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Effect of Early Feeding on Intestinal Permeability and Inflammation Markers in Infants with Genetic Susceptibility to Type 1 Diabetes: A Randomized Clinical Trial.

J Pediatr 2021 Jul 19. Epub 2021 Jul 19.

Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland; Department of Pediatrics, Tampere University Hospital, Tampere, Finland. Electronic address:

Objectives: To assess whether weaning to an extensively hydrolyzed formula (EHF) decreases gut permeability and/or markers of intestinal inflammation in infants with HLA-conferred diabetes susceptibility, when compared with conventional formula.

Study Design: By analyzing 1468 expecting biological parent pairs for HLA-conferred susceptibility for type 1 diabetes, 465 couples (32%) potentially eligible for the study were identified. After further parental consent, 332 babies to be born were randomized at 35 gestational week. Read More

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Validating the Michigan Hand Outcomes Questionnaire in patients with rheumatoid arthritis using Rasch analysis.

PLoS One 2021 22;16(7):e0254984. Epub 2021 Jul 22.

Section of Plastic Surgery, Michigan Medicine, Ann Arbor, Michigan, United States of America.

Introduction: The Michigan Hand Outcomes Questionnaire (MHQ) is a patient-reported outcome measure previously validated in patients with rheumatoid arthritis (RA) using classical test theory. Rasch analysis is a more rigorous method of questionnaire validation that has not been used to test the psychometric properties of the MHQ in patients with RA. The objective of this study is to evaluate the validity and reliability of the MHQ for measuring outcomes in patients with RA with metacarpophalangeal joint deformities. Read More

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Habitat use and nursery evaluation for the longnose stingray Hypanus guttatus (Bloch & Schneider, 1801) using vertebral microchemistry.

J Fish Biol 2021 Jul 22. Epub 2021 Jul 22.

Laboratório de Dinâmica de Populações Marinhas (DIMAR), Departamento de Pesca e Aquicultura, Universidade Federal Rural de Pernambuco, Recife, Pernambuco, Brazil.

Here, we use vertebral microchemistry to investigate the habitat use patterns of the longnose stingray Hypanus guttatus in the northern and northeastern regions of Brazil, and to evaluate the existence of potential nurseries of the species. Samples were collected in Maranhão, Rio Grande do Norte, and Pernambuco states between 2008 and 2019. Trace element concentrations of Ba:Ca, Mg:Ca, Mn:Ca, and Sr. Read More

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Intensive Blood Pressure Lowering and DWI Lesions in Intracerebral Hemorrhage: Exploratory Analysis of the ATACH-2 Randomized Trial.

Neurocrit Care 2021 Jul 22. Epub 2021 Jul 22.

Department of Neurology J. P. Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Background: With the increasing use of magnetic resonance imaging in the assessment of acute intracerebral hemorrhage, diffusion-weighted imaging hyperintense lesions have been recognized to occur at sites remote to the hematoma in up to 40% of patients. We investigated whether blood pressure reduction was associated with diffusion-weighted imaging hyperintense lesions in acute intracerebral hemorrhage and whether such lesions are associated with worse clinical outcomes by analyzing imaging data from a randomized trial.

Methods: We performed exploratory subgroup analyses in an open-label randomized trial that investigated acute blood pressure lowering in 1000 patients with intracerebral hemorrhage between May 2011 and September 2015. Read More

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Immediate Bystander Cardiopulmonary Resuscitation to Sudden Cardiac Arrest During Sports is Associated with Improved Survival-a Video Analysis.

Sports Med Open 2021 Jul 22;7(1):50. Epub 2021 Jul 22.

Heart Centre, Amsterdam University Medical Centre, AMC, Meibergdreef 9, 1105, AZ, Amsterdam, the Netherlands.

Background: Sudden cardiac arrest (SCA) during sports can be the first symptom of yet undetected cardiovascular conditions. Immediate chest compressions and early defibrillation offer SCA victims the best chance of survival, which requires prompt bystander cardiopulmonary resuscitation (CPR).

Aims: To determine the effect of rapid bystander CPR to SCA during sports by searching for and analyzing videos of these SCA/SCD events from the internet. Read More

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Large-scale collaboration in ENIGMA-EEG: A perspective on the meta-analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity.

