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Diagnostic performance of 2D shear wave elastography in predicting liver fibrosis in patients with chronic hepatitis B and C: a histopathological correlation study.

Abdom Radiol (NY) 2021 Mar 16. Epub 2021 Mar 16.

Department of Infectious Diseases, Gazi University, 06500, Beşevler, Ankara, Turkey.

Purpose: In this study, we investigated the diagnostic efficacy of 2D-Shear Wave Elastography (2D-SWE) in detecting stages of liver fibrosis and determining the disease-specific cut-off values in patients with chronic hepatitis B and C infection, using histopathological analysis as the reference method.

Method: Our study included 103 consecutive adult patients with chronic hepatitis B and C infection (CHB and CHC) who had liver biopsy within three months of elastography examination. A real-time 2D-SWE was performed using the LOGIQ E9 system (GE Medical Systems, Wisconsin, USA). Read More

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Contrast-enhanced voiding urosonography in the diagnosis of intrarenal reflux.

J Ultrasound 2021 Feb 26. Epub 2021 Feb 26.

Children's Hospital Zagreb, Ul. Vjekoslava Klaića 16, 10000, Zagreb, Croatia.

Purpose: Although contrast-enhanced urosonography (ceVUS) has shown capable diagnostic accuracy for the diagnosis of vesicoureteral reflux (VUR) in children, the ability of ceVUS to detect intrarenal reflux (IRR) is considered limited. The purpose of our study is to assess the ability of ceVUS to detect IRR as well as its association with age, gender, and the grade of VUR.

Methods: This study included 5153 children who were referred to our clinic for ceVUS. Read More

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February 2021

Hepatic Vein Contrast-Enhanced Ultrasound Subharmonic Imaging Signal as a Screening Test for Portal Hypertension.

Dig Dis Sci 2021 Jan 4. Epub 2021 Jan 4.

Department of Radiology, Thomas Jefferson University, 132 South 10th Street, Philadelphia, PA, 19107, USA.

Background: Portal hypertension is the underlying cause of most complications associated with cirrhosis, with the hepatic venous pressure gradient (HVPG) used for diagnosis and disease progression. Subharmonic imaging (SHI) is a contrast-specific imaging technique receiving at half the transmit frequency resulting in better tissue suppression.

Aims: To determine whether the presence of optimized SHI signals inside the hepatic vein can be used as a screening test for portal hypertension. Read More

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January 2021

Liver Elastography in Healthy Children Using Three Different Systems - How Many Measurements Are Necessary?

Ultraschall Med 2020 Dec 21. Epub 2020 Dec 21.

Medicine, Haraldsplass Diakonale Sykehus AS, Bergen, Norway.

Purpose:  Liver elastography is increasingly being applied in screening for and follow-up of pediatric liver disease, and has been shown to correlate well with fibrosis staging through liver biopsy. Because time is of the essence when examining children, we wanted to evaluate if a reliable result can be achieved with fewer acquisitions.

Materials And Methods:  243 healthy children aged 4-17 years were examined after three hours of fasting. Read More

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December 2020

Intraoperative Characterization of Pancreatic Tumors Using Contrast-Enhanced Ultrasound and Shear Wave Elastography for Optimization of Surgical Strategies.

J Ultrasound Med 2020 Oct 30. Epub 2020 Oct 30.

Department of Radiology, University Hospital Regensburg, Regensburg, Germany.

Objectives: To evaluate intraoperative contrast-enhanced ultrasound (IoCEUS) and intraoperative shear wave elastography (IoSWE) for characterization of focal pancreatic lesions (FPLs) in correlation with postoperative histologic results. Thereby, the impact of intraoperative ultrasound (US) on pancreas surgery was evaluated.

Methods: Intraoperative CEUS and SWE data from 54 patients, who underwent pancreas surgery between 2017 and 2019, were analyzed retrospectively. Read More

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October 2020

Muscle Echogenicity and Changes Related to Age and Body Mass Index.

JPEN J Parenter Enteral Nutr 2020 Oct 27. Epub 2020 Oct 27.

Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA.

Introduction: Muscle fibers are lost and replaced by fat- and fibrous-tissue infiltration during aging. This process decreases muscle quality and influences tissue appearance on ultrasound images over time. Increased muscle "echogenicity" represents changes caused by fat- and fibrous-tissue infiltration and can be quantified with recently developed software. Read More

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October 2020

Evaluation of the Reproducibility of Bolus Transit Quantification With Contrast-Enhanced Ultrasound Across Multiple Scanners and Analysis Software Packages-A Quantitative Imaging Biomarker Alliance Study.

