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Endomyocardial fibrosis: a restrictive cardiomyopathy in developing countries.

Arch Cardiol Mex 2021 ;91(2):196-201

División de Cardiología, Fundación CardioInfantil IC, Universidad El Bosque, Facultad de Medicina y Ciencias de la salud.

Objective: Endomyocardial fibrosis (EF) is an unusual restrictive cardiomyopathy. In Latin America there are few reports. Here, we made a description of patients diagnosed with EF in Colombia. Read More

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January 2021

Idioventricular rhythm and shock after a honeybee sting.

Arch Cardiol Mex 2021 ;91(2):186-189

Department of Endocrinology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

Objective: The objective of this study was to describe the case of a 19-year-old male presenting with bradycardia and hypotension after a honeybee sting making a review of the literature and pathophysiology of the cardiovascular and electrocardiogram (EKG) changes after a bee sting.

Methods: The patient's airway was inspected and secured. Electrocardiogram with an idioventricular rhythm at 41' bpm. Read More

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January 2021

Kisspeptin Levels in Girls with Precocious Puberty: A Systematic Review and Meta-Analysis.

Horm Res Paediatr 2021 Apr 22:1-10. Epub 2021 Apr 22.

Postgraduate Program in Health Sciences, Faculdade de Medicina do ABC/Centro Universitário Saúde ABC, Santo André, Brazil.

Background/aims: Kisspeptin (KP) is a key player in the regulation of the release of gonadotropin-releasing hormone (GnRH), which increases the secretion of gonadotropin during puberty to establish reproductive function and regulate the hypothalamic-pituitary-gonadal axis. Premature activation of GnRH secretion leads to idiopathic/central gonadotropin-dependent precocious puberty (CPP). We aimed to compare the blood KP concentrations in girls with CPP and healthy controls. Read More

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Topical 15% Resorcinol Is Associated with High Treatment Satisfaction in Patients with Mild to Moderate Hidradenitis Suppurativa.

Dermatology 2021 Apr 22:1-4. Epub 2021 Apr 22.

Department of Dermatology, Alicante University General Hospital, Alicante, Spain.

Background: Topical 15% resorcinol is commonly used in clinical practice for the treatment of nodules and abscesses in patients with hidradenitis suppurativa (HS). It has been shown to be clinically effective in some small studies, but data on satisfaction perceived by patients are lacking. The Treatment Satisfaction Questionnaire for Medication (TSQM) version 1. Read More

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Prophylactic Treatment in Hereditary Angioedema Is Associated with Reduced Anxiety in Patients in Leipzig, Germany.

Int Arch Allergy Immunol 2021 Apr 22:1-8. Epub 2021 Apr 22.

Department of Dermatology, Venereology and Allergology, University Hospital Leipzig, Leipzig, Germany.

Background: Hereditary angioedema (HAE) is associated with relevant disease-related burden. We aimed at investigating prevalence of depression and anxiety in patients with HAE in Leipzig, Germany.

Methods: Questionnaire-based evaluation of medical history, Angioedema Control Test (AECT), Angioedema Quality of Life Questionnaire (AE-QoL), Generalized Anxiety Disorder Scale-7 (GAD-7), and Hospital Anxiety and Depression Scale (HADS). Read More

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Repeatability of quantitativeF-FET PET in glioblastoma.

Biomed Phys Eng Express 2021 Apr 22. Epub 2021 Apr 22.

7033 Wisconsin Institute for Medical Research Department of Medical Physics, University of Wisconsin at Madison, 1111 Highland Avenue, Madison, Madison, Wisconsin, 53705, UNITED STATES.

Purpose: O-(2-[F]fluoroethyl)-L-tyrosine (FET), a PET radiotracer of amino acid uptake, has shown potential for diagnosis and treatment planning in patients with glioblastoma (GBM). To improve quantitative assessment of FET PET imaging, we evaluated the repeatability of uptake of this tracer in patients with GBM.

Methods: Test-retest FET PET imaging was performed on 8 patients with histologically confirmed GBM, who previously underwent surgical resection of the tumour. Read More

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Automatic identification of respiratory events based on nasal airflow and respiratory effort of chest and abdomen.

Physiol Meas 2021 Apr 22. Epub 2021 Apr 22.

