56,367 results match your criteria perfusion imaging

Myocardial Perfusion and Viability imaging in Coronary Artery Disease: Clinical Value in Diagnosis, Prognosis and Therapeutic Guidance.

Am J Med 2021 Apr 14. Epub 2021 Apr 14.

Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address:

Coronary artery disease is a leading cause of morbidity and mortality worldwide. Non-invasive imaging tests play a significant role in diagnosing coronary artery disease, as well as risk stratification and guidance for revascularization. Myocardial perfusion imaging, including single photon emission computed tomography and positron emission tomography, has been widely employed. Read More

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The importance of heart and brain imaging in children and adolescents with Multisystem Inflammatory Syndrome in Children (MIS-C).

Rheumatol Int 2021 Apr 17. Epub 2021 Apr 17.

Department of Pediatrics, Metropolitan Hospital, Piraeus, Greece.

Multisystem Inflammatory Syndrome in Children (MIS-C) recently reported in a minority of children affected by SARS-CoV-2, mimics Kawasaki disease (KD), a medium vessel vasculitis of unknown cause. In contrast to acute COVID-19 infection, which is usually mild in children, 68% of patients with MIS-C will need intensive care unit. Myocarditis and coronary artery ectasia/aneurysm are included between the main cardiovascular complications in MIS-C. Read More

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Neuroplacentology in congenital heart disease: placental connections to neurodevelopmental outcomes.

Pediatr Res 2021 Apr 16. Epub 2021 Apr 16.

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Children with congenital heart disease (CHD) are living longer due to effective medical and surgical management. However, the majority have neurodevelopmental delays or disorders. The role of the placenta in fetal brain development is unclear and is the focus of an emerging field known as neuroplacentology. Read More

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Individual calculation of perfusion activity based on ventilation efficiency for V/P-SPECT.

Nuklearmedizin 2021 Apr 16. Epub 2021 Apr 16.

Klinik für Radiologie und Neuroradiologie - Abteilung für Nuklearmedizin, Klinikum Dortmund gGmbH, Dortmund, Germany.

Aim:  Implementation of the individual calculation of perfusion activity to ensure the guideline-compliant ratio of perfusion to ventilation (P/V-ratio) of ≥ 3 in the diagnosis of acute pulmonary embolism (PE) using V/P-SPECT.

Material And Methods:  50 consecutive V/P-SPECT examinations, in which a standard activity of 160 MBq was applied for perfusion imaging, are evaluated retrospectively. Based on this patient group an activity factor is determined, which provides a correlation between the applied perfusion activity and the expected perfusion counts of the gamma camera. Read More

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Pulmonary infarction in acute pulmonary embolism.

Thromb Res 2021 Apr 1;202:162-169. Epub 2021 Apr 1.

Department of Medicine - Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

Pulmonary infarction results from occlusion of the distal pulmonary arteries leading to ischemia, hemorrhage and ultimately necrosis of the lung parenchyma. It is most commonly caused by acute pulmonary embolism (PE), with a reported incidence of around 30%. Following an occlusion of the pulmonary artery, the bronchial arteries are recruited as primary source of perfusion of the pulmonary capillaries. Read More

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Multi-Source Transfer Learning via Multi-Kernel Support Vector Machine Plus for B-Mode Ultrasound-Based Computer-Aided Diagnosis of Liver Cancers.

IEEE J Biomed Health Inform 2021 Apr 16;PP. Epub 2021 Apr 16.

B-mode ultrasound (BUS) imaging is a routine tool for diagnosis of liver cancers, while contrast-enhanced ultrasound (CEUS) provides additional information to BUS on the local tissue vascularization and perfusion to promote diagnostic accuracy. In this work, we propose to improve the BUS-based computer aided diagnosis for liver cancers by transferring knowledge from the multi-view CEUS images, including the arterial phase, portal venous phase, and delayed phase, respectively. To make full use of the shared labels of paired of BUS and CEUS images to guide knowledge transfer, support vector machine plus (SVM+), a specifically designed transfer learning (TL) classifier for paired data with shared labels, is adopted for this supervised TL. Read More

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Non-invasive assessment of heterogeneity of gliomas using diffusion and perfusion MRI: correlation with spatially co-registered PET.

