10,850 results match your criteria pericardial biopsy


Contemporary contribution of cardiac surgery for the treatment of cardiomyopathies and pericardial diseases.

Minerva Cardiol Angiol 2021 Aug 2. Epub 2021 Aug 2.

Cardiothoracic Department, University Hospital of Udine, Udine, Italy.

Cardiomyopathy refers to a spectrum of heterogeneous myocardial disorders characterized by morphological and structural alterations leading eventually to heart failure, by affecting cardiac filling and/or the cardiac systolic function. Heart transplantation is currently the gold standard surgical treatment for patients with heart failure, with a median survival in adults of 12 years according to international registries. However, the limited available donor pool does not allow its extensive employment. Read More

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THE PATHOLOGY OF EARLY FAILURE IN MITROFLOW PERICARDIAL VALVE BIOPROSTHESIS (12A/LX).

Cardiovasc Pathol 2021 Jul 29:107373. Epub 2021 Jul 29.

Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Cardiovascular Pathology, University of Padua Medical School, Padua, Italy. Electronic address:

Background: Limited mid-term durability of 12A/LX Mitroflow bioprosthesis has been reported. Aim of the study was to ascertain the pathologic substrates and possible mechanisms of structural valve deterioration in explants from animals and humans.

Methods: Nine aortic 12A/LX Mitroflow bioprostheses were explanted from juvenile sheep, mean time from implant 95. Read More

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Cardiac hemangioma producing pericardial effusion detected on thoracoscopic pericardial fenestration.

Ann Thorac Surg 2021 Jul 28. Epub 2021 Jul 28.

Division of General Thoracic Surgery, Kohka Public Hospital, and Department of Thoracic Surgery, National University Corporation, Shiga University of Medical Science, Shiga, Japan.

A 76-year-old woman presented with dyspnea. Computed tomography showed massive pericardial effusion, so percutaneous catheter drainage was performed. The usual causes of exudate were ruled out, and no diagnosis was reached. Read More

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Definition of a critical bleed in patients with immune thrombocytopenia: Communication from the ISTH SSC Subcommittee on Platelet Immunology.

J Thromb Haemost 2021 Aug;19(8):2082-2088

Department of Medicine, McMaster Centre for Transfusion Research, McMaster University, Hamilton, ON, Canada.

Background: Immune thrombocytopenia (ITP) is an autoimmune disease characterized by low platelet counts and increased risk of bleeding. In preparation for an upcoming guideline, the ITP Emergency Management Guideline Panel, including clinical experts in hematology, emergency medicine, research methodology, and patient representatives, identified the need for a standardized definition of a critical ITP bleed. The goal of the definition was to distinguish critical bleeds from bleeds that may not require urgent treatment, typically in the context of severe thrombocytopenia. Read More

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Isolated Lupus-Associated Protein-Losing Enteropathy in a Resource-Limited Centre.

Cureus 2021 Jun 22;13(6):e15826. Epub 2021 Jun 22.

Medicine, Teaching Hospital, Batticaloa, LKA.

Systemic lupus erythematosus (SLE) is a relatively common autoimmune disease with recently reported cases of lupus-associated protein-losing enteropathy (LUPLE) as an unusual manifestation. It is a well-recognized clinical entity predominantly affecting middle-aged Asian females. LUPLE is diagnosed by exclusion of possible causes for hypoalbuminemia in a patient with positive anti-nuclear antibody (ANA). Read More

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Morphologic investigation on perceval S, a sutureless pericardial valve prosthesis: Collagen integrity after collapsing-ballooning and structural valve deterioration at distance.

Int J Cardiol 2021 Jul 27. Epub 2021 Jul 27.

Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Cardiovascular Pathology, University of Padua Medical School, Padua, Italy. Electronic address:

Perceval S is a self-expandable, stent-mounted bioprosthetic valve, with glutaraldehyde treated bovine pericardium, processed with homocysteic acid as an anti-calcification treatment. The stent is crimpable but the valve insertion is done surgically via a shorter procedure which does not require sutures. OBJECTIVES: MATERIAL AND METHODS: RESULTS: CONCLUSIONS: Collapsing and ballooning do not alter cusp collagen periodicity. Read More

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Tissue response, macrophage phenotype, and intrinsic calcification induced by cardiovascular biomaterials: Can clinical regenerative potential be predicted in a rat subcutaneous implant model?

