36,795 results match your criteria perinatal health


Rotational Thromboelastometry in Neonates Admitted to a Neonatal Intensive Care Unit: A Large Cross-sectional Study.

Semin Thromb Hemost 2021 Jun 15. Epub 2021 Jun 15.

Laboratory of Haematology and Blood Bank Unit, "Attikon" Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

The aim of the present study was to assess the coagulation profile in neonatal critical illness using rotational thromboelastometry (ROTEM), and to investigate its association with disease severity and its potential prognostic role in this clinical setting. Over a period of 67 months (July 2014-February 2020) 423 critically ill neonates with confirmed or suspected sepsis, perinatal hypoxia, or respiratory distress syndrome, hospitalized in our neonatal intensive care unit were included in the study. Demographic, clinical, and laboratory data were recorded on admission day and arterial blood was analyzed on ROTEM analyzer using the standard extrinsically activated rotational thromboelastometry assay (EXTEM). Read More

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Risk Factors Associated with Preterm Prelabor Rupture of Membranes after Cord Occlusion in Monochorionic Diamniotic Twins.

Fetal Diagn Ther 2021 Jun 15:1-7. Epub 2021 Jun 15.

BCNatal Fetal Medicine Research Center, Hospital Clínic and Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain.

Introduction: Preterm prelabor rupture of membranes (PPROM) is a common complication after fetal surgeries. The aim of this study was to assess risk factors for and outcomes after PPROM following cord occlusion (CO) in monochorionic diamniotic (MCDA) pregnancies.

Methods: This was a retrospective cohort study of 188 consecutive MCDA pregnancies treated by bipolar or laser CO, either primarily because of discordant malformation (dMF) or severe selective fetal growth restriction (sFGR), or secondarily when complete bichorionization was not possible in case of twin-to-twin transfusion syndrome (TTTS) or sFGR. Read More

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Comparison between Cerebroplacental Ratio and Umbilicocerebral Ratio in Predicting Adverse Perinatal Outcome in Pregnancies Complicated by Late Fetal Growth Restriction: A Multicenter, Retrospective Study.

Fetal Diagn Ther 2021 Jun 15:1-9. Epub 2021 Jun 15.

Center for High Risk Pregnancy and Fetal Care, Department of Obstetrics and Gynecology, University of Chieti, Chieti, Italy.

Introduction: The role of cerebroplacental ratio (CPR) or umbilicocerebral ratio (UCR) to predict adverse intrapartum and perinatal outcomes in pregnancies complicated by late fetal growth restriction (FGR) remains controversial.

Methods: This was a multicenter, retrospective cohort study involving 5 referral centers in Italy and Spain, including singleton pregnancies complicated by late FGR, as defined by Delphi consensus criteria, with a scan 1 week prior to delivery. The primary objective was to compare the diagnostic accuracy of the CPR and UCR for the prediction of a composite adverse outcome, defined as the presence of either an adverse intrapartum outcome (need for operative delivery/cesarean section for suspected fetal distress) or an adverse perinatal outcome (intrauterine death, Apgar score <7 at 5 min, arterial pH <7. Read More

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Evaluation and impact of fetal physiology training on fetal heart rate analysis.

J Gynecol Obstet Hum Reprod 2021 Jun 12:102185. Epub 2021 Jun 12.

Univ. Lille, EA 4489 - Perinatal Environment and Health, F-59000 Lille, France; CHU Lille, Department of Obstetrics, F-59000 Lille, France.

Introduction: Evaluation of fetal well-being during labor is based on fetal heart rate (FHR) analysis, which requires physiology expertise. The aim of the present study was to assess medical residents' fetal physiology training in terms of theoretical knowledge, FHR interpretation, and use of second-line examinations.

Methods: This single-center, prospective study of obstetrics and gynecology residents (N=34) at CHU de Lille Hospital (Lille, France) was conducted from November 2017 to November 2018. Read More

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Fertility treatment with clomiphene citrate and childhood epilepsy: a nationwide cohort study.

Hum Reprod 2021 Jun 14. Epub 2021 Jun 14.

Perinatal Epidemiology Research Unit and Department of Pediatrics, Aarhus University Hospital, Aarhus N, Denmark.

