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Should Transanal Total Mesorectal Excision Be Implemented in Medium-Sized Colorectal Unit? Technical and Oncological Outcome.

Ann Coloproctol 2021 Jul 28. Epub 2021 Jul 28.

Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.

Purpose: This study was performed to evaluate the outcome of implementation of transanal total mesorectal excision (TaTME) for low rectal cancer in a regional hospital and in comparison to laparoscopic (Lap) TME.

Methods: Consecutive patients with low rectal cancer of which the lowest border of the tumour was located beween 1 and 5 cm from the puborectalis who underwent TME at North District Hospital between January 2013 and December 2019 were included. Clinical, operative, and pathologic outcomes were compared between Lap TME and TaTME. Read More

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Benzo[a]pyrene diol epoxide-induced transformed cells identify the significance of hsa_circ_0051488, a ERCC1-derived circular RNA in pulmonary squamous cell carcinoma.

Mol Carcinog 2021 Jul 28. Epub 2021 Jul 28.

Department of Toxicology, School of Public Health, China Medical University, Shenyang, Liaoning, China.

ERCC1 is a gene for repairing DNA damage whose function is related to carcinogenic-induced tumorigenesis and the effectiveness of platinum therapies. Circular RNAs (circRNAs) are products of posttranscriptional regulation with pleiotropic effects on the pathogenesis of lung cancer. We aim to identify that specific circRNAs derived from ERCC1 can regulate key biological processes involved in the development of lung cancer. Read More

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Characteristics and progression-free survival of Afro-Caribbean men with metastatic hormone-sensitive prostate cancer at the time of diagnosis.

Prostate 2021 Jul 28. Epub 2021 Jul 28.

CHU de Pointe-à-Pitre, Univ Antilles, Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail), Pointe-à-Pitre, France.

Introduction And Objectives: Metastatic hormone-sensitive prostate cancer (mHSPC) accounts for 12% of prostate cancers diagnosed in Guadeloupe according to the Guadeloupean cancer registry. Most published studies have been conducted on the Caucasian population, whereas data concerning mHSPC in the Afro-Caribbean population are lacking. We aimed to describe the patient characteristics and estimate the progression-free survival of men with mHSPC in an Afro-Caribbean population according to the available treatment. Read More

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A Collaborative Partnership between the Multicenter Handoff Collaborative and an Electronic Health Record Vendor.

Appl Clin Inform 2021 May 28;12(3):647-654. Epub 2021 Jul 28.

Department of Anesthesiology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States.

Objectives:  The operating room is a specialized, complex environment with many factors that can impede effective communication during transitions of care between anesthesia clinicians. We postulated that an efficient, accessible, standardized tool for intraoperative handoffs built into standard workflow would improve communication and handoff safety. Most institutions now use an electronic health record (EHR) system for patient care and have independently designed intraoperative handoff tools, but these home-grown tools are not scalable to other organizations and lack vendor-supported features. Read More

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Radiation Exposure in the Neonatal Intensive Care Unit in Newborns and Staff.

Am J Perinatol 2021 Jul 28. Epub 2021 Jul 28.

Department of Radiology, Bursa Uludag University Faculty of Medicine, Bursa, Turkey.

Objective:  Portable X-rays remain one of the most frequently used diagnostic procedures in neonatal intensive care units (NICU). Premature infants are more sensitive to radiation-induced harmful effects. Dangers from diagnostic radiation can occur with stochastic effects. Read More

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Implementation of European Society of Gastrointestinal Endoscopy (ESGE) recommendations for small-bowel capsule endoscopy into clinical practice: Results of an official ESGE survey.

Endoscopy 2021 Jul 28. Epub 2021 Jul 28.

Pomeranian Medical University, Department of Social Medicine and Public Health, Faculty of Health Science, Szczecin, Poland.

Background:  We aimed to document international practices in small-bowel capsule endoscopy (SBCE), measuring adherence to European Society of Gastrointestinal Endoscopy (ESGE) technical and clinical recommendations.