Invest Radiol 2020 10;55(10):643-656

Department of Radiology, University of Michigan, Ann Arbor.

Objectives: Contrast enhanced ultrasound (CEUS) is now broadly used clinically for liver lesion detection and characterization. Obstacles to the efforts to quantify perfusion with CEUS have been the lack of a standardized approach and undocumented reproducibility. The use of multiple scanners and different analysis software packages compounds the degree of variability. Read More

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October 2020

Contrast-enhanced Ultrasound Identifies Patent Feeding Vessels in Transarterial Chemoembolization Patients With Residual Tumor Vascularity.

Ultrasound Q 2020 Sep;36(3):218-223

Department of Radiology, Thomas Jefferson University.

Transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC) often requires retreatment and identification of feeding vessels supplying the residual/recurrent tumor is an important step in treatment planning. The objective of this study was to determine if contrast-enhanced ultrasound (CEUS) could correctly identify the vessel supplying the residual tumor. To date, 69 patients have undergone CEUS follow-up of HCC TACE therapy at our institution as part of an ongoing institutional review board approved trial (NCT02764801). Read More

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September 2020

Three-dimensional shear wave elastography on conventional ultrasound scanners with external vibration.

Phys Med Biol 2020 11 5;65(21):215009. Epub 2020 Nov 5.

Department of Radiology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, United States of America.

Two-dimensional (2D) ultrasound shear wave elastography (SWE) has been widely used for soft tissue properties assessment. Given that shear waves propagate in three dimensions (3D), extending SWE from 2D to 3D is important for comprehensive and accurate stiffness measurement. However, implementation of 3D SWE on a conventional ultrasound scanner is challenging due to the low volume rate (tens of Hertz) associated with limited parallel receive capability of the scanner's hardware beamformer. Read More

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November 2020

Techniques for Improving Ultrasound Visualization of Biopsy Markers in Axillary Lymph Nodes.

J Clin Imaging Sci 2020 18;10:21. Epub 2020 Apr 18.

Department of Radiology, Division of Medical Physics, Mayo Clinic, Rochester, China.

Objective: Biopsy markers are often placed into biopsy-proven metastatic axillary lymph nodes to ensure later accurate node excision. Ultrasound is the preferred imaging modality in the axilla. However, sonographic identification of biopsy markers after neoadjuvant therapy can be challenging. Read More

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The Number of Central Lymph Nodes on Preoperative Ultrasound Predicts Central Neck Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Prospective Cohort Study.

Int J Endocrinol 2020 14;2020:2698659. Epub 2020 Apr 14.

Department of Ultrasound, China-Japan Friendship Hospital, Beijing, China.

To evaluate the effectiveness of the number of central compartment lymph nodes (CLNs) on ultrasound (US) in predicting CLN metastasis (CLNM). We prospectively studied 309 papillary thyroid cancer (PTC) patients who underwent thyroidectomy with CLN dissection at our center from May 2017 to July 2017. The number and features of CLNs were evaluated preoperatively US. Read More

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Are there different cut-off values for staging liver fibrosis using 2D-SWE implemented on different systems from the same manufacturer?

Med Ultrason 2020 03;22(1):7-12

Deparment of Gastroenterology and Hepatology, "Victor Babes" University of Medicine and Pharmacy Timisoara.

Aim: To evaluate the range of liver stiffness (LS) cut-off values for predicting different stages of liver fibrosis (LF) for 2D-SWE-GE implemented on three different systems from General Electric Healthcare (LOGIQ E9, LOGIQ S8, LOGIQ P9).

Material And Method: We performed a comparative study evaluating the performance of 2D-SWE-GE (LOGIQ E9, S8, P9) for predicting different stages of LF using Transient Elastography (TE) as the reference method. All patients (with or without chronic hepatopathies) were evaluated by TE, 331 patients were included in the LOGIQ E9 study, 179 in the LOGIQ S8 study and 234 in the LOGIQ P9 study. Read More

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Repeatability and Agreement of Shear Wave Speed Measurements in Phantoms and Human Livers Across 6 Ultrasound 2-Dimensional Shear Wave Elastography Systems.

Invest Radiol 2020 04;55(4):191-199

From the Department of Radiology, Cincinnati Children's Hospital Medical Center.