Biomedical Engineering, Beijing Institute Of Technology School of Life Science, Beijing, CHINA.

Objective: Disease may cause changes in the individual's respiratory pattern, which can be measured as parameters for evaluating disease, usually through manually annotated polysomnographic recordings. In this study, a machine learning model based on nasal airflow and respiratory effort of chest and abdomen is proposed to automatically identify respiratory events, including normal breathing event, hypopnea event and apnea event.

Approach: The nasal airflow and chest-abdominal respiratory effort signals were collected from Polysomnography (PSG). Read More

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Validation of a 4D-MRI guided liver SBRT strategy for implementation on the MR-linac.

Phys Med Biol 2021 Apr 22. Epub 2021 Apr 22.

Department of Radiation Oncology, Nederlands Kanker Instituut - Antoni van Leeuwenhoek Ziekenhuis, Amsterdam, Noord-Holland, NETHERLANDS.

Accurate tumor localization for image-guided liver SBRT is challenging due to respiratory motion and poor tumor visibility on conventional X-ray based images. Novel integrated MRI and radiotherapy systems enable direct in-room tumor visualization, potentially increasing treatment accuracy. As these systems currently do not provide a 4D image-guided radiotherapy strategy, we developed a 4D-MRI guided liver SBRT workflow and validated all steps for implementation on the Unity MR-linac. Read More

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High body mass index and pre-existing autoimmune disease are associated with an increased risk of immune-related adverse events in cancer patients treated with PD-(L)1 inhibitors across different solid tumors.

ESMO Open 2021 Apr 19;6(3):100107. Epub 2021 Apr 19.

Dutch Medicines Evaluation Board (CBG-MEB), Utrecht, The Netherlands.

Background: Treatment with anti-PD-(L)1 antibodies, approved for several oncology indications, can lead to immune-related adverse events (irAEs). We aimed to investigate risk factors associated with an increased reporting of irAEs in patients treated with PD-(L)1 inhibitors approved for solid tumor indications.

Patients And Methods: A retrospective review was performed of individual data from patients in phase II/III registrational studies for PD-(L)1 inhibitors in solid tumors. Read More

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Wrapping double-mattress anastomosis for pancreaticojejunostomy in minimally invasive pancreaticoduodenectomy can significantly reduce postoperative pancreatic fistula rate compared with conventional pancreaticojejunostomy in open surgery: An analysis of a propensity score-matched sample.

Surg Oncol 2021 Apr 9;38:101577. Epub 2021 Apr 9.

Department of Surgery, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.

Background: Minimally invasive pancreaticoduodenectomy (MIPD), including laparoscopic pancreaticoduodenectomy (LPD) and robotic pancreaticoduodenectomy (RPD), is technically demanding because of pancreaticojejunostomy (PJ). Postoperative pancreatic fistula (POPF) is the most serious complication of MIPD and open pancreaticoduodenectomy (OPD). Contrary to expectations, conventional PJ in MIPD did not improve POPF rate and length of hospital stay. Read More

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Evaluation of stapes mobilization in the 21st century for conductive hearing loss in the otosclerotic ear.

Am J Otolaryngol 2021 Apr 16;42(5):103059. Epub 2021 Apr 16.

Department of Otolaryngology - Head and Neck Surgery, Drexel University College of Medicine, 219 N. Broad Street, 10th Floor, Philadelphia, PA 19107, United States of America; Lankenau Institute for Medical Research, Philadelphia, PA 19107, United States of America. Electronic address:

Purpose: Compare outcomes of stapes mobilization and stapedectomy performed by a single surgeon for the otosclerosis.

Materials And Methods: A retrospective chart review of adult patients who underwent stapes mobilization or stapedectomy for otosclerosis was performed. Operative notes reviewed; patients included if diagnosed with otosclerosis without another otologic disease that could contribute to their hearing loss and all required data were available. Read More

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Outcomes of complex primary total knee arthroplasties performed with custom cutting guides.

Knee 2021 Apr 19;30:106-112. Epub 2021 Apr 19.

Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA. Electronic address:

Background: Total knee arthroplasty (TKA) is particularly challenging in patients with marked deformities or existing hardware due to the inability to use traditional instrumentation. One potential technique to mitigate this obstacle is the use of patient-specific cutting guides. The purpose of this study was to evaluate the use of custom cutting guides in complex primary TKAs. Read More

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False malalignment after computer-navigated total knee arthroplasty.

Knee 2021 Apr 19;30:100-105. Epub 2021 Apr 19.

Department of Orthopaedic Surgery, Chiba Rehabilitation Center, Chiba, Japan.

Background: Although computer navigation has improved component alignment in total knee arthroplasty (TKA), radiographic outliers are reported with a wide range in literature even using this technique. We hypothesized that the postoperative malalignment after computer-navigated TKA was partially derived from the inherent problems with two-dimensional (2D) measurement such as inaccuracies in measurement due to the knee position during the radiographic examination and the direction of the X-ray beam. We therefore conducted this study to determine how often knees with malalignment on 2D imaging were truly mal-aligned on three-dimensional (3D) reconstructed imaging. Read More

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Emergency handover of critical patients. A systematic review.

Int Emerg Nurs 2021 Apr 19;56:100997. Epub 2021 Apr 19.

Nursing Department, Universitat Rovira Virgili, Campus Terres de l'Ebre, Avenue Remolins, 13-15, 43500 Tortosa, Tarragona, Spain. Electronic address:

Background: Emergency handover of critical patients is used to describe the moment of union between prehospital and hospital health team. However, the literature shows several definitions leading to great heterogeneity.

Purpose: To study the emergency handover of critical patients between two critical-emergency care wards performed by emergency nurses worldwide and to identify the features of these processes. Read More

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The circACC1/miR-29c-3p/FOXP1 network plays a key role in gastric cancer by regulating cell proliferation.

Biochem Biophys Res Commun 2021 Apr 19;557:221-227. Epub 2021 Apr 19.

The Department of Ultrasound Medicine, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710061, China. Electronic address:

Although substantial progress has been made in early detection and treatment of GC, this disease remains a major burden worldwide. CircRNAs have potential as prognostic and diagnostic biomarkers in tumorigenesis. Therefore, we aimed to clarify the role and mechanism of circACC1 in GC cell proliferation. Read More

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Pregnancy in women with psoriatic arthritis: A systematic literature review of disease activity and adverse pregnancy outcomes.

Semin Arthritis Rheum 2021 Apr 15;51(3):530-538. Epub 2021 Apr 15.

Deutsches Rheuma-Forschungszentrum Berlin, Programmbereich Epidemiologie und Versorgungsforschung, Berlin, Germany.

Background: There is limited robust evidence on the course of pregnancy and its outcomes in women with psoriatic arthritis (PsA) on which to base recommendations for the management of these patients.

Objective: The primary objective was to review available data on (I) disease activity during pregnancy and on (II) adverse pregnancy outcomes (APO) in women with PsA. Secondly, neonatal outcomes and treatment of the rheumatic disease were investigated. Read More

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Low skeletal muscle mass predicts poor clinical outcomes in patients with abdominal trauma.

Nutrition 2021 Mar 4;89:111229. Epub 2021 Mar 4.

Department of Intensive Care Unit, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province, China. Electronic address:

Objective: The aim of this study was to investigate whether low skeletal muscle mass is associated with clinical outcomes in patients with abdominal trauma.

Methods: Patients presenting to our institution with abdominal trauma from January 2010 to April 2020 were retrospectively included. Low skeletal muscle mass was defined, using computed tomography, as skeletal muscle index (SMI) at the third lumbar vertebra below the lowest sex-specific quartile within 1 wk of admission. Read More

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The clinical and prognostic role of ALK in glioblastoma.

Pathol Res Pract 2021 Apr 15;221:153447. Epub 2021 Apr 15.

Department of Oncology, AUSL Bologna, Bologna, Italy.

Background: anaplastic lymphoma kinase (ALK) overexpression and gene alterations have been detected in several malignancies, with prognostic and therapeutic implications. However, few studies investigated the correlation between ALK altered expression and prognosis in patients with glioblastoma (GBM).

Methods: We performed an evaluation of ALK overexpression and structural/quantitative chromosome alterations through immune-histochemical assay (IHC with D5F3 antibody) and fluorescent in situ hybridization (FISH) in patients with isocitrate dehydrogenase (IDH) wild type (wt) GBM. Read More

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The clinical effect of early enteral nutrition in liver-transplanted patients: a systematic review and meta-analysis.

