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Impact of the Global COVID-19 Pandemic on the Incidence, Presentation, and Management of Pediatric Appendicitis: Lessons Learned from the First Wave.

Eur J Pediatr Surg 2021 Jun 23. Epub 2021 Jun 23.

Department of Pediatric Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt (Main), Germany.

The fast-evolving nature of the coronavirus disease 2019 (COVID-19) pandemic has led to unprecedented clinical, logistical, and socioeconomical challenges for health-care systems worldwide. While several studies have analyzed the impact on the presentation and management of acute appendicitis (AA) in the adult population, there is a relative paucity of similar research in pediatric patients with AA. To date, there is some evidence that the incidence of simple AA in children may have decreased during the first lockdown period in spring 2020, whereas the number of complicated AA cases remained unchanged or increased slightly. Read More

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Bridging the Gap Between the Intensive Care Unit and the Acute Medical Care Unit.

Am J Crit Care 2021 May;30(3):193-200

Liron Sinvani is an associate professor, Division of Hospital Medicine, Department of Medicine, Zucker School of Medicine at Hofstra/Northwell, and an assistant professor, Feinstein Institutes for Medical Research, Northwell Health.

Background: Despite a growing cohort of intensive care unit (ICU) survivors, little is known about the early ICU aftercare period.

Objective: To identify gaps in early ICU aftercare and factors associated with poor hospital outcomes.

Methods: A multisite, retrospective study (January 1 to December 31, 2017) was conducted among randomly selected patients admitted to the medical ICU and subsequently transferred to acute medical care units. Read More

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Frequency of Clinical Alarms in Intensive Care Units and Nurses' Sensitivity to Them: An Observational Study.

Am J Crit Care 2021 May;30(3):186-192

Ülkü Yapucu Güneş is a professor, Fundamentals of Nursing Department, Faculty of Nursing, Ege University, Bornova-Izmir, Turkey.

Background: All clinical alarms require nurses to respond even if an intervention is not needed. Nurses are expected to respond appropriately to each alarm and establish priorities among their care practices accordingly. This study was conducted to examine the number and types of clinical device alarms used in intensive care units, the duration of their activation, and nurses' degree of sensitivity to them. Read More

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Can Xenobiotics Alter the Sex Ratio of Crocodilians in the Wild?

Satomi Kohno

Sex Dev 2021 Jun 23:1-8. Epub 2021 Jun 23.

Aquatic Toxicology Laboratory, Department of Biological Sciences, Saint Cloud State University, St. Cloud, Minnesota, USA.

All crocodilians exhibit temperature-dependent sex determination without sex chromosomes. This temperature dependency can be overridden by exposure to estrogen via estrogen receptor 1. Thus, the sex ratio of crocodilian species is vulnerable to estrogenic xenobiotics. Read More

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Intrusion Errors and Progression of Cognitive Deficits in Older Adults with Mild Cognitive Impairment and PreMCI States.

Dement Geriatr Cogn Disord 2021 Jun 23:1-8. Epub 2021 Jun 23.

Center for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA.

Introduction: Among persons with amnestic mild cognitive impairment (aMCI), intrusion errors on subscales that measure proactive semantic interference (PSI) may be among the earliest behavioral markers of elevated Alzheimer's disease brain pathology. While there has been considerable cross-sectional work in the area, it is presently unknown whether semantic intrusion errors are predictive of progression of cognitive impairment in aMCI or PreMCI (not cognitively normal but not meeting full criteria for MCI).

Methods: This study examined the extent to which the percentage of semantic intrusion errors (PIE) based on total responses on a novel cognitive stress test, the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L), could predict clinical/cognitive outcomes over an average 26-month period in older adults initially diagnosed with aMCI, PreMCI, and normal cognition. Read More

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Prevalence, healthcare resource utilization and mortality of Lennox-Gastaut syndrome: retrospective linkage cohort study.

Seizure 2021 Jun 9;91:159-166. Epub 2021 Jun 9.

Evidence Synthesis, Modeling, Communications, Evidera, The Ark, 201 Talgarth Road, London W6 8BJ, UK. Electronic address:

Purpose: To retrospectively investigate the prevalence, demography, antiseizure medication (ASM) usage, healthcare resource utilization (HCRU), and mortality of patients with Lennox-Gastaut syndrome (LGS) in primary and secondary care in the UK.