Objectives: Ultrasound shear wave elastography (SWE) is an imaging technique that quantifies liver stiffness. However, comparison data across newest ultrasound systems are sparse. The purpose of this study was to assess repeatability and agreement of shear wave speeds (SWSs) across 6 ultrasound 2-dimensional (2D) SWE systems. Read More

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Shear-Wave Elastography Variability Analysis and Relation with Kidney Allograft Dysfunction: A Single-Center Study.

Diagnostics (Basel) 2020 Jan 13;10(1). Epub 2020 Jan 13.

Department of Medical Imaging, Iuliu Hațieganu University of Medicine and Pharmacy Cluj-Napoca, Croitorilor Str., no. 19-23, 400162 Cluj-Napoca, Romania.

Shear-wave elastography (SWE) showed the absence or presence of significant differences among stable kidney allograft function and allograft dysfunction. We evaluated the variability of kidney allograft stiffness in relation to allograft dysfunction, respectively, in terms of a correlation of stiffness with patients' characteristics. A single-center prospective study on patients who had undergone renal transplantation was conducted between October 2017 and November 2018. Read More

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January 2020

Noninvasive assessment of liver fibrosis in a real-world cohort of patients with known or suspected chronic liver disease using 2D-shear wave elastography.

Eur J Gastroenterol Hepatol 2020 12;32(12):1559-1565

Department of Gastroenterology and Gastrointestinal Oncology.

Objectives: We aimed to investigate the diagnostic accuracy of liver stiffness measurement (LSM) by 2D-shear wave elastography (2D-SWE, GE, Logiq E9) in patients with known or suspected chronic liver disease and to define cutoff values for the different stages of fibrosis.

Methods: First, we retrospectively enrolled 21 patients in a pilot study and validated the results in a prospective cohort of 70 patients between May 2017 and February 2019. In all patients, LSM and liver biopsy were performed. Read More

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December 2020

Ultrasonographic evaluation of umbilical structures in Holstein calves: A comparison between healthy calves and calves affected by umbilical disorders.

J Dairy Sci 2020 Mar 25;103(3):2578-2590. Epub 2019 Dec 25.

Department of Veterinary Medicine, University of Teramo, Teramo 64100 Italy.

The aim of this study was to evaluate, during the first 4 wk of life, the involution of umbilical structures in clinically healthy calves and in calves affected by umbilical disorders, in both B-mode and color Doppler ultrasonography. The present study was carried out on 63 Holstein Friesian calves, divided into 3 different groups: group H (clinically healthy, n = 17), group A, (affected by omphaloarteritis, n = 24), and group V (affected by omphalophlebitis, n = 22). B-mode ultrasonography was performed at weekly intervals, using a portable device (LOGIQ Book XP, GE Healthcare, Little Chalfont, UK) and a linear multifrequency 7 to 10 MHz probe. Read More

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Use of Pocket-Sized Ultrasound Device in the Diagnosis of Shoulder Pathology.

Clin J Sport Med 2020 01;30(1):20-24

Division of Shoulder and Sports Medicine Surgery, Department of Orthopaedic Surgery, University of California San Francisco Medical Center, San Francisco, California; and.

Objective: Musculoskeletal ultrasound imaging is increasingly being used for static and dynamic imaging of tendons, muscles, ligaments, and bones. New, hand-held, pocket-sized ultrasounds are more portable and affordable. The purpose of this study was to evaluate the feasibility of pocket-sized ultrasound to diagnose shoulder pathology. Read More

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January 2020

Point of care, clinician-performed laryngeal ultrasound and pediatric vocal fold movement impairment.

Int J Pediatr Otorhinolaryngol 2020 Feb 9;129:109773. Epub 2019 Nov 9.

Texas Children's Hospital, Pediatric Otolaryngology, 6701 Fannin, Mark Wallace Tower, Suite 540, Houston, TX, 77030, USA; Baylor College of Medicine, Department of Otolaryngology Head and Neck Surgery, 1977 Butler St., 5th floor, Houston, TX, 77030, USA. Electronic address:

Introduction: Vocal fold movement impairment (VFMI) is a well-known sequela of cervical and thoracic procedures performed in the vicinity of the recurrent laryngeal nerve. Interpretation of flexible nasolaryngoscopy (FNL) can be difficult in young children due to crying, secretions, and obstructing supraglottic structures. We have previously published on the use of radiologist performed and interpreted, laryngeal ultrasound (LUS) to evaluate vocal fold mobility with substantial agreement with FNL in infants in the cardiovascular intensive care unit. Read More

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February 2020

Passive hallux adduction decreases lateral plantar artery blood flow: a preliminary study of the potential influence of narrow toe box shoes.