J Biomed Mater Res A 2021 Jul 29. Epub 2021 Jul 29.

Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

The host immune response to an implanted biomaterial, particularly the phenotype of infiltrating macrophages, is a key determinant of biocompatibility and downstream remodeling outcome. The present study used a subcutaneous rat model to compare the tissue response, including macrophage phenotype, remodeling potential, and calcification propensity of a biologic scaffold composed of glutaraldehyde-fixed bovine pericardium (GF-BP), the standard of care for heart valve replacement, with those of an electrospun polycarbonate-based supramolecular polymer scaffold (ePC-UPy), urinary bladder extracellular matrix (UBM-ECM), and a polypropylene mesh (PP). The ePC-UPy and UBM-ECM materials induced infiltration of mononuclear cells throughout the thickness of the scaffold within 2 days and neovascularization at 14 days. Read More

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Primary Pericardial Mesothelioma: A Population-Based Propensity Score-Matched Analysis.

Semin Thorac Cardiovasc Surg 2021 Jul 25. Epub 2021 Jul 25.

Division of Cardiac Surgery, Boston Medical Center, Boston University School of Medicine, Boston, MA. Electronic address:

Primary pericardial mesothelioma is a rare malignancy of the mesothelial lining of the pericardium. This study aimed to evaluate the clinical characteristics and survival outcomes of these patients using a US population-based cancer database. We queried the Surveillance, Epidemiology, and End Results program (1973-2015). Read More

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Leukemic Infiltration of Myocardium Presenting as Cardiac Arrest.

JACC Case Rep 2021 Jun 16;3(6):922-927. Epub 2021 Jun 16.

Smidt Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Clinically significant myocardial infiltration by leukemic cells is a rare phenomenon. We describe a case of a 47-year-old woman with newly diagnosed acute myeloid leukemia and pleuritic chest pain with rapid cardiopulmonary decompensation. Post-mortem analyses showed fibrinous pericarditis and extensive leukemic infiltration of the myocardium. Read More

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Ventricular Tachycardia: A Rare Case of Myocardial Silicosis.

JACC Case Rep 2020 Nov 18;2(14):2256-2259. Epub 2020 Nov 18.

Aurora Center for Advanced Atrial Fibrillation Therapies, Aurora Cardiovascular and Thoracic Services, Aurora St. Luke's Medical Center, Advocate Aurora Health, Milwaukee, Wisconsin.

Chronic exposure to silica is a recognized health hazard. Manifestations of pulmonary and extrapulmonary silicosis are well described. Secondary pulmonary arterial hypertension and pericardial involvement are described, but myocardial involvement has not been reported. Read More

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November 2020

Constrictive Pericarditis Caused by IgG4-Related Disease Requiring Pericardiectomy After Partial Response to Corticosteroids.

JACC Case Rep 2020 Aug 19;2(10):1558-1563. Epub 2020 Aug 19.

Department of Cardiothoracic Surgery, NYU Langone Medical Center, New York, New York.

Immunoglobulin G4-related disease is a systemic fibroinflammatory disease; pericardial involvement has occasionally been reported in publications. A 79-year-old man with biopsy-proven immunoglobulin G4-related disease with pleural involvement was admitted in acute heart failure, with imaging and hemodynamic studies consistent with constrictive pericarditis. He was treated with corticosteroids for 2 months with partial response manifest by decreases in pericardial thickening and immunoglobulin G4 levels. Read More

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Fat-Finding Mission: Primary Pleomorphic Liposarcoma of the Heart and Pericardium.

JACC Case Rep 2020 Aug 19;2(10):1520-1526. Epub 2020 Aug 19.

Departments of Surgery, Internal Medicine, Radiology, and Pathology, Advent Health Orlando, Orlando, Florida.

Primary cardiac liposarcomas are rare tumors with a poor prognosis and no well-defined imaging characteristics or treatment guidelines. Here, we present a case of primary pleomorphic liposarcoma of the heart and pericardium with multimodality imaging findings and our institution's treatment approach. (). Read More

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Epicardial Nodules as the Initial Manifestation of Immunoglobulin G4-Related Pericarditis.