Study Question: Is fertility treatment with clomiphene citrate associated with an increased risk of childhood epilepsy, including specific subtypes of epilepsy?

Summary Answer: Fertility treatment with clomiphene citrate may be associated with a small increased risk of idiopathic generalized epilepsy and focal epilepsy in childhood.

What Is Known Already: Clomiphene citrate is among the most commonly prescribed drugs for fertility treatment. However, concerns have been raised as to whether the treatment may harm the developing fetus. Read More

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Swedish intrauterine growth reference ranges for estimated fetal weight.

Sci Rep 2021 Jun 14;11(1):12464. Epub 2021 Jun 14.

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

Fetal growth restriction is a strong risk factor for perinatal morbidity and mortality. Reliable standards are indispensable, both to assess fetal growth and to evaluate birthweight and early postnatal growth in infants born preterm. The aim of this study was to create updated Swedish reference ranges for estimated fetal weight (EFW) from gestational week 12-42. Read More

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Immune modulation via adipose derived Mesenchymal Stem cells is driven by donor sex in vitro.

Sci Rep 2021 Jun 14;11(1):12454. Epub 2021 Jun 14.

Women and Babies Research, Perinatal Medicine, The University of Sydney, Faculty of Medicine and Health, and Northern, Sydney Local Health District Research (Kolling Institute), St Leonards, NSW, 2065, Australia.

Mesenchymal stromal/stem cells (MSCs) are currently being used in clinical trials as proposed treatments for a large range of genetic, immunological, orthopaedic, cardiovascular, endocrine and neurological disorders. MSCs are potent anti-inflammatory mediators which are considered immune evasive and employ a large range of secreted vesicles to communicate and repair damaged tissue. Despite their prolific use in therapy, sex specific mechanism of action is rarely considered as a potential confounding factor for use. Read More

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Transcutaneous Bilirubin Monitoring in Preterm Infants of 23 to 34 Weeks' Gestation.

Am J Perinatol 2021 Jun 14. Epub 2021 Jun 14.

Department of Pediatrics, Banner-University Medical Center Phoenix, Phoenix, Arizona.

Objective:  The study aimed to evaluate the validity of transcutaneous bilirubin (TcB) measurements at three sites in premature infants born at 23 to 34 weeks' gestational age (GA) compared with total serum bilirubin (TSB) measurements.

Study Design:  A prospective study was conducted at Banner - University Medical Center Phoenix, where informed consent was obtained from the infant's parent or legally authorized representative. Cohort A was comprised of infants 23 to 28 weeks' GA and Cohort B contained subjects 29 to 34 weeks' GA. Read More

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Governance of maternity services: Effects on the management of perinatal deaths and bereavement services.

Midwifery 2021 May 28;101:103049. Epub 2021 May 28.

Pregnancy Loss Research Group, The Irish Centre for Maternal and Child Health Research (INFANT), University College Cork, Cork University Maternity Hospital, 5th floor, Wilton, Cork, Ireland; Cork University Maternity Hospital, Wilton, Cork, Ireland.

Background: External inquiries are carried out following adverse maternal/perinatal events, to examine the care provided and make recommendations to improve it. Clinical governance ensures that organisations promote high-quality care and are accountable for the care they provide, thus contributing to its improvement.

Objective: This study examined how Irish perinatal bereavement services and the management of perinatal deaths (including events leading up to the deaths) were affected by developments in maternity services governance as described in ten Irish enquiry reports published over 14 years (2005-18). Read More

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Exploring Perinatal Indicators of Infant Social-Emotional Development: A Review of the Replicated Evidence.

Clin Child Fam Psychol Rev 2021 Jun 14. Epub 2021 Jun 14.

Deakin University, Centre for Social and Early Emotional Development, Geelong, Australia.

The importance of infant social-emotional development for outcomes across the lifecourse has been amply demonstrated. Despite this, most screening measures of social-emotional development are designed for children 18 months of age and over, with a clear gap in earlier infancy. No systematic review has yet harvested the evidence for candidate indicators in the perinatal window. Read More

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Brief Advice, Nicotine Replacement Therapy Sampling, and Active Referral for Expectant Fathers Who Smoke Cigarettes: A Randomized Clinical Trial.

JAMA Intern Med 2021 Jun 14. Epub 2021 Jun 14.