Methods: Patients with confirmed LGS were anonymously identified from the UK Clinical Practice Research Datalink (CPRD) GOLD database (01/01/1987-31/10/2018) using the LGS Read Code (F250500). Probable LGS was identified using the International Classification of Diseases-10/Read Code for epilepsy (Hospital Episode Statistics [HES]/CPRD) plus rufinamide prescription. Read More

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How to switch disease-modifying treatments in multiple sclerosis: Guidelines from the French Multiple Sclerosis Society (SFSEP).

Mult Scler Relat Disord 2021 Jun 10;53:103076. Epub 2021 Jun 10.

Service de Neurologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

Background: Today, there are no recommendations on switching disease-modifying treatments (DMTs) in multiple sclerosis (MS).

Objectives: To establish guidelines on switching DMTs MS.

Methods: A Steering Committee composed of seven MS experts from the French Group for Recommendations in Multiple Sclerosis (France4MS) defined 15 proposals. Read More

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Are other tick-borne infections overlooked in patients investigated for Lyme neuroborreliosis? A large retrospective study from South-eastern Sweden.

Ticks Tick Borne Dis 2021 Jun 4;12(5):101759. Epub 2021 Jun 4.

Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Linköping University, Linköping, Sweden; Department of Infectious Diseases, Region Östergötland County, Linköping/Norrköping, Sweden.

In Europe, the hard tick Ixodes ricinus is considered the most important vector of human zoonotic diseases. Human pathogenic agents spread by I. ricinus in Sweden include Borrelia burgdorferi sensu lato (s. Read More

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Two novel variants in PLOD1 causing hydrocephalus in female newborn with kyphoscoliotic Ehlers-Danlos syndrome.

Eur J Med Genet 2021 Jun 20:104269. Epub 2021 Jun 20.

Department of Neonatology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

The kyphoscoliotic Ehlers-Danlos syndrome (kEDS) is a rare autosomal recessive connective tissue disorder characterized by hyperextensible skin and joints, kyphoscoliosis, and severe muscle hypotonia at birth. Causal variants have been identified in PLOD1 resulting in lysyl hydroxylase deficiency responsible for kEDS. However, the detailed phenotype of kEDS during the perinatal period is still poorly recognized. Read More

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The effect of selected in ovo green light photostimulation periods on post-hatch broiler growth and somatotropic axis activity.

Poult Sci 2021 Apr 30;100(8):101229. Epub 2021 Apr 30.

Department of Animal Sciences, The Hebrew University of Jerusalem, Robert H. Smith Faculty of Agriculture, Food and Environment, Rehovot 76100, Israel.

Targeted in ovo green light (GL) photostimulation during the last days of broiler egg incubation increases embryonic expression of the somatotropic axis, similar to in ovo green light photostimulation from embryonic day (ED) 0 to the end of incubation. The aim of this study was to examine the effect of selected in ovo GL photostimulation periods on post-hatch broiler growth. Four hundred twenty fertile broiler eggs were divided into 7 treatment groups: the first incubated in the dark (standard conditions) as a negative control; the second incubated under monochromatic GL from ED0-ED20 (positive control); the third group incubated under monochromatic GL light from ED15-ED20; the fourth, fifth and sixth groups were incubated under monochromatic GL on ED16, ED17, and ED18, respectively; and the seventh group was incubated under monochromatic GL from ED18-ED20. Read More

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Comparison of Cost and Complication Rates for Profiling Hospital Performance in Lumbar Fusion for Spondylolisthesis.

Spine J 2021 Jun 20. Epub 2021 Jun 20.

Departments of Neurological Surgery.

Background Context: There is growing interest among payers in profiling hospital value and quality-of-care, including both the cost and safety of common surgeries, such as lumbar fusion. Nonetheless, there is sparse evidence describing the statistical reliability of such measures when applied to lumbar fusion for spondylolisthesis.

Purpose: To evaluate the reliability of 90-day inpatient hospital costs, overall complications, and rates of serious complications for profiling hospital performance in lumbar fusion surgery for spondylolisthesis. Read More

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Cooling Blankets in Hospitalized Patients: Time to Reevaluate.

Am J Med Sci 2021 Jun 20. Epub 2021 Jun 20.

Jane and Dayton Brown Division of Infectious Diseases at the Barbara and Donald Zucker School of Medicine at Northwell/Hofstra University, 400 Community Drive, Manhasset, NY 11030, United States. Electronic address:

Background: The therapeutic benefits and rationale for treating fevers with external cooling methods remain unclear. We aimed to describe the clinical settings in which cooling blankets (CBs) are used.

