10,483 results match your criteria performance estimating


Pixelwise H-score: A novel digital image analysis-based metric to quantify membrane biomarker expression from immunohistochemistry images.

PLoS One 2021 27;16(9):e0245638. Epub 2021 Sep 27.

Tumor Morphology Group, Oncology Research and Development, Pfizer Inc., San Diego, California, United States of America.

Immunohistochemistry (IHC) assays play a central role in evaluating biomarker expression in tissue sections for diagnostic and research applications. Manual scoring of IHC images, which is the current standard of practice, is known to have several shortcomings in terms of reproducibility and scalability to large scale studies. Here, by using a digital image analysis-based approach, we introduce a new metric called the pixelwise H-score (pix H-score) that quantifies biomarker expression from whole-slide scanned IHC images. Read More

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September 2021

Semiparametric estimation for nonparametric frailty models using nonparametric maximum likelihood approach.

Stat Methods Med Res 2021 Sep 27:9622802211037072. Epub 2021 Sep 27.

Department of Statistics, Seoul National University, South Korea.

A consequence of using a parametric frailty model with nonparametric baseline hazard for analyzing clustered time-to-event data is that its regression coefficient estimates could be sensitive to the underlying frailty distribution. Recently, there has been a proposal for specifying both the baseline hazard and the frailty distribution nonparametrically, and estimating the unknown parameters by the maximum penalized likelihood method. Instead, in this paper, we propose the nonparametric maximum likelihood method for a general class of nonparametric frailty models, i. Read More

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September 2021

Estimating the drivers of urban economic complexity and their connection to economic performance.

R Soc Open Sci 2021 Sep 22;8(9):210670. Epub 2021 Sep 22.

Analysis Group Inc., Boston MA, USA.

Estimating the capabilities, or inputs of production, that drive and constrain the economic development of urban areas has remained a challenging goal. We posit that capabilities are instantiated in the complexity and sophistication of urban activities, the know-how of individual workers, and the city-wide collective know-how. We derive a model that indicates how the value of these three quantities can be inferred from the probability that an individual in a city is employed in a given urban activity. Read More

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September 2021

Experimental Study of a Deep-Learning RGB-D Tracker for Virtual Remote Human Model Reconstruction.

Int J Telemed Appl 2021 15;2021:5551753. Epub 2021 Sep 15.

Networked Robotics and Sensing Laboratory, School of Engineering Science, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6.

Tracking movements of the body in a natural living environment of a person is a challenging undertaking. Such tracking information can be used as a part of detecting any onsets of anomalies in movement patterns or as a part of a remote monitoring environment. The tracking information can be mapped and visualized using a virtual avatar model of the tracked person. Read More

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September 2021

The Effects of Age, Biological Maturation and Sex on the Development of Executive Functions in Adolescents.

Front Physiol 2021 10;12:703312. Epub 2021 Sep 10.

Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium.

The development of executive functions (EF) has been widely investigated and is associated with various domains of expertise, such as academic achievement and sports performance. Multiple factors are assumed to influence the development of EF, among them biological maturation. Currently the effect of biological maturation on EF performance is largely unexplored, in contrast to other domains like physical development or sports performance. Read More

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September 2021

Estimating the Complier Average Causal Effect in a Meta-analysis of Randomized Clinical Trials with Binary Outcomes Accounting for Noncompliance: A Generalized Linear Latent and Mixed Model Approach.

Am J Epidemiol 2021 Sep 25. Epub 2021 Sep 25.

Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota.

Noncompliance, a common problem in randomized clinical trials (RCTs), can bias estimation of the effect of treatment receipt using a standard intention-to-treat analysis. The complier average causal effect (CACE) measures the effect of an intervention in the latent subpopulation that would comply with their assigned treatment. Although several methods have been developed to estimate the CACE in analyzing a single RCT, methods for estimating the CACE in a meta-analysis of RCTs with noncompliance await further development. Read More

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September 2021

Per-COVID-19: A Benchmark Dataset for COVID-19 Percentage Estimation from CT-Scans.

J Imaging 2021 Sep 18;7(9). Epub 2021 Sep 18.

University Polytechnique Hauts-de-France, University Lille, CNRS, Centrale Lille, UMR 8520-IEMN, F-59313 Valenciennes, France.