Acta Radiol 2021 Apr 15:2841851211006913. Epub 2021 Apr 15.

Department of Nuclear Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, PR China.

Background: Heterogeneity of gliomas challenges the neuronavigated biopsy and oncological therapy. Diffusion and perfusion magnetic resonance imaging (MRI) can reveal the cellular and hemodynamic heterogeneity of tumors. Integrated positron emission tomography (PET)/MRI is expected to be a non-invasive imaging approach to characterizing glioma. Read More

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Contrast-Enhanced Ultrasound: A Useful Tool to Study and Monitor Hepatic Tumors Treated with Histotripsy.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 Apr 15;PP. Epub 2021 Apr 15.

Histotripsy is a novel non-invasive non-thermal, non-ionizing, and precise treatment technique for tissue destruction. Contrast-enhanced ultrasound (CEUS) improves the detection, characterization, and follow-up of hepatic lesions because it depicts accurately the vascular perfusion of both normal hepatic tissue and hepatic tumors. We present the spectrum of imaging findings of CEUS after histotripsy treatment of hepatic tumors. Read More

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Arterial Spin Labeling Magnetic Resonance Imaging in Healthy Adults: Mathematical Model Fitting to Assess Age-Related Perfusion Pattern.

Korean J Radiol 2021 Apr 1. Epub 2021 Apr 1.

Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.

Objective: To investigate the age-dependent changes in regional cerebral blood flow (CBF) in healthy adults by fitting mathematical models to imaging data.

Materials And Methods: In this prospective study, 90 healthy adults underwent pseudo-continuous arterial spin labeling imaging of the brain. Regional CBF values were extracted from the arterial spin labeling images of each subject. Read More

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Association between perihematomal perfusion and intracerebral hemorrhage shape.

Neuroradiology 2021 Apr 14. Epub 2021 Apr 14.

Neuroradiology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.

Purpose: The pathophysiological determinants of irregular intracerebral hemorrhage (ICH) shape are unclear. We aimed at characterizing the relationship between perihematomal perfusion and ICH shape.

Methods: A single-center cohort of patients with primary ICH was analyzed. Read More

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Longitudinal MRI brain findings in the R1349Q pathogenic variant of .

Radiol Case Rep 2021 Jun 28;16(6):1276-1279. Epub 2021 Mar 28.

Division of Child Neurology, Indiana University School of Medicine, Indianapolis, IN.

Pathogenic gene variants are associated with a spectrum of disorders including migraine with or without hemiplegia, ataxia, epilepsy, and developmental disability. We present a case of a pathogenic variant (c.4046G>A, p. Read More

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Neurovascular coupling dysfunction in end-stage renal disease patients related to cognitive impairment.

J Cereb Blood Flow Metab 2021 Apr 14:271678X211007960. Epub 2021 Apr 14.

Department of Medical Imaging, First Affiliated Hospital of Xi'an, Jiaotong University, Xi'an, China.

We aimed to investigate the neurovascular coupling (NVC) dysfunction in end-stage renal disease (ESRD) patients related with cognitive impairment. Twenty-five ESRD patients and 22 healthy controls were enrolled. To assess the NVC dysfunctional pattern, resting-state functional MRI and arterial spin labeling were explored to estimate the coupling of spontaneous neuronal activity and cerebral blood perfusion based on amplitude of low-frequency fluctuation (ALFF)-cerebral blood flow (CBF), fractional ALFF (fALFF)-CBF, regional homogeneity (ReHo)-CBF, and degree centrality (DC)-CBF correlation coefficients. Read More

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Oxygen Pathway Limitations in Patients with Chronic Thromboembolic Pulmonary Hypertension.

Circulation 2021 Apr 15. Epub 2021 Apr 15.

Baker Heart and Diabetes Institute, Melbourne, Australia; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium; University Hospitals Leuven, Leuven, Belgium.