J Foot Ankle Res 2019 4;12:50. Epub 2019 Nov 4.

1Department of Exercise Sciences, Brigham Young University, 106 Smith Fieldhouse, Provo, UT 84602 USA.

Background: Blood flow is essential in maintaining tissue health. Thus, compromised blood flow can prevent tissue healing. An adducted hallux, as seen inside a narrow shoe, may put passive tension on the abductor hallucis, compressing the lateral plantar artery into the calcaneus and restricting blood flow. Read More

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Prospective comparison of 2D-shearwave elastography in both liver lobes in healthy subjects and in patients with chronic liver disease.

Scand J Gastroenterol 2019 Sep 21;54(9):1138-1145. Epub 2019 Aug 21.

Department of Gastroenterology and Gastrointestinal Oncology, University Medical Center Goettingen , Goettingen , Germany.

2D-shearwave elastography is an established method for liver stiffness measurement (LSM). However, the success rate of LSM using the recommended standard technique in the right lobe is limited by several factors. We aimed to compare LSM in the right and left liver lobe in order to evaluate whether LSM in the left lobe could be an alternative if measurements in the right lobe are not feasible. Read More

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September 2019

Shear wave elastography correlates with liver fibrosis scores in pediatric patients with liver disease.

Pediatr Radiol 2019 12 15;49(13):1742-1753. Epub 2019 Aug 15.

Department of Gastroenterology, SSM Health Cardinal Glennon Children's Hospital and St. Louis University School of Medicine, St. Louis, MO, USA.

Background: While liver biopsy remains the gold standard, given the procedure risks and sampling errors, there is a need for reliable noninvasive biomarkers of hepatic fibrosis.

Objective: Determine the accuracy of two-dimensional shear wave elastography (2-D SWE) in predicting the histological severity of liver fibrosis in pediatric patients with known or suspected liver disease.

Materials And Methods: Subjects 0-18 years old with known or suspected liver disease and liver biopsy within 30 days (n=70) were included. Read More

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December 2019

Comparison of ultrasound-guided transversus abdominis plane (TAP) block versus local infiltration during paediatric laparoscopic surgeries.

Indian J Anaesth 2019 May;63(5):356-360

Department of Anesthesiology, Seth Gordhandas Sunderdas Medical College, King Edward Memorial Hospital, Mumbai, Maharashtra, India.

Background And Aims: The purpose of this study was to compare the analgesic efficacy of ultrasonography-guided transversus abdominis plane (TAP) blocks with local port site infiltration in children undergoing laparoscopic surgeries.

Methods: After ethics committee approval and informed consent, 92 children aged 2-12 years posted for laparoscopic surgeries were randomly divided into Group T and Group L. Port site infiltration was performed in Group L by the surgeon at the time of port placement and end of surgery with 0. Read More

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The Diagnostic Value of 3D Power Doppler Ultrasound Combined With VOCAL in the Vascular Distribution of Breast Masses.

Acad Radiol 2020 02 30;27(2):198-203. Epub 2019 Apr 30.

Department of Ultrasound, the third affiliated hospital of Zhengzhou University, No. 7 Kangfu Qian Street, Erqi District, Zhengzhou, 450052, China. Electronic address:

Rationale And Objectives: This study uses a three-dimensional energy Doppler technique combined with the Virtual Organ Computer-aided Analysis (VOCAL) method in order to determine the diagnostic threshold of blood flow index in breast tumors to provide a reference for evaluation and treatment options.

Materials And Methods: We collected 322 solid lesions which had been operated. Each lesion met the definite pathological diagnosis; collected lesions included 262 cases of benign lesions and 60 cases of malignant lesions. Read More

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February 2020

Ultrasound grayscale image quality comparison between a 2D intracavitary transducer and a 3D intracavitary transducer used in 2D mode: A phantom study.

J Appl Clin Med Phys 2019 Jun 19;20(6):134-140. Epub 2019 Apr 19.

Department of Radiology, Mayo Clinic, Rochester, MN, USA.

Purpose: It is unclear if a 3D transducer with the special design of mechanical swing or 2D array could provide acceptable 2D grayscale image quality for the general diagnosis purpose. The aim of this study is to compare the 2D image quality of a 3D intracavitary transducer with a conventional 2D intracavitary transducer using clinically relevant phantom experiments.