Methods:  Participants reached through the ESGE contact list completed a 52-item web-based survey.

Results:  217 responded from 47 countries (176 and 41, respectively, from countries with or without a national society affiliated to ESGE). Read More

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Efficacy and Safety of Awake CT-guided Percutaneous Balloon Compression of Trigeminal Ganglion for Trigeminal Neuralgia.

Pain Med 2021 Jul 28. Epub 2021 Jul 28.

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, CA, 94305, USA.

Objectives: To describe the method and clinical efficacy of awake CT-guided percutaneous balloon compression (PBC) as a treatment for trigeminal neuralgia (TN).

Design: In this case-series, TN patients were treated with awake CT-guided PBC and followed for treatment efficacy and complications for 12 months.

Setting: A single-center study. Read More

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Rheumatoid factor positivity in antineutrophil cytoplasmic antibody-associated vasculitis: a distinct clinical entity or innocent bystander?

Rheumatology (Oxford) 2021 Jul 28. Epub 2021 Jul 28.

Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

Objective: To investigate the significance of rheumatoid factor (RF) positivity in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients.

Methods: AAV patients were divided into groups as follows: RF (+)/ANCA (+) (n = 94), RF (-)/ANCA (+) (n = 80), RF (+)/ANCA (-) (n = 15), and RF (-)/ANCA (-) (n = 25). Their clinical data, organ involvement patterns, laboratory data, and patient outcomes were assessed. Read More

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Association between diastolic stress test and H2FPEF score.

Arch Cardiol Mex 2021 Jul 28. Epub 2021 Jul 28.

Fellow of the American College of Cardiology (FACC) and the European Society of Cardiology (FESC); FEHFA, Department of Internal Medicine, Universidad de Antioquia, Medellín, Colombia.

Objective: Heart failure with preserved ejection fraction is a highly prevalent disease; some advances for improving the diagnosis are the development of the H2FPEF score and the diastolic stress test for the evaluation of diastolic function. The objective is to describe the clinical and echocardiographic characteristics of patients referred for stress tests, and the association between the H2FPEF score and the results of the diastolic test.

Methods: This is an analytical, observational, retrospective study. Read More

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An evaluation of diagnostic tests in a case series of suspected leptospirosis patients seen in primary care.

N Z Med J 2021 Jul 30;134(1539):33-43. Epub 2021 Jul 30.

Professor of Veterinary Public Health, Molecular Epidemiology and Public Health Laboratory, School of Veterinary Science, Massey University, Palmerston North.

Aims: This study describes 47 presentations of suspected leptospirosis in general practice in New Zealand. Our primary aim was to assess the laboratory diagnosis of leptospirosis in these patients, by comparing polymerase chain reaction (PCR) tests, microscopic agglutination test (MAT) and culture results.

Methods: Patients suspected of leptospirosis were recruited from general practices in the Waikato (n=17) and Wairoa (n=30) between August 2011 and June 2015. Read More

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Association between nuclear factor of activated T cells C2 polymorphisms and treatment response in rheumatoid arthritis patients receiving tumor necrosis factor-alpha inhibitors.

Pharmacogenet Genomics 2021 Jul 26. Epub 2021 Jul 26.

College of Pharmacy, Chungbuk National University, Yeonje-ri, Osong-eup, Heungdeok-gu, Cheongju-si College of Pharmacy, Ajou University, Worldcup-ro, Yeongtong-gu, Suwon Division of Rheumatology, Department of Internal Medicine, Chungbuk National University Hospital, 1sunhwan-ro, Seowon-gu, Cheongju Department of Rheumatology, Ajou University School of Medicine, Worldcup-ro, Yeongtong-gu, Suwon, Republic of Korea.

