6,341 results match your criteria performed cytological


'Rollover' abdominal paracentesis versus standard technique: protocol of a crossover randomized comparative trial.

Future Oncol 2021 Jun 22. Epub 2021 Jun 22.

Department of Internal Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, 160012, India.

The sensitivity of single abdominal paracentesis for diagnosis of peritoneal carcinomatosis in patients with malignant ascites is 40-70%. Tumor cells shed from the peritoneum settle preferentially in certain recesses of the peritoneum. We aim to compare the standard technique of abdominal paracentesis versus a rollover technique in a randomized crossover study to assess the cytological yield in patients suspected to have peritoneal carcinomatosis. Read More

View Article and Full-Text PDF

Natural Orifice Endoscopic Thyroidectomy via Transoral Vestibular Approach (TOVA): Single Surgeon Experience from North India.

Indian J Otolaryngol Head Neck Surg 2021 Jun 7;73(2):160-166. Epub 2020 Jul 7.

Department of Endocrine Surgery, SGPGIMS, 226014 Lucknow, India.

The transoral vestibular approach (TOVA) is the shortest route for endoscopic thyroidectomy (ET) to approach the thyroid and is a totally scar free procedure, hence it has a clear cosmetic advantage not only over conventional open thyroid surgery but also over other remote access approaches for ET like axilla, breast and chest wall approaches. The aim of this study was to evaluate the feasibility, safety and our initial outcomes of TOVA and highlight the advantages of 3D endoscopic equipment in remote access thyroid surgery. We reviewed our prospectively maintained database who underwent ET. Read More

View Article and Full-Text PDF

Changes in Thyroid fine needle aspiration practice during the Covid-19 pandemic.

Cytopathology 2021 Jun 16. Epub 2021 Jun 16.

University of Milan, Department of Oncology and Hematology-Oncology, Milan, Italy.

Purpose: to investigate the diagnostic accuracy of a different sample preparation protocol for fine needle aspiration cytology (FNAC) of thyroid nodules established during the COVID-19.

Methods: from April 2020, conventional smears during FNAC were ceased according to the World Health Organization recommendations due to the increased infection risk for operators, and a new liquid based cytology only protocol (LBC) was adopted. FNACs performed between April 2020 and July 2020 (COVID-19 group) were retrospectively compared with FNACs performed between December 2019 and March 2020 (pre-COVID-19 group). Read More

View Article and Full-Text PDF

Predictive factors of malignancy in pediatric patients with thyroid nodules and performance of the Italian classification (SIAPEC 2014) in the outcome of the cytological FNA categories.

Endocrine 2021 Jun 14. Epub 2021 Jun 14.

Department of Pediatric Endocrinology, Regina Margherita Children's Hospital, Turin, Italy.

Purpose: The rate of malignancy (ROM) among pediatric studies using the Bethesda System is 39.5% and 41.5% for atypia of undetermined significance/follicular lesion of undetermined significance and for suspected follicular neoplasm, respectively. Read More

View Article and Full-Text PDF

Factors Responsible for Non-Diagnostic Cytology on Ultrasound-Guided Fine-Needle Aspiration of Thyroid Nodules.

Cureus 2021 May 11;13(5):e14955. Epub 2021 May 11.

Radiology, Dr. Ziauddin Hospital, Karachi, PAK.

Introduction Fine-needle aspiration (FNA) is a well-recognized procedure for the diagnosis of thyroid nodules, with the advantage of being safe and inexpensive. Fine-needle aspiration cytology (FNAC) is mainly performed for nodules showing suspicious sonographic features that may require thyroidectomy. Even when FNAC is performed under sonographic guidance, the cytological specimen obtained may be inadequate, leading to a non-diagnostic outcome. Read More

View Article and Full-Text PDF

Ultrastructural Analysis of Volumetric Histotripsy Bio-effects in Large Human Hematomas.

Ultrasound Med Biol 2021 Jun 8. Epub 2021 Jun 8.

Laboratory for Industrial and Medical Ultrasound, Physics Faculty, M. V. Lomonosov Moscow State University, Moscow, Russian Federation; Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, Washington, USA.

Large-volume soft tissue hematomas are a serious clinical problem, which, if untreated, can have severe consequences. Current treatments are associated with significant pain and discomfort. It has been reported that in an in vitro bovine hematoma model, pulsed high-intensity focused ultrasound (HIFU) ablation, termed histotripsy, can be used to rapidly and non-invasively liquefy the hematoma through localized bubble activity, enabling fine-needle aspiration. Read More

View Article and Full-Text PDF

Line-field confocal optical coherence tomography for actinic keratosis and squamous cell carcinoma: a descriptive study.