Brain Behav 2021 Jul 21:e02188. Epub 2021 Jul 21.

Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia.

Background And Purpose: The ENIGMA-EEG working group was established to enable large-scale international collaborations among cohorts that investigate the genetics of brain function measured with electroencephalography (EEG). In this perspective, we will discuss why analyzing the genetics of functional brain activity may be crucial for understanding how neurological and psychiatric liability genes affect the brain.

Methods: We summarize how we have performed our currently largest genome-wide association study of oscillatory brain activity in EEG recordings by meta-analyzing the results across five participating cohorts, resulting in the first genome-wide significant hits for oscillatory brain function located in/near genes that were previously associated with psychiatric disorders. Read More

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Analyzing the Proliferation of Social Media Use Among Orthopaedic Surgery Residency Programs.

JB JS Open Access 2021 Jul-Sep;6(3). Epub 2021 Jul 19.

Department of Orthopaedics, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

Social media can influence how students and residents learn about and select graduate medical education programs. COVID-19-related travel restrictions forced residencies to adapt their recruitment strategies. The objective of our investigation was to characterize the prevalence of social media use by orthopaedic surgery residency programs and to examine any change over time before the COVID-19 pandemic and leading up to the 2020 to 2021 virtual interview season. Read More

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CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice.

Asian J Androl 2021 Jul 16. Epub 2021 Jul 16.

Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan.

Gene expression analyses suggest that more than 1000-2000 genes are expressed predominantly in mouse and human testes. Although functional analyses of hundreds of these genes have been performed, there are still many testis-enriched genes whose functions remain unexplored. Analyzing gene function using knockout (KO) mice is a powerful tool to discern if the gene of interest is essential for sperm formation, function, and male fertility in vivo. Read More

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Oral antibiotics and risk of new colorectal adenomas during surveillance follow-up.

Cancer Epidemiol Biomarkers Prev 2021 Jul 21. Epub 2021 Jul 21.

Department of Medicine, University of North Carolina at Chapel Hill.

Background: Antibiotics may increase colorectal neoplasia risk by modifying the gut microbiome. It is unknown whether use is associated with the risk of new colorectal adenomas among individuals with prior adenomas.

Methods: We performed a secondary analysis of 4 randomized clinical trials for the chemoprevention of colorectal adenomas. Read More

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MDContactCom: a tool to identify differences of protein molecular dynamics from two MD simulation trajectories in terms of interresidue contacts.

Bioinformatics 2021 Jul 21. Epub 2021 Jul 21.

Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, 135-0064, Japan.

Summary: Comparing results from multiple MD simulations performed under different conditions is essential during the initial stages of analysis. We propose a tool called MD Contact Comparison (MDContactCom) that compares residue-residue contact fluctuations of two MD trajectories, quantifies the differences, identifies sites that exhibit large differences, and visualizes those sites on the protein structure. Using this method, it is possible to identify sites affected by varying simulation conditions and reveal the path of propagation of the effect even when differences between the 3D structure of the molecule and the fluctuation RMSF of each residue is unclear. Read More

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Basic emergency obstetric and newborn care service availability and readiness in Nepal: Analysis of the 2015 Nepal Health Facility Survey.

PLoS One 2021 21;16(7):e0254561. Epub 2021 Jul 21.

School of Public Health and Community Medicine, BP Koirala Institute of Health Sciences, Dharan, Nepal.

Background: Achieving maternal and newborn related Sustainable Development Goals targets is challenging for Nepal, mainly due to poor quality of maternity services. In this context, we aim to assess the Basic Emergency Obstetric and Newborn Care (BEmONC) service availability and readiness in health facilities in Nepal by analyzing data from Nepal Health Facility Survey (NHFS), 2015.

Methods: We utilized cross-sectional data from the nationally representative NHFS, 2015. Read More

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Robust and efficient software for reference-free genomic diversity analysis of GBS data on diploid and polyploid species.

Mol Ecol Resour 2021 Jul 20. Epub 2021 Jul 20.