School of Nursing, The University of Hong Kong, Hong Kong Special Administrative Region (SAR), China.

Importance: Pregnancy presents an opportunity to engage expectant fathers in smoking cessation, but evidence from randomized clinical trials is scarce.

Objective: To evaluate the effectiveness of a proactive, combined intervention for smoking cessation in expectant fathers.

Design, Setting, And Participants: This pragmatic randomized clinical trial in prenatal clinics in 7 public hospitals in Hong Kong proactively recruited and enrolled 1053 participants from October 10, 2018, to February 8, 2020. Read More

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Distinct maternal and fetal pregnancy outcomes in women with sickle cell disease can be predicted using routine clinical and laboratory data.

Br J Haematol 2021 Jun 14. Epub 2021 Jun 14.

Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

We aimed to identify risk factors for adverse outcomes in pregnancies of women with sickle cell disease (SCD) and develop risk prediction models. Models were derived from a retrospective cohort of pregnant women with SCD and constructed using generalised estimating equation logistic regression, with clustering by woman. Maternal event(s) consisted of acute anaemia; cardiac, pulmonary, hepatobiliary, musculoskeletal, skin, splenic, neurological or renal complications, multi-organ failure, venous thromboembolism, admission-requiring vaso-occlusive events (VOE), red cell transfusion, mortality or hypertensive disorder of pregnancy. Read More

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Metabolic Hormone Profiles in Breast Milk From Mothers of Moderate-Late Preterm Infants Are Associated With Growth From Birth to 4 Months in a Sex-Specific Manner.

Front Nutr 2021 28;8:641227. Epub 2021 May 28.

The Liggins Institute, University of Auckland, Auckland, New Zealand.

Differing environmental conditions experienced by mother-infant dyads may influence composition of the milk received by the infant. As a consequence, diverse milk compositional profiles may contribute to different postnatal outcomes, especially in infants facing adverse perinatal environments. We investigated whether variability in milk concentrations of key metabolic hormones is associated with different growth outcomes in infants born preterm, a perinatal complication known to impact on infant growth. Read More

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Timing intrapartum management based on the evolution and duration of fetal heart rate patterns.

J Matern Fetal Neonatal Med 2021 Jun 13:1-6. Epub 2021 Jun 13.

Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, FL, USA.

One of the most important challenges in obstetrics is to determine the appropriate time to deliver the fetus without exposing the mother to unnecessary operative interventions. The use of continuous cardiotocography (cCTG) during labor has resulted in dramatic reductions in intrapartum fetal deaths, but fetal central nervous system (CNS) injury and cerebral palsy (CP) rates have remain relatively unchanged as related to the use of cCTG . In our view, this is due to continuing inability to recognize progressive fetal deterioration and intervene promptly prior to the development of fetal CNS injury. Read More

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Health professional perspectives on an antenatal mental health screening program in a private hospital.

Aust N Z J Obstet Gynaecol 2021 Jun 13. Epub 2021 Jun 13.

Gidget Foundation Australia, Sydney, New South Wales, Australia.

Background: Perinatal mental ill-health is a global health priority. Mental health screening during pregnancy is a routine part of clinical practice in many public hospital obstetric services across Australia, but implementation in the private hospital system has lagged.

Aims: This study explored health professionals' perspectives on the Pre-admission Midwife Appointment Program (PMAP), an antenatal mental health screening program at the Mater Hospital, Sydney. Read More

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Care practices and outcomes of extremely preterm neonates born at 22-24 weeks -A single centre experience.

J Neonatal Perinatal Med 2021 Jun 5. Epub 2021 Jun 5.

Newborn Services, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.

Background: Wide variation in the care practices and survival rates of neonates born at peri-viable gestational ages of 22 +0 -24 +6 weeks exists. This study elucidates the postnatal risk factors for morbidity/mortality, contrasts the care practices and short-term outcomes of this vulnerable group of preterm neonates from a single center with others.

Methods: Retrospective study of neonates born at 22 +0 -24 +6 weeks in a level 3 neonatal intensive care unit in UK, over a period of 4 years (2016-2019). Read More

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Monitoring outpatient antibiotic utilization using reimbursement and retail sales data: a population-based comparison in France, 2012-17.