Clin Exp Dermatol 2021 Jun 11. Epub 2021 Jun 11.

Department of Dermatology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

Background: Early and accurate diagnosis of cutaneous squamous cell carcinoma (SCC) and actinic keratosis (AK) is fundamental to reduce their morbidity and to select the correct treatment. Line-field confocal optical coherence tomography (LC-OCT) is a new imaging device that can characterize healthy skin and basal cell carcinoma, but no large studies are available on keratinocyte cell tumours.

Objectives: To identify and describe LC-OCT criteria associated with SCC and AK and to compare LC-OCT findings in these tumours. Read More

View Article and Full-Text PDF

Bronchoalveolar Lavage Fluid Cytology in Healthy Cynomolgus Macaques.

Front Vet Sci 2021 25;8:679248. Epub 2021 May 25.

Laboratoire de Biologie Clinique, VetAgro-Sup, Campus vétérinaire Marcy l'Etoile, Marcy L'Etoile, France.

Bronchoalveolar lavage, or BAL, is a minimally invasive procedure frequently used for clinical and non-clinical research, allowing studies of the respiratory system. Macaques are the most widely used non-human primate models in biomedical research. However, very little information is available in the literature concerning BAL cytology in macaques. Read More

View Article and Full-Text PDF

The difficulty to diagnose cervical cancer developing in the perinatal period with the first-trimester cytology: A retrospective study.

J Obstet Gynaecol Res 2021 Jun 9. Epub 2021 Jun 9.

Department of Obstetrics and Gynecology, Hokkaido University Hospital, Sapporo, Japan.

Aim: Cytological cervical cancer screening for pregnant women is routinely performed and still plays an essential role in Japan because of the considerably low rate of human pappillomavirus (HPV) vaccination. Though almost all pregnant women undergo cytological screening at their first trimester, we experienced invasive cervical cancers (ICC) diagnosed during pregnancy or postpartum period. We investigated the characteristics of perinatally diagnosed ICCs to clarify the difficulty in diagnosis during the pregnancy. Read More

View Article and Full-Text PDF

[Chemotherapy for breast cancer during pregnancy: about a case].

Pan Afr Med J 2021 11;38:255. Epub 2021 Mar 11.

Faculté de Médecine d'Antananarivo, Antananarivo, Madagascar.

The management of breast cancer during pregnancy is a challenge for physicians due to mother´s desire to carry the pregnancy to term despite the need for chemotherapy. This study reports the case of a 37-year-old multiparous woman at 20 weeks and 4 days of amenorrhea (WA). She was hospitalized for dyspnoea (stage IV according to New York Heart Association (NYHA) classification). Read More

View Article and Full-Text PDF

Thyroid nodules with indeterminate cytology: association between nodule size, histopathological characteristics and clinical outcome in differentiated thyroid carcinomas - a multicenter retrospective cohort study on 761 patients.

Updates Surg 2021 Jun 7. Epub 2021 Jun 7.

General Surgery Unit, Parma University Hospital, Parma, Italy.

A great number of surgical diagnostic procedures are performed every year for thyroid nodules that are included in undetermined cytological classes that reveal to be malignant thyroid carcinomas in one-third of cases. In the most recent guidelines, lobectomy is the most recommended surgical approach for this classes of nodules, but total thyroidectomy is the recommended treatment for undetermined nodules larger than 4 cm. The main study aim is to support or question the dimensional criteria as an independent clinical decision element for undetermined thyroid nodules management. Read More

View Article and Full-Text PDF

Applying Probe Electrospray Ionization Mass Spectrometry to Cytological Diagnosis: A Preliminary Study by Using Cultured Lung Cancer Cells.

Acta Cytol 2021 Jun 7:1-10. Epub 2021 Jun 7.

Department of Pathology and Laboratory Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan,

Objectives: Cytology and histology are 2 indispensable diagnostic tools for cancer diagnosis, which are rapidly increasing in importance with aging populations. We applied mass spectrometry (MS) as a rapid approach for swiftly acquiring nonmorphological information of interested cells. Conventional MS, which primarily rely on promoting ionization by pre-applying a matrix to cells, has the drawback of time-consuming both on data acquisition and analysis. Read More

View Article and Full-Text PDF

Cytological and molecular diagnosis of Hürthle cell thyroid tumors: Analysis of three cases.