Objectives: Nuclear factor of activated T cells C2 (NFATC2) is known as a member of the transcription family and enhances tumor necrosis factor-alpha (TNF-α) synthesis in human T cells at the gene transcription level. Although NFATC2 has a potential role in rheumatoid arthritis (RA) progression and treatment, no study has investigated the association between NFATC2 gene polymorphisms and response status in RA patients receiving TNF-α inhibitors. This study aimed to examine the effects of polymorphisms in NFATC2, a TNF-α transcription factor, on response to TNF-α inhibitors. Read More

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Feasibility and Outcomes of Corneal Transplantation Performed at Rural Centers: An Extension of the Pyramidal Model of Enhanced Eye Care at Rural Outreach.

Cornea 2021 Jul 28. Epub 2021 Jul 28.

Allen Foster Community Eye Health Research Centre, Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye Care, LV Prasad Eye Institute, Hyderabad, India; Indian Health Outcomes, Public Health and Economics (IHOPE) Research Centre, LVPEI, Hyderabad, Telangana, India; Cornea Service, The Cornea Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India; Brien Holden Eye Research Centre, LV Prasad Eye Institute, Hyderabad, India; and School of Optometry and Vision Science, University of New South Wales, Sydney, Australia.

Purpose: The aim of this study was to report on the feasibility of setting up a system of corneal transplants at rural outreach centers and report the outcomes of the first 111 cases.

Methods: Retrospective analysis of the outcomes of corneal transplantation performed on patients with optical indications between March 2016 and September 2019 at 4 secondary (rural) centers. The centers are a part of a network in the pyramidal model developed by L V Prasad Eye Institute. Read More

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Blast Wound Dehiscence During Descemet Membrane Endothelial Keratoplasty Rebubbling in a Previous Penetrating Keratoplasty: A Case Report.

Cornea 2021 Jul 28. Epub 2021 Jul 28.

The Royal Liverpool University Hospital, Liverpool, United Kingdom; Department of Clinical Science and Translational Medicine, University of Rome Tor Vergata, Rome, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy; Department of Neurological and Vision Sciences, Eye Clinic, University of Brescia, Brescia, Italy; Department of Eye and Vision Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom; and Instituto Universitario Fernandez-Vega, Universidad de Oviedo and Fundacion de Investigacion Oftalmologica, Oviedo, Spain.

Purpose: The purpose of this study was to describe a rare complication of Descemet membrane endothelial keratoplasty (DMEK) rebubbling.

Methods: An 86-year-old woman with bilateral penetrating keratoplasty (PK) performed 20 years previously for Fuchs endothelial dystrophy underwent DMEK surgery for endothelial corneal decompensation in the left eye. Surgery was complicated in the postoperative period by repeated DMEK graft detachments requiring rebubbling. Read More

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Descemet Stripping Automated Endothelial Keratoplasty in Pediatric Age Group: A Decade of Our Experience.

Cornea 2021 Jul 28. Epub 2021 Jul 28.

Centre for Rare Eye Diseases and Ocular Genetics, L V Prasad Eye Institute, Hyderabad, India; The Cornea Institute, L V Prasad Eye Institute, Hyderabad, India; Jasti V Ramanamma Children's Eye Care Center, L V Prasad Eye Institute, Hyderabad, India; Ophthalmic Biophysics, L V Prasad Eye Institute, Hyderabad, India; Ramayamma International Eye Bank, L V Prasad Eye Institute, Hyderabad, India; and Department of Ophthalmology and Visual Sciences and Pathology, University of Illinois College of Medicine, Chicago, IL.

Purpose: This study was to report the outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK) in managing corneal endothelial disorders in children less than 14 years of age.

Methods: Medical records of 180 DSAEK performed, between 2008 and 2020, on 167 eyes of 111 children who had a visually significant endothelial dysfunction were retrospectively reviewed for the primary etiology of corneal decompensation, time of the onset and duration of cloudiness, preoperative visual acuity, the technique of endothelial keratoplasty, surgical modifications, and reintervention.

Results: Median age at surgical intervention was 7. Read More

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Intraoperative Measures to Reduce the Risk of COVID-19 Transmission During Minimally Invasive Procedures: A Systematic Review and Critical Appraisal of Societies' Recommendations.

