19,371 results match your criteria perfusion magnetic


Low conductivity on electrical properties tomography demonstrates unique tumor habitats indicating progression in glioblastoma.

Eur Radiol 2021 Apr 20. Epub 2021 Apr 20.

Department of Tomographic Imaging, Philips Research Laboratories, Hamburg, Germany.

Objectives: Tissue conductivity measurements made with electrical properties tomography (EPT) can be used to define temporal changes in tissue habitats on longitudinal multiparametric MRI. We aimed to demonstrate the added insights for identifying tumor habitats obtained by including EPT with diffusion- and perfusion-weighted MRI, and to evaluate the use of these tumor habitats for determining tumor treatment response in post-treatment glioblastoma.

Methods: Tumor habitats were developed from EPT, diffusion-weighted, and perfusion-weighted MRI in 60 patients with glioblastoma who underwent concurrent chemoradiotherapy. Read More

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Image-based personalization of computational models for predicting response of high-grade glioma to chemoradiation.

Sci Rep 2021 Apr 19;11(1):8520. Epub 2021 Apr 19.

Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA.

High-grade gliomas are an aggressive and invasive malignancy which are susceptible to treatment resistance due to heterogeneity in intratumoral properties such as cell proliferation and density and perfusion. Non-invasive imaging approaches can measure these properties, which can then be used to calibrate patient-specific mathematical models of tumor growth and response. We employed multiparametric magnetic resonance imaging (MRI) to identify tumor extent (via contrast-enhanced T-weighted, and T-FLAIR) and capture intratumoral heterogeneity in cell density (via diffusion-weighted imaging) to calibrate a family of mathematical models of chemoradiation response in nine patients with unresected or partially resected disease. Read More

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Myxofibrosarcoma: Another mimicker of meningioma.

Neurocirugia (Astur) 2021 Apr 16. Epub 2021 Apr 16.

Department of Radiology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil. Electronic address:

Primary intracranial malignant fibrous histiocytoma (MFH), or myxofibrosarcoma, is an extremely rare condition, with only a few cases reported in the literature. We report a case of a dural-based myxofibrosarcoma in a previously healthy 42-year-old man that was initially presumed to be an atypical meningioma. The findings based on conventional and advanced magnetic resonance sequences, including diffusion-weighted imaging, perfusion weighted imaging and proton magnetic resonance spectroscopy, as well as histopathological aspects, are discussed. Read More

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Detection of age related differences in CBF with PCASL using 2 post label delays.

Clin Imaging 2021 Apr 12;79:36-42. Epub 2021 Apr 12.

Department of Magnetic Resonance, Shanxi Cardiovascular Hospital, Taiyuan, China.

Background: The brain is reliant on an abundant and uninterrupted CBF for normal neural function because it is an organ with high metabolic activity and limited ability to store energy.

Purpose: This study aimed to compare age-related variations in CBF measured with PCASL.

Methods: This prospective study included healthy volunteers at the Radiology Department of Shanxi Cardiovascular Hospital between October 2018 and July 2019. Read More

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Magnetic resonance imaging-based changes in vascular morphology and cerebral perfusion in subacute ischemic stroke.

J Cereb Blood Flow Metab 2021 Apr 17:271678X211010071. Epub 2021 Apr 17.

Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Stroke Research Berlin, Berlin, Germany.

MRI-based vessel size imaging (VSI) allows for assessment of cerebral microvasculature and perfusion. This exploratory analysis of vessel size (VS) and density (Q; both assessed via VSI) in the subacute phase of ischemic stroke involved sixty-two patients from the BAPTISe cohort ('Biomarkers And Perfusion--Training-Induced changes after Stroke') nested within a randomized controlled trial (intervention: 4-week training relaxation). Relative VS, Q, cerebral blood volume (rCBV) and -flow (rCBF) were calculated for: ischemic lesion, perilesional tissue, and region corresponding to ischemic lesion on the contralateral side (mirrored lesion). Read More

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Contributions of Cerebral Blood Flow to Associations Between Blood Pressure Levels and Cognition: The Age, Gene/Environment Susceptibility-Reykjavik Study.