Clin Res Hepatol Gastroenterol 2021 Apr 19;45(3):101594. Epub 2021 Apr 19.

Nursing Department, Huashan Hospital Affiliated to Fudan University, No.12 Urumqi Middle Road, Jing'an District, Shanghai 200040, China. Electronic address:

Background: Appropriate nutritional support is critical for patients undergoing liver transplantation (LT). Early enteral nutrition (EEN) has been considered effective in critically ill patients. However, the clinical effect of EEN on liver-transplanted patients is unclear. Read More

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SHIRODKAR CERCLAGE: OBSTETRICAL AND NEONATAL OUTCOMES IN A SINGLE-CENTER COHORT OF 55 CASES.

J Gynecol Obstet Hum Reprod 2021 Apr 19:102152. Epub 2021 Apr 19.

Assistance Publique-Hôpitaux de Paris, Service de Gynécologie-Obstétrique, Hôpital Louis Mourier, Colombes; Université de Paris, Paris; FHU PREMA, Paris and Colombes; Inserm UMR1137 IAME, Paris FRANCE. Electronic address:

Background: Cervical insufficiency is thought to be responsible for 10% of preterm deliveries. Shirodkar cerclage is among the available techniques ranging from McDonald's to definitive procedures, however the indications for the prevention of preterm births and mid-trimester miscarriages are still poorly delineated.

Objective: To describe the characteristics, obstetrical and neonatal outcomes of pregnancies with Shirodkar cerclage procedures. Read More

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The effect of prophylactic antiepileptic medications in aneurysmal subarachnoid hemorrhage patients: A retrospective review.

Clin Neurol Neurosurg 2021 Apr 2;205:106633. Epub 2021 Apr 2.

Department of Neurosurgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA. Electronic address:

Objective: The current literary evidence suggests but does not heavily endorse the use of prophylactic antiepileptic drugs (AEDs) after aneurysmal subarachnoid hemorrhage. Literature continues to emerge suggesting not only a lack of efficacy but associated poor outcomes. This study is a retrospective review comparing seizure incidence in aneurysmal subarachnoid patients between those given prophylactic AEDs and those not. Read More

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Microscopic navigation-guided fence post technique for maximal tumor resection during glioma surgery.

World Neurosurg 2021 Apr 19. Epub 2021 Apr 19.

Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto, Japan.

Background: The fence post technique, which involves the insertion of catheters as fence posts around a tumor, has been widely used to demarcate the tumor border for maximal resection of intraparenchymal tumors, such as glioma. However, a standard procedure for fence post insertion has not been established yet, and there are some limitations. To overcome this problem, a simple microscopic navigation-guided fence post (NGFP) method was developed. Read More

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Comparison of minimally invasive total versus subtotal resection of spinal tumors: a systematic review and meta-analysis.

World Neurosurg 2021 Apr 19. Epub 2021 Apr 19.

Department of Neurological Surgery, University of California, Irvine, CA, USA. Electronic address:

Objective: With the advent of minimally invasive techniques, minimally invasive spine surgery (MISS) has become a realistic option for many spine cases. This study aims to evaluate the operative and clinical outcomes of MISS for total versus subtotal tumor resection from current evidence.

Methods: A literature search was performed using the search term, (Minimally invasive surgery OR MIS) AND (spine tumor OR spinal tumor). Read More

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Role for Fibrin Glue (Sealant) in Seroma Reduction After Inguinal Lymphadenectomy; A Randomized Controlled Trial.

Int J Surg 2021 Apr 19:105950. Epub 2021 Apr 19.

Department of General Surgery, Faculty of Medicine, Menoufia University, Egypt.

Background: Seroma is one of the most commonly encountered morbidities after inguinal lymph node dissection (ILND). It causes much nuisance to both patients and doctors and its presence can lead to many complications. This study aimed to evaluate the role and impact of using fibrin glue to decrease seroma formation in patients undergoing ILND. Read More

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Use of a Novel Fluorescent Catheter to Locate the Ureters During Total Laparoscopic Hysterectomy.

