63,601 results match your criteria perfusion coronary

Heart transplantation from controlled donation after circulatory death using thoracoabdominal normothermic regional perfusion and cold storage.

J Card Surg 2021 Jun 12. Epub 2021 Jun 12.

Transplant Coordination Unit and Service of Intensive Care, University Hospital Marqués de Valdecilla-IDIVAL, Santander, Spain.

Background: Heart transplantation from controlled donation after the circulatory determination of death (cDCDD) may be an option to increase the pool of grafts for transplantation.

Materials And Methods: Initial experiences on cDCDD heart transplantation were based on the direct procurement of the heart followed by preservation with ex situ perfusion devices. Later, the use of thoracoabdominal normothermic regional perfusion (TA-NRP) has emerged as an option to recover hearts. Read More

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Anomalous Aortic Origin of the Coronary Arteries - State of the Art Management and Surgical Techniques.

Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2021 ;24:85-94

Coronary Artery Anomalies Program, Texas Children's Hospital; Houston, Texas; Division of Congenital Heart Surgery, Michael E. DeBakey Department of Surgery, Texas Children's Hospital, Baylor College of Medicine; Houston, Texas. Electronic address:

Anomalous aortic origin of a coronary artery (AAOCA) can be associated with myocardial ischemia and sudden cardiac arrest. We describe and compare the management and surgical techniques for patients with AAOCA. Patients presenting to the Coronary Artery Anomalies Program are evaluated and managed following a standardized approach. Read More

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January 2021

Treatment of a massive pseudoaneurysm originating from the ascending aorta with an off-the-shelf stent graft.

Eur J Cardiothorac Surg 2021 Jun 11. Epub 2021 Jun 11.

Department of Cardiovascular and Thoracic Surgery, MediClin Heart Institute Lahr/Baden, Lahr, Germany.

A 73-year-old patient who underwent an emergency coronary bypass surgery in our institution and who required postoperative extracorporeal membrane oxygenation support in December 2019 presented in August 2020 with a rapidly growing subxiphoidal, pulsating swelling. A computed tomography scan revealed a massive mediastinal pseudoaneurysm originating from an 8-mm Dacron graft that was sutured to the ascending aorta during the index surgery for arterial extracorporeal membrane oxygenation cannulation. Due to the location and extent of the pseudoaneurysm, an open surgical revision was deemed high risk. Read More

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Cardiac arrest complicating cardiogenic shock: from pathophysiological insights to Impella-assisted cardiopulmonary resuscitation in a pheochromocytoma-induced Takotsubo cardiomyopathy-a case report.

Eur Heart J Case Rep 2021 Mar 22;5(3):ytab092. Epub 2021 Mar 22.

Department of Cardiology, Santa Chiara Hospital, 2, Largo Medaglie d'Oro, 38122 Trento, Italy.

Background: A 'catecholamine storm' in a case of pheochromocytoma can lead to a transient left ventricular dysfunction similar to Takotsubo cardiomyopathy. A cardiogenic shock can thus develop, with high left ventricular end-diastolic pressure and a reduction in coronary perfusion pressure. This scenario can ultimately lead to a cardiac arrest, in which unloading the left ventricle with a peripheral left ventricular assist device (Impella) could help in achieving the return of spontaneous circulation (ROSC). Read More

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Endovascular treatment of coronary subclavian steal syndrome: a case series highlighting the diagnostic usefulness of a multimodality imaging approach.

Eur Heart J Case Rep 2021 Mar 29;5(3):ytab056. Epub 2021 Mar 29.

Department of Cardiology, Instituto Cardiovascular, Hospital Clínico San Carlos, C/Profesor Martín Lagos S/N, 28040 Madrid, Spain.

Background: Coronary subclavian steal syndrome (CSSS) is an uncommon complication observed in patients after coronary artery bypass surgery with left internal mammary artery (LIMA) grafts. It is defined as coronary ischaemia due to reversal flow from the LIMA to the left subclavian artery (SA) when a proximal left SA stenosis is present. In practice, the entire clinical spectrum of ischaemic heart disease, ranging from asymptomatic patients to acute myocardial infarction, may be encountered. Read More

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Effects of a cognitive stress challenge on myocardial perfusion and plasma cortisol in coronary heart disease patients with depression.

Stress Health 2009 Aug 8;25(3):267-278. Epub 2009 Jan 8.

Department of Medicine (Cardiology), Emory University School of Medicine, Atlanta, GA, USA.

