101,022 results match your criteria perinatal

Reduced fetal growth velocity and weight loss are associated with adverse perinatal outcome in fetuses at risk of growth restriction.

Am J Obstet Gynecol 2022 Jun 22. Epub 2022 Jun 22.

Institute of Developmental and Reproductive Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK; Department of Fetal Medicine, Queen Charlotte's and Chelsea Hospital, Imperial College NHS Trust, London, UK. Electronic address:

Background: While fetal size is associated with adverse perinatal outcome, the relationship between fetal growth velocity and adverse perinatal outcome is unclear.

Objectives: To evaluate the relationship between fetal growth velocity and signs of cerebral blood flow redistribution, and their association with birthweight and adverse perinatal outcome.

Study Design: Secondary analysis of the TRUFFLE 2 multicentre observational prospective feasibility study of fetuses at risk of fetal growth restriction between 32 and 36 weeks (n=856) evaluated by ultrasound biometry and umbilical and middle cerebral artery Doppler. Read More

View Article and Full-Text PDF

Effect of intervention delivered by lay maternal care providers to improve outcome and parenting skills among adolescents with perinatal depression in Nigeria (the RAPiD study): A cluster randomized controlled trial.

J Affect Disord 2022 Jun 22. Epub 2022 Jun 22.

Lady Davis Institute, Jewish General Hospital, Montreal, Canada.

Background: Perinatal depression is more common and is associated with greater negative consequences among adolescents than adults. Psychosocial interventions designed for adults may be inadequate at addressing the unique features of adolescent perinatal depression.

Methods: In a two-arm parallel cluster randomized trial conducted in thirty primary maternal care clinics in Ibadan, Nigeria (15-intervention and 15-control) we compared age-appropriate intervention consisting of problem-solving therapy, behavioral activation, parenting skills training, and parenting support from a self-identified adult to care as usual. Read More

View Article and Full-Text PDF

Congenital anomalies and perinatal outcomes following blastocyst vs cleavage-stage embryo transfer: systematic review and network meta-analysis.

Ultrasound Obstet Gynecol 2022 Jun 25. Epub 2022 Jun 25.

Assisted Reproduction Unit, Second Department of Obstetrics and Gynecology, Medical School, National and Kapodistrian University of Athens, "Aretaieion" University Hospital, 76 Vas. Sofias Av., 11528, Athens, Greece.

Objective: To compare the reported events of congenital anomalies of newborns and perinatal outcomes of pregnancies resulting from blastocyst and cleavage-stage embryo transfers following assisted reproduction, through a pairwise meta-analysis, and the same outcomes between pregnancies resulting from fresh-blastocyst, frozen-blastocyst, fresh-cleavage and frozen-cleavage embryo transfers, through a network meta-analysis.

Methods: A search was performed in PubMed, Scopus, and CENTRAL and registers for ongoing studies, from inception to February 2022 for randomized controlled trials (RCTs) with any sample size and cohort studies including at least 100 live births per cohort, comparing events of congenital anomalies of the newborns and perinatal outcomes of pregnancies following fresh/frozen embryo transfer at cleavage stage (D2-3) vs. transfer at blastocyst stage (D5-7). Read More

View Article and Full-Text PDF

Maternal and Perinatal Risk Factors for Infantile Hemangioma: A Matched Case-Control Study with a Large Sample Size.

Dermatol Ther (Heidelb) 2022 Jun 25. Epub 2022 Jun 25.

Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, 37 Guo-Xue-Xiang, Chengdu, 610041, China.

Introduction: Infantile hemangioma (IH) is the most common benign tumor in infancy, but information about its pathogenesis is limited. The aim of this study was to determine maternal and perinatal risk factors for IH.

Methods: A total of 1033 IH patients were enrolled in the study between 2017 and 2020. Read More

View Article and Full-Text PDF

Methods of induction of labor after cesarean with no prior vaginal delivery - perinatal outcomes.

Int J Gynaecol Obstet 2022 Jun 25. Epub 2022 Jun 25.

Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat-Gan, Israel.

Objective: To study the association between the method of induction of labor (IOL) and perinatal outcomes, among women undergoing labor after cesarean (LAC) with no prior vaginal delivery.