Surg Laparosc Endosc Percutan Tech 2021 Jul 28. Epub 2021 Jul 28.

Medical Affairs, Ethicon Inc., Cincinnati, OH.

Background: The coronavirus 2019 pandemic and the hypothetical risk of virus transmission through aerosolized CO2 or surgical smoke produced during minimally invasive surgery (MIS) procedures have prompted societies to issue recommendations on measures to reduce this risk. The aim of this systematic review is to identify, summarize and critically appraise recommendations from surgical societies on intraoperative measures to reduce the risk of severe acute respiratory syndrome coronavirus 2 transmission to the operative room (OR) staff during MIS.

Methods: Medline, Embase, and Google Scholar databases were searched using a search strategy or free terms. Read More

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Photographic Nasal Soft Tissue Analysis From Preadolescence to Young Adulthood: Anthropometric Measurements.

J Craniofac Surg 2021 Jul 27. Epub 2021 Jul 27.

Department of Anatomy, Faculty of Medicine, Hitit University, Çorum Department of Anatomy, Faculty of Medicine, Tokat Gaziosmanpaşa University, Tokat, Turkey.

Abstract: The nose has a tremendous effect on facial esthetics and overall facial harmony, accordingly it contributes to the physical appearance of individuals. The aim of this study is to establish sex-related nasal soft tissue norms for preadolescents, adolescents, and young adults in Anatolian population. A total of 300 volunteers (150 males and 150 females) with ages varying from 10 to 24 years were divided into 6 subgroups according to gender and educational status. Read More

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Fully Guided Zygomatic Implant Surgery.

J Craniofac Surg 2021 Jul 27. Epub 2021 Jul 27.

Tuscan Dental Institute, Private Practice, Vicenza Tuscan Dental Institute, Padova Tuscan Dental Institute, Lido di Camaiore Private Practice, Tuscan Dental Institute, Naples, Italy.

Introduction: Rehabilitating a severely atrophic maxilla is a complex procedure. In case of severe resorption, zygomatic implants are indicated and loading of the implants at the end of the surgery is desirable. We present a new method by means of guided surgery for the placement of zygomatic implants, using specially designed metal templates that should be supported by bone. Read More

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Immediate Resection and Reconstruction of Encephalocele in the Craniofacial Region.

J Craniofac Surg 2021 Jul 27. Epub 2021 Jul 27.

Department of Neurosurgery, Third People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.

Introduction: Congenital meningoencephalocele is a herniation of brain and meninges through a skull base defect. It may result not only in neural defects, sensorimotor deficits, neurological morbidities, visual impairment, impaired nasal function, and a potential risk of intracranial infection. Goals of surgery include removal or repositioning of nonfunctional cerebral tissue, closure of the dura, and reconstruction of skeletal and cutaneous structures. Read More

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Association between serum uric acid level and mortality in China.

Chin Med J (Engl) 2021 Jul 27. Epub 2021 Jul 27.

Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Beijing 100034, China Key Laboratory of Renal Disease, National Health Commission of the People's Republic of China, Beijing 100034, China Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Peking University, Ministry of Education, Beijing 100034, China Research Units of Diagnosis and Treatment of Immune-mediated Kidney Diseases, Chinese Academy of Medical Sciences; Beijing 100034, China.

Background: Whether there is an association between serum uric acid (SUA) level and risk of mortality in the general population remains unclear. Based on the China National Survey of Chronic Kidney Disease linked to mortality data, a population-based cohort study was performed to investigate the association between SUA level and all-cause mortality, cardiovascular disease (CVD) mortality, and cancer mortality in China.

Methods: The survival status of participants in the cross-sectional survey was identified from January 1, 2006 to December 31, 2017. Read More

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Comparative effectiveness and safety of 32 pharmacological interventions recommended by guidelines for coronavirus disease 2019: a systematic review and network meta-analysis combining 66 trials.

