Search Our Scientific Publications & Authors

Z Orthop Unfall 2021 Apr 19. Epub 2021 Apr 19.

Department of Plastic, Aesthetic, Reconstructive and Hand Surgery, Asklepios Hospital Harburg, Hamburg, Germany.

Background: Reconstruction of lower extremity soft tissue defects is an exceptional surgical challenge, especially in multimorbid, elderly and severely ill patients with their thin and tense local soft-tissue conditions and increased perioperative risk. The distally based peroneus brevis muscle flap (DPBM), a local flap based on the muscular branches of the fibular artery, could pose a pragmatic solution. The objective of this study was to evaluate and quantify DPBM defect reconstruction in the lower leg, especially in elderly, multimorbid and severely ill patients. Read More

Phys Med 2021 Apr 16;84:72-79. Epub 2021 Apr 16.

Department of Electronics, Information and Bioengineering, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy. Electronic address:

Purpose: To evaluate changes in diffusion and perfusion-related properties of white matter (WM) induced by proton therapy, which is capable of a greater dose sparing to organs at risk with respect to conventional X-ray radiotherapy, and to eventually expose early manifestations of delayed neuro-toxicities.

Methods: Apparent diffusion coefficient (ADC) and IVIM parameters (D, D* and f) were estimated from diffusion-weighted MRI (DWI) in 46 patients affected by meningioma and treated with proton therapy. The impact on changes in diffusion and perfusion-related WM properties of dose and time, as well as the influence of demographic and pre-treatment clinical information, were investigated through linear mixed-effects models. Read More

Clin Imaging 2021 Apr 12;79:36-42. Epub 2021 Apr 12.

Department of Magnetic Resonance, Shanxi Cardiovascular Hospital, Taiyuan, China.

Background: The brain is reliant on an abundant and uninterrupted CBF for normal neural function because it is an organ with high metabolic activity and limited ability to store energy.

Purpose: This study aimed to compare age-related variations in CBF measured with PCASL.

Methods: This prospective study included healthy volunteers at the Radiology Department of Shanxi Cardiovascular Hospital between October 2018 and July 2019. Read More

Am J Transplant 2021 Apr 19. Epub 2021 Apr 19.

Latner Thoracic Research Laboratories, Toronto Lung Transplant Program, University Health Network, Toronto, ON, Canada.

Ex vivo lung perfusion (EVLP) has being increasingly used for the pre-transplant assessment of extended-criteria donor lungs. Mathematical models to predict lung acceptance during EVLP have not been reported so far. Thus, we hypothesized that predictors of lung acceptance could be identified and used to develop a mathematical model describing the clinical decision-making process used in our institution. Read More

J Am Podiatr Med Assoc 2021 Mar;111(2)

Background: Diabetic foot ulcers combined with ischemia and infection can be difficult to treat. Few studies have quantified the level of blood supply and infection control required to treat such complex diabetic foot ulcers. We aimed to propose an index for ischemia and infection control in diabetic chronic limb-threatening ischemia (CLTI) with forefoot osteomyelitis. Read More

Dis Colon Rectum 2021 Apr 13. Epub 2021 Apr 13.

University of California, Irvine, Orange, CA Kaiser Permanente LAMC, Los Angeles, CA Washington University School of Medicine, St Louis, MO Houston Methodist Hospital, Houston, TX University of South Florida, Tampa, FL Suburban Surgical Associates, St Louis, MO University of Cincinnati Physicians, Cincinnati, OH University of Nevada School of Medicine Johns Hopkins University, Baltimore, MD MD Anderson Cancer Center - Baptist Medical Center, Jacksonville, FL University of California, San Francisco, San Francisco, CA Ochsner Clinic Foundation, New Orleans, LA NSLIJ/Hofstra North Shore School of Medicine At Lenox Hill Hospital, New York, NY Mount Sinai, New York, NY Medical College of South Carolina, Charleston, SC Baylor University Medical Center, Dallas, TX Cleveland Clinic Foundation, Cleveland, OH.

Background: Indocyanine green fluoroscopy has been shown to improve anastomotic leak rates in early phase trials.

Objective: We hypothesized that the use of fluoroscopy to ensure anastomotic perfusion may decrease anastomotic leak following low anterior resection.

Design: We performed a 1:1 randomized, controlled, parallel study. Read More

Ann Nucl Med 2021 Apr 19. Epub 2021 Apr 19.