Method: A retrospective study including all women with no prior vaginal delivery undergoing IOL for LAC between 3/2011 - 1/2021. Oxytocin administration following prelabor rupture of membranes, oxytocin administration only, extraamniotic balloon and amniotomy were compared. Read More

View Article and Full-Text PDF

Maternal and perinatal outcomes in women ≥40 years undergoing induction of labor compared with women <35 years: Results from 4027 mothers.

J Obstet Gynaecol Res 2022 Jun 25. Epub 2022 Jun 25.

Fetal Medicine Unit, Department Obstetrics, Gynecology, Reproductive Medicine, Hospital Universitari Quiron Dexeus, Barcelona, Spain.

Aim: Cesarean section is known to be increased with advanced maternal age in women undergoing induction of labor (IOL), but there is less information regarding other possible adverse maternal and fetal outcomes.

Methods: Retrospective cohort study of singleton, nulliparous, at-term women undergoing IOL between January 2007 and September 2020. Outcomes studied were: cesarean section, failed induction rate, fetal distress, post-partum hemorrhage, post-partum hysterectomy, and need of transfusion. Read More

View Article and Full-Text PDF

Cost reduction in screening for retinopathy of prematurity in the Netherlands by comparing different screening strategies.

Acta Ophthalmol 2022 Jun 25. Epub 2022 Jun 25.

Department of Biomedical Data Sciences, Unit Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands.

Purpose: Evaluate possibilities to reduce the number of infants screened for retinopathy of prematurity (ROP) and investigate costs and number of infants detected of current and alternative screening strategies in the Netherlands.

Methods: Prospective population-based study including clinical data from all infants born in 2017 and referred for ROP screening (NEDROP-2 study). Cost and effects of screening strategies were evaluated that differed on the criteria gestational age (GA), birth weight (BW) and presence of one or more specific risk factor(s) (RF): mechanical ventilation, sepsis, necrotizing enterocolitis, postnatal corticoids and/or hypotension treated with inotropic agents. Read More

View Article and Full-Text PDF

An example of parenchymal renal sparing in the context of complex malformations due to a novel mutation in the PBX1 gene.

Birth Defects Res 2022 Jun 25. Epub 2022 Jun 25.

UOC Genetica Medica, IRCCS Istituto Giannina Gaslini, Genoa, Italy.

Introduction: PBX1 encodes the pre-B cell leukemia factor 1, a Three Amino acid Loop Extension (TALE) transcription factor crucial to regulate basic developmental processes. PBX1 loss-of-function variants have been initially described in association with renal malformations in both isolated and syndromic forms.

Case Report: Herein, we report a male infant presenting multiple organ malformations (cleidosternal dysostosis, micrognathia, left lung hypoplasia, wide interatrial defect, pulmonary hypertension, total anomalous pulmonary venous return, intestinal malrotation) and carrying the heterozygous de novo c. Read More

View Article and Full-Text PDF

Risk factors of extrauterine growth restriction in very preterm infants with bronchopulmonary dysplasia: a multi-center study in China.

BMC Pediatr 2022 Jun 24;22(1):363. Epub 2022 Jun 24.

Department of Pediatrics, Peking University Third Hospital, Beijing, China.

Objective: Nutritional deficiency soon after birth is a risk factor of chronic lung disease (bronchopulmonary dysplasia, BPD). Afflicted infants are further prone to inadequate growth during hospitalization (extrauterine growth restriction, EUGR). This multi-center retrospective study investigated risk factors of EUGR, specifically in very preterm infants with BPD. Read More

View Article and Full-Text PDF

The trend in delayed childbearing and its potential consequences on pregnancy outcomes: a single center 9-years retrospective cohort study in Hubei, China.

BMC Pregnancy Childbirth 2022 Jun 24;22(1):514. Epub 2022 Jun 24.

Department of Pediatrics, Taixing People Hospital, Taizhou, Jiangsu, China.

Background: Due to the advancement of modern societies, the proportion of women who delay childbearing until or beyond 30 years has dramatically increased in the last three decades and has been linked with adverse maternal-neonatal outcomes.

Objective: To determine the trend in delayed childbearing and its negative impact on pregnancy outcomes.