Exertional intolerance is a limiting and often crippling symptom in patients with chronic thromboembolic pulmonary hypertension (CTEPH). Traditionally the etiology has been attributed to central factors, including ventilation-perfusion mismatch, increased pulmonary vascular resistance and right heart dysfunction and uncoupling. Pulmonary endarterectomy and, balloon pulmonary angioplasty provide substantial improvement of functional status and hemodynamics. Read More

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Occult Hepatocellular Carcinoma Associated with Transjugular Intrahepatic Portosystemic Shunts in Liver Transplant Recipients.

Liver Transpl 2021 Apr 14. Epub 2021 Apr 14.

Hospital of the University of Pennsylvania, Department of Surgery, Philadelphia, PA, USA.

Introduction: Transplant eligibility for hepatocellular carcinoma (HCC) is determined by the imaging identification of tumor burden within Milan criteria. Transjugular intrahepatic portosystemic shunts (TIPS) reduce portal hypertension but may impact HCC visualization. It was hypothesized that the presence of pre-transplant TIPS would correlate with occult HCC and reduced survival. Read More

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Novel non-Invasive Biomarkers of Prodromal Alzheimer's Disease: the Role of Optical Coherence Tomography (OCT) and OCT-Angiography (OCT-A).

Eur J Neurol 2021 Apr 14. Epub 2021 Apr 14.

Section of Neurology, Laboratory of Clinical Neurochemistry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

Background: A reduction of retinal thickness and an alteration of retinal perfusion have been found in Alzheimer's disease (AD). Nowadays retinal layers and retinal perfusion can be evaluated by means of non-invasive imaging techniques, i.e. Read More

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Surgical outcome and prognostic factors in epilepsy patients with MR-negative focal cortical dysplasia.

PLoS One 2021 14;16(4):e0249929. Epub 2021 Apr 14.

Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Objective: Focal cortical dysplasia (FCD) represents a heterogeneous group of disorders of the cortical formation and is one of the most common causes of epilepsy. Magnetic resonance imaging (MRI) is the modality of choice for detecting structural lesions, and the surgical prognosis in patients with MR lesions is favorable. However, the surgical prognosis of patients with MR-negative FCD is unknown. Read More

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Imaging in whole organ pancreatic transplants and a multimodality review of its complications.

Br J Radiol 2021 Apr 14:20200106. Epub 2021 Apr 14.

Academic Department of Surgery, Imperial College, and Department of Renal & Transplant Services, Imperial College Healthcare NHS Trust, London, UK.

This pictorial review will describe the normal anatomy of whole organ pancreatic transplants and the common surgical variants with which the radiologist should be familiar. Complications may be divided into (1) vascular: arterial occlusion and stenosis, venous thrombosis, pseudoaneurysms and arteriovenous fistulae, (2) parenchymal complications such as pancreatitis and the variety of peripancreatic collections, and (3) enteric complications including leak and fistula formation. The radiologist plays a crucial role in the initial assessment of graft anatomy and perfusion, prompt diagnosis, and increasingly, in the management of complications. Read More

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Effects of Perfusion Pressures on Podocyte Loss in the Isolated Perfused Mouse Kidney.

Cell Physiol Biochem 2021 Apr;55(S4):1-12

Division of Nephrology and Clinical Immunology, RWTH Aachen University Hospital, Aachen, Germany,

Background/aims: Podocytes are lost in most glomerular diseases, leading to glomerulosclerosis and progressive kidney disease. It is generally assumed, that podocytes are exposed to the filtration flow and thus to significant shear forces driving their detachment from the glomerular basement membrane (GBM). In this context, foot process effacement has been proposed as potential adaptive response to increase adhesion of podocytes to the GBM. Read More

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Coronary sinus size and ischemia improvement after reducer implantation; "one size to fit them all?"

Catheter Cardiovasc Interv 2021 Apr 14. Epub 2021 Apr 14.

Interventional Cardiology Unit, GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.