J Antimicrob Chemother 2021 Jun 13. Epub 2021 Jun 13.

Université de Paris, Epidemiology and Statistics Research Center-CRESS, INSERM, Obstetrical, Perinatal and Pediatric Epidemiology research team, F-75004, Paris, France.

Objectives: To assess whether a retail sales database could be used to monitor antibiotic utilization in the outpatient setting at the national level.

Methods: We extracted 2012-17 outpatient antibiotic extrapolated retail sales (IQVIA's Xponent) and reimbursement data from the National Health Insurance (SNDS) in metropolitan France. We compared estimates of antibiotic use and consumption [number of antibiotic drug deliveries (DrID) and defined daily doses (DID) per 1000 inhabitants per day]. Read More

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Studying Executive Directors and Supervisors Views of Organizational and Policy-Level Challenges Faced by Community Health Workers.

J Ambul Care Manage 2021 Jun 11. Epub 2021 Jun 11.

Graduate School of Social Service, Fordham University, New York City, New York (Drs Rahman and Ross and Ms Hopwood); Mothers & Babies Perinatal Network of SCNY, Inc, Binghamton, New York (Ms Chesna); and Columbia School of Social Work, New York City, New York (Ms Rama Tatikola).

Within the United States, there is an absence of a national community health worker (CHW) program. There is substantial regional and state-based variability in the population served by CHWs, their disease focus, and availability of training, supervision, and other supports. This article seeks to respond to the call in the literature to work collaboratively with CHW professional associations to identify, reflect, and respond to CHW workforce development and sustainability issues. Read More

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Experiences of stigma among individuals in recovery from opioid use disorder in a rural setting: A qualitative analysis.

J Subst Abuse Treat 2021 May 21;130:108488. Epub 2021 May 21.

Maine Maternal Opioid Misuse Initiative (MaineMOM), MaineHealth Director of Perinatal IMAT, 22 Bramhall Street, Portland, ME 04102, United States.

Introduction: Stigma is a barrier to accessing treatment and support services for individuals with substance use disorder. Stigma is negatively associated with completion of treatment for substance use disorder and management of recovery.

Objective: To learn from individuals in recovery from opioid use disorder in a largely rural area about how their personal experiences of stigma affected their ability to enter into treatment and stay in recovery. Read More

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The impact of prolonged second-stage in twins on perinatal outcomes.

Int J Gynaecol Obstet 2021 Jun 12. Epub 2021 Jun 12.

Department of Obstetrics and Gynecology, Rambam Health Care Campus, Haifa, Israel.

Objective: To assess the duration of the second stage of labor in twin pregnancies in relation to maternal and neonatal outcomes.

Methods: A retrospective study between 2014-2020. Eligible cases were twin pregnancies who reached the second stage. Read More

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Comparison of the fertility of tumor suppressor gene-deficient C57BL/6 mouse strains reveals stable reproductive aging and novel pleiotropic gene.

Sci Rep 2021 Jun 11;11(1):12357. Epub 2021 Jun 11.

Department of Radiobiology and Hygiene Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka Yahatanishi-ku, Kitakyushu, 807-8555, Japan.

Tumor suppressor genes are involved in maintaining genome integrity during reproduction (e.g., meiosis). Read More

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Maternal Psychiatric Conditions, Treatment With Selective Serotonin Reuptake Inhibitors, and Neurodevelopmental Disorders.

Biol Psychiatry 2021 Apr 14. Epub 2021 Apr 14.

Division of Research, Kaiser Permanente Northern California, Oakland, California.

Background: This study aims to clarify relationships of maternal psychiatric conditions and selective serotonin reuptake inhibitor (SSRI) use during preconception and pregnancy with risk of neurodevelopmental disorders in offspring.

Methods: We used data from the Study to Explore Early Development, a multisite case-control study conducted in the United States among children born between 2003 and 2011. Final study group classifications of autism spectrum disorder (ASD) (n = 1367), developmental delays or disorders (DDs) (n = 1750), and general population controls (n = 1671) were determined by an in-person standardized developmental assessment. Read More

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Chlamydia pecorum detection in aborted and stillborn lambs from Western Australia.

Vet Res 2021 Jun 11;52(1):84. Epub 2021 Jun 11.