Department of Systems and Computing Engineering, Universidad de los Andes, Bogotá, Colombia.

Genotyping-by-Sequencing (GBS) is a widely used and cost-effective technique for obtaining large numbers of genetic markers from populations by sequencing regions adjacent to restriction cut sites. Although a standard reference-based pipeline can be followed to analyze GBS reads, a reference genome is still not available for a large number of species. Hence, reference-free approaches are required to generate the genetic variability information that can be obtained from a GBS experiment. Read More

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Analyzing anisotropic exchange in a pentanuclear Os2Ni3 complex.

Chemistry 2021 Jul 20. Epub 2021 Jul 20.

TU Kaiserslautern Fachbereich Chemie: Technische Universitat Kaiserslautern Fachbereich Chemie, Fachbereich Chemie, GERMANY.

Spin Hamiltonian parameters of a pentanuclear Os III 2 Ni II 3 cyanometallate complex are derived from ab initio wave function based calculations, namely valence-type configuration interaction calculations with a complete active space including spin-orbit interaction (CASOCI) in a singlestep procedure. While fits of experimental data performed so far could reproduce the data but the resulting parameters were not satisfactory, the parameters derived in the present work reproduce experimental data and at the same time have a reasonable size.  Exchange interactions (both isotropic and anisotropic) obtained from CASOCI have to be scaled by a factor of 2. Read More

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Oncogenic circDHTKD1 promotes tumor growth and metastasis of oral squamous cell carcinoma in vitro and in vivo via upregulating miR-326-mediated GAB1.

Braz J Med Biol Res 2021 16;54(10):e10837. Epub 2021 Jul 16.

Department of Stomatology, The Second Affiliated Hospital of Hainan Medical University, Hainan, China.

Circular RNAs (circRNAs) have been extensively elucidated with regard to their significant implications in oral squamous cell carcinoma (OSCC). This study performed the functional investigation of circRNA dehydrogenase E1 and transketolase domain containing 1 (circDHTKD1) in OSCC. RNA expression levels of different molecules were measured via quantitative real-time polymerase chain reaction (qRT-PCR). Read More

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Evaluation of Three Feasibility Tools for Identifying Patient Data and Biospecimen Availability: Comparative Usability Study.

JMIR Med Inform 2021 Jul 21;9(7):e25531. Epub 2021 Jul 21.

Institute for Medical Informatics and Biometry, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.

Background: To meet the growing importance of real-word data analysis, clinical data and biosamples must be timely made available. Feasibility platforms are often the first contact point for determining the availability of such data for specific research questions. Therefore, a user-friendly interface should be provided to enable access to this information easily. Read More

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Early morning kidney transplantation: Perioperative complications.

Arch Ital Urol Androl 2021 Jun 28;93(2):158-161. Epub 2021 Jun 28.

Urology and Renal Transplantation Department, Coimbra University Hospital Centre, Coimbra.

Introduction: To reduce cold ischemia time (CIT), many kidney transplants are performed in the early morning. Conducting complex surgeries in the early morning may influence the surgeon's technical capacity and rate of surgical complications (SC).

Aim: Evaluate the influence of surgery start hour (SSH) regarding duration of surgery (DS), immediate diuresis (ID), SC and acute rejection (AR); evaluate the influence of CIT regarding SC, ID, and AR. Read More

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Exploration of the Molecular Targets and Mechanisms of Suxiao Xintong Dropping Pills for Myocardial Infarction by Network Pharmacology Method.

Biosci Rep 2021 Jul 21. Epub 2021 Jul 21.

Affiliated Nanping First Hospital, Fujian Medical University, Nanping, Fujian Province, China.

Background: Suxiao Xintong dropping pills (SXXTDP), a traditional Chinese medicine, is widely applied for treating myocardial infarction (MI). However, its therapy mechanisms are still unclear. Therefore, this research is designed to explore the molecular mechanisms of SXXTDP in treating MI. Read More

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Exploring data management content in doctoral nursing handbooks.

J Med Libr Assoc 2021 Apr;109(2):248-257

Clinical Assistant Professor, Department of Women, Children, and Family Health Science, University of Illinois-Chicago College of Nursing, Director of Nursing Research, University of Illinois Hospital & Health Sciences System, Chicago, IL.