Mol Clin Oncol 2021 Jul 28;15(1):149. Epub 2021 May 28.

Department of Surgery, Novosibirsk State Medical University, Novosibirsk 630091, Russia.

The cytological diagnosis of Hürthle cell (oncocytic) thyroid tumors by means of fine-needle aspiration biopsy represents a challenge, as Hürthle cell polymorphism and atypia alone are not indications of malignancy. In our recent work, an original diagnostic algorithm was proposed, which identified and typed malignant thyroid tumors by analyzing the molecular markers of cytological preparations. The aim of the present study was to assess the effectiveness of this algorithm at detecting Hürthle cell thyroid tumors in clinical samples used for cytological examination. Read More

View Article and Full-Text PDF

The impact of the CervicalCheck controversy on provision of colposcopy services in Ireland: A cohort study.

Eur J Obstet Gynecol Reprod Biol 2021 May 24;262:228-231. Epub 2021 May 24.

Department of Colposcopy, The National Maternity Hospital, Dublin, Ireland.

Objectives: In 2018, an inquiry into the Irish Cervical Cancer screening programme (CervicalCheck) was initiated, following publicised cases of non-disclosure regarding internal audit results of cytology screening in women diagnosed with cervical cancer. The inquiry attracted widespread media coverage and the government offered women free, out of programme screening. We investigated whether the controversy led to an increase in referrals based on clinical suspicion and the impact on waiting times for abnormal cytology. Read More

View Article and Full-Text PDF

[Application of cell transfer technique in the diagnosis of fine needle aspiration cytology].

Zhonghua Bing Li Xue Za Zhi 2021 Jun;50(6):615-619

Department of Pathology,Beijing Hospital,National Center of Gerontology;Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.

To study the application of cell transfer technology to solve the problem of the limited number of fine needle aspiration cytology (FNAC) smears for various immunocytochemistry (ICC) staining and other auxiliary tests, and to enhance accurate cytological diagnosis. Thirty-four cases of FNAC smears from January 2020 to April 2020 in the Department of Pathology of Beijing Hospital were collected for investigation of the cell transfer technique. The materials in the most cell smear were divided and transferred to several glass slides. Read More

View Article and Full-Text PDF

Cell Block Optimization: A Comparative Study of Quality Variables in 4 Different Cell Block Methods.

Acta Cytol 2021 Jun 2:1-7. Epub 2021 Jun 2.

Translational Obstetrics Group, Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia.

Objective: The cell block (CB) is an important adjunct to cytological preparations in diagnostic cytopathology. Optimizing cellular material in the CB is essential to the success of ancillary studies such as immunohistochemistry (IHC) and molecular studies (MS). Our aim was to identify which CB method was most suitable in a variety of specimen types and levels of cellularity. Read More

View Article and Full-Text PDF

A Preliminary Study of Deep-Learning Algorithm for Analyzing Multiplex Immunofluorescence Biomarkers in Body Fluid Cytology Specimens.

Acta Cytol 2021 Jun 2:1-6. Epub 2021 Jun 2.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles (UCLA), Los Angeles, California, USA.

Introduction: Multiplex biomarker analysis of cytological body fluid specimens is often used to assist cytologists in distiguishing metastatic cancer cells from reactive mesothelial cells. However, evaluating biomarker expression visually may be challenging, especially when the cells of interest are scant. Deep-learning algorithms (DLAs) may be able to assist cytologists in analyzing multiple biomarker expression at the single cell level in the multiplex fluorescence imaging (MFI) setting. Read More

View Article and Full-Text PDF

Nationwide Rereview of Normal Cervical Cytologies before High-Grade Cervical Lesions or before Invasive Cervical Cancer.

Acta Cytol 2021 Jun 2:1-8. Epub 2021 Jun 2.

Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.

Sweden has experienced an unexpected >30% increase in cervical cancer incidence among women with normal cytological screening results. We therefore performed a nationwide assessment of false-negative cytology before invasive cervical cancer. The Swedish national cervical screening registry identified 2,150 normal cytologies taken up to 10 years before 903 cases of invasive cervical cancer. Read More

View Article and Full-Text PDF

Automated Analysis of Cerebrospinal Fluid Cells Using Commercially Available Blood Cell Analysis Devices-A Critical Appraisal.