Hypertension 2021 Apr 19:HYPERTENSIONAHA12016894. Epub 2021 Apr 19.

From the Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institute of Health, Baltimore, MD (J.E.M., O.M., L.J.L.).

Cerebral hypoperfusion leads to adverse sequalae including dementia. Midlife higher blood pressure (BP) can lead to low cerebral blood flow (CBF), but older persons may need higher BP to maintain cerebral perfusion. We investigated the associations among late-life BP, CBF, and cognition. Read More

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Functional and Economic Impact of INOCA and Influence of Coronary Microvascular Dysfunction.

JACC Cardiovasc Imaging 2021 Apr 7. Epub 2021 Apr 7.

Division of Cardiovascular Medicine and the Cardiac Imaging Center, University of Virginia Health System, Charlottesville, Virginia, USA; Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, Virginia, USA. Electronic address:

Objectives: This study sought to better characterize the quality of life and economic impact in patients with symptoms of ischemia and no obstructive coronary disease (INOCA) and to identify the influence of coronary microvascular dysfunction (CMD).

Background: Patients with INOCA have a high symptom burden and an increased incidence of major adverse cardiac events. CMD is a frequent cause of INOCA. Read More

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Myocardial Fibrosis and Inflammation by CMR Predict Cardiovascular Outcome in People Living With HIV.

JACC Cardiovasc Imaging 2021 Apr 7. Epub 2021 Apr 7.

Institute of Experimental and Translational Cardiac Imaging, DZHK (German Centre for Cardiovascular Research) Centre for Cardiovascular Imaging, University Hospital Frankfurt, Frankfurt am Main, Germany; Department of Cardiology, University Hospital Warsaw, Warsaw, Poland. Electronic address:

Objectives: The goal of this study was to examine prognostic relationships between cardiac imaging measures and cardiovascular outcome in people living with human immunodeficiency virus (HIV) (PLWH) on highly active antiretroviral therapy (HAART).

Background: PLWH have a higher prevalence of cardiovascular disease and heart failure (HF) compared with the noninfected population. The pathophysiological drivers of myocardial dysfunction and worse cardiovascular outcome in HIV remain poorly understood. Read More

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Correlation between quantitative perfusion histogram parameters of DCE-MRI and PTEN, P-Akt and m-TOR in different pathological types of lung cancer.

BMC Med Imaging 2021 Apr 17;21(1):73. Epub 2021 Apr 17.

Department of Radiology, The Second Affiliated Hospital of Zhejiang University, Hangzhou, 310009, China.

Background: To explore if the quantitative perfusion histogram parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) correlates with the expression of PTEN, P-Akt and m-TOR protein in lung cancer.

Methods: Thirty-three patients with 33 lesions who had been diagnosed with lung cancer were enrolled in this study. They were divided into three groups: squamous cell carcinoma (SCC, 15 cases), adenocarcinoma (AC, 12 cases) and small cell lung cancer (SCLC, 6 cases). Read More

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Magnetic resonance imaging of salivary gland tumours: Key findings for imaging characterisation.

Eur J Radiol 2021 Apr 10;139:109716. Epub 2021 Apr 10.

Department of Experimental and Clinical Biomedical Sciences, Radiodiagnostic Unit n. 2, Careggi University Hospital, Largo Brambilla 3, Florence, 50134, Italy. Electronic address:

Salivary gland tumours are rare, representing only 3% of all head and neck neoplasms, with the parotid gland being the most common site (80 %). The risk of malignancy is inversely proportional to the size of the gland: lesions arising in the sublingual or minor salivary glands are more likely to be malignant, whereas parotid gland neoplasms are mostly benign. Fine needle aspiration cytology and core needle biopsy are considered the most accurate modalities for the diagnosis of a salivary gland neoplasm; however, they are not always conclusive due to procedural sampling errors and for the presence of a cytological / histological overlap between benign and malignant tumours. Read More

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Myocardial Perfusion and Viability imaging in Coronary Artery Disease: Clinical Value in Diagnosis, Prognosis and Therapeutic Guidance.