Chin Med J (Engl) 2021 Jul 27. Epub 2021 Jul 27.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing 100191, China Department of Clinical Epidemiology and EBM, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China Primary Care Unit, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB18RN, UK Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton L8S4K1, Canada Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China.

Background: The global pandemic coronavirus disease 2019 (COVID-19) has become a major public health problem and presents an unprecedented challenge. However, no specific drugs were currently proven. This study aimed to evaluate the comparative efficacy and safety of pharmacological interventions in patients with COVID-19. Read More

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The Role of Immunohistochemistry for Primary Oral Diagnosis in a Brazilian Oral Pathology Service.

Appl Immunohistochem Mol Morphol 2021 Jul 28. Epub 2021 Jul 28.

Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.

A proper antibody panel selection is one of the most important factors to reach an adequate diagnosis in challenging cases. This retrospective study was designed to determine the contribution of immunohistochemistry (IHC) in the primary diagnosis of oral diseases in one of the main services of oral pathology in the State of São Paulo, Brazil, and to identify the most common antibodies used, and recommend diagnostic algorithms based on our experience with challenging lesions. A total of 1698 IHC stains were performed in 401 cases from a total of 28,804 cases received from public dental clinics and private dental practitioners within a period of 13 years, representing a frequency of 1. Read More

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Recurrence Rate and Risk Factors of Recurrence in Benign Paroxysmal Positional Vertigo: a Single-Center Long-Term Prospective Study With a Large Cohort.

Ear Hear 2021 Jul 27. Epub 2021 Jul 27.

Department of Otorhinolaryngology-Head and Neck Surgery, Yonsei University Wonju College of Medicine, Wonju, Korea Department of Otorhinolaryngology, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea These authors contributed equally to this work.

Objective: This study aimed to assess the long-term recurrence rate and correlations between recurrence and potential risk factors in patients with benign paroxysmal positional vertigo (BPPV).

Design: A total of 548 consecutive patients who demonstrated typical posterior or horizontal BPPV between January 2010 and December 2012 were included in this prospective study. All patients were contacted by phone every 6 months for 5 years and were asked to revisit the clinic when they experienced positional vertigo to be reexamined for recurrence. Read More

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Increased risk for central serous chorioretinopathy in nephrotic syndrome patients: A population-based cohort study.

J Chin Med Assoc 2021 Jul 26. Epub 2021 Jul 26.

Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC Department of Nephrology, Department of Internal Medicine, Fu Jen Catholic University Hospital, Taipei, Taiwan, ROC Department of Ophthalmology, Songshan Branch of Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC School of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC Taiwanese Injury Prevention and Safety Promotion Association, Taipei, Taiwan, ROC Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC.

Background: Nephrotic syndrome (NS) is characterized by various etiologies that damage the glomerulus. Central serous chorioretinopathy (CSCR) is a retinal disease characterized by neurosensory detachment of the retina. Several case reports have described the relationship between both. Read More

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Association between Comorbidities and Preserved Ratio Impaired Spirometry: Using the Korean National Health and Nutrition Examination Survey IV-VI.

Respiration 2021 Jul 28:1-9. Epub 2021 Jul 28.

Department of Public Health Science, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.

Background: Preserved ratio impaired spirometry (PRISm) patients have more frequent respiratory symptoms and an increased risk of mortality. However, studies on comorbidities in these patients are lacking.

Objectives: We investigated the association between PRISm and comorbidities using the Korea National Health and Nutrition Examination Survey (KNHANES). Read More

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Role of Up-Front Primary Tumor Resection and Tumor Sidedness in the Survival of Synchronous Metastatic Colon Cancer Patients.

Dig Surg 2021 Jul 28:1-7. Epub 2021 Jul 28.

Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Introduction: Uncertainty exists about a possible survival benefit of primary tumor resection (PTR) in synchronous metastatic colon cancer (mCC). Since sidedness of the primary tumor is regarded as an important prognostic factor, our objective was to study the interaction between PTR and sidedness in synchronous mCC.