Department of Health Science, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Objective: Phase analysis is expected to improve the accuracy of myocardial ischemia diagnosis in conjunction with myocardial perfusion and wall motion imaging and quantification. Although previous studies have reported perfusion image disagreements in relation to radionuclides, a few reports have examined the influences of radionuclides on phase analysis. We evaluated the influences of different radionuclides on stress-induced left ventricular mechanical dyssynchrony by phase analysis using electrocardiogram (ECG)-gated myocardial perfusion single photon emission computed tomography (SPECT) (MPS) imaging in patients with ischemic heart disease (IHD). Read More

J Vis Exp 2021 Apr 5(170). Epub 2021 Apr 5.

Department of Physiology & The Institute for Digital Medicine (WisDM), National University of Singapore; Mechanobiology Institute, National University of Singapore; Institute of Bioengineering and Nanotechnology, A*STAR; NUS Graduate School for Integrative Sciences and Engineering; CAMP, Singapore-MIT Alliance for Research and Technology;

Primary hepatocytes are widely used in basic research on liver diseases and for toxicity testing in vitro. The two-step collagenase perfusion procedure for primary hepatocyte isolation is technically challenging, especially in portal vein cannulation. The procedure is also prone to occasional contamination and variations in perfusion conditions due to difficulties in the assembly, optimization, or maintenance of the perfusion setup. Read More

Curr Eye Res 2021 Apr 19:1-8. Epub 2021 Apr 19.

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

: To assess the anti-neovascularization effect of a novel peptide NT/K-CFY derived from the kringle domain of neurotrypsin.: Cell migration, lumen formation and cell proliferation assays were performed to determine the anti-neovascularization effect of NT/K-CFY in primary human umbilical vein endothelial cells (HUVECs). Chick chorioallantoic membrane (CAM) and oxygen-induced retinopathy (OIR) models were established to assess the anti-angiogenic role of NT/K-CFY . Read More

Perfusion 2021 Apr 19:2676591211011039. Epub 2021 Apr 19.

Clinical Research Support Office, ASO Iizuka Hospital, Iizuka city, Fukuoka, Japan.

Introduction: Extracorporeal membrane oxygenation (ECMO) and Continuous renal replacement therapy (CRRT) are treatments for critically ill patients with respiratory failure and acute kidney injury. However, no reliable factors have been identified to predict survival in patients treated with both ECMO and CRRT. The aim of this study was to identify prognostic factors for discharging intensive care unit (ICU) patients who required CRRT during ECMO. Read More

J Neurosurg Sci 2021 Apr 16. Epub 2021 Apr 16.

Department of Neurosurgery, University Hospital Zurich, Clinical Neuroscience Centre, Zurich, Switzerland -

Objective: To systematically review the literature on surgical revascularization techniques for flow-augmentation of the frontal areas and/or anterior cerebral artery (ACA) territory in children with Moyamoya vasculopathy (MMV), to elucidate the current surgical practice and describe the outcome associated to the different techniques.

Evidence Acquisition: The systematic review followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. MEDLINE, Web of Science and EMBASE were searched up to April 2020. Read More

J Card Surg 2021 Apr 19. Epub 2021 Apr 19.

Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, Jiangsu, China.

Background: Preoperative malperfusion of acute type A aortic dissection (ATAAD) remains a catastrophic complication that is associated with high postoperative morbidity and mortality. The relationship between malperfusion and long-term survival in the Chinese population is unknown.

Methods: A total of 771 patients who underwent ATAAD surgery between January 2009 and December 2018 at our center were included. Read More

Front Oncol 2021 23;11:648528. Epub 2021 Mar 23.

Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands.

Purpose: Relative cerebral blood volume (rCBV) is the most widely used parameter derived from DSC perfusion MR imaging for predicting brain tumor aggressiveness. However, accurate rCBV estimation is challenging in enhancing glioma, because of contrast agent extravasation through a disrupted blood-brain barrier (BBB), and even for nonenhancing glioma with an intact BBB, due to an elevated steady-state contrast agent concentration in the vasculature after first passage. In this study a thorough investigation of the effects of two different leakage correction algorithms on rCBV estimation for enhancing and nonenhancing tumors was conducted. Read More

Evid Based Complement Alternat Med 2021 1;2021:6644625. Epub 2021 Apr 1.

Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou 310053, China.

Objective: By comparing the differences in microcirculatory responses of the heart and lung meridians induced by moxibustion on these two meridians, respectively, this study aimed to investigate the specificity for site-to-site association on body surface between different meridians.

Methods: Eighty healthy adults were enrolled and divided into the lung meridian intervention group and heart meridian intervention group in a ratio of 1 : 1. Three-channel laser Doppler flowmetry was used to monitor microcirculatory responses for the heart and lung meridians. Read More

Clin Hemorheol Microcirc 2021 Apr 13. Epub 2021 Apr 13.

