of Neurology, Chengdu, Sichuan, China; University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

The current study screened major depression in people with epilepsy (PWE) during the epidemic of the novel coronavirus-related disease COVID-19, in order to identify whether the outbreak generated negative psychological impact on PWE. A Chinese version of the Neurological Disorders Depression Inventory for Epilepsy (C-NDDI-E), a self-reporting depression inventory, was applied for rapid detection of major depression. Assessment was carried out online during three different periods (prior to, during, and after the outbreak of COVID-19), with the aim of identifying changes in prevalence of depression and associated risk factors. Read More

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Damage of the ocular surface from indoor suntanning-Insights from in vivo confocal microscopy.

Cont Lens Anterior Eye 2021 Apr 8:101438. Epub 2021 Apr 8.

Department of Social Medicine and Healthcare Organization, Medical University, Varna, Bulgaria.

Purpose: To evaluate the ocular surface at the microstructural level of adults who habitually undertake indoor-suntanning utilising in vivo confocal microscopy.

Methods: Participants were prospectively recruited and enrolled into either а study group (n = 75) with a history UV indoor tanning, or a control group (n = 75) with no prior history of artificial tanning. The study group participated in voluntary tanning sessions performed with standard equipment and maintained their usual routine for eye protection. Read More

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Routine Laboratory Screening for Acetaminophen and Salicylate Ingestion in Preadmission Psychiatric Patients Is Unnecessary.

Ann Emerg Med 2021 Apr 8. Epub 2021 Apr 8.

Zablocki Veterans Administration Medical Center, Milwaukee, WI.

Study Objective: Screening preadmission psychiatric patients for acetaminophen or salicylate overdose is unnecessary in the absence of specific clinical concern for medication ingestion.

Methods: This was a multicenter retrospective cohort study of 3 Veteran's Administration emergency departments that medically evaluate patients prior to psychiatric admission. During the 10-year study period, these departments followed screening protocols that required the measurement of acetaminophen and salicylate levels on every patient prior to psychiatric admission. Read More

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Clinical impact of the heart team on the outcomes of surgical aortic valve replacement among octogenarians.

J Thorac Cardiovasc Surg 2021 Mar 11. Epub 2021 Mar 11.

Department of Cardiac Surgery, Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada. Electronic address:

Objectives: The effectiveness of a multidisciplinary heart team in the management of patients with severe symptomatic aortic stenosis is unknown. This study evaluated the impact of a heart team on the outcomes of surgical aortic valve replacement in octogenarians.

Methods: Between May 2007 and January 2016, 528 patients aged 80 years or more were referred to our institutional heart team for a transcatheter aortic valve replacement. Read More

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Inversion of T Waves on Admission is Associated with Mortality in Spontaneous Intracerebral Hemorrhage.

J Stroke Cerebrovasc Dis 2021 Apr 8;30(6):105776. Epub 2021 Apr 8.

Neurosciences Intensive Care Unit, Department of Neurology, University of Chicago Medicine and Biological Sciences, Chicago, Illinois, USA; Section of Neurosurgery, Department of Surgery, University of Chicago Medicine and Biological Sciences, Chicago, IL, USA. Electronic address:

Introduction: Cardiac dysfunction directly caused by spontaneous intracerebral hemorrhage (ICH) is a poorly understood phenomenon, and its impact on outcome is still uncertain. The aim of this study is to investigate the relationship between electrocardiographic (EKG) abnormalities and mortality in ICH.

Methods: This is a retrospective study analyzing EKG patterns on admission in patients admitted with ICH at a tertiary care center over an eight-year period. Read More

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Second stem cell transplantation for relapsed refractory light chain (AL) amyloidosis.

Transplant Cell Ther 2021 Apr 8. Epub 2021 Apr 8.

Division of Hematology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background: Autologous stem cell transplantation (ASCT) is an effective treatment modality in light chain (AL) amyloidosis but can be offered only to a subset of patients. The feasibility, benefit and risks of second ASCT (ASCT2) were rarely reported .

Objective: To assess the utility of ASCT2 in AL amyloidosis and to identify the target population with the greatest benefit . Read More

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Internalizing and externalizing problems across childhood and psychotic-like experiences in young-adulthood: The role of developmental period.

Schizophr Res 2021 Apr 7;231:108-114. Epub 2021 Apr 7.

Department of Psychology and Human Development, University College London, London WC1H 0AA, United Kingdom.

Background: Psychopathology in childhood and adolescence, commonly indexed by co-occurring internalizing and externalizing problem behaviors, has been found to predict psychotic-like experiences (PLEs) in adults. However, studies to date have rarely examined internalizing and externalizing problem behaviors simultaneously or identified in which developmental period do these problem behaviors predict PLEs in adults. This study tests to what extent internalizing and externalizing problem behaviors in childhood (4-9 years) or adolescence (11-16 years) predict PLEs in young-adulthood (18 years). Read More

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Long-term postoperative opioid prescription after cholecystectomy or gastric by-pass surgery: a retrospective observational study.

Scand J Pain 2021 Apr 12. Epub 2021 Apr 12.

Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.

Objectives: Opioids are commonly prescribed post-surgery. We investigated the proportion of patients who were prescribed any opioids 6-12 months after two common surgeries - laparoscopic cholecystectomy and gastric by-pass (GBP) surgery. A secondary aim was to examine risk factors prior to surgery associated with the prescription of any opioids after surgery. Read More

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The association of rocuronium dosing and first-attempt intubation success in adult emergency department patients.

CJEM 2021 Apr 10. Epub 2021 Apr 10.

Department of Emergency Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Background: The recommended rocuronium dose for rapid sequence intubation is 1.0 mg/kg; however, the optimal dose for emergency airway management is not clear. We assessed the relationship between rocuronium dose and first-attempt success among emergency department (ED) patients undergoing rapid sequence intubation. Read More

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The Impact of Antipsychotic Formulations on Time to Medication Discontinuation in Patients with Schizophrenia: A Dutch Registry-Based Retrospective Cohort Study.

CNS Drugs 2021 Apr 10. Epub 2021 Apr 10.

Department of Psychiatry, Erasmus Medical Centre, Epidemiological and Social Psychiatric Research Institute, Rotterdam, the Netherlands.

Background: Many patients with schizophrenia discontinue antipsychotic medication, frequently with adverse outcomes. Although different antipsychotic formulations are associated with different times to discontinuation, not much is known about discontinuation rates with oral-weekly formulations. Such a formulation of penfluridol is available in both the Netherlands and several other countries. Read More

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Randomized clinical trial to compare the efficacy of ivermectin versus placebo to negativize nasopharyngeal PCR in patients with early COVID-19 in Peru (SAINT-Peru): a structured summary of a study protocol for randomized controlled trial.

Trials 2021 Apr 9;22(1):262. Epub 2021 Apr 9.

School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, Peru.

Objectives: The primary objective is to determine the effect of a daily dose of ivermectin administered in three consecutive days to non-severe COVID-19 patients with no more than 96 hours of symptoms, on the detection of SARS-CoV-2 RNA by PCR from nasopharyngeal swabs at day seven post-treatment initiation. The secondary objectives are: 1. To assess the efficacy of ivermectin to reduce the SARS-CoV-2 viral load in the nasopharyngeal swab on days 4, 7, 14 and 21 post-treatment initiation 2. Read More

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