Methods: In this retrospective study, we used data from 2 first-line phase 3 randomized controlled trials (RCTs). Read More

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Markers of the Endothelial Glycocalyx Are Improved following Kidney Transplantation.

Kidney Blood Press Res 2021 Jul 28:1-7. Epub 2021 Jul 28.

Department of Renal Medicine, Eastern Health, Box Hill, Victoria, Australia.

Introduction: The endothelial glycocalyx on the vascular luminal surface contributes to endothelial health and function. Damage to this layer is indicative of vascular injury, reflected by increased levels of its shed constituents in serum and an increase in the perfused boundary region (PBR) when measured in sublingual capillaries using the GlycoCheck™ device. We aimed to examine the longitudinal effects of kidney transplantation on the glycocalyx by measuring biochemical markers of the glycocalyx and endothelial dysfunction and the PBR. Read More

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CYP24A1 and SLC34A1 Pathogenic Variants Are Uncommon in a Canadian Cohort of Children with Hypercalcemia or Hypercalciuria.

Horm Res Paediatr 2021 Jul 28:1-9. Epub 2021 Jul 28.

Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.

Objectives: Biallelic pathogenic variants in CYPA24A1 and SLC34A1 are causes of idiopathic infantile hypercalcemia. Pathogenic variants in both may also give rise to hypercalciuria with nephrocalcinosis or nephrolithiasis without previous hypercalcemia (renal group). Our objective was to examine the frequency of CYP24A1 or SLC34A1 variants in children with early hypercalcemia or late-onset hypercalciuria. Read More

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Long-Term Amnioinfusion through an Intrauterine Catheter in Preterm Premature Rupture of Membranes before 26 Weeks of Gestation: A Retrospective Multicenter Study.

Fetal Diagn Ther 2021 Jul 28:1-6. Epub 2021 Jul 28.

Department of Gynecology, Fertility, and Fetal Therapy, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.

Introduction: The objective of this study was to elucidate the efficacy of long-term amnioinfusion on perinatal outcomes in patients with preterm premature rupture of membranes (PPROM) before 26 weeks' gestation.

Material: A total of 31 patients with PPROM at a periviable gestational age (21 + 0-25 + 0 weeks) were enrolled. Long-term amnioinfusion was performed in 22 patients, and 9 patients did not receive amnioinfusion. Read More

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COVID-19 and Sudden Unexpected Community Deaths in Lusaka, Zambia, Africa - A Medico-Legal Whole-Body Autopsy Case Series.

Int J Infect Dis 2021 Jul 5;109:160-167. Epub 2021 Jul 5.

Ministry of Home Affairs, Office of the State Forensic Pathologist, Nationalist Road, Lusaka, Zambia; University Teaching Hospitals, Department of Pathology and Microbiology, Nationalist Road, Lusaka, Zambia.

Background: Data from Africa regarding sudden and unexpected COVID-19 community deaths and underlying pathological, demographic, and co-morbidity features require definition.

Methods: We performed a case series of COVID-19-related deaths seen at Forensic Post-Mortem examination of sudden and unexpected Community Deaths in Lusaka, Zambia, Africa. Whole-body Post-Mortem examinations were performed according to Standard Operating Procedures. Read More

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Evidence of slow and variable choice-stepping reaction time in cancer survivors with chemotherapy-induced peripheral neuropathy.

Gait Posture 2021 Jul 21;89:178-185. Epub 2021 Jul 21.

Prince of Wales Clinical School, University of New South Wales, Kensington, Australia; Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is reported to affect up to 70 % of cancer survivors. Despite evidence that CIPN-related impairments often translate into balance and mobility deficits, the effects on stepping and quality of gait, well-documented risk factors for falls, are unclear.

Aims: (i) Establish choice-stepping reaction time (CSRT) performance in survivors with CIPN compared to young and older healthy controls and people with Parkinson's disease; (ii) document walking stability; (iii) investigate relationships between stepping and gait data to objective and patient-reported outcomes. Read More

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