7,760 results match your criteria perianal

Risk Factors for Developing Hidradenitis Suppurativa in Patients With Inflammatory Bowel Disease: A Retrospective Case-Control Study.

J Can Assoc Gastroenterol 2021 Aug 28;4(4):165-172. Epub 2020 Jul 28.

Division of Gastroenterology, Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Background: Hidradenitis suppurativa (HS) is associated with inflammatory bowel disease (IBD), though risk factors remain to be determined.

Aim: To characterize HS among a cohort of IBD patients and identify risk factors for its development.

Methods: This was a retrospective case-control study at the ambulatory IBD centre at Mount Sinai Hospital from inception to May 2019. Read More

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Axillary Paget disease with a visible satellite: a case report and literature review.

Diagn Pathol 2021 Aug 1;16(1):69. Epub 2021 Aug 1.

Department of General Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, No.168 Litang Road, Changping District, Beijing, 102218, China.

Background: Extramammary Paget disease (EMPD) is an uncommon malignancy affecting apocrine gland-bearing skin, such as vulvar, perianal, axillary and penoscrotal areas. Paget cells are sometimes detected outside clinical border in a phenomenon called subclinical extension. Satellite is one of the patterns of subclinical extension which is likely to be invisible. Read More

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HPV-induced condylomata acuminata treated by Photodynamic Therapy in comparison with Trichloroacetic Acid: a randomized clinical trial.

Photodiagnosis Photodyn Ther 2021 Jul 29:102465. Epub 2021 Jul 29.

Sao Carlos Institute of Physics, University of Sao Paulo, Brazil.

Objectives: This is a randomized controlled clinical trial comparing photodynamic Therapy (PDT) and the application of trichloracetic acid (TAA) in the treatment of HPV condyloma in the perianal and vulva regions. Design, Randomised controlled, open label, trial. They were allocated to each treatment following randomization by a computer program. Read More

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Deep Herpes.

Am J Surg Pathol 2021 Jul 29. Epub 2021 Jul 29.

Pathology Service, Massachusetts General Hospital and Harvard Medical School, Boston Department of Pathology, Newton-Wellesley Hospital, Newton, MA Department of Pathology, Michigan Medicine, University of Michigan, Ann Arbor, MI Departments of Pathology Dermatology, University of Arkansas for Medical Sciences, Little Rock Johnson Dermatology Clinic, Fort Smith, AR Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon Geisel School of Medicine at Dartmouth, Hanover, NH.

Herpes viruses are known for infecting epithelial cells and manifesting as vesicles. However, herpes viruses can also infect stromal cells. While established in the ocular setting, cutaneous stromal herpes (deep herpes) is previously unreported and may evade clinical and microscopic detection. Read More

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Inter-reader agreement of the Society of Abdominal Radiology-American Gastroenterological Association (SAR-AGA) consensus reporting for key phenotypes at MR enterography in adults with Crohn disease: impact of radiologist experience.

Abdom Radiol (NY) 2021 Jul 29. Epub 2021 Jul 29.

Department of Radiology, NYU Langone Health, New York, NY, 10016, USA.

Purpose: To assess inter-reader agreement of key features from the SAR-AGA recommendations for the interpretation and reporting of MRE in adult patients with CD, focusing on the impact of radiologist experience on inter-reader agreement of CD phenotypes.

Methods: Two experienced and two less-experienced radiologists retrospectively evaluated 99 MRE in CD patients (50 initial MRE, 49 follow-up MRE) performed from 1/1/2019 to 3/20/2020 for the presence of active bowel inflammation (stomach, proximal small bowel, ileum, colon), stricture, probable stricture, penetrating disease, and perianal disease. The MRE protocol did not include dedicated perianal sequences. Read More

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A Standardized Evaluation Method for Assessing Patients With Genital Dyschromia.

Cureus 2021 Jun 22;13(6):e15840. Epub 2021 Jun 22.

Medicine, Bahiana School of Medicine and Public Health, Salvador, BRA.

Objective The population's ever-growing concern with genital aesthetic dysfunctions reflects an increasing demand in the field of intimate aesthetics. For this reason, as well as the lack of a standardized evaluation, this paper aims to develop a form that facilitates the initial investigation of aesthetic genital dysfunctions.  Methods An evaluation form for female and male genital dyschromia was developed between July and November 2018. Read More

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Approach to medical therapy in perianal Crohn's disease.

World J Gastroenterol 2021 Jul;27(25):3693-3704

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, United States.