Am J Med 2021 Apr 14. Epub 2021 Apr 14.

Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address:

Coronary artery disease is a leading cause of morbidity and mortality worldwide. Non-invasive imaging tests play a significant role in diagnosing coronary artery disease, as well as risk stratification and guidance for revascularization. Myocardial perfusion imaging, including single photon emission computed tomography and positron emission tomography, has been widely employed. Read More

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The importance of heart and brain imaging in children and adolescents with Multisystem Inflammatory Syndrome in Children (MIS-C).

Rheumatol Int 2021 Apr 17. Epub 2021 Apr 17.

Department of Pediatrics, Metropolitan Hospital, Piraeus, Greece.

Multisystem Inflammatory Syndrome in Children (MIS-C) recently reported in a minority of children affected by SARS-CoV-2, mimics Kawasaki disease (KD), a medium vessel vasculitis of unknown cause. In contrast to acute COVID-19 infection, which is usually mild in children, 68% of patients with MIS-C will need intensive care unit. Myocarditis and coronary artery ectasia/aneurysm are included between the main cardiovascular complications in MIS-C. Read More

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Non-invasive assessment of heterogeneity of gliomas using diffusion and perfusion MRI: correlation with spatially co-registered PET.

Acta Radiol 2021 Apr 15:2841851211006913. Epub 2021 Apr 15.

Department of Nuclear Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, PR China.

Background: Heterogeneity of gliomas challenges the neuronavigated biopsy and oncological therapy. Diffusion and perfusion magnetic resonance imaging (MRI) can reveal the cellular and hemodynamic heterogeneity of tumors. Integrated positron emission tomography (PET)/MRI is expected to be a non-invasive imaging approach to characterizing glioma. Read More

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Arterial Spin Labeling Magnetic Resonance Imaging in Healthy Adults: Mathematical Model Fitting to Assess Age-Related Perfusion Pattern.

Korean J Radiol 2021 Apr 1. Epub 2021 Apr 1.

Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.

Objective: To investigate the age-dependent changes in regional cerebral blood flow (CBF) in healthy adults by fitting mathematical models to imaging data.

Materials And Methods: In this prospective study, 90 healthy adults underwent pseudo-continuous arterial spin labeling imaging of the brain. Regional CBF values were extracted from the arterial spin labeling images of each subject. Read More

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Neurovascular coupling dysfunction in end-stage renal disease patients related to cognitive impairment.

J Cereb Blood Flow Metab 2021 Apr 14:271678X211007960. Epub 2021 Apr 14.

Department of Medical Imaging, First Affiliated Hospital of Xi'an, Jiaotong University, Xi'an, China.

We aimed to investigate the neurovascular coupling (NVC) dysfunction in end-stage renal disease (ESRD) patients related with cognitive impairment. Twenty-five ESRD patients and 22 healthy controls were enrolled. To assess the NVC dysfunctional pattern, resting-state functional MRI and arterial spin labeling were explored to estimate the coupling of spontaneous neuronal activity and cerebral blood perfusion based on amplitude of low-frequency fluctuation (ALFF)-cerebral blood flow (CBF), fractional ALFF (fALFF)-CBF, regional homogeneity (ReHo)-CBF, and degree centrality (DC)-CBF correlation coefficients. Read More

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Oxygen Pathway Limitations in Patients with Chronic Thromboembolic Pulmonary Hypertension.

Circulation 2021 Apr 15. Epub 2021 Apr 15.

Baker Heart and Diabetes Institute, Melbourne, Australia; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium; University Hospitals Leuven, Leuven, Belgium.

Exertional intolerance is a limiting and often crippling symptom in patients with chronic thromboembolic pulmonary hypertension (CTEPH). Traditionally the etiology has been attributed to central factors, including ventilation-perfusion mismatch, increased pulmonary vascular resistance and right heart dysfunction and uncoupling. Pulmonary endarterectomy and, balloon pulmonary angioplasty provide substantial improvement of functional status and hemodynamics. Read More

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Surgical outcome and prognostic factors in epilepsy patients with MR-negative focal cortical dysplasia.