Aim: Coronary sinus (CS) reducer implantation is associated with symptomatic relief of patients with refractory angina. However, 15% to 30% of the patients do not respond to this treatment. Aim if this study was to evaluate the effect of CS size in the effectiveness of the device. Read More

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Profound gating error and flattened time-volume curve from inefficient triggering from improper setting of ECG leads in myocardial perfusion SPECT.

J Nucl Cardiol 2021 Apr 13. Epub 2021 Apr 13.

Department of Nuclear Medicine, Taleghani Educational Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Yaman St., Velenjak, Tehran, 1985711151, Iran.

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Unconventional non-amino acidic PET radiotracers for molecular imaging in gliomas.

Eur J Nucl Med Mol Imaging 2021 Apr 13. Epub 2021 Apr 13.

Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Stanford University, Stanford, CA, USA.

Purpose: The objective of this review was to explore the potential clinical application of unconventional non-amino acid PET radiopharmaceuticals in patients with gliomas.

Methods: A comprehensive search strategy was used based on SCOPUS and PubMed databases using the following string: ("perfusion" OR "angiogenesis" OR "hypoxia" OR "neuroinflammation" OR proliferation OR invasiveness) AND ("brain tumor" OR "glioma") AND ("Positron Emission Tomography" OR PET). From all studies published in English, the most relevant articles were selected for this review, evaluating the mostly used PET radiopharmaceuticals in research centers, beyond amino acid radiotracers and 2-[F]fluoro-2-deoxy-D-glucose ([F]FDG), for the assessment of different biological features, such as perfusion, angiogenesis, hypoxia, neuroinflammation, cell proliferation, tumor invasiveness, and other biological characteristics in patients with glioma. Read More

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ADC, D, f dataset calculated through the simplified IVIM model, with MGMT promoter methylation, age, and ECOG, in 38 patients with wildtype IDH glioblastoma.

Data Brief 2021 Apr 15;35:106950. Epub 2021 Mar 15.

Department of Radiation Oncology, Sunnybrook Health Sciences Center, University of Toronto, Toronto, ON, Canada.

Patients undergoing standard chemoradiation post-resection had MRIs at radiation planning and fractions 10 and 20 of chemoradiation. MRIs were 1.5T and 3D T2-FLAIR, pre- and post-contrast 3D T1-weighted (T1) and echo planar DWI with three b-values (0, 500, and 1000s/mm) were acquired. Read More

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Intratumor heterogeneity is biomarker specific and challenges the association with heterogeneity in multimodal functional imaging in head and neck squamous cell carcinoma.

Eur J Radiol 2021 Mar 31;139:109668. Epub 2021 Mar 31.

Department of Oncology, Section of Radiotherapy, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Rationale: Tumor biopsy cannot detect heterogeneity and an association between heterogeneity in functional imaging and molecular biology will have an impact on both diagnostics and treatment possibilities.

Purpose: Multiparametric imaging can provide 3D information on functional aspects of a tumor and may be suitable for predicting intratumor heterogeneity. Here, we investigate the correlation between intratumor heterogeneity assessed with multiparametric imaging and multiple-biopsy immunohistochemistry. Read More

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Enhancement degree of brain metastases: correlation analysis between enhanced T2 FLAIR and vascular permeability parameters of dynamic contrast-enhanced MRI.

Eur Radiol 2021 Apr 13. Epub 2021 Apr 13.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Objectives: To investigate the correlation between enhancement degrees of brain metastases on contrast-enhanced T2-fluid-attenuated inversion recovery (CE-T2 FLAIR) and vascular permeability parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).

Methods: Thirty-nine patients with brain metastases were prospectively collected. They underwent non-enhanced T2 FLAIR, DCE-MRI, CE-T2 FLAIR, and contrast-enhanced three-dimensional brain volume imaging (CE-BRAVO). Read More

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Accuracy of quantitative diffusion-weighted imaging for differentiating benign and malignant pancreatic lesions: a systematic review and meta-analysis.

Eur Radiol 2021 Apr 13. Epub 2021 Apr 13.

School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Background: A variety of imaging techniques can be used to evaluate diffusion characteristics to differentiate malignant and benign pancreatic lesions. The diagnostic performance of diffusion parameters has not been systematic assessed.