Perianal Crohn's disease remains a challenging condition to treat and can have a substantial negative impact on quality of life. It often requires combined surgical and medical interventions. Anti-tumor necrosis factor (anti-TNF) therapy, including infliximab and adalimumab, remain preferred medical therapies for perianal Crohn's disease. Read More

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Treatment response to eribulin and anlotinib in lung metastases from rare perianal adenoid cystic carcinoma: a case report.

Anticancer Drugs 2021 Jul 30. Epub 2021 Jul 30.

Department of Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu Department of Laboratory Medicine, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Department of Geriatric Oncology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.

Adenoid cystic carcinoma (ACC) is a rare salivary glands tumor and often displays aggressive behavior with frequent relapse and metastasis. The terminal ACC lacks standard treatment guidelines and is always accompanied by poor prognosis. Here, we report a case of rare perianal ACC who received resection and palliative adjuvant radiation. Read More

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Forgotten Surgical Gauze: A Rare Cause of Recurrent Perianal Fistula.

J Coll Physicians Surg Pak 2021 Aug;31(8):1007-1008

Department of General Surgery, Sharif Medical & Dental College, Raiwind Road, Lahore, Pakistan.

Null. Read More

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Role of Diffusion-Weighted Imaging in the Evaluation of Perianal Fistulae.

Indian J Radiol Imaging 2021 Jan 23;31(1):91-101. Epub 2021 May 23.

Department of Radio-Diagnosis, Tezpur Medical College and Hospital, Tezpur, Assam, India.

 Magnetic resonance imaging (MRI) is the imaging modality of choice for evaluating perianal fistulae, due to its ability to show the relationship of perianal fistulae with anal sphincters, fistula extensions, secondary ramifications and associated complications.  To evaluate the role of diffusion-weighted MRI in the evaluation of perianal fistulae.  A hospital-based cross-sectional study. Read More

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January 2021

Managing Complex Perianal Fistulizing Disease.

J Laparoendosc Adv Surg Tech A 2021 Jul 27. Epub 2021 Jul 27.

Department of Colorectal Surgery, Digestive Disease Surgical Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Perianal disease is a particularly morbid phenotype of Crohn's disease, affecting up to one third of patients, with a significantly diminished quality of life. Conventional medical therapy and surgical interventions have limited efficacy. Medical treatment options achieve long-term durable remission in only a third of patients. Read More

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A Retrospective Study of Touchless Spray for Pediatric Perineal Burns Treatment.

J Burn Care Res 2021 Jul 26. Epub 2021 Jul 26.

Department of Surgery, Division of Pediatric Surgery, Children's Hospital of Michigan/Wayne State University, Detroit, MI, USA.

Background: Silver-based topical treatments have seen widespread use for the management of burns due to silver's antimicrobial activity. Recent studies suggest silver nanoparticles could negatively impact healing time due to their toxic effect on keratinocytes and fibroblasts at higher concentrations [1, 2]. Zinc oxide antimicrobial activity has been demonstrated in vitro [3, 4] and results from animal studies are promising for burn management [5]. Read More

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Perianal superficial CD34-positive fibroblastic tumor: A case report.

World J Clin Cases 2021 Jul;9(20):5605-5610

Department of Pathology, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou 412007, Hunan Province, China.

Background: Superficial CD34-positive fibroblast tumors (SCPFTs) are newly recognized fibroblast and myofibroblast tumors representing intermediate tumors. To the best of our knowledge, fewer than 50 cases have been reported. Perianal SCPFT has not been previously reported. Read More

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Perianal pyoderma gangrenosum.

Cir Esp (Engl Ed) 2021 Jul 22. Epub 2021 Jul 22.

Departamento de Cirugía, Hospital de Barbastro, Barbastro, Huesca, Spain.

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A Novel Technique for the Treatment of a Case of Verneuil's Disease of Perineum and Axillary Regions.

Surg J (N Y) 2021 Jul 19;7(3):e163-e167. Epub 2021 Jul 19.

Department of General Surgery, Centre Hospitalier Universitaire Geitaoui, Lebanon.

Hidradenitis suppurativa (HS) is a chronic inflammatory disease involving apocrine glands of the skin. It carries out an important burden on the daily life of the patient. Unfortunately, it presents a major concern for medical care management in the absence of clear guidelines for proper medical and surgical treatment. Read More

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Advanced Regenerative Medicine Strategies for Treatment of Perianal Fistula in Crohn's Disease.

Inflamm Bowel Dis 2021 Jul 22. Epub 2021 Jul 22.

Division of Colorectal Surgery, Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran.