Cells 2021 May 18;10(5). Epub 2021 May 18.

Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, 30559 Hannover, Germany.

The analysis of cells in the cerebrospinal fluid (CSF) is a routine procedure that is usually performed manually using the Fuchs-Rosenthal chamber and cell microscopy for cell counting and differentiation. In order to reduce the requirement for manual assessment, automated analyses by devices mainly used for blood cell analysis have been also used for CSF samples. Here, we summarize the current state of investigations using these automated devices and critically review their limitations. Read More

View Article and Full-Text PDF

Diffusion-weighted imaging diagnostic algorithm in patients with suspected pleural malignancy.

Eur Radiol 2021 May 28. Epub 2021 May 28.

Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical University, No. 127 Changle West Road, Xi'an, 710032, China.

Objectives: The purpose of this study was to analyze the diagnostic performance and clinical application of diffusion-weighted imaging (DWI) in patients with suspected pleural malignancy (PM).

Methods: A retrospective review of patients with suspected PM was performed from March 2014 to August 2018 (NCT02320617). All patients underwent chest DWI and computed tomography (CT) with cytological or histopathological findings as reference standards. Read More

View Article and Full-Text PDF

Thyroid metastasis from adenoid cystic carcinoma of the lung: a case report and literature review.

J Surg Case Rep 2021 May 20;2021(5):rjab178. Epub 2021 May 20.

Department of General Surgery, Luigi Sacco University Hospital, 20157 Milan, Italy.

Both adenoid cystic carcinoma (ACC) and thyroid metastasis are quite peculiar clinical presentations. ACC is a malignant salivary gland-type tumour mostly found in the head and neck district, but that can arise from different organs. Due to its rarity, it can pose problems in the diagnostic and therapeutic management. Read More

View Article and Full-Text PDF

Pathological and Cytological Studies on Hepatocellular Carcinoma in Cattle Slaughtered at Bishoftu Elfora Abattoir, Central Ethiopia.

Authors:
Mesfin Mathewos

Vet Med Int 2021 5;2021:6649172. Epub 2021 May 5.

School of Veterinary Medicine, Wolaita Sodo University, P. O. Box 138, Wolaita Sodo, Ethiopia.

Hepatocellular carcinoma (HCC) is one of the most common neoplasms that has been described in many domestic animal species. Hence, the disease has significant economic importance; thus, this study aimed to describe the cytopathological characteristics of hepatocellular carcinomas in cattle slaughtered at Bishoftu Elfora Abattoir, Central Ethiopia. A cross-sectional study design with a purposive sampling technique was performed from October 2017 to May 2018 using macroscopic, histopathologic, and cytological methods. Read More

View Article and Full-Text PDF

Impact of preterm birth on the cellular characteristics of neonatal buccal cells.

Cytopathology 2021 May 25. Epub 2021 May 25.

Division of Perinatology, Department of Gynecology and Obstetrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Objective: To demonstrate the impact of preterm birth on the cytological, cytomorphometrical, and nuclear parameters of neonatal buccal smears.

Methods: This study consisted of Early Preterm Neonates (EPN; ≤34th gestational week [gw]; n = 36), Late Preterm Neonates (LPN; 34th to <37th gw; n = 46), and Term Neonates (control; ≥37th gw; n = 56). Cytological evaluation and buccal cytome assay were performed using Papanicolaou and Feulgen methods, respectively. Read More

View Article and Full-Text PDF

Diagnostic utility of BAP1 for malignant pleural mesothelioma in pleural fluid specimens with atypical morphology.

Cytopathology 2021 May 25. Epub 2021 May 25.

Department of Anatomical Pathology, PathWest Laboratory Medicine, QEII Medical Centre, Nedlands, WA, Australia.

Objective: To assess the utility of BRCA1-associated protein 1 (BAP1) immunohistochemistry (IHC) for the diagnosis of malignant pleural mesothelioma (MPM) in fluid samples with atypical cytology.

Methods: Pleural fluid samples with an atypical mesothelial proliferation (diagnostic categories: 'atypical' and 'suspicious') received between January 2015 and March 2018 at a tertiary referral centre were identified. Results of routine IHC testing were recorded for each case. Read More

View Article and Full-Text PDF

Preventive use of a topical anti-inflammatory glucocorticoid in atopic dogs without clinical sign of otitis does not affect ear canal microbiota and mycobiota.