Centre for Animal Production and Health, Murdoch University, South Street, Murdoch, WA, 6150, Australia.

Lamb survival is an important welfare and productivity issue for sheep industries worldwide. Lower lamb survival has been reported for primiparous ewes, but the causes of this are not well studied. The aim of this study was to determine causes of perinatal deaths for lambs born to primiparous ewes in Western Australia, and identify if infectious diseases are implicated. Read More

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"I Wanted to Be There as a Father, but I Couldn't": A Qualitative Study of Fathers' Experiences of Postpartum Depression and Their Help-Seeking Behavior.

Am J Mens Health 2021 May-Jun;15(3):15579883211024375

Department of Public Health, Section for Health Promotion and Population Health, Aarhus University, Denmark.

Postpartum depression (PPD) is one of the most common mental health problems among new parents. Past studies have examined PPD in women; however, the condition is less understood in men. This study aimed to explore the lived experiences of men or fathers with PPD and to understand the barriers and facilitators of help-seeking among fathers with PPD. Read More

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Feelings about pregnancy and mother-infant bonding as predictors of persistent psychological distress in the perinatal period: The Japan Environment and Children's Study.

J Psychiatr Res 2021 May 30;140:132-140. Epub 2021 May 30.

Hyogo Regional Center for the Japan Environment and Children's Study, Hyogo College of Medicine, Nishinomiya, Japan; Department of Public Health, Hyogo College of Medicine, Nishinomiya, Japan. Electronic address:

Feelings about pregnancy and mother-infant bonding are associated with maternal mental health before and after childbirth. The current study examined factors associated with persistent distress at 12 months after childbirth among mothers with psychological distress in the first trimester, using data from the Japan Environment and Children's Study (JECS). Feelings about pregnancy were assessed using a questionnaire in the first trimester, and maternal mental health was assessed using the Kessler 6 (K6) in the first trimester and at 12 months after childbirth. Read More

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Phosphodiesterase-5 inhibitors in Pregnancy: Systematic review and meta-analysis of maternal and perinatal safety and clinical outcomes.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

Mater Research Institute - University of Queensland, Level 3 Aubigny Place, Raymond Terrace, South Brisbane, Queensland 4101, Australia; Faculty of Medicine, University of Medicine, Whitty Building, Annerley Road, South Brisbane, Queensland 4101, Australia; NHMRC Stillbirth Centre For Research Excellence, Mater Research Institute, South Brisbane, Queensland 4101, Australia. Electronic address:

Objective: Phosphodiesterase-5 inhibitors have recently been used for the treatment of severe early onset pre-eclampsia and fetal growth restriction. There are however concerns that they may increase the risk of neonatal morbidity and mortality. The aim of this systematic review was to assess the safety profile and clinical outcomes of phosphodiesterase-5 inhibitors use in pregnancy. Read More

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Characterizing Hypertensive Disorders of Pregnancy Among Medicaid Recipients in a Nonexpansion State.

J Womens Health (Larchmt) 2021 Jun 10. Epub 2021 Jun 10.

Department of Health Care Organization and Policy, School of Public Health, The University of Alabama at Birmingham, Birmingham, Alabama, USA.

The incidence of hypertensive disorders of pregnancy (HDP) are on the rise in the United States, especially in the South, which has a heavy chronic disease burden and large number of Medicaid nonexpansion states. Sizeable disparities in HDP outcomes exist by race/ethnicity, geography, and health insurance coverage. Our objective is to explore HDP in the Alabama Medicaid maternity population, and the association of maternal sociodemographic, clinical, and care utilization characteristics with HDP diagnosis. Read More

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Clinical characteristics, management, and short term outcome of neonates born to mothers with COVID-19 in a tertiary care hospital in India.

J Trop Pediatr 2021 Jun 11. Epub 2021 Jun 11.

ICMR-National Institute for Research in Reproductive Health, Mumbai, India.

Lay Summary: The current pandemic of COVID-19 has affected all the countries globally. However, the adverse impact of the pandemic is more seen in the low-income and middle-income countries (LMICs). Although there is evidence on the adverse impact of the SARS-CoV-2 on the health of mothers and neonates, the evidence is mainly from high-income countries. Read More

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