Department of Ultrasound, The First Affiliated Hospital of Hainan Medical University, Haikou, China.

Background: The contrast-enhanced ultrasound (CEUS) liver imaging reporting and data system (LI-RADS) is a relative new algorithm for hepatocellular carcinoma (HCC) assessment.

Objective: To validate the diagnostic efficiency of the intravascular perfusion based CEUS LI-RADS for HCC.

Methods: Archives of 873 patients with focal liver lesions (FLLs) undergoing CEUS were reviewed, and target images were read by two sonologists independently according to the CEUS LI-RADS. Read More

Clin Hemorheol Microcirc 2021 Apr 13. Epub 2021 Apr 13.

Department of Surgical Research and Techniques, Medical School, University of Pécs, Pécs, Hungary.

Background: Ischemia-reperfusion injury (IRI) can cause insufficient microcirculation of the transplanted organ and results in a diminished and inferior graft survival rate.

Objective: This study aimed to investigate the effect of different doses of an anti-diabetic drug, Pioglitazone (Pio), on endoplasmic reticulum stress and histopathological changes, using an in situ perfusion rat model.

Methods: Sixty male Wistar rats were used and were divided into six groups, consisting of the control group, vehicle-treated group and four Pio-treated groups (10, 20, 30 and 40 mg/kg Pio was administered). Read More

Clin Neurophysiol 2021 Mar 24. Epub 2021 Mar 24.

Department of Biomedical Sciences, University of Sassari, Sassari, Italy. Electronic address:

Objective: To explore the cortical areas targeted by acute transcutaneous trigeminal nerve stimulation (TNS) in patients with drug-resistant epilepsy (DRE) using single photon emission computed tomography (SPECT).

Methods: Ten patients with DRE underwent brain SPECT at baseline and immediately after a 20-minute TNS (0.25 ms; 120 Hz; 30 s ON and 30 s OFF) applied bilaterally to the infraorbital nerve. Read More

J Cereb Blood Flow Metab 2021 Apr 17:271678X211010071. Epub 2021 Apr 17.

Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Stroke Research Berlin, Berlin, Germany.

MRI-based vessel size imaging (VSI) allows for assessment of cerebral microvasculature and perfusion. This exploratory analysis of vessel size (VS) and density (Q; both assessed via VSI) in the subacute phase of ischemic stroke involved sixty-two patients from the BAPTISe cohort ('Biomarkers And Perfusion--Training-Induced changes after Stroke') nested within a randomized controlled trial (intervention: 4-week training relaxation). Relative VS, Q, cerebral blood volume (rCBV) and -flow (rCBF) were calculated for: ischemic lesion, perilesional tissue, and region corresponding to ischemic lesion on the contralateral side (mirrored lesion). Read More

J Cereb Blood Flow Metab 2021 Apr 17:271678X211009382. Epub 2021 Apr 17.

The Irish Longitudinal Study on Ageing, Trinity College Dublin, Dublin, Ireland.

Due to its cardiovascular effects sedentary behaviour might impact cerebrovascular function in the long term, affecting cerebrovascular regulatory mechanisms and perfusion levels. Consequently this could underly potential structural brain abnormalities associated with cognitive decline. We therefore assessed the association between sedentary behaviour and brain measures of cerebrovascular perfusion and structural abnormalities in community-dwelling older adults. Read More

Hypertension 2021 Apr 19:HYPERTENSIONAHA12016894. Epub 2021 Apr 19.

From the Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institute of Health, Baltimore, MD (J.E.M., O.M., L.J.L.).

Cerebral hypoperfusion leads to adverse sequalae including dementia. Midlife higher blood pressure (BP) can lead to low cerebral blood flow (CBF), but older persons may need higher BP to maintain cerebral perfusion. We investigated the associations among late-life BP, CBF, and cognition. Read More

Pediatr Pulmonol 2021 Apr 18. Epub 2021 Apr 18.

Department of Pediatrics, National Hospital Organization Maizuru Medical Center, Maizuru, Kyoto, Japan.

Background: Ventilated neonates with hypoxemic respiratory failure (HRF) may show a ventilation-perfusion (V/Q) mismatch.

Objective: To evaluate the difference between the Bohr (V ) and Enghoff (V ) dead spaces in infants by using volumetric capnography based on ventilator graphics and capnograms.

Methods: This study enrolled 46 ventilated infants (mean birth weight, 2239 ± 640 g; mean gestational age, 35. Read More

Neurosurg Rev 2021 Apr 17. Epub 2021 Apr 17.