Vet Dermatol 2021 May 25. Epub 2021 May 25.

Department for Clinical Sciences B67, Faculty of Veterinary Medicine, Université de Liège, Quartier Vallée 2, B44, Boulevard de Colonster 3, Liège, 4000, Belgium.

Background: Otitis externa is associated with a lack of bacterial/fungal diversity in atopic dermatitis. Clinical experience has shown that use of topical corticosteroids in the ear canal (EC) can prevent otitis. No data are available on the impact of this treatment on the EC microbiota. Read More

View Article and Full-Text PDF

Foreign body reaction to ruptured follicular cysts in dogs.

Vet Med Sci 2021 May 22. Epub 2021 May 22.

Laboratory of Veterinary Pathology, College of Veterinary Medicine, Chonnam National University, Gwangju, Korea.

Background: Cutaneous cysts are common in dogs, and surgical resection is the recommended treatment. However, additional therapy may be required for ruptured follicular cysts with severe cutaneous complications.

Case Presentation: A 3-year-old neutered male Samoyed was presented with multifocal masses on the forelimbs. Read More

View Article and Full-Text PDF

Ultrasound-guided fine needle aspiration of ovarian masses: Assessment of diagnostic accuracy and risk stratification using a categorical reporting system.

Cytopathology 2021 Jul 20;32(4):441-458. Epub 2021 May 20.

Department of Cytology and Gynecologic Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Introduction: The present study was undertaken to assess the accuracy of fine needle aspiration cytology (FNAC) and cell-block immunocytochemistry, and to estimate the risk of malignancy, using a categorical reporting system, in the diagnosis of ovarian masses.

Methods: This was a 5-year retrospective study of FNAs of ovarian masses. The cytological diagnoses were categorised as inadequate, non-neoplastic, benign neoplasms, indeterminate for malignancy, suspicious for malignancy and malignant neoplasms. Read More

View Article and Full-Text PDF

EBUS in optimizing non-small cell lung cancer diagnosis and treatment.

Med Pharm Rep 2021 Apr 29;94(2):176-184. Epub 2021 Apr 29.

Leon Daniello Pulmonology Hospital, Cluj-Napoca, Romania.

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a commonly used minimally invasive method for the diagnosis and staging of lung cancer. In order to improve its diagnostic accuracy, rapid on-site cytologic evaluation (ROSE) is being utilized in some institutions. ROSE, performed by a cytopathologist in the examination room, allows the assessment of the adequacy of the collected samples, identifies malignant cells and sometimes establishes diagnosis on the spot, thus improving diagnostic sensitivity. Read More

View Article and Full-Text PDF

Incidence, clinical patterns, and risk factors of postpartum uterine diseases in dairy cows from high-altitude tropical herds.

J Dairy Sci 2021 May 14. Epub 2021 May 14.

One Health and Veterinary Innovative Research and Development Group (OHVRI-Group), Department of Theriogenology, College of Veterinary Medicine, University of Antioquia, PO Box 050010, Medellín, Colombia.

The cow's uterus sustains bacterial contamination and active inflammation after calving as part of the normal physiological process of uterine involution. Although the definition, incidence, and risk factors for postpartum uterine diseases (PUD) have been documented in annual calving systems with high-producing cows on total mixed ration, the literature contains little information for other production systems. The objective of this study was to quantify the incidence risk and factors associated with metritis, clinical endometritis, and cytological endometritis in high-altitude tropical dairy herds in a pasture-based system. Read More

View Article and Full-Text PDF

Multimodal hyperspectroscopy – the use of digital technology in cervical cancer screening

Orv Hetil 2021 05 16;162(20):790-799. Epub 2021 May 16.

1 Debreceni Egyetem, Általános Orvostudományi Kar, Szülészeti és Nőgyógyászati Intézet, Debrecen, Nagyerdei krt. 98., 4032.

Összefoglaló. Bevezetés: Bevezetés: A citológiai alapú méhnyakrákszűrés átmeneti kategóriáinak optimális menedzselése a humán papillomavírus (HPV) szűrése és tipizálása ellenére jelenleg is kihívás. Vizsgálatunk célja a modern cervixspektroszkópiának (multimodális hiperspektroszkópia - MHS), egy azonnali eredményt nyújtó, digitális technológiára épülő módszernek a vizsgálata volt a citológiai alapú méhnyakszűrés találati biztonságának javítására. Read More

View Article and Full-Text PDF