Design: We conducted a retrospective chart review of CB use in adult patients admitted to our tertiary care center over a one-year period. Read More

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Correlation between ambulatory blood pressure monitoring and office blood pressure measurement in patients with hypertension: A Community Study.

Am J Med Sci 2021 Jun 20. Epub 2021 Jun 20.

Medical Affairs Department, Eris Life Sciences, Ahmedabad. Electronic address:

Background: The current gold standard for blood pressure (BP) measurements is based on office BP measurements (OBPMs) by a sphygmomanometer or a digital device. Ambulatory BP measurement (ABPM) is a noninvasive method for continuous monitoring of BP over a 24-hour period during routine activities of the patient. Thus, ABPM offers multiple BP readings during the patients' daily routine as compared to the single reading by OBPM at rest. Read More

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Determinants of distinct trajectories of fatigue in patients undergoing chemotherapy for a metastatic colorectal cancer: 6-month follow-up using Growth Mixture Modeling.

J Pain Symptom Manage 2021 Jun 20. Epub 2021 Jun 20.

Univ. Paul Valéry Montpellier 3, Univ. Montpellier, EPSYLON EA 4556, F34000, Montpellier, France; Epidaure Prevention Department, Montpellier Cancer Institute, Montpellier, France.

Objective: This longitudinal prospective and observational study was designed to identify fatigue trajectories during a 6-month period of chemotherapy in patients with metastatic colorectal cancer, and examine the psychosocial factors predicting these trajectories. Associations between fatigue and survival were also investigated.

Methods: A total of 169 patients (M=64. Read More

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Population Dynamic Regulators in an Empirical Predator-Prey System.

J Theor Biol 2021 Jun 20:110814. Epub 2021 Jun 20.

Inst. of Marine Res, PO Box 1870, Bergen 5817, Norway. Electronic address:

Capelin (Mallotus villosus) is a short-lived (1-4 years) fish species, that plays a crucial role by dominating the intermediate trophic level in the Barents Sea. Several episodes of extreme biomass decline (collapse) have been observed during the last three decades. We postulate that these collapses might be regulated by food availability (bottom-up effect) and/or by time discrepancy between capelin feeding and abundance of its prey (match-mismatch hypothesis). Read More

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Crystalline Sponge Affinity Screening: A Fast Tool for Soaking Condition Optimization without the Need of X-ray Diffraction Analysis.

Eur J Pharm Sci 2021 Jun 20:105884. Epub 2021 Jun 20.

Discovery and Development Technologies (DDTech), Merck KGaA, Frankfurter Strasse 250, 64293 Darmstadt, Germany.

Structural elucidation of small molecules only available in low quantity (nanogram) is one of the big advantages of the crystalline sponge method. The optimization of various soaking parameters is crucial for effective analyte absorption and repetitive positioning in the pores of the crystal. Time-consuming X-ray diffraction measurements are necessary for data collection and confirmation of successful guest inclusion. Read More

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One-Year Clinical and Imaging Follow-up After Exercise-Based Treatment for Acute Complete Adductor Longus Tendon Avulsions in Athletes: A Prospective Case Series.

Am J Sports Med 2021 Jun 23:3635465211015996. Epub 2021 Jun 23.

Erasmus MC Center for Groin Injuries, Department of Orthopaedics, Erasmus MC University Medical Centre, Rotterdam, the Netherlands.

Background: Complete avulsions of the adductor longus tendon are serious injuries, yet we have few data to inform clinical decisions on management. Previous studies are limited by a lack of detailed follow-up.

Purpose: To describe detailed clinical and imaging measures 1 year after complete proximal adductor longus avulsion injuries in athletes who received exercise-based treatment. Read More

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The Impact of COVID-19 on Speech-Language Pathologists Engaged in Clinical Practices With Elevated Coronavirus Transmission Risk.

Am J Speech Lang Pathol 2021 Jun 23:1-13. Epub 2021 Jun 23.

Department of Otolaryngology - Head and Neck Surgery, Division of Laryngology, Stanford University School of Medicine, CA.