PLoS One 2021 14;16(4):e0249929. Epub 2021 Apr 14.

Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Objective: Focal cortical dysplasia (FCD) represents a heterogeneous group of disorders of the cortical formation and is one of the most common causes of epilepsy. Magnetic resonance imaging (MRI) is the modality of choice for detecting structural lesions, and the surgical prognosis in patients with MR lesions is favorable. However, the surgical prognosis of patients with MR-negative FCD is unknown. Read More

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Coronary sinus size and ischemia improvement after reducer implantation; "one size to fit them all?"

Catheter Cardiovasc Interv 2021 Apr 14. Epub 2021 Apr 14.

Interventional Cardiology Unit, GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.

Aim: Coronary sinus (CS) reducer implantation is associated with symptomatic relief of patients with refractory angina. However, 15% to 30% of the patients do not respond to this treatment. Aim if this study was to evaluate the effect of CS size in the effectiveness of the device. Read More

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Enhancement degree of brain metastases: correlation analysis between enhanced T2 FLAIR and vascular permeability parameters of dynamic contrast-enhanced MRI.

Eur Radiol 2021 Apr 13. Epub 2021 Apr 13.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Objectives: To investigate the correlation between enhancement degrees of brain metastases on contrast-enhanced T2-fluid-attenuated inversion recovery (CE-T2 FLAIR) and vascular permeability parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).

Methods: Thirty-nine patients with brain metastases were prospectively collected. They underwent non-enhanced T2 FLAIR, DCE-MRI, CE-T2 FLAIR, and contrast-enhanced three-dimensional brain volume imaging (CE-BRAVO). Read More

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Accuracy of quantitative diffusion-weighted imaging for differentiating benign and malignant pancreatic lesions: a systematic review and meta-analysis.

Eur Radiol 2021 Apr 13. Epub 2021 Apr 13.

School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Background: A variety of imaging techniques can be used to evaluate diffusion characteristics to differentiate malignant and benign pancreatic lesions. The diagnostic performance of diffusion parameters has not been systematic assessed.

Purpose: We aimed to investigate the diagnostic efficacy of quantitative diffusion-weighted imaging (DWI) for pancreatic lesions. Read More

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Rapamycin restores brain vasculature, metabolism, and blood-brain barrier in an inflammaging model.

Geroscience 2021 Apr 13. Epub 2021 Apr 13.

Oklahoma Nathan Shock Center for Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Rapamycin (RAPA) is found to have neuro-protective properties in various neuroinflammatory pathologies, including brain aging. With magnetic resonance imaging (MRI) techniques, we investigated the effect of RAPA in a lipopolysaccharide (LPS)-induced inflammaging model in rat brains. Rats were exposed to saline (control), or LPS alone or LPS combined with RAPA treatment (via food over 6 weeks). Read More

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Cardiac magnetic resonance stress and rest perfusion with T1 mapping: Is it ready to assess for ischaemic heart disease?

Int J Cardiol 2021 Apr 12. Epub 2021 Apr 12.

Division of Cardiology, Department of Medicine, Queen Mary Hospital, Hong Kong, SAR, China.

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Metabolic imaging with hyperpolarized C pyruvate magnetic resonance imaging in patients with renal tumors-Initial experience.

Cancer 2021 Apr 12. Epub 2021 Apr 12.

Department of Radiology and Biomedical Imaging, University of California-San Francisco, San Francisco, California.

Background: Optimal treatment selection for localized renal tumors is challenging because of their variable biologic behavior and limitations in the preoperative assessment of tumor aggressiveness. The authors investigated the emerging hyperpolarized (HP) C magnetic resonance imaging (MRI) technique to noninvasively assess tumor lactate production, which is strongly associated with tumor aggressiveness.