J Minim Invasive Gynecol 2021 Apr 19. Epub 2021 Apr 19.

Department of Obstetrics and Gynecology, Medical Park Shonan, Fujisawa, Kanagawa, Japan.

Ureteral injury can occur during total laparoscopic hysterectomy (TLH). This report documents our experience in using the Near-infrared Ray Catheter (NIRC™), a newly developed fluorescent ureteral catheter made of material that contains a fluorescent dye, to improve visualization of the ureters. We have used the device in three patients between 40 and 50 years of age (mean, 46. Read More

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Perioperative Outcomes for Centers Routinely Admitting Postoperative Endovascular Aortic Aneurysm Repair to the ICU.

J Am Coll Surg 2021 Apr 16. Epub 2021 Apr 16.

Division of Vascular and Endovascular Surgery, Boston Medical Center, Boston University School of Medicine, Boston, MA. Electronic address:

Background: Intensive care unit (ICU) admission after endovascular aortic aneurysm repair (EVAR) varies across medical centers. We evaluated the association of postoperative ICU utilization with perioperative and long-term outcomes after EVAR.

Study Design: The Vascular Quality Initiative (2003-2019) was queried for index elective EVARs. Read More

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A Leg to Stand On: Trauma Center Designation and Association with Rate of Limb Salvage in Patients Suffering Severe Lower Extremity Injury.

J Am Coll Surg 2021 Apr 19. Epub 2021 Apr 19.

Department of Plastic and Reconstructive Surgery, Loyola University Medical Center, Maywood, IL USA; Department of Surgery, Edward Hines Jr. Veterans Administration Hospital, Hines, IL.

Background: Mangled extremities are one of the most difficult injuries for trauma surgeons to manage. We compare limb salvage rates for a limb-threatening lower extremity injury managed at Level I versus Level II trauma centers (TCs).

Study Design: We identified all adult patients with a limb-threatening injury who underwent primary amputation or limb salvage (LS) using the American College of Surgeons (ACS) Trauma Quality Improvement Program database at ACS Level I vs. Read More

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The Subscapularis Sparing Windowed Anterior Technique (SWAT) Total Shoulder Arthroplasty.

J Shoulder Elbow Surg 2021 Apr 19. Epub 2021 Apr 19.

Florida Orthopedic Institute / Foundation for Orthopaedic Research & Education (FOI/FORE), 13020 Telecom Pkwy N, Tampa, FL 33637, USA.

Background: Traditionally, total shoulder arthroplasty (TSA) involves detaching the subscapularis tendon either through tenotomy or lesser tuberosity osteotomy. A subscapularis sparing approach avoids detachment, but may make recreation of the anatomy more difficult because of limited exposure. The primary aim of this study was to evaluate the ability to recreate the proximal humeral geometry and to assess for osteophyte removal with this technique. Read More

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Universal immunohistochemistry for Lynch Syndrome: a systematic review and meta-analysis of 58,580 colorectal carcinomas.

Clin Gastroenterol Hepatol 2021 Apr 19. Epub 2021 Apr 19.

Department of Clinical Genetics, Leiden University Medical Center. Electronic address:

Background And Aims: Lynch Syndrome is a form of hereditary colorectal cancer (CRC), caused by pathogenic germline variants (PV) in DNA mismatch repair genes. Currently, many Western countries perform universal immunohistochemistry testing on CRC to increase the identification of LS patients and their relatives. For a clear understanding of health benefits and costs, data on its outcomes are required: proportions of LS, sporadic MMR-deficient (MMRd) cases, and unexplained MMRd cases. Read More

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COVID-19 may increase the risk of insulin resistance in adult patients without diabetes: A 6-month prospective study.

Endocr Pract 2021 Apr 19. Epub 2021 Apr 19.

Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China. Electronic address:

Objective: During the coronavirus disease 2019 (COVID-19) pandemic, exploring insulin resistance and β-cell activity is important for understanding COVID-19-associated new-onset diabetes. This study aimed to assess insulin sensitivity and fasting insulin secretion in COVID-19 patients without diabetes on admission and at 3 and 6 months after discharge.

Methods: This 6-month prospective study assessed data from the records of 64 patients without diabetes diagnosed with COVID-19 at Wenzhou Central Hospital, China. Read More

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