JACC Case Rep 2020 Aug 19;2(10):1505-1509. Epub 2020 Aug 19.

Department of Cardiovascular Surgery, Chiba-Nishi General Hospital, Matsudo, Japan.

Immunoglobulin G4 (IgG4)-related pericarditis, an immune-mediated fibro-inflammatory condition, is a rare yet life-threatening disease presenting with constrictive pericarditis. We describe a case of IgG4-related pericarditis presenting with epicardial nodules successfully treated with corticosteroids. This case highlights the clinical significance of assessing IgG4-related pericarditis in the diagnostic workup of pericardial masses. Read More

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Giant pericardial mass case report: role of echocardiography.

AME Case Rep 2021 25;5:23. Epub 2021 Jul 25.

Division of Cardiology, Sant' Eugenio Hospital, Rome, Italy.

Cardiac masses are rare and they are distinguished in tumors and non-tumoral masses. Primary pericardial masses are very rare and they are often asymptomatic, even if they can present with sudden cardiac death. The diagnosis of these masses is often accidental and they are generally identified with echocardiography; their characterization is usually performed by cardiac magnetic resonance imaging (MRI) but the definitive diagnosis is achieved by tissue biopsy. Read More

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The toxicity mechanism of toxic compounds from Euphorbiae pekinensis Radix on zebrafish embryos.

Biomed Pharmacother 2021 Jun 1;138:111521. Epub 2021 Apr 1.

Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:

Euphorbiae pekinensis Radix (EP) is effective in treating various diseases, but it's toxicity is a major obstacle in use in clinical. Although EP was processed with vinegar to reduce it's toxicity, the detailed mechanism of toxicity in EP have not been clearly delineated. This study investigate the toxicity attenuation-mechanism of Euphorbiae pekinensis after being processed with vinegar (VEP) and the toxic mechanism of four compounds from EP on zebrafish embryos. Read More

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Thoracic Benign Cystic Mesothelioma.

Acta Chir Belg 2021 Jul 26:1-6. Epub 2021 Jul 26.

University of Health Sciences Turkey, Ankara City Hospital, Department of Thoracic Surgery and Lung Transplantation, Ankara, Turkey.

Background: Benign cystic mesotheliomas (BCMs), also known as multilocular mesothelial inclusion cysts, inflammatory inclusion cysts or multicystic mesothelial proliferation, are frequently observed in females and are localised localised in the pelvic peritoneum. They are rarely present in the thoracic and mediastinal areas; however, these locations have been reported in a few cases in the literature.

Case Presentation: We present the case of a woman with an intrathoracic BCM. Read More

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Every Beat You Take-The Wilms' Tumor Suppressor WT1 and the Heart.

Int J Mol Sci 2021 Jul 18;22(14). Epub 2021 Jul 18.

CNRS, INSERM, iBV, Université Côte d'Azur, 06107 Nice, France.

Nearly three decades ago, the Wilms' tumor suppressor Wt1 was identified as a crucial regulator of heart development. Wt1 is a zinc finger transcription factor with multiple biological functions, implicated in the development of several organ systems, among them cardiovascular structures. This review summarizes the results from many research groups which allowed to establish a relevant function for Wt1 in cardiac development and disease. Read More

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Massive left ventricular thrombosis in pericardial decompression syndrome.

Echocardiography 2021 Jul 19. Epub 2021 Jul 19.

Department of Cardiology, St. Luke's University Health Network, Bethlehem, Pennsylvania, USA.

Background: Pericardial decompression syndrome (PDS) is defined as paradoxical hemodynamic deterioration associated with left, right, or bi-ventricular dilation and systolic dysfunction following pericardiocentesis. It is uncommon yet under-recognized, underreported, and associated with significant morbidity and mortality.

Case Report: We report a unique case of PDS associated with left ventricular (LV) systolic dysfunction and massive apical thrombosis following surgical removal of 800 ml of pericardial fluid in a 72-year-old man with undiagnosed lung cancer. Read More

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Cardiac magnetic resonance imaging in unclear cases of ventricular interdependence: a case series.