Methods: Eleven patients with renal tumors underwent HP C pyruvate MRI before surgical resection. Read More

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Muscle damage in response to a single bout of high intensity concentric exercise in patients with Pompe disease.

Ann Transl Med 2021 Mar;9(5):389

Department of Neurology, Medical School, University of Pécs, Pécs, Hungary.

Background: In Pompe disease, resistance exercise could be an effective treatment to delay motor function impairment, however, the acute effects of this exercise modality are unclear.

Methods: In a prospective cohort study, we compared responses to a single bout of resistance exercise by serum markers of muscle damage and quantitative muscle magnetic resonance imaging (MRI) in patients (n=12) and age- and gender-matched healthy controls (n=12). Participants performed 50 maximal effort concentric knee flexions on a dynamometer. Read More

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Delayed Endovascular Thrombectomy for Ischemic Stroke in a Young Woman with No Known Risk Factors: A Case Report.

Am J Case Rep 2021 Apr 12;22:e930291. Epub 2021 Apr 12.

University of Nevada, Reno School of Medicine, Reno, NV, USA.

BACKGROUND National guidelines and consensus statements suggest a 24-hour window for endovascular recanalization in patients presenting with acute ischemic stroke due to large-vessel occlusion. However, the safety and efficacy of extending the window for intervention remains to be definitively established. CASE REPORT A healthy 26-year-old woman presented with headache, left-sided hemiplegia, and rightward gaze palsy 2 days after a minor trauma. Read More

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Clinical use of indocyanine green during nerve-sparing surgery for deep endometriosis.

Fertil Steril 2021 Apr 8. Epub 2021 Apr 8.

Department of Obstetrics and Gynecology, Kurashiki Medical Center, Okayama, Japan.

Objective: To describe the anatomic and technical highlights of a novel nerve-sparing surgery in deep endometriosis (DE) using near-infrared (NIR) fluorescence technology and indocyanine green (ICG).

Design: Stepwise demonstration of this method with narrated video footage.

Setting: An urban general hospital. Read More

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Influence of motion correction on the visual analysis of cardiac magnetic resonance stress perfusion imaging.

MAGMA 2021 Apr 11. Epub 2021 Apr 11.

Department of Cardiology, Academic Teaching Hospital Agatharied of the Ludwig-Maximilians-University Munich, Agatharied, Germany.

Objective: Image post-processing corrects for cardiac and respiratory motion (MoCo) during cardiovascular magnetic resonance (CMR) stress perfusion. The study analyzed its influence on visual image evaluation.

Materials And Methods: Sixty-two patients with (suspected) coronary artery disease underwent a standard CMR stress perfusion exam during free-breathing. Read More

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Impaired Autoregulation Following Resuscitation Correlates with Outcome in Pediatric Patients: A Pilot Study.

Acta Neurochir Suppl 2021 ;131:97-101

Pediatric Intensive Care Unit, University Children's Hospital of Tuebingen, Tuebingen, Germany.

In children with a traumatic brain injury, the duration of autoregulation impairment correlates with the neurological outcome. This pilot study explored whether a similar relation exists in nontraumatic hypoxic-ischemic brain injury following resuscitation.We investigated 11 children after resuscitation. Read More

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January 2021

Ferumoxytol-enhanced magnetic resonance T1 reactivity for depiction of myocardial hypoperfusion.

NMR Biomed 2021 Apr 8:e4518. Epub 2021 Apr 8.

Physics and Biology in Medicine Graduate Program, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

Myocardial T1 reactivity, defined as the relative change in T1 between rest and vasodilator-induced stress, has been proposed as a magnetic resonance imaging (MRI) biomarker of tissue perfusion. We hypothesize that the superparamagnetic iron-oxide nanoparticle, ferumoxytol, sensitizes T1 to changes in the intramyocardial vascular compartment and improves the sensitivity and specificity of T1 reactivity as an imaging biomarker of tissue perfusion. We aim to assess the diagnostic performance of ferumoxytol-enhanced (FE) myocardial T1 reactivity in swine models of myocardial hypoperfusion. Read More

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