Objective: While data management (DM) is an increasing responsibility of doctorally prepared nurses, little is understood about how DM education and expectations are reflected within student handbooks. The purpose of this study was to assess the inclusion of DM content within doctoral nursing student handbooks.

Methods: A list of 346 doctoral programs was obtained from the American Association of Colleges of Nursing (AACN). Read More

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Development and Validation of the Stroke Symptom Cluster Scale Among Korean Stroke Survivors: Mixed-Methods Design.

Rehabil Nurs 2021 Jul 20. Epub 2021 Jul 20.

College of Nursing, Chungnam National University, Daejeon, South Korea College of Nursing, Woosuk University, Wanju-gun, South Korea College of Medicine, Chungnam National University, Daejeon, South Korea.

Purpose: This study aimed to develop and validate the Stroke Symptom Cluster Scale for Korean Adults (SSCS-K) for stroke survivors.

Design: An exploratory sequential study with a mixed-methods design was performed.

Methods: In the development stage, a qualitative study with in-depth interviews was conducted with 27 stroke patients. Read More

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Sequencing for germline mutations in Swedish breast cancer families reveals novel breast cancer risk genes.

Sci Rep 2021 Jul 19;11(1):14737. Epub 2021 Jul 19.

Department of Molecular Medicine and Surgery, Karolinska Institute, Solna, Stockholm, Sweden.

Identifying genetic cancer risk factors will lead to improved genetic counseling, cancer prevention and cancer care. Analyzing families with a strong history of breast cancer (BC) has been a successful method to identify genes that contribute to the disease. This has led to discoveries of high-risk genes like the BRCA-genes. Read More

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Analysis of the foot load in subjects with prevalent unilateral chewing.

J Biol Regul Homeost Agents 2021 Mar-Apr;35(2 Suppl. 1):1-8

Department of Medicine and Surgery, Centre of Neuroscience of Milan, University of Milano Bicocca, Milan, Italy.

The relationship between occlusion and posture has been and is still strongly debated. This study examines 40 male and female healthy subjects, (11 males and 29 females, average age: 26.27 years, st dv: 3. Read More

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An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions.

J Vis Exp 2021 Jun 30(172). Epub 2021 Jun 30.

The Goodman Faculty of Life Sciences, Bar-Ilan University; Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University;

The structure of the gut tissue facilitates close and mutualistic interactions between the host and the gut microbiota. These cross-talks are crucial for maintaining local and systemic homeostasis; changes to gut microbiota composition (dysbiosis) associate with a wide array of human diseases. Methods for dissecting host-microbiota interactions encompass an inherent tradeoff among preservation of physiological tissue structure (when using in vivo animal models) and the level of control over the experiment factors (as in simple in vitro cell culture systems). Read More

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The global prevalence of depression, anxiety, stress, and, insomnia and its changes among health professionals during COVID-19 pandemic: A rapid systematic review and meta-analysis.

Heliyon 2021 Jul 26;7(7):e07393. Epub 2021 Jun 26.

Institute of Statistical Research and Training, University of Dhaka, Bangladesh.

Background: During the COVID-19 pandemic, the health professionals who are at the frontline of this crisis have been facing extreme psychological disorders. This research aims to provide an overall scenario of the prevalence of depression, anxiety, stress, as well as insomnia and to inspect the changes in these prevalence over time by analyzing the existing evidence during this COVID-19 pandemic.

Methods: A systematic search was performed on March 30, 2021, in PubMed, MEDLINE, Google Scholar databases, and Web of Science. Read More

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Identification of Genotypes Using by Actin Gene and Molecular Based Methods in Southwest of Iran.

Rep Biochem Mol Biol 2021 Apr;10(1):135-143

Department of Medical Parasitology, Faculty of Allied Medical Sciences, Ilam University of Medical Sciences, Ilam, Iran.

Background: is a sexually transmitted protozoan parasite and the causative agent of trichomoniasis. The genetic characterization of isolates shows notable genetic variation in this parasite. In the present study, we aimed to identify the genotypes based on analyzing of actin gene in women specimens referred to health centers of Ilam city, southwest Iran. Read More

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Identification of genes predicting unfavorable prognosis in hepatitis B virus-associated hepatocellular carcinoma.