Eur Heart J Case Rep 2021 Jul 18;5(7):ytab223. Epub 2021 Jul 18.

Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati Medical Center, 234 Goodman Street, Cincinnati, OH 45219, USA.

Background : Diagnosis of constrictive pericarditis requires demonstration of interventricular interdependence which can prove difficult even with invasive haemodynamics. Its treatment requires invasive surgical procedures prior to which diagnostic certainty is necessary. Cardiac magnetic resonance imaging (MRI) is an underutilized tool for identification of this pathology. Read More

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Diffuse Linear Pattern of Pericardial FDG Activity in Pericardial Metastasis From Squamous Cell Lung Carcinoma.

Clin Nucl Med 2021 Jul 20. Epub 2021 Jul 20.

From the Department of Cardiothoracic Surgery, The Second Affiliated Hospital, Jiaxing University, Jiaxing, Zhejiang Province Department of Nuclear Medicine, Changhai Hospital, Navy Medical University Department of Pathology, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.

Abstract: Pericardial metastasis usually shows focal pericardial FDG activity. Diffuse linear pattern of pericardial FDG activity is uncommon. We present a case of pericardial metastasis from squamous cell lung carcinoma showing diffuse linear pericardial FDG activity mimicking tuberculous pericarditis. Read More

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Sternal Metastasis of Brain Meningioma - A Case Report.

Anticancer Res 2021 Aug;41(8):4039-4043

Department of Orthopaedic Surgery, Hiroshima University, Hiroshima, Japan.

Background: Metastases of meningiomas are infrequent and the site of extracranial metastasis such as the bone is extremely rare.

Case Report: A 75-year-old male had a history of five sessions of surgery and gamma-knife treatment for brain meningioma over a period of 29 years. He visited our hospital because he noticed a swelling in his anterior chest 2 years and 6 months after the final treatment. Read More

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Cardiac Tamponade as a Manifestation of Clear Cell Renal Cell Carcinoma.

Cureus 2021 Jun 15;13(6):e15658. Epub 2021 Jun 15.

Pulmonology, Hospital Universitario San Juan Alicante, San Juan Alicante, ESP.

Some solid cancers (such as lung, breast, and esophageal cancer, and melanoma) can lead to pericardial effusion by metastatic spread, potentially provoking hemodynamic instability. Detection by echocardiography is therefore essential. Pericardiocentesis can help restore cardiac function and provide fluid for establishing an etiology through cytological, microbiological, and cellularity analysis. Read More

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Mediastinal Low-Grade Fibromyxoid Sarcoma With FUS-CREB3L2 Gene Fusion.

Cureus 2021 Jun 11;13(6):e15606. Epub 2021 Jun 11.

Oncology, Charleston Area Medical Center (CAMC), Charleston, USA.

Low-grade fibromyxoid sarcoma (LGFMS) is a rare subclass of sarcoma. Histologically, they are characterized by bland-appearing fibroblastic spindle cells and are similar to sclerosing epithelioid fibrosarcoma (SEF) subtype. The standard treatment of this aggressive tumor subtype is surgical removal with wide excision in conjunction with doxorubicin chemotherapy. Read More

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A Clinico-Pathologic Approach to the Differential Diagnosis of Pericardial Tumors.

Curr Cardiol Rep 2021 07 16;23(9):119. Epub 2021 Jul 16.

Department of Pathology, The Cleveland Clinic, 9500 Euclid Avenue/Desk L25, Cleveland, Ohio, 44195, USA.

Purpose Of Review: Tumors of the pericardium are rare, but a wide variety of congenital, infectious, inflammatory, and neoplastic processes have been reported. Pericardial tumors can be categorized as non-neoplastic or neoplastic. Neoplastic lesions can be further divided into benign or malignant, with malignancies being either primary or secondary (metastatic). Read More

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Malignant Müllerian Adenocarcinoma Manifesting With Cardiac Tamponade and Pleural Effusion.

Cureus 2021 Jul 7;13(7):e16233. Epub 2021 Jul 7.

Pulmonary and Critical Care Medicine, University of Florida Health - Jacksonville, Jacksonville, USA.