Purpose: We aimed to investigate the diagnostic efficacy of quantitative diffusion-weighted imaging (DWI) for pancreatic lesions. Read More

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Pulmonary Functional Imaging: Part 2-State-of-the-Art Clinical Applications and Opportunities for Improved Patient Care.

Radiology 2021 Apr 13:204033. Epub 2021 Apr 13.

From the Department of Radiology, Penn Medicine, University of Pennsylvania, Philadelphia, Pa (W.B.G.); Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine (SKKU-SOM), Seoul, South Korea (K.S.L.); Department of Radiology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wis (M.L.S.); Departments of Medicine and Medical Biophysics, Robarts Research Institute, Western University, London, Canada (G.P.); Department of Radiology, Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea (J.B.S.); Department of Radiology and Joint Research Laboratory of Advanced Medical Imaging, Fujita Health University School of Medicine, Toyoake, Japan (Y.O.); and Center for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis St, Boston, MA 02215 (H.H.).

Pulmonary functional imaging may be defined as the regional quantification of lung function by using primarily CT, MRI, and nuclear medicine techniques. The distribution of pulmonary physiologic parameters, including ventilation, perfusion, gas exchange, and biomechanics, can be noninvasively mapped and measured throughout the lungs. This information is not accessible by using conventional pulmonary function tests, which measure total lung function without viewing the regional distribution. Read More

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Rapamycin restores brain vasculature, metabolism, and blood-brain barrier in an inflammaging model.

Geroscience 2021 Apr 13. Epub 2021 Apr 13.

Oklahoma Nathan Shock Center for Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Rapamycin (RAPA) is found to have neuro-protective properties in various neuroinflammatory pathologies, including brain aging. With magnetic resonance imaging (MRI) techniques, we investigated the effect of RAPA in a lipopolysaccharide (LPS)-induced inflammaging model in rat brains. Rats were exposed to saline (control), or LPS alone or LPS combined with RAPA treatment (via food over 6 weeks). Read More

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Spatial heterogeneity of oxygenation and haemodynamics in breast cancer resolved in vivo by conical multispectral optoacoustic mesoscopy.

Light Sci Appl 2020 Apr 13;9(1):57. Epub 2020 Apr 13.

Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Ingolstädter Landstr. 1, D-85764, Neuherberg, Germany.

The characteristics of tumour development and metastasis relate not only to genomic heterogeneity but also to spatial heterogeneity, associated with variations in the intratumoural arrangement of cell populations, vascular morphology and oxygen and nutrient supply. While optical (photonic) microscopy is commonly employed to visualize the tumour microenvironment, it assesses only a few hundred cubic microns of tissue. Therefore, it is not suitable for investigating biological processes at the level of the entire tumour, which can be at least four orders of magnitude larger. Read More

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CT perfusion based ASPECTS improves the diagnostic performance of early ischemic changes in large vessel occlusion.

BMC Med Imaging 2021 Apr 12;21(1):67. Epub 2021 Apr 12.

Department of Radiology, Changhai Hospital of Shanghai, Navy Medical University (Second Military Medical University), No. 168 Changhai Road, Shanghai, 200433, China.

Background: ASPECTS scoring method varies, but which one is most suitable for predicting the prognosis still unclear. We aimed to evaluate the diagnostic performance of Automated (Auto)-, noncontrast CT (NCCT)- and CT perfusion (CTP) -ASPECTS for early ischemic changes (EICs) in acute ischemic stroke patients with large vessel occlusion (LVO) and to explore which scoring method is most suitable for predicting the clinical outcome.

Methods: Eighty-one patients with anterior circulation LVO were retrospectively enrolled and grouped as having a good (0-2) or poor (3-6) clinical outcome using a 90-day modified Rankin Scale score. Read More

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Cardiac magnetic resonance stress and rest perfusion with T1 mapping: Is it ready to assess for ischaemic heart disease?

Int J Cardiol 2021 Apr 12. Epub 2021 Apr 12.

Division of Cardiology, Department of Medicine, Queen Mary Hospital, Hong Kong, SAR, China.

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