29,618 results match your criteria perinatal mortality

Rotational Thromboelastometry in Neonates Admitted to a Neonatal Intensive Care Unit: A Large Cross-sectional Study.

Semin Thromb Hemost 2021 Jun 15. Epub 2021 Jun 15.

Laboratory of Haematology and Blood Bank Unit, "Attikon" Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

The aim of the present study was to assess the coagulation profile in neonatal critical illness using rotational thromboelastometry (ROTEM), and to investigate its association with disease severity and its potential prognostic role in this clinical setting. Over a period of 67 months (July 2014-February 2020) 423 critically ill neonates with confirmed or suspected sepsis, perinatal hypoxia, or respiratory distress syndrome, hospitalized in our neonatal intensive care unit were included in the study. Demographic, clinical, and laboratory data were recorded on admission day and arterial blood was analyzed on ROTEM analyzer using the standard extrinsically activated rotational thromboelastometry assay (EXTEM). Read More

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Comparison between Cerebroplacental Ratio and Umbilicocerebral Ratio in Predicting Adverse Perinatal Outcome in Pregnancies Complicated by Late Fetal Growth Restriction: A Multicenter, Retrospective Study.

Fetal Diagn Ther 2021 Jun 15:1-9. Epub 2021 Jun 15.

Center for High Risk Pregnancy and Fetal Care, Department of Obstetrics and Gynecology, University of Chieti, Chieti, Italy.

Introduction: The role of cerebroplacental ratio (CPR) or umbilicocerebral ratio (UCR) to predict adverse intrapartum and perinatal outcomes in pregnancies complicated by late fetal growth restriction (FGR) remains controversial.

Methods: This was a multicenter, retrospective cohort study involving 5 referral centers in Italy and Spain, including singleton pregnancies complicated by late FGR, as defined by Delphi consensus criteria, with a scan 1 week prior to delivery. The primary objective was to compare the diagnostic accuracy of the CPR and UCR for the prediction of a composite adverse outcome, defined as the presence of either an adverse intrapartum outcome (need for operative delivery/cesarean section for suspected fetal distress) or an adverse perinatal outcome (intrauterine death, Apgar score <7 at 5 min, arterial pH <7. Read More

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Swedish intrauterine growth reference ranges for estimated fetal weight.

Sci Rep 2021 Jun 14;11(1):12464. Epub 2021 Jun 14.

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

Fetal growth restriction is a strong risk factor for perinatal morbidity and mortality. Reliable standards are indispensable, both to assess fetal growth and to evaluate birthweight and early postnatal growth in infants born preterm. The aim of this study was to create updated Swedish reference ranges for estimated fetal weight (EFW) from gestational week 12-42. Read More

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Differences in Postmortem Investigation Following Perinatal Death.

Am J Perinatol 2021 Jun 14. Epub 2021 Jun 14.

Department of Pediatrics, Neonatal Division, Brooke Army Medical Center, Fort Sam Houston, Texas.

Objective:  The study aimed to describe the postmortem investigation patterns for perinatal deaths and compare the degree of investigation between stillbirths and early neonatal deaths.

Study Design:  We conducted a single-center retrospective review of all perinatal deaths from 2011 to 2017. Perinatal death was defined as intrauterine fetal death at ≥20 weeks' gestation, plus neonatal deaths within the first 7 days of life. Read More

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Distinct maternal and fetal pregnancy outcomes in women with sickle cell disease can be predicted using routine clinical and laboratory data.

Br J Haematol 2021 Jun 14. Epub 2021 Jun 14.

Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

We aimed to identify risk factors for adverse outcomes in pregnancies of women with sickle cell disease (SCD) and develop risk prediction models. Models were derived from a retrospective cohort of pregnant women with SCD and constructed using generalised estimating equation logistic regression, with clustering by woman. Maternal event(s) consisted of acute anaemia; cardiac, pulmonary, hepatobiliary, musculoskeletal, skin, splenic, neurological or renal complications, multi-organ failure, venous thromboembolism, admission-requiring vaso-occlusive events (VOE), red cell transfusion, mortality or hypertensive disorder of pregnancy. Read More

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Care practices and outcomes of extremely preterm neonates born at 22-24 weeks -A single centre experience.