Department of Neurosurgery, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074, Aachen, Germany.

Aneurysmal subarachnoid hemorrhage (SAH) is associated with a high mortality rate and may leave surviving patients severely disabled. After the initial hemorrhage, clinical outcome is further compromised by the occurrence of delayed cerebral ischemia (DCI). Overweight and obesity have previously been associated with protective effects in the post-bleeding phase. Read More

Peptides 2021 Apr 15:170552. Epub 2021 Apr 15.

Center for Preclinical Research, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, via Pace 9, 20100, Milan, Italy.

The increasing use of marginal lungs for transplantation encourages novel approaches to improve graft quality. Melanocortins and their receptors (MCRs) exert multiple beneficial effects in pulmonary inflammation. We tested the idea that treatment with the synthetic α-melanocyte-stimulating hormone analogue [Nle4,D-Phe7]-α-MSH (NDP-MSH) during ex-vivo-lung-perfusion (EVLP) could exert positive influences in lungs exposed to different injuries. Read More

JACC Cardiovasc Imaging 2021 Apr 7. Epub 2021 Apr 7.

Lab of Inflammation and Cardiometabolic Diseases, National Heart, Lung and Blood Institute, Bethesda, Maryland, USA. Electronic address:

JACC Cardiovasc Imaging 2021 Apr 7. Epub 2021 Apr 7.

Division of Cardiovascular Medicine and the Cardiac Imaging Center, University of Virginia Health System, Charlottesville, Virginia, USA; Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, Virginia, USA. Electronic address:

Objectives: This study sought to better characterize the quality of life and economic impact in patients with symptoms of ischemia and no obstructive coronary disease (INOCA) and to identify the influence of coronary microvascular dysfunction (CMD).

Background: Patients with INOCA have a high symptom burden and an increased incidence of major adverse cardiac events. CMD is a frequent cause of INOCA. Read More

JACC Cardiovasc Imaging 2021 Apr 7. Epub 2021 Apr 7.

JACC Cardiovasc Imaging 2021 Apr 7. Epub 2021 Apr 7.

Institute of Experimental and Translational Cardiac Imaging, DZHK (German Centre for Cardiovascular Research) Centre for Cardiovascular Imaging, University Hospital Frankfurt, Frankfurt am Main, Germany; Department of Cardiology, University Hospital Warsaw, Warsaw, Poland. Electronic address:

Objectives: The goal of this study was to examine prognostic relationships between cardiac imaging measures and cardiovascular outcome in people living with human immunodeficiency virus (HIV) (PLWH) on highly active antiretroviral therapy (HAART).

Background: PLWH have a higher prevalence of cardiovascular disease and heart failure (HF) compared with the noninfected population. The pathophysiological drivers of myocardial dysfunction and worse cardiovascular outcome in HIV remain poorly understood. Read More

BMC Pregnancy Childbirth 2021 Apr 17;21(1):308. Epub 2021 Apr 17.

Research Institute, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.

Background: A lack of information on specific and interventional factors for stillbirth has made designing preventive strategies difficult, and the stillbirth rate has declined more slowly than the neonatal death rate. We compared the prevalence of stillbirth among the offspring of women with or without abnormal placental perfusion (APP).

Methods: We conducted a hospital-based retrospective cohort study involving women with a singleton pregnancy between 2012 and 2016 (N = 41,632). Read More

BMC Med Imaging 2021 Apr 17;21(1):73. Epub 2021 Apr 17.

Department of Radiology, The Second Affiliated Hospital of Zhejiang University, Hangzhou, 310009, China.

Background: To explore if the quantitative perfusion histogram parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) correlates with the expression of PTEN, P-Akt and m-TOR protein in lung cancer.

Methods: Thirty-three patients with 33 lesions who had been diagnosed with lung cancer were enrolled in this study. They were divided into three groups: squamous cell carcinoma (SCC, 15 cases), adenocarcinoma (AC, 12 cases) and small cell lung cancer (SCLC, 6 cases). Read More

Mol Biol Rep 2021 Apr 17. Epub 2021 Apr 17.

Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

It has been documented that aging increases the risk of cardiovascular disease including myocardial ischemia/reperfusion (IR) injury and acute myocardial infarction. In this study, we aimed to investigate the individual or combined effects of nicotinamide mononucleotide (NMN) and melatonin (Mel) treatment on apoptotic markers, expression of SIRT3, and FOXO1, and infarct size of the aged myocardium subjected to IR injury. Sixty aged Wistar rats (22-24 months) were assigned to five groups including sham, IR, NMN+IR, Mel+IR, and NMN+Mel+IR (combination therapy). Read More