Although it is well established that coronary heart disease (CHD) patients with depression exhibit increased mortality compared with equally ill cardiac patients without depression, the mechanisms mediating this effect remain obscure. Depression is characterized by vulnerability to stress and heightened stress responsiveness, and stress can theoretically act through several biological pathways to contribute to excess mortality from CHD. Mechanisms connecting stress, depression and cardiovascular mortality have not been previously explored in detail. Read More

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Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19: protocol design of COVID-HEART-a UK, multicentre, observational study.

J Cardiovasc Magn Reson 2021 Jun 10;23(1):77. Epub 2021 Jun 10.

Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, LS2 9JT, UK.

Background: Although coronavirus disease 2019 (COVID-19) is primarily a respiratory illness, myocardial injury is increasingly reported and associated with adverse outcomes. However, the pathophysiology, extent of myocardial injury and clinical significance remains unclear.

Methods: COVID-HEART is a UK, multicentre, prospective, observational, longitudinal cohort study of patients with confirmed COVID-19 and elevated troponin (sex-specific > 99th centile). Read More

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Outcome of right ventricular assist device implantation following left ventricular assist device implantation: Systematic review and meta-analysis.

Perfusion 2021 Jun 11:2676591211024817. Epub 2021 Jun 11.

Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland.

Objectives: The main aim was a systematic evaluation of the current evidence on outcomes for patients undergoing right ventricular assist device (RVAD) implantation following left ventricular assist device (LVAD) implantation.

Methods: This systematic review was registered on PROSPERO (CRD42019130131). Reports evaluating in-hospital as well as follow-up outcome in LVAD and LVAD/RVAD implantation were identified through Ovid Medline, Web of Science and EMBASE. Read More

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The use of near-infrared spectroscopy in the diagnosis of peripheral artery disease: A systematic review.

Vascular 2021 Jun 10:17085381211025174. Epub 2021 Jun 10.

70309Kaunas University of Technology, Kaunas, Lithuania.

Background: Peripheral arterial disease is a stenosis or occlusion of peripheral arteries that results in compromised blood flow and muscle ischemia. The available diagnostic methods are mostly used to measure and visualize blood flow and are not useful in the evaluation of perfusion, especially in diabetic patients, which is now considered to be a research priority by most of the vascular societies around the world as this is still a relatively poorly studied phenomenon.

Objective: The aim of this review is to explore the clinical significance of muscle tissue oxygenation monitoring in lower-extremity peripheral artery disease diagnosis using the near-infrared spectroscopy method. Read More

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Utility of nuclear cardiovascular imaging in the cardiac intensive care unit.

J Nucl Cardiol 2021 Jun 9. Epub 2021 Jun 9.

Cleveland Clinic Heart, Thoracic, Institute Cleveland Clinic, 9500 Euclid Ave. J1-5, Cleveland, OH, 44195, USA.

The contemporary Cardiac Intensive Care Unit (CICU) has evolved into a complex unit that admits a heterogeneous mix of patients with a wide range of acute cardiovascular diseases often complicated by multi-organ failure. Although electrocardiography (ECG) and echocardiography are well-established as first-line diagnostic modalities for assessing patients in the CICU, nuclear cardiology imaging has emerged as a useful adjunctive diagnostic modality. The versatility, safety and accuracy of nuclear imaging (e. Read More

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Advances in Myocardial Perfusion MR Imaging: Physiological Implications, the Importance of Quantitative Analysis, and Impact on Patient Care in Coronary Artery Disease.

Magn Reson Med Sci 2021 Jun 9. Epub 2021 Jun 9.

Department of Radiology, Mie University Graduate School of Medicine.

Stress myocardial perfusion imaging (MPI) is the preferred test in patients with intermediate-to-high clinical likelihood of coronary artery disease (CAD) and can be used as a gatekeeper to avoid unnecessary revascularization. Cardiac magnetic resonance (CMR) has a number of favorable characteristics, including: (1) high spatial resolution that can delineate subendocardial ischemia; (2) comprehensive assessment of morphology, global and regional cardiac functions, tissue characterization, and coronary artery stenosis; and (3) no radiation exposure to patients. According to meta-analysis studies, the diagnostic accuracy of perfusion CMR is comparable to positron emission tomography (PET) and perfusion CT, and is better than single-photon emission CT (SPECT) when fractional flow reserve (FFR) is used as a reference standard. Read More

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Impaired skeletal muscle fatigue resistance during cardiac hypertrophy is prevented by functional overload- or exercise-induced functional capillarity.