A 54-year-old woman with a past medical history of untreated stage IV Müllerian adenocarcinoma presented for dyspnea. She was found to have a large right-sided pleural effusion through basic radiology and clinically improved after a CT-guided therapeutic thoracocentesis. However, the patient rapidly deteriorated shortly afterward. Read More

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A rare case of cardiac metastasis from uterine cervical adenocarcinoma.

J Cardiol Cases 2021 Jul 13;24(1):30-33. Epub 2020 Dec 13.

Resident of Cardiology, Department of Cardiovascular Disease, Hazrat-e Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran.

Metastatic cardiac tumors are rare and are usually from lung, breast, and esophageal cancers. Although uterine cervical cancer is relatively common, its metastasis to the heart is extremely rare. Herein, we report an unusual case of metastatic cervical adenocarcinoma to the heart presenting with a huge right atrial mass and tamponade. Read More

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Metastatic malignant peripheral nerve sheath tumor. A diagnostic surprise.

Monaldi Arch Chest Dis 2021 May 6;91(2). Epub 2021 May 6.

Department of Pulmonary Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry.

Malignant peripheral nerve sheath tumours (MPNSTs) are rare soft tissue tumors that arise from pre-existing plexiform neurofibromas or within a normal peripheral nerve. They are aggressive tumors with high rates of recurrence and distant metastases, the most common sites of metastasis being the lung followed by bone. A 46 year old gentleman presented with breathlessness and chest pain three years after post amputation of left thumb for an ulcerative growth. Read More

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Nonskeletal injuries related to cardiopulmonary resuscitation: An autopsy study.

J Forensic Sci 2021 Jul 12. Epub 2021 Jul 12.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

The current standard technique for cardiopulmonary resuscitation (CPR), initially described in the early 1960s, has quickly become the expected response for all persons found without a pulse or respiration. Despite the potentially lifesaving properties of external cardiac massage, the mainstay of resuscitation, it consists of repeated blunt force trauma to the chest, which can lead to extensive traumatic skeletal and nonskeletal injuries. Numerous autopsy-based studies have documented the incidence and patterns of rib and sternal fractures associated with attempted CPR, but there is relatively little data on the incidence and severity of nonskeletal CPR-related injuries. Read More

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Progressive Heart Failure and Death as the Initial Manifestation of NK/T-Cell Lymphoma: A Case Report and Literature Review.

Front Cardiovasc Med 2021 24;8:685736. Epub 2021 Jun 24.

Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.

Natural killer/T-cell (NK/T-cell) lymphoma is a rare-type non-Hodgkin lymphoma derived from NK cells or cytotoxic T cells. Here, we present a case of a 40-year-old woman who experienced quick-developed global heart failure and then was diagnosed with NK/T-cell lymphoma through lymphoid biopsy. Neither transthoracic echocardiography nor any radiological images detected a mass in her heart or pericardium. Read More

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Finding the bubble: atypical and unusual extrapulmonary air in the chest.

Radiologia (Engl Ed) 2021 Jul-Aug;63(4):358-369

Servicio de Radiodiagnóstico, Hospital Vall de Hebron, Barcelona, Spain.

Objective: To describe the radiologic findings of extrapulmonary air in the chest and to review atypical and unusual causes of extrapulmonary air, emphasizing the importance of the diagnosis in managing these patients.

Conclusion: In this article, we review a series of cases collected at our center that manifest with extrapulmonary air in the thorax, paying special attention to atypical and uncommon causes. We discuss the causes of extrapulmonary according to its location: mediastinum (spontaneous pneumomediastinum with pneumorrhachis, tracheal rupture, dehiscence of the bronchial anastomosis after lung transplantation, intramucosal esophageal dissection, Boerhaave syndrome, tracheoesophageal fistula in patients with esophageal tumors, bronchial perforation and esophagorespiratory fistula due to lymph-node rupture, and acute mediastinitis), pericardium (pneumopericardium in patients with lung tumors), cardiovascular (venous air embolism), pleura (bronchopleural fistulas, spontaneous pneumothorax in patients with malignant pleural mesotheliomas and primary lung tumors, and bilateral pneumothorax after unilateral lung biopsy), and thoracic wall (infections, transdiaphragmatic intercostal hernia, and subcutaneous emphysema after lung biopsy). Read More

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