Material And Methods: A tertiary hospital-based retrospective study was conducted in Wuhan University Renmin Hospital, Hubei Province, China, during the years 2011-2019. Read More

View Article and Full-Text PDF

Continuous positive airway pressure treatment of obstructive sleep apnea and hypertensive complications in high-risk pregnancy.

Sleep Breath 2022 Jun 24. Epub 2022 Jun 24.

Department of Neurology, Wisconsin Sleep, Wisconsin Institute for Sleep and Consciousness, School of Medicine and Public Health, University of Wisconsin-Madison, 1685 Highland Ave, Madison, WI, 53705, USA.

Purpose: To evaluate whether or not continuous positive airway pressure (CPAP) treatment in pregnancies complicated by obstructive sleep apnea (OSA) is associated with a decrease in hypertensive disorders of pregnancy.

Methods: This was a retrospective cohort study of perinatal outcomes in women who underwent objective OSA testing and treatment as part of routine clinical care during pregnancy. Where diagnostic criteria for OSA were reached (respiratory event index (REI) ≥ 5 events per hour), patients were offered CPAP therapy. Read More

View Article and Full-Text PDF

Analysis of commonly expressed genes between first trimester fetal heart and placenta cell types in the context of congenital heart disease.

Sci Rep 2022 Jun 24;12(1):10756. Epub 2022 Jun 24.

Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL, 32610, USA.

Congenital heart disease (CHD) is often associated with fetal growth abnormalities. During the first trimester of pregnancy, the heart and placenta develop concurrently, and share key developmental pathways. It is hypothesized that defective morphogenesis of either organ is synergistically linked. Read More

View Article and Full-Text PDF

How are women with a disability identified in maternity services in Australia? A cross-sectional survey of maternity managers.

Women Birth 2022 Jun 21. Epub 2022 Jun 21.

Judith Lumley Centre, La Trobe University, Bundoora, VIC 3086, Australia; School of Nursing & Midwifery, La Trobe University, Bundoora, VIC 3086, Australia.

Background: Women with a disability have poorer perinatal outcomes, but little is known about the prevalence of women with a disability accessing maternity services, how they are identified and what care and services are available. Estimates suggest that nine percent of women of childbearing age have a disability.

Aim: To explore how public maternity services in Australia identify pregnant women with a disability, what (if any) routine disability identification questions are used, and to examine availability and adequacy of services for women. Read More

View Article and Full-Text PDF

Lung ultrasound of the dependent lung detects real-time changes in lung volume in the preterm lamb.

Arch Dis Child Fetal Neonatal Ed 2022 Jun 24. Epub 2022 Jun 24.

Neonatal Research, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.

Background: Effective lung protective ventilation requires reliable, real-time estimation of lung volume at the bedside. Neonatal clinicians lack a readily available imaging tool for this purpose.

Objective: To determine the ability of lung ultrasound (LUS) of the dependent region to detect real-time changes in lung volume, identify opening and closing pressures of the lung, and detect pulmonary hysteresis. Read More

View Article and Full-Text PDF

Perinatal exposure to glyphosate- based herbicides induced neurodevelopmental behaviors impairments and increased oxidative stress in the prefrontal cortex and hippocampus in offspring.

Int J Dev Neurosci 2022 Jun 24. Epub 2022 Jun 24.

Programa de Pós-Graduação em Biociências Aplicadas à Saúde, Universidade Federal de Alfenas-Unifal-MG, Alfenas, Brazil.

Glyphosate is the organophosphate pesticide most widely used in the world. Recent studies correlate exposure to glyphosate and the emergence of neurodevelopmental disorders. Therefore, it was objective to propose a rat model of perinatal exposure to glyphosate- based herbicides (HBG) to study associated neurodevelopmental disorders. Read More

View Article and Full-Text PDF

A Quality Improvement Effort to Reduce Inpatient Opioid Consumption following Cesarean Delivery.

Am J Perinatol 2022 Jun 24. Epub 2022 Jun 24.

Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, United States.

Objective: The amount of opioid prescribed following cesarean delivery is commonly in excess of patients' needs. An additional concern in a breastfeeding mother is neonatal opioid exposure. A maximum daily dose of 30 mg of oxycodone is recommended in breastfeeding women. Read More

View Article and Full-Text PDF

Impaired fasting glucose in pregnancy: improved perinatal outcomes with active glycemic management.