Regenerative medicine is an emerging therapeutic method that aims to reconstruct tissues and organs. This advanced therapeutic approach has demonstrated great potential in addressing the limitations of medical and surgical procedures for treating perineal fistula in patients with Crohn's disease. Recent developments in stem cell technology have led to a massive good manufacturing practices (GMPs) production of various stem cells, including mesenchymal and embryonic cells, along with induction of pluripotent stem cells to repair damaged tissues in the fistula. Read More

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Adult-onset perianal Langerhans cell histiocytosis presenting as pruritus ani: a case report and review of the literature.

J Med Case Rep 2021 Jul 22;15(1):357. Epub 2021 Jul 22.

Departments of Surgery, Texas Tech University Health Sciences Center, El Paso, TX, USA.

Background: Langerhans cells belong to the histiocytic system and give rise to two tumors: Langerhans cell histiocytosis and Langerhans cell sarcoma. Clinical aggressiveness and degree of atypia distinguish the two neoplasms. Langerhans cell histiocytosis can infiltrate a single or multiple organ systems and particularly affects bone, skin, and lymph nodes. Read More

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Algorithm of rational approach to reconstruction in Fournier's disease.

Open Med (Wars) 2021 9;16(1):1028-1037. Epub 2021 Jul 9.

Plastic and Reconstructive Surgery Unit, Centre Hospitalier Universitaire Bichat Claude-Bernard, Paris, France.

Background: Fournier's gangrene is a rare form of necrotizing fasciitis that affects the genital area up to the perineal region and sometimes the abdominal wall.

Objectives: Our article aims to show that in the treatment of extensive forms of Fournier's gangrene, correct use of flap and skin grafts and a quick reconstruction of the exposed tissues avoid scarring retraction of the testicles and deformation of the penis.

Materials And Methods: We retrospectively reviewed the clinical and photographic data of Fournier's gangrene cases treated at our Institute. Read More

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Perianal and Luminal Relapse Following Perianal Surgical Intervention in Crohn's Disease.

Int J Gen Med 2021 13;14:3387-3396. Epub 2021 Jul 13.

Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People's Republic of China.

Background And Aims: Fistula relapse occurs in 20-30% of patients with perianal Crohn's disease (PCD) despite optimal medico-surgical management. We aimed in this study to assess the rate of perianal and luminal relapse after surgically induced remission and to determine factors associated with fistula relapse.

Methods: Consecutive perianal CD patients who achieved clinical remission after surgery for fistulising PCD from January 2013 to January 2019 were included. Read More

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Injection of Aluminum Potassium Sulfate and Tannic Acid in the Treatment of Fecal Incontinence: A Single-Center Observational Study.

Ann Coloproctol 2021 Jul 21. Epub 2021 Jul 21.

Department of Proctology, Kunimoto Hospital, Asahikawa, Hokkaido, Japan.

Purpose: Perianal injection of bulking agents is an attractive treatment option for patients with mild to moderate fecal incontinence (FI). Various bulking agents have been used for injection therapy, but the optimal injection materials and methods are yet to be standardized. This study aimed to evaluate the effects of injection therapy using aluminum potassium sulfate and tannic acid (ALTA) in the management of FI. Read More

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Pediatric Vulvar Lichen Sclerosus-A Review of the Literature.

Int J Environ Res Public Health 2021 07 4;18(13). Epub 2021 Jul 4.

Chair and Department of Gynecology, Obstetrics and Oncological Gynecology, Medical University of Silesia in Katowice, Markiefki 87, 40-211 Katowice, Poland.

Vulvar lichen sclerosus (VLS) is a chronic inflammatory condition affecting the anogenital region, which may present in a prepubertal or adolescent patient. The most popular theories are its autoimmune and genetic conditioning, although theories concerning hormonal and infectious etiology have also been raised. The most common presenting symptoms of VLS is vulva pruritus, discomfort, dysuria and constipation. Read More

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Perianal Plasmablastic Lymphoma Masquerading as a Buschke-Löwenstein-like Tumour in an HIV-infected Patient with Recurrent Anal Condyloma.

Eur J Case Rep Intern Med 2021 11;8(7):002552. Epub 2021 Jun 11.

Department of Pathology and Laboratory Medicine, The University of Texas Health Sciences Center at Houston, McGovern Medical School, Houston, Texas, USA.