J Physiol 2021 Jun 9. Epub 2021 Jun 9.

School of Biomedical Sciences, University of Leeds, UK.

Key Points: Capillary rarefaction is hypothesised to contribute to impaired exercise tolerance in cardiovascular disease, but it remains a poorly exploited therapeutic target for improving skeletal muscle performance. Using an abdominal aortic coarctation rat model of compensatory cardiac hypertrophy, we determine the efficacy of aerobic exercise for the prevention of, and mechanical overload for restoration of hind limb muscle fatigue resistance and microvascular impairment in the early stages of heart disease. Impaired muscle fatigue resistance was found after development of cardiac hypertrophy, but this impairment was prevented by low intensity aerobic exercise and recovered after mechanical stretch due to muscle overload. Read More

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Immunological Comparison of Pregnant Dahl Salt-Sensitive and Sprague Dawley Rats Commonly Used to Model Characteristics of Preeclampsia.

Am J Physiol Regul Integr Comp Physiol 2021 06 9. Epub 2021 Jun 9.

Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, United States.

The pregnant Dahl salt-sensitive (S) rat is an established pre-clinical model of superimposed spontaneous preeclampsia characterized by exacerbated hypertension, increased urinary protein excretion, and increased fetal demise. Because of the underlying immune system dysfunction present in preeclamptic pregnancies in humans, we hypothesized that the pregnant Dahl S rat would also have an altered immune status. Immune system activation was assessed during late pregnancy in the Dahl S model and compared to healthy pregnant Sprague Dawley (SD) rats subjected to either a sham procedure or a procedure to reduce uterine perfusion pressure (RUPP). Read More

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Ex Situ Perfusion of Hearts Donated After Euthanasia: A Promising Contribution to Heart Transplantation.

Transplant Direct 2021 Mar 22;7(3):e676. Epub 2021 Feb 22.

Department of Cardiothoracic Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Organ donation after euthanasia is performed in an increasing number of countries. In this donation after circulatory death procedure, it has not been possible to donate the heart. Recent literature, however, reports positive results of heart donation after circulatory death. Read More

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Anesthetic management in lung transplantation: Our single-center experience.

Turk Gogus Kalp Damar Cerrahisi Derg 2021 Apr 26;29(2):191-200. Epub 2021 Apr 26.

Department of Anesthesiology and Reanimation, Kartal Koşuyolu High Specialization Education and Research Hospital, Istanbul, Turkey.

Background: In this study, we aimed to discuss our anesthesia management strategies, experiences, and outcomes in patients undergoing lung transplantation.

Methods: Between December 2016 and December 2018, a total of 53 patients (43 males, 10 females; mean age: 46.1±13 years; range, 14 to 64 years) undergoing lung transplantation in our center were included. Read More

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Optimizing the diagnosis and assessment of chronic thromboembolic pulmonary hypertension with advancing imaging modalities.

Pulm Circ 2021 Apr-Jun;11(2):20458940211007375. Epub 2021 May 24.

Cardiothoracic Imaging, University of California San Diego, La Jolla, CA, USA.

Imaging is key to nearly all aspects of chronic thromboembolic pulmonary hypertension including management for screening, assessing eligibility for pulmonary endarterectomy, and post-operative follow-up. While ventilation/perfusion scintigraphy, the gold standard technique for chronic thromboembolic pulmonary hypertension screening, can have excellent sensitivity, it can be confounded by other etiologies of pulmonary malperfusion, and does not provide structural information to guide operability assessment. Conventional computed tomography pulmonary angiography has high specificity, though findings of chronic thromboembolic pulmonary hypertension can be visually subtle and unrecognized. Read More

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Georgian Med News 2021 Apr(313):158-162

I. Javakhishvili Tbilisi State Universitety, Institute of Morphology, Georgia.

Research in recent years has shown that pulsating flow during cardiopulmonary bypass can prevent the development of a number of perfusion complications inherent in continuous blood flow. On the other hand, attempts to pulsate with roller and centrifugal pumps, which are structurally DC pumps, are fraught with complications. However, these pumps are clinically tested and are successfully used for the implementation of direct blood flow. Read More

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Pre-Operative Cardiovascular Testing before Liver Transplantation.

Am J Cardiol 2021 Jun 5. Epub 2021 Jun 5.

Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC.

End-stage liver disease (ESLD) is increasingly prevalent and shares many risk factors with coronary artery disease (CAD). No specific guidelines exist for pre-liver transplant evaluation of CAD, and pretransplant cardiovascular testing varies widely. The aim of this study is to characterize pre-transplant cardiac testing practices with post-transplant clinical outcomes. Read More

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The many sides of oxidative stress during coronary artery bypass surgery.

Perfusion 2021 Jun 9:2676591211024814. Epub 2021 Jun 9.

Department of Cardiovascular Surgery, Kütahya Health Sciences University Evliya Celebi Training and Research Hospital, Kütahya, Turkey.

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[Surgical treatment of Stanford type A aortic dissection after thoracic endovascular aortic repair].

Zhonghua Wai Ke Za Zhi 2021 Jun;59(6):520-524

Department of Cardiovascular Surgery, Henan Chest Hospital, Zhengzhou 450001, China.

To examine the surgical treatment of Stanford type A aortic dissection (type A dissection) after thoracic endovascular aortic repair (TEVAR). The data of 58 patients with reoccurrence of type A dissection after TEVAR admitted into the Department of Cardiovascular Surgery, Henan Chest Hospital from February 2012 to January 2020 were analyzed retrospectively. There were 40 males and 18 females, aged (57. Read More

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Diagnostic Value of Extracellular Volume Quantification and Myocardial Perfusion Analysis at CT in Cardiac Amyloidosis.

Radiology 2021 Jun 8:204192. Epub 2021 Jun 8.

From the Department of Radiology (J.F.D., R.N., V.T., H.D., I.S., V.C., F.R., H.K.), Department of Cardiology (A.Z., A.G., M.K., S.O., S.G., E.T., T.D.), National Referral Centre for Cardiac Amyloidosis (J.F.D., A.Z., A.G., M.K., S.O., S.G., E.T., T.D.), and Department of Public Health (E.A.), Henri Mondor Hospital, University Paris Est Créteil, Assistance Publique-Hôpitaux de Paris, 51 av Mal de Lattre de Tassigny, 94000 Créteil, France.

Background CT can provide information regarding myocardial perfusion and expansion of the extracellular space, which is relevant to patients with cardiac amyloidosis (CA). Purpose To evaluate the role of CT in the diagnosis and prognosis of CA. Materials and Methods In this prospective study (Commission National de l'Informatique et des Libertés registration no. Read More

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How to get the optimal defibrillation lead parameters using myocardial perfusion scintigraphy in patients with coronary artery disease.

Int J Cardiovasc Imaging 2021 Jun 7. Epub 2021 Jun 7.

Department of Surgical Arrhythmology and Cardiac Pacing, Cardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Sciences, Kievskaya st., 111a, Tomsk, Russian Federation, 634012.

The conventional criteria for a defibrillation lead (DL) implantation don't take into account presence of scar or deep ischemia in the myocardium. This may impair a proper functioning of the DL. We sought to optimize the DL implantation placement using rest myocardial perfusion scintigraphy (MPS), which allow detecting areas of myocardial hypoperfusion (MH). Read More

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The Genetically Engineered Heart as a Bridge to Allotransplantation in Infants Just Around the Corner?

Ann Thorac Surg 2021 Jun 4. Epub 2021 Jun 4.

Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL.

Background: Mortality for infants on the heart transplant wait list remains unacceptably high, and available mechanical circulatory support is suboptimal. Our goal is to demonstrate the feasibility of utilizing genetically engineered pig (GEP) heart as a bridge to allotransplantation by transplantation of a GEP heart in a baboon.

Methods: Four baboons underwent orthotopic cardiac transplantation from GEP donors. Read More

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An Antegrade Perfusion Method for Cardiomyocyte Isolation from Mice.

J Vis Exp 2021 May 19(171). Epub 2021 May 19.

Department of Physiology, Shiga University of Medical Science.

In basic research using mouse heart, isolating viable individual cardiomyocytes is a crucial technical step to overcome. Traditionally, isolating cardiomyocytes from rabbits, guinea pigs or rats has been performed via retrograde perfusion of the heart with enzymes using a Langendorff apparatus. However, a high degree of skill is required when this method is used with a small mouse heart. Read More

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Cardioprotective Effect of Quercetin against Ischemia/Reperfusion Injury Is Mediated Through NO System and Mitochondrial K-ATP Channels.