Am J Perinatol 2022 Jun 24. Epub 2022 Jun 24.

Perinatology, Kaiser Permanente Oakland Medical Center, Oakland, United States.

Objective: To assess the association between active glycemic management and large for gestational age (LGA) neonates and cesarean delivery (CD) among pregnant women with impaired fasting glucose (IFG).

Study Design: Retrospective cohort study using electronic health record data of women with IFG who delivered at Kaiser Permanente Northern California from 2012-2017. IFG was defined as isolated fasting glucose ≥95 mg/dL. Read More

View Article and Full-Text PDF

Being a mother under the COVID-19 pandemic lockdown: Evaluation of perinatal anxiety, prenatal attachment, and maternal-infant attachment.

Am J Perinatol 2022 Jun 24. Epub 2022 Jun 24.

Obstetrics and Gynecology, TC Saglik Bakanligi Izmir Il Saglik Mudurlugu Izmir Saglik Bilimleri Universitesi Tepecik Egitim ve Arastirma Hastanesi, Izmir, Turkey.

Objectives: The COVID-19 pandemic has caused both physical and emotional stress throughout the population due to its worldwide impact. The unknowns about the disease, the social isolation, and pregnant women's concerns regarding exposure to the COVID-19, inaccessibility to necessary care, and the possibility of harm to their fetus, may cause increased psychological distress during the perinatal period. We aimed to evaluate the association between perinatal anxiety, prenatal attachment, and maternal-infant attachment status among women with those who delivered their child in a tertiary care center with rigid hospital restrictions. Read More

View Article and Full-Text PDF

Deglutition-related cardiorespiratory events.

Early Hum Dev 2022 Jun 10;171:105602. Epub 2022 Jun 10.

Division of Neonatal-Perinatal Medicine, Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, United States of America. Electronic address:

View Article and Full-Text PDF

The Formula Industry is a Powerful Influence on Breastfeeding.

Diane L Spatz

MCN Am J Matern Child Nurs 2022 Jul-Aug 01;47(4):229

Dr. Diane L. Spatz is a Professor of Perinatal Nursing & the Helen M. Shearer Professor of Nutrition at the University of Pennsylvania. She holds a joint appointment with the Center for Pediatric Nursing Research & Evidence Based Practice at Children's Hospital of Philadelphia where she is a nurse scientist in lactation. Dr. Spatz can be reached via email at

View Article and Full-Text PDF

Determinants of obstructed labour and its adverse outcomes among women who gave birth in Hawassa University referral Hospital: A case-control study.

PLoS One 2022 24;17(6):e0268938. Epub 2022 Jun 24.

Department of Midwifery, College of Medicine and Health Science, Ambo University, Ambo, Ethiopia.

Background: Globally, obstructed labour accounted for 22% of maternal morbidities and up to 70% of perinatal deaths. It is one of the most common preventable causes of maternal and perinatal mortality in low-income countries. However, there are limited studies on the determinants of obstructed labor in Ethiopia. Read More

View Article and Full-Text PDF

Effect of an antenatal diet and lifestyle intervention and maternal BMI on cord blood DNA methylation in infants of overweight and obese women: The LIMIT Randomised Controlled Trial.

PLoS One 2022 24;17(6):e0269723. Epub 2022 Jun 24.

Discipline of Obstetrics & Gynaecology and The Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia.

Background: To investigate the effect of an antenatal diet and lifestyle intervention, and maternal pre-pregnancy overweight or obesity, on infant cord blood DNA methylation.

Methods: We measured DNA methylation in 645 cord blood samples from participants in the LIMIT study (an antenatal diet and lifestyle intervention for women with early pregnancy BMI ≥25.0 kg/m2) using the Illumina 450K BeadChip array, and tested for any differential methylation related to the intervention, and to maternal early pregnancy BMI. Read More

View Article and Full-Text PDF

Perinatal Depression and Beyond-Implications for Research Design and Clinical Management.

JAMA Netw Open 2022 Jun 1;5(6):e2218978. Epub 2022 Jun 1.

Institute of Higher Education and Healthcare Sciences, University of Lausanne, Lausanne, Switzerland.

View Article and Full-Text PDF

Estimates of Stillbirths, Neonatal Mortality, and Medically Vulnerable Live Births in Amhara, Ethiopia.