Plasmablastic lymphoma (PBL) commonly presents as a primary (de novo) oral or extraoral mucocutaneous or nodal mass lesion in patients with HIV/AIDS. PBL developing as a secondary malignancy at the same location as a pre-existing tumour is extremely rare and has never been reported in association with longstanding or recurrent anal condyloma. A Buschke-Löwenstein tumour is a rare gigantic, locally destructive condyloma that is usually located in the anogenital region. Read More

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Getting the most out of MRI in perianal fistula: update on surgical techniques and radiological features that define surgical options.

Clin Radiol 2021 Jul 12. Epub 2021 Jul 12.

Robin Phillips' Fistula Research Unit, St Mark's Hospital, Watford Road, Harrow HA1 3UJ, UK; Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK. Electronic address:

Perianal fistulas affect approximately 2 in 10,000 people, causing symptoms such as pain and discharge, which can have a debilitating effect on a patient's quality of life. Surgical treatment, which can offer a potential cure or palliation of symptoms, must be considered carefully in cases with extensive sphincter involvement. In complex cases, the use of preoperative magnetic resonance imaging (MRI) can help to determine the best course of operative action. Read More

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Antimicrobial photodynamic and photobiomodulation adjuvant therapies for the treatment of perianal abscess.

Photodiagnosis Photodyn Ther 2021 Jul 11;35:102437. Epub 2021 Jul 11.

Graduate Dentistry Program, Ibirapuera University. São Paulo, SP, Brazil.

Although the treatment and management options for perianal abscess vary considerably, most cases require incision and drainage. Whatever the clinical approach selected, it is imperative to monitor patients to identify postoperative signs and symptoms which suggest treatment failure or further complications, such as sepsis, recurrent abscess, and fistula formation. Considering the debate on the role of postoperative antibiotic therapy for patients with perianal abscess and the significant discomfort caused by the infection, the present study aimed to report a clinical case in which antimicrobial photodynamic therapy (aPDT) and photobiomodulation therapy (PBMT) were used after incision and drainage of a simple perianal abscess. Read More

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Comparative perianal fistula closure rates following autologous adipose tissue-derived stem cell transplantation or treatment with anti-tumor necrosis factor agents after seton placement in patients with Crohn's disease: a retrospective observational study.

Stem Cell Res Ther 2021 Jul 13;12(1):401. Epub 2021 Jul 13.

Department of Colon and Rectal Surgery, Asan Medical Center, University of College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.

Background: Perianal fistula is one of the most common complications in Crohn's disease, and various medical and surgical treatments are being tried. The aim of this study was to compare the perianal fistula closure rates following treatment with anti-tumor necrosis factor (TNF) agents or autologous adipose tissue-derived stem cell (auto-ASC) transplantation with Crohn's disease (CD).

Methods: CD patients who underwent seton placement for perianal fistula from January 2015 to December 2019 at a tertiary referral center were retrospectively reviewed. Read More

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Feline cystadenomatosis affecting the ears and skin of 57 cats (2011-2019).

J Feline Med Surg 2021 Jul 13:1098612X211024498. Epub 2021 Jul 13.

Department of Immunology, Harvard Medical School, Boston, MA, USA.

Objectives: This study aimed to understand epidemiological factors associated with feline cystadenomatosis, including signalment and papillomavirus PCR status. Cystadenomatosis is an uncommon condition primarily involving the ceruminous and apocrine skin and ear glands.

Methods: This was a retrospective case series. Read More

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Minimal Lateral Internal Sphincterotomy (LIS): Is It Enough to Cut Less Than the Conventional Tailored LIS?

Ann Coloproctol 2021 Jul 9. Epub 2021 Jul 9.

Department of Surgery, Seoul Song Do Hospital, Seoul, Korea.

Purpose: Anal fissure is a common anorectal condition, yet its pathogenesis remains unclear. Lateral internal sphincterotomy (LIS) is the gold standard treatment for chronic anal fissures that do not respond to conservative treatment; however, it has a risk of anal incontinence. We believe that fibrosis of the internal anal sphincter is an important factor in the pathogenesis of chronic anal fissure. Read More

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Stem cell injection for complex anal fistula in Crohn's disease: A single-center experience.

World J Gastroenterol 2021 Jun;27(24):3643-3653

Department of Proctology, Krankenhaus Barmherzige Brueder, Regensburg 93049, Germany.

Background: Despite tremendous progress in medical therapy and optimization of surgical strategies, considerable failure rates after surgery for complex anal fistula in Crohn's disease have been reported. Therefore, stem cell therapy for the treatment of complex perianal fistula can be an innovative option with potential long-term healing.

Aim: To evaluate the results of local administration of allogenic, adipose-derived mesenchymal stem cells (darvadstrocel) for complex anal Crohn's fistula. Read More

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