J Neonatal Perinatal Med 2021 Jun 5. Epub 2021 Jun 5.

Newborn Services, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.

Background: Wide variation in the care practices and survival rates of neonates born at peri-viable gestational ages of 22 +0 -24 +6 weeks exists. This study elucidates the postnatal risk factors for morbidity/mortality, contrasts the care practices and short-term outcomes of this vulnerable group of preterm neonates from a single center with others.

Methods: Retrospective study of neonates born at 22 +0 -24 +6 weeks in a level 3 neonatal intensive care unit in UK, over a period of 4 years (2016-2019). Read More

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Predictors of mortality in premature babies with respiratory distress syndrome treated by early rescue surfactant therapy.

J Neonatal Perinatal Med 2021 Jun 7. Epub 2021 Jun 7.

Department of Pediatrics, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Objective: To determine the predictors of mortality following early rescue surfactant therapy in preterm babies with respiratory distress syndrome.

Study Design: Prospective cohort study enrolling babies between 28 weeks to 34 weeks with respiratory distress syndrome requiring early rescue surfactant therapy. For statistical analysis babies were further divided into two subgroups: survivors and non-survivors. Read More

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Pregnancy and Viral infections: Mechanisms of fetal damage, diagnosis and prevention of neonatal adverse outcomes from cytomegalovirus to SARS-CoV-2 and Zika virus.

Biochim Biophys Acta Mol Basis Dis 2021 Jun 9:166198. Epub 2021 Jun 9.

Fetal and Perinatal Medicine and Surgery Unit, Medical and Surgical Department of Fetus, Newborn and Infant - "Bambino Gesù" Children's Hospital IRCCS, Rome, Italy.

Some maternal infections, contracted before or during pregnancy, can be transmitted to the fetus, during gestation (congenital infection), during labor and childbirth (perinatal infection) and through breastfeeding (postnatal infection). The agents responsible for these infections can be viruses, bacteria, protozoa, fungi. Among the viruses most frequently responsible for congenital infections are Cytomegalovirus (CMV), Herpes simplex 1-2, Herpes virus 6, Varicella zoster. Read More

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Naringenin prevents pregnancy-induced hypertension via suppression of JAK/STAT3 signaling pathway in mice.

Int J Clin Pract 2021 Jun 12:e14509. Epub 2021 Jun 12.

Department of Obstetrics, ZiBo Central Hospital, No.54 of Gongqingtuan West Road, Zhangdian District, Zibo, 255000, Shandong, China.

Background: Pregnancy-induced hypertension (PIH) is characterized by high blood pressure during pregnancy, which causes perinatal and maternal mortality. Inflammation, oxidative stress and the JAK2/STAT3 signaling pathway have been reported to play critical roles in the pathogenies of PIH. Due to the safety and side effects of current treatments for PIH, searching for new therapeutic agents is urgently needed. Read More

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Comparison of the fertility of tumor suppressor gene-deficient C57BL/6 mouse strains reveals stable reproductive aging and novel pleiotropic gene.

Sci Rep 2021 Jun 11;11(1):12357. Epub 2021 Jun 11.

Department of Radiobiology and Hygiene Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka Yahatanishi-ku, Kitakyushu, 807-8555, Japan.

Tumor suppressor genes are involved in maintaining genome integrity during reproduction (e.g., meiosis). Read More

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Chlamydia pecorum detection in aborted and stillborn lambs from Western Australia.

Vet Res 2021 Jun 11;52(1):84. Epub 2021 Jun 11.

Centre for Animal Production and Health, Murdoch University, South Street, Murdoch, WA, 6150, Australia.