Ann Transl Med 2021 Jun;9(12):975

Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: To identify potential key genes predicting unfavorable prognosis in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC).

Methods: Gene expression profiles of GSE121248, GSE62232, and GSE55092 from the GEO database were obtained and analyzed. Differentially expressed genes (DEGs) between HBV-associated HCC tissues and adjacent normal tissues were screened by the limma package and Venn diagram software. Read More

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Vitamin D can safely reduce asthma exacerbations among corticosteroid-using children and adults with asthma: a systematic review and meta-analysis of randomized controlled trials.

Nutr Res 2021 Jun 13;92:49-61. Epub 2021 Jun 13.

Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230601, China.

Previous studies have failed to draw a consistent conclusion over the effect of vitamin D administration on asthma. We hypothesized that vitamin D supplementation could improve the clinical efficacy of corticosteroids in patients with asthma as measured by exacerbations, Asthma Control Test (ACT) score, and lung function in order to maintain asthma control. We searched Web of Science, PubMed, the Cochrane Library, and ScienceDirect up through January 20, 2021 for randomized controlled trials analyzing the effect of vitamin D supplementation on asthma exacerbation. Read More

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LCAT3, a novel m6A-regulated long non-coding RNA, plays an oncogenic role in lung cancer via binding with FUBP1 to activate c-MYC.

J Hematol Oncol 2021 Jul 17;14(1):112. Epub 2021 Jul 17.

Center for Uterine Cancer Diagnosis and Therapy Research of Zhejiang Province, Women's Reproductive Health Key Laboratory of Zhejiang Province, Department of Gynecologic Oncology, Women's Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang, China.

Background: Long non-coding RNAs (lncRNAs) are important epigenetic regulators, which play critical roles in diverse physiological and pathological processes. However, the regulatory mechanism of lncRNAs in lung carcinogenesis remains elusive. Here, we characterized a novel oncogenic lncRNA, designated as Lung Cancer Associated Transcript 3 (LCAT3). Read More

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Robotic surgery at ABC Medical Center: first 500 procedures experience.

Gac Med Mex 2021 ;157(2):181-186

Surgery Service Line Management. Robotic Surgery Committee, Centro Médico ABC, Mexico City, Mexico.

Background: Robotic surgery is a technological advance that is used in multiple surgical specialties in the world. Its acceptance in various areas has been supported by comparative studies with laparoscopic surgery and open surgery.

Objective: To document the robotic surgery program initial experience in a private hospital of Mexico City by analyzing its results and complications. Read More

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January 2021

Focal osteolysis and corrosion at the junction of Precice Stryde intramedullary lengthening device : preliminary clinical, radiological, and metallurgic analysis of 57 lengthened segments.

Bone Joint Res 2021 Jul;10(7):425-436

Pediatric Orthopedics, Deformity Reconstruction and Foot Surgery, University Hospital of Muenster, Muenster, Germany.

Aims: This study aims to enhance understanding of clinical and radiological consequences and involved mechanisms that led to corrosion of the Precice Stryde (Stryde) intramedullary lengthening nail in the post market surveillance era of the device. Between 2018 and 2021 more than 2,000 Stryde nails have been implanted worldwide. However, the outcome of treatment with the Stryde system is insufficiently reported. Read More

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Integrating Risk Assessment and Decision-Making Methods in Analyzing the Dynamics of COVID-19 Epidemics in Davao City, Mindanao Island, Philippines.

Risk Anal 2021 Jul 16. Epub 2021 Jul 16.

School of Chemical Engineering, University of Queensland, Australia.

The COVID-19 pandemic has become a public health crisis in the Philippines and the attention of national and local health authorities is focused on managing the fluctuating COVID-19 cases. This study presents a method that integrates risk management tools into health care decision-making processes to enhance the understanding and utilization of risk-based thinking in public health decision making. The risk assessment consists of the identification of the key risk factors of the COVID-19 contagion via bow-tie diagrams. Read More

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