JAMA Netw Open 2022 Jun 1;5(6):e2218534. Epub 2022 Jun 1.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Importance: Data on birth outcomes and early mortality are scarce, especially in settings with limited resources. Total births, both stillbirths and live births, are often not counted, yet such data are critical to allocate resources and target interventions to improve survival.

Objective: To estimate the prevalence of stillbirths, neonatal deaths, and medically vulnerable phenotypes, such as preterm births, small-for-gestational-age (SGA), large-for-gestational-age (LGA), and low-birth-weight (LBW) births, in a setting where these key indicators remain largely unknown. Read More

View Article and Full-Text PDF

Prevalence of Perinatal Depression and Anxiety in Both Parents: A Systematic Review and Meta-analysis.

JAMA Netw Open 2022 Jun 1;5(6):e2218969. Epub 2022 Jun 1.

Department of Primary Care and Population Health, Institute of Epidemiology and Health Care, University College London, London, United Kingdom.

Importance: New and expectant parents experience perinatal mood disorders, with consequences to parenting ability, bonding with the neonate, interpersonal relationships, and health and well-being of parents. Research shows that maternal and paternal perinatal mood disorders are associated, but no recent systematic review has addressed the prevalence of perinatal mood disorders in both mothers and fathers (parental dyad).

Objective: To examine the prevalence of perinatal mood disorders in parental dyads and identify factors associated with perinatal mood disorders in parental dyads. Read More

View Article and Full-Text PDF

Pituitary stalk interruption syndrome: phenotype, predictors, and pathophysiology of perinatal events.

Pituitary 2022 Jun 24. Epub 2022 Jun 24.

Department of Endocrinology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, 400012, India.

Purpose: There is limited data regarding Pituitary Stalk Interruption Syndrome (PSIS) from India. Moreover, the pathophysiological link between perinatal events and PSIS is unclear. We aim to elucidate the predictors of PSIS among patients with growth hormone deficiency (GHD) and perinatal events in PSIS by comparing cohorts of PSIS and genetically proven GHD without PSIS. Read More

View Article and Full-Text PDF

Presepsin levels in neonatal cord blood are not influenced by maternal SARS-CoV-2 infection.

Clin Chem Lab Med 2022 Jun 24. Epub 2022 Jun 24.

Neonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Rome, Italy.

Objectives: Coronavirus disease (COVID-19) can present with various symptoms and can involve multiple organs. Women infected during pregnancy have a higher incidence of obstetrical complications and infants born to "positive" mothers may get the infection with different manifestations. Presepsin seems to be a promising sepsis biomarker in adults and neonates. Read More

View Article and Full-Text PDF

Severe smallness as predictor of adverse neonatal outcome in suspected late SGA fetuses: systematic review and meta-analysis.

Ultrasound Obstet Gynecol 2022 Jun 24. Epub 2022 Jun 24.

Fetal Medicine Research Center, BCNatal. Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Universitat de Barcelona, Barcelona, Catalonia, Spain.

Objective: To investigate the performance of severe smallness (estimated fetal weight [EFW] <3rd percentile) among suspected small-for-gestational-age (SGA) fetuses for the prediction of adverse perinatal outcomes.

Methods: A systematic search was launched to identify relevant studies held by the most relevant electronic databases. Random-effects modelling served to generate hierarchical summary receiver-operating characteristic curves (HSROCs). Read More

View Article and Full-Text PDF

Association between the COVID-19 pandemic and pertussis derived from multiple nationwide data sources, France, 2013 to 2020.

Euro Surveill 2022 Jun;27(25)

Institut Pasteur, Université Paris Cité, Biodiversity and Epidemiology of Bacterial Pathogens, Paris, France.

BackgroundInterventions to mitigate the COVID-19 pandemic may impact other respiratory diseases.AimsWe aimed to study the course of pertussis in France over an 8-year period including the beginning of the COVID-19 pandemic and its association with COVID-19 mitigation strategies, using multiple nationwide data sources and regression models.MethodsWe analysed the number of French pertussis cases between 2013 and 2020, using PCR test results from nationwide outpatient laboratories (Source 1) and a network of the paediatric wards from 41 hospitals (Source 2). Read More

View Article and Full-Text PDF