Lamb survival is an important welfare and productivity issue for sheep industries worldwide. Lower lamb survival has been reported for primiparous ewes, but the causes of this are not well studied. The aim of this study was to determine causes of perinatal deaths for lambs born to primiparous ewes in Western Australia, and identify if infectious diseases are implicated. Read More

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Phosphodiesterase-5 inhibitors in Pregnancy: Systematic review and meta-analysis of maternal and perinatal safety and clinical outcomes.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

Mater Research Institute - University of Queensland, Level 3 Aubigny Place, Raymond Terrace, South Brisbane, Queensland 4101, Australia; Faculty of Medicine, University of Medicine, Whitty Building, Annerley Road, South Brisbane, Queensland 4101, Australia; NHMRC Stillbirth Centre For Research Excellence, Mater Research Institute, South Brisbane, Queensland 4101, Australia. Electronic address:

Objective: Phosphodiesterase-5 inhibitors have recently been used for the treatment of severe early onset pre-eclampsia and fetal growth restriction. There are however concerns that they may increase the risk of neonatal morbidity and mortality. The aim of this systematic review was to assess the safety profile and clinical outcomes of phosphodiesterase-5 inhibitors use in pregnancy. Read More

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Clinical characteristics, management, and short term outcome of neonates born to mothers with COVID-19 in a tertiary care hospital in India.

J Trop Pediatr 2021 Jun 11. Epub 2021 Jun 11.

ICMR-National Institute for Research in Reproductive Health, Mumbai, India.

Lay Summary: The current pandemic of COVID-19 has affected all the countries globally. However, the adverse impact of the pandemic is more seen in the low-income and middle-income countries (LMICs). Although there is evidence on the adverse impact of the SARS-CoV-2 on the health of mothers and neonates, the evidence is mainly from high-income countries. Read More

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Outcomes of sustained fetal tachyarrhythmias after transplacental treatment.

Heart Rhythm O2 2021 Apr 9;2(2):160-167. Epub 2021 Mar 9.

Obstetric and Maternal Fetal Medicine and EA7328.

Background: Fetal tachyarrhythmia is a condition that may lead to cardiac dysfunction, hydrops, and death. Despite a transplacental treatment, failure to obtain or maintain sinus rhythm may occur.

Objective: We aimed to analyze the perinatal outcomes of sustained fetal tachyarrhythmias after in utero treatment. Read More

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Analysis of Factors Associated With Variability and Acidosis of the Umbilical Artery pH at Birth.

Front Pediatr 2021 25;9:650555. Epub 2021 May 25.

Department of Health Sciences Program, Universidad Católica de Murcia (UCAM), Guadalupe, Murcia, Spain.

Perinatal asphyxia is a significant contributing factor for neonatal morbidity and mortality. The aim of this study was to investigate the clinical factors associated with umbilical artery pH variability and fetal acidosis at birth. This is a single center cross-sectional study in a public regional hospital in southeastern Spain from January to December 2019. Read More

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Changes in trends and outcomes of eclampsia: a success story from Qatar.

Qatar Med J 2019 20;2019(1):10. Epub 2019 Sep 20.

Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar.

Preeclampsia and eclampsia are two hypertensive disorders of pregnancy that significantly contribute to higher morbidity and mortality rates. Eclampsia is the occurrence of seizures in patients with preeclampsia without any previous history of seizure disorders. The incidence and prevalence of eclampsia varies, and there is scarce literature about the prevalence and trends of eclampsia in the Arabian Gulf countries. Read More

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September 2019

Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia.

Circulation 2021 Jun 11. Epub 2021 Jun 11.

Center for Lung Regenerative Medicine, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Pulmonary hypertension (PH) is a common complication in patients with Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV), a severe congenital disorder associated with mutations in the gene. While the loss of alveolar microvasculature causes PH in ACDMPV patients, it is unknown whether increasing neonatal lung angiogenesis could prevent PH and right ventricular (RV) hypertrophy. We used echocardiography, RV catheterization, immunostaining and biochemical methods to examine lung and heart remodeling and RV output in mice carrying the mutation (identified in ACDMPV patients). Read More

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Maternal and Fetal Vascular Lesions of Malperfusion in the Placentas Associated with Fetal and Neonatal Death: Results of a Prospective Observational Study.