Purpose This study assessed and described potential clinical practice changes secondary to COVID-19 that emerged as an early response to the pandemic for speech-language pathologists (SLPs) engaged in voice, alaryngeal, and swallowing activities that may increase the risk of virus transmission. Method SLPs from the United States and Canada ( = 665) who were engaged in clinical activities that might elevate the risk of COVID-19 exposure completed an online survey regarding their clinical practices. Topics assessed included potential clinical service modifications, COVID-19 testing and health, and potential financial impacts in the early time period of the pandemic. Read More

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The Effects of Vaccine Standing Orders on Pediatric Vaccination Rates: A Pilot Study.

S D Med 2021 Feb;74(2):54-57

Monument Health, Spearfish, South Dakota.

Introduction: Vaccinations are one of the greatest public health achievements of the 20th century, leading to a reduction in morbidity and mortality associated with the infectious diseases they prevent. Unfortunately, vaccination rates within the U.S. Read More

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February 2021

Vitamin D status in children with intestinal failure who have achieved enteral autonomy.

Nutr Clin Pract 2021 Jun 23. Epub 2021 Jun 23.

Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Connecticut Children's Medical Center, Hartford, Connecticut, USA.

Background: Vitamin D deficiency is highly prevalent in children with intestinal failure (IF) who receive parenteral nutrition (PN), but data on vitamin D status after achieving enteral autonomy (EA) are limited. We aimed to evaluate the prevalence of vitamin D deficiency in this population while exploring clinical variables that may be associated with its development.

Methods: A retrospective review was performed on 29 children with IF who had achieved EA. Read More

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Clinical Outcomes After 4.5 Years of Eliglustat Therapy for Gaucher Disease Type 1: Phase 3 ENGAGE Trial Final Results.

Am J Hematol 2021 Jun 23. Epub 2021 Jun 23.

Sanofi Genzyme, Cambridge, MA, USA.

Eliglustat, an oral substrate reduction therapy, is approved for eligible adults with Gaucher disease type 1. In the Phase 3 ENGAGE trial of previously untreated adults with Gaucher disease type 1, eliglustat-treated patients had statistically significant improvements in organ volumes and hematologic parameters compared with placebo in the 9-month primary analysis. We report final outcomes by time on eliglustat among all patients who participated in the ENGAGE trial and extension. Read More

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Organ donation in the ICU - a survey on next of kin response in two Swiss academic centres.

Swiss Med Wkly 2021 Jun 23;151:w20515. Epub 2021 Jun 23.

Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.

Aim Of The Study: In the Swiss population, attitudes to organ donation are mostly positive. However, a high refusal rate by the next of kin may be observed. We aimed to investigate potential underlying reasons. Read More

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Comparison of the Safety of Prophylactic Anticoagulants After Intracranial Surgery.

Neurosurgery 2021 Jun 23. Epub 2021 Jun 23.

Department of Neurosurgery, University of California, Los Angeles, Los Angeles, California, USA.

Background: Venous thromboembolism (VTE) represents a rare but preventable postoperative complication. Unfractionated heparin (UH) and low-molecular-weight heparin (LMWH) are used to prevent VTE, but comparative studies of their safety and efficacy in the neurosurgical context are limited.

Objective: To determine the relative safety and efficacy of UH and LMWH for prophylaxis after cranial surgery. Read More

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Cyclophosphamide-induced inflammation of taste buds and cytoprotection by amifostine.

Chem Senses 2021 Jun 23. Epub 2021 Jun 23.

Department of Biology and Vermont Chemosensory Group, University of Vermont, 109 Carrigan Drive, Burlington, Vermont, United States of America.

Taste buds in the oral cavity have a complex immune system regulating normal functions and inflammatory reactions. Cyclophosphamide (CYP), a chemotherapy drug, has wide ranging disruptive effects on the taste system including loss of taste function, taste sensory cells, and capacity for taste cell renewal. In bladder epithelium, CYP also induces inflammation. Read More

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Suspected vertical transmission of Chagas disease caused by DTU TcIV in an infection probably transmitted orally, during anoutbreak in the Brazilian Amazon.

Rev Inst Med Trop Sao Paulo 2021 18;63:e48. Epub 2021 Jun 18.

Universidade de São Paulo, Faculdade de Medicina, São Paulo, São Paulo, Brazil.

This study describes difficulties in the monitoring of a child born during an oral outbreak of Chagas disease, in which there are several indications that the transmission occurred through the congenital route: 1. the mother was in the third trimester of pregnancy when she was infected; 2. She presented high parasitemia at the time of delivery; 3. Read More

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Current situation of Chagas disease vectors (Hemiptera, Reduviidae) in Southern Rio Grande do Sul State, Brazil.