Methods: All measurements were performed on a GE Logiq E9 scanner with both a 2D (IC5-9-D) and a 3D (RIC5-9-D) transducer used in 2D mode. Read More

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Normal Liver Stiffness Values in Children: A Comparison of Three Different Elastography Methods.

J Pediatr Gastroenterol Nutr 2019 05;68(5):706-712

National Centre for Ultrasound in Gastroenterology.

Objectives: Noninvasive tests for the evaluation of liver fibrosis are particularly helpful in children to avoid general anesthesia and potential complications of invasive tests. We aimed to establish reference values for 2 different elastography methods in a head-to-head comparison for children and adolescents 4 to 17 years, using transient elastography as common reference in a subset.

Methods: A total of 243 healthy participants aged 4 to 17 years were examined by a single observer with a full liver B-mode scan before elastography, following a minimum of 3 hours fasting. Read More

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Evaluation of liver stiffness by 2D-SWE in combination with non-invasive parameters as predictors for esophageal varices in patients with advanced chronic liver disease.

Scand J Gastroenterol 2019 Mar 17;54(3):342-349. Epub 2019 Mar 17.

a Department of Gastroenterology and Gastrointestinal Oncology , University Medical Centre Goettingen , Goettingen , Germany.

Esophageal varices (EV) are common complications in patients with advanced chronic liver disease (ACLD). Non-invasive parameters to exclude EV in patients with ACLD would be desirable. The aim of this study was the evaluation of liver stiffness measurement (LSM) using 2D-shear wave elastography (GE Logiq E9) and other non-invasive parameters as predictors for EV. Read More

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EchoScopy in scanning abdominal diseases; a prospective single center study.

Med Ultrason 2019 Feb;21(1):8-15

Medical Clinic 2, Caritas-Krankenhaus Bad Mergentheim, Academic Teaching Hospital of the University of Würzburg, Germany.

Background And Aims: The introduction of a new type of small handheld ultrasound device brings greater portability and affordability in a different setting. The basic ultrasound approach with these handheld devices has been defined by European Federation of Societies of Ultrasound in Medicine and Biology (EFSUMB) as "EchoScopy". The current study aimed to assess the image quality, indications and limitations of a portable pocket "EchoScopy" performed first compared with a high-end ultrasound system (second) in abdominal diseases. Read More

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February 2019

Three-Dimensional Subharmonic Aided Pressure Estimation for Assessing Arterial Plaques in a Rabbit Model.

J Ultrasound Med 2019 Jul 17;38(7):1865-1873. Epub 2018 Dec 17.

Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania.

Objectives: To investigate 3-dimensional subharmonic aided pressure estimation (SHAPE) for measuring intraplaque pressure and the pressure gradient across the plaque cap as novel biomarkers for potentially predicting plaque vulnerability.

Methods: Twenty-seven rabbits received a high-cholesterol diet for 2 weeks before a balloon catheter injury to denude the endothelium of the aorta, followed by 8 to 10 weeks of the high-cholesterol diet to create arteriosclerotic plaques. SHAPE imagings of the resulting plaques were performed 12, 16, and 20 weeks after injury using a LOGIQ 9 scanner with a 4D10L probe (GE Healthcare, Milwaukee, WI) before and during an infusion of Definity (Lantheus Medical Imaging, North Billerica, MA) and Sonazoid (GE Healthcare, Oslo, Norway). Read More

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Liver Stiffness Measured by 2-Dimensional Shear Wave Elastography: Prospective Evaluation of Healthy Volunteers and Patients With Liver Cirrhosis.

J Ultrasound Med 2019 Jul 11;38(7):1769-1777. Epub 2018 Dec 11.

Department Gastroenterology and Gastrointestinal Oncology, University Medical Center Goettingen, Goettingen, Germany.

Objectives: We aimed to establish normal values for liver stiffness measurement, performed by 2-dimensional shear wave elastography (LOGIQ E9; GE Healthcare, Wauwatosa, WI), in healthy volunteers, patients with nonhepatic morbidities, and patients with histologically confirmed liver cirrhosis.

Methods: A total of 175 participants were included between July 2016 and February 2018. Three cohorts were analyzed: healthy volunteers (n = 68), patients with healthy livers but nonhepatic morbidities (n = 57), and patients with liver cirrhosis (n = 50). Read More

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