Am J Obstet Gynecol 2021 Jun 7. Epub 2021 Jun 7.

Columbia University, New York NY USA.

Background: Fetal death, one of the major adverse pregnancy outcomes, is especially common in low and middle-income countries. Placental lesions may play an important role in the etiology of fetal and possibly neonatal death. Prior research relating placental lesions to fetal death causation was often hindered by the lack of agreement on a placental classification scheme. Read More

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'It looks like a breadbox': a pilot study investigating implementation of the Pepi-Pod® program with Aboriginal families in metropolitan South Australia.

Prim Health Care Res Dev 2021 Jun 10;22:e29. Epub 2021 Jun 10.

Child and Family Health Services, SA Health, Adelaide, SA, Australia.

Aims: To collaboratively explore the cultural acceptance of the Pepi-Pod® program as an alternate safe sleep space and to explore the process of implementing the Pepi-Pod® program in a mainstream health service for Aboriginal families living in urban South Australia.

Background: Aboriginal and Torres Strait Islander infants continue to die from sudden infant death syndrome (SIDS) and sudden unexpected death in infancy (SUDI) at rates three to four times greater than other infants born in Australia despite Council of Australian Governments commitment to halve the gap in the Indigenous infant mortality rate by 2018. The Pepi-Pod® program is evidenced in New Zealand and Queensland to provide a culturally appropriate safe sleep alternative that contributes to the reduction of SIDS and SUDI. Read More

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Pregnancy-related acute kidney injury at high altitude: a retrospective observational study in a single center.

BMC Nephrol 2021 Jun 9;22(1):215. Epub 2021 Jun 9.

Department of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Background: Pregnancy-related acute kidney injury (Pr-AKI) is associated with maternal and fetal morbidity and mortality. There are few studies focusing on Pr-AKI at high altitude in the literature.

Objectives: to investigate the incidence, etiology, clinical features and maternal-fetal outcomes of Pr-AKI in women living at high altitude. Read More

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Mapping Hospital-Based Lactation Care Provided to Bereaved Mothers: A Basis for Quality Improvement.

Breastfeed Med 2021 Jun 9. Epub 2021 Jun 9.

Research School of Social Sciences, Australian National University, Acton, Australia.

The study aimed to identify and map the factors that shape the delivery of hospital-based lactation care for bereaved mothers to inform quality improvement initiatives targeting hospital-based lactation care. Focus groups and interviews were conducted at three large hospitals in Australia with 113 health professionals including obstetricians, neonatologists, midwives, neonatal nurses, lactation consultants, social workers or pastoral care workers, Human Milk Bank (HMB) staff, and perinatal bereavement nurses. Thematic and interactional data analysis identified the nature, scope, and pattern of bereavement lactation care. Read More

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Epidemiology and outcomes of infants after cardiopulmonary resuscitation in the neonatal or pediatric intensive care unit from a national registry.

Resuscitation 2021 Jun 6;165:14-22. Epub 2021 Jun 6.

Division of Neonatology, Department of Pediatrics, The Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19104, United States; Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, United States.

Aim: Cardiopulmonary resuscitation (CPR) in hospitalized infants is a relatively uncommon but high-risk event associated with mortality. The study objective was to identify factors associated with mortality and survival among infants who receive CPR in the neonatal intensive care unit (NICU) or pediatric intensive care unit (PICU).

Methods: Retrospective observational study of infants with an index CPR event in the NICU or PICU between 1/1/06 and 12/31/18 in the American Heart Association's Get With The Guidelines-Resuscitation registry. Read More

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Target volume-guarantee in high-frequency oscillatory ventilation for preterm respiratory distress syndrome: Low volumes and high frequencies lead to adequate ventilation.

Pediatr Pulmonol 2021 Jun 9. Epub 2021 Jun 9.