Rev Inst Med Trop Sao Paulo 2021 18;63:e47. Epub 2021 Jun 18.

Universidade Federal de Pelotas, Instituto de Biologia, Programa de Pós-Graduação em Parasitologia, Pelotas, Rio Grande do Sul, Brazil.

Chagas disease (CD) has been considered endemic in the South of Rio Grande do Sul (RS) State, Brazil. This study aimed at evaluating the occurrence of Trypanosoma cruzi vectors based on the main species captured in Southern Rio Grande do Sul State from 2008 to 2019. The study area comprised counties that belong to the 3rd Regional Health Coordination (RHC) and to the 7th RHC, whose headquarters are in Pelotas and Bage, respectively. Read More

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Influence of unstable shoes on women with lumbopelvic postpartum pain: randomized clinical trial.

Sao Paulo Med J 2021 Jun 11. Epub 2021 Jun 11.

PT, MSc, PhD. Senior Lecturer and Researcher, School of Sport Sciences, Universidad Europea de Madrid, Villaviciosa de Odón, Madrid, Spain.

Background: Back pain is a normal symptom during pregnancy and is expected to become worse beyond the first three months after childbirth.

Objectives: To determine the effectiveness of wearing unstable shoes instead of conventional shoes, regarding pain intensity, low back mobility and stability, among women with lumbopelvic pain (LPP) during the postpartum period.

Design And Setting: Prospective, single-blinded, randomized clinical trial conducted at a podiatry and physiotherapy clinical center. Read More

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Classification of homogeneous regions of vegetation cover in the State of Rio Grande do Sul, Brazil and its temporal dynamics, using AVHRR GIMMS and MODIS data sets.

An Acad Bras Cienc 2021 16;93(3):e20201278. Epub 2021 Jun 16.

Programa de Pós-Graduação em Sensoriamento Remoto, Universidade Federal do Rio Grande do Sul, Centro Estadual de Pesquisas em Sensoriamento Remoto e Meteorologia, Av. Bento Gonçalves, 9500, Setor 5, Prédio 44202, 91501-970 Porto Alegre, RS, Brazil.

This study aimed to classify the homogeneous regions of vegetation cover, which occur in Rio Grande do Sul, formed by clustering of pixels with same pattern of temporal variability of the Normalized Difference Vegetation Index (NDVI) of AVHRR GIMMS and MODIS series and to compare their temporal dynamics. We use K means cluster analysis for defining homogeneous regions, based on the temporal variability of GIMMS (8 km spatial resolution) and MODIS (1 km spatial resolution) NDVI data sets, using monthly images mean from 2000 to 2008 (overlapping period); and we analyzed the annual pattern of NDVI. Accuracy assessment was done with Landsat images. Read More

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Comparison of two pandemics: H1N1 and SARS-CoV-2.

Rev Assoc Med Bras (1992) 2021 Jan;67(1):115-119

Karadeniz Technical University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology - Trabzon, Turkey.

Objective: We aimed to compare the clinical, epidemiological, and prognostic features of the H1N1 pandemic in 2009 and the severe acute respiratory syndrome coronavirus 2 pandemic in 2020.

Methods: This retrospective study involved subjects from seven centers that were admitted and found to be positive for H1N1 or COVID-19 real-time polymerase chain reaction test.

Results: A total of 143 patients with H1N1 and 309 patients with COVID-19 were involved in the study. Read More

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January 2021

Association between autism spectrum disorder and changes in the central auditory processing in children.

Rev Assoc Med Bras (1992) 2021 Jan;67(1):156-162

Universidade Federal de Santa Catarina - Florianópolis (SC), Brasil.

Objective: To verify the scientific evidence on the association between Autistic Spectrum Disorder and Central Auditory Processing Disorder in children, aiming to answer the following research question: What is the association between Autistic Spectrum and Alteration of Auditory Processing in Children?

Methods: Studies were chosen through the combination based on the Medical Subject Heading Terms (MeSH): [(auditory processing) and (children) and (autism) and (neurological disorders)]. The MEDLINE (PubMed), LILACS, and SciELO databases were used. The analyzed papers covered a ten-year period, from 2010 to 2020. Read More

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January 2021