Cell J 2021 Jul 26;23(2):184-190. Epub 2021 May 26.

The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.Email:

Objective: Quercetin (Que) is a plant-derived polyphenolic compound, that was shown to possess anti-inflammatory activity in myocardial ischemia/reperfusion (I/R) models ; however, detailed mechanisms of its anti-inflammatory effects remain unclear. This study aimed to examine the effects of quercetin postconditioning (QPC) on I/R-induced inflammatory response in a rat model and evaluate the role of the mitochondrial K-ATP (mitoK) channels and NO system in this regard.

Materials And Methods: In this experimental study, hearts of male Wistar rats (250 ± 20 g) perused by Langendorff apparatus, were subjected to 30 minutes of global ischemia followed by 55 minutes reperfusion, and Que was added to the perfusion solution immediately at the onset of reperfusion. Read More

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Phosphorylation in Novel Mitochondrial Creatine Kinase Tyrosine Residues Render Cardioprotection against Hypoxia/Reoxygenation Injury.

J Lipid Atheroscler 2021 May 19;10(2):223-239. Epub 2021 Jan 19.

Cardiovascular and Metabolic Disease Center, Smart Marine Therapeutics Center, Inje University, Busan, Korea.

Objective: Ischemic cardiomyopathy (ICM) is the leading cause of heart failure. Proteomic and genomic studies have demonstrated ischemic preconditioning (IPC) can assert cardioprotection against ICM through mitochondrial function regulation. Considering IPC is conducted in a relatively brief period, regulation of protein expression also occurs very rapidly, highlighting the importance of protein function modulation by post-translational modifications. Read More

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Development of Quality Indicators for the Management of Acute Type A Aortic Dissection.

Can J Cardiol 2021 Jun 3. Epub 2021 Jun 3.

Division of Cardiac Surgery, Department of Surgery, Western University, London, ON.

In an effort to further improve surgical outcomes in patients with acute type A aortic dissection (ATAD), the Canadian Thoracic Aortic Collaborative (CTAC), with the support of the Canadian Society of Cardiac Surgeons (CSCS), endeavored to develop quality indicators (QIs) for the management of patients with ATAD. After two successive consultations with the CTAC membership, 11 QIs were selected and separated into 5 broad categories: pre-operative (time from presentation to diagnosis, time from presentation to the operating room), intra-operative (use of hypothermic circulatory arrest and antegrade cerebral perfusion), 30-day outcomes (30-day rates of all-cause mortality, 30-day rates of new post-operative stroke), 1-year outcomes (1-year rates of follow-up imaging, 1-year rates of all-cause mortality, and 1-year rates of surgical re-intervention), and institutional (institutional surgical volumes, individual surgical volumes and presence of institutional aortic disease teams). The purpose of this manuscript was to describe the process by which QIs for the management of ATAD were developed and the feasibility by which they may be collected using existing clinical and administrative data sources. Read More

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Myocardial perfusion recovery induced by an α-calcitonin gene-related peptide analogue.

J Nucl Cardiol 2021 Jun 4. Epub 2021 Jun 4.

Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark.

Background: Endogenous calcitonin gene-related peptide (CGRP) induces cardioprotective effects through coronary vasodilation. However, the systemic administration of CGRP induces peripheral vasodilation and positive chronotropic and inotropic effects. This study aims to examine the net effect on coronary perfusion of the systemically administered α-calcitonin gene-related peptide analogue, SAX, in rats during myocardial infarction. Read More

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An ex vivo physiologic and hyperplastic vessel culture model to study intra-arterial stent therapies.

Biomaterials 2021 May 29;275:120911. Epub 2021 May 29.

Department of Anesthesiology, School of Medicine, Yale University, New Haven, CT, 06519, USA; Department of Biomedical Engineering, School of Medicine, Yale University, New Haven, CT, 06519, USA. Electronic address:

Conventional in vitro methods for biological evaluation of intra-arterial devices such as stents fail to accurately predict cytotoxicity and remodeling events. An ex vivo flow-tunable vascular bioreactor system (VesselBRx), comprising intra- and extra-luminal monitoring capabilities, addresses these limitations. VesselBRx mimics the in vivo physiological, hyperplastic, and cytocompatibility events of absorbable magnesium (Mg)-based stents in ex vivo stent-treated porcine and human coronary arteries, with in-situ and real-time monitoring of local stent degradation effects. Read More

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