Division of Neonatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Background And Objectives: Respiratory distress syndrome (RDS) and ventilation-induced lung injury lead to significant morbidity in preterm infants. High-frequency oscillatory ventilation with volume-guarantee (HFOV-VG) has been used as a rescue therapy and might lead to lower rates of death and bronchopulmonary dysplasia, especially when using low tidal volumes and high frequencies. The aim of the study was to define HFOV-VG parameters leading to adequate ventilation in the first 72 h of preterm RDS using a low volume and high-frequency strategy. Read More

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Womb to womb: Maternal litter size and birth weight but not adult characteristics predict early neonatal death of offspring in the common marmoset monkey.

PLoS One 2021 9;16(6):e0252093. Epub 2021 Jun 9.

Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, United States of America.

A singular focus on maternal health at the time of a pregnancy leaves much about perinatal mortality unexplained, especially when there is growing evidence for maternal early life effects. Further, lumping stillbirth and early neonatal death into a single category of perinatal mortality may obscure different causes and thus different avenues of screening and prevention. The common marmoset monkey (Callithrix jacchus), a litter-bearing nonhuman primate, is an ideal species in which to study the independent effects of a mother's early life and adult phenotypes on pregnancy outcomes. Read More

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Clinical significance of S100B protein in pregnant woman with early- onset severe preeclampsia.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

Department of Obstetrics, Maternal and child health hospital of Hunan Province Changsha, Hunan, China.

Objectives: Preeclampsia is one of the most feared complications of pregnancy, which can progress rapidly to serious complications such as death of both mother and fetus. To present, the leading cause of preeclampsia is still debated. The purpose of this article was to explore the clinical significance of S100B protein, a kind of Ca2+ -sensor protein, in the early-onset severe preeclampsia. Read More

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The role of oligohydramnios and fetal growth restriction in adverse pregnancy outcomes in preeclamptic patients.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

Bursa Yüksek İhtisas Training and Research Hospital Department of Gynecology and Obstetrics, Bursa, Turkey.

Objectives: We aimed to compare perinatal outcomes of oligohydramnios or fetal growth restriction with normal amniotic fluid index and fetal growth in preeclampsia and to compare the outcomes of only oligohydramnios, only fetal growth restriction and oligohydramnios with fetal growth restriction preeclamptic groups.

Material And Methods: A total of 743 preeclamptic patients were evaluated between June 2016 and 2020. Patients were divided into two groups: preeclampsia with oligohydramnios or fetal growth restriction (n = 237) and preeclampsia with normal amniotic fluid index and fetal growth (n = 506). Read More

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Serum S100B Protein Concentrations in SGA/FGR newborns.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

Department of Neonatology, Children Clinical Hospital, Medical University of Warsaw, Poland.

Objectives: Fetal growth restriction is associated with chronic fetal hypoxia, poor perinatal outcome and increased perinatal mortality. There are no reliable methods to detect cell damage in the central nervous system (CNS) in these patients. The findings of increased an acidic calcium-binding protein (S100B) concentration in biological fluids of infants after brain injury have supported the use of S100B as a biochemical marker of CNS damage. Read More

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Pulmonary arterial hypertension in pregnancy-a systematic review of outcomes in the modern era.

Pulm Circ 2021 Apr-Jun;11(2):20458940211013671. Epub 2021 May 14.

Division of Cardiology, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada.

Pregnancy is hazardous with pulmonary arterial hypertension, but maternal mortality may have fallen in recent years. We sought to systematically evaluate pulmonary arterial hypertension and pregnancy-related outcomes in the last decade. We searched for articles describing outcomes in pregnancy cohorts published between 2008 and 2018. Read More

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Prevalence-pattern and risk factors of Cesarean section in a multiethnic cohort.

Pak J Med Sci 2021 May-Jun;37(3):711-715

Sajid Malik, Human Genetics Program, Department of Zoology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan.

Objective: This study was aimed to elucidate the prevalence-pattern and determinant of cesarean section (CS) in a multiethnic cohort from Pakistan.

Methods: Through a cross-sectional study design, women delivering at a tertiary care center were recruited during 2013-2017. Data on socio-demographic variables, obstetric complications and birth outcome were obtained. Read More

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