COVID-19 infection recognition is a very important step in the fight against the COVID-19 pandemic. In fact, many methods have been used to recognize COVID-19 infection including Reverse Transcription Polymerase Chain Reaction (RT-PCR), X-ray scan, and Computed Tomography scan (CT- scan). In addition to the recognition of the COVID-19 infection, CT scans can provide more important information about the evolution of this disease and its severity. Read More

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September 2021

Metaheuristics for Pharmacometrics.

CPT Pharmacometrics Syst Pharmacol 2021 Sep 25. Epub 2021 Sep 25.

Department of Biostatistics, University of California Los Angeles, California, USA.

Metaheuristics is a powerful optimization tool that is increasingly used across disciplines to tackle general purpose optimization problems. Nature-inspired metaheuristic algorithms is a subclass of metaheuristic algorithms and have been shown to be particularly flexible and useful in solving complicated optimization problems in computer science and engineering. A common practice with metaheuristics is to hybridize it with another suitably chosen algorithm for enhanced performance. Read More

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September 2021

Are social stories beneficial for oral health promotion in preschool children with special healthcare needs?

Authors:
Rachel Osborne

Evid Based Dent 2021 Jan;22(3):116-117

Leeds Dental Institute, Leeds, UK.

Design A 24-month randomised, two-armed, double-blinded, parallel controlled trial.Methods Participants were recruited from educational centres for children with special healthcare needs (SHCN) aged 2-6 years. Out of the 37 special needs schools in Hong Kong, 19 were randomly selected, of which 16 met the inclusion criteria. Read More

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January 2021

Derivation and validation of a risk score for admission to the Intensive Care Unit in patients with COVID-19.

Rev Clin Esp (Barc) 2021 Sep 14. Epub 2021 Sep 14.

Departamento de Medicina Interna, Hospital Regional de Málaga, Instituto de Investigación Biomédica (IBIMA), Universidad de Málaga, Málaga, Spain.

Background: This work aims to identify and validate a risk scale for admission to intensive care units (ICU) in hospitalized patients with coronavirus disease 2019 (COVID-19).

Methods: We created a derivation rule and a validation rule for ICU admission using data from a national registry of a cohort of patients with confirmed SARS-CoV-2 infection who were admitted between March and August 2020 (N = 16,298). We analyzed the available demographic, clinical, radiological, and laboratory variables recorded at hospital admission. Read More

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September 2021

Prediction Model Performance With Different Imputation Strategies: A Simulation Study Using a North American ICU Registry.

Pediatr Crit Care Med 2021 Sep 24. Epub 2021 Sep 24.

Department of Statistics, University of British Columbia, Vancouver, BC, Canada. Research Institute, BC Children's Hospital, Vancouver, BC, Canada. Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, BC, Canada. Department of Pediatrics, Division of Critical Care, University of British Columbia, Vancouver, BC, Canada.

Objectives: To evaluate the performance of pragmatic imputation approaches when estimating model coefficients using datasets with varying degrees of data missingness.

Design: Performance in predicting observed mortality in a registry dataset was evaluated using simulations of two simple logistic regression models with age-specific criteria for abnormal vital signs (mentation, systolic blood pressure, respiratory rate, WBC count, heart rate, and temperature). Starting with a dataset with complete information, increasing degrees of biased missingness of WBC and mentation were introduced, depending on the values of temperature and systolic blood pressure, respectively. Read More

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September 2021

Clinical Staging of Mass-Forming Intrahepatic Cholangiocarcinoma: Computed Tomography Versus Magnetic Resonance Imaging.

Hepatol Commun 2021 Aug 24. Epub 2021 Aug 24.

Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

We compared the performance of computed tomography (CT) and magnetic resonance imaging (MRI) for preoperative clinical staging of mass-forming intrahepatic cholangiocarcinoma (iCCA), using the eighth American Joint Committee on Cancer (AJCC) system. This retrospective, multicenter, cohort study consecutively identified patients who underwent partial hepatectomy for mass-forming iCCA and had preoperative CT and MRI performed from January 2009 to December 2015. CT and MRI characteristics were used to determine clinical stage based on the eighth AJCC system. Read More

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Discriminatory ability of mid-upper arm circumference in identifying overweight and obese adolescents: Findings from the comprehensive national nutrition survey, India.

Authors:
Nitika Nitika

Indian J Public Health 2021 Jul-Sep;65(3):269-274

Department of Community Medicine, Independent Public Health Consultant, 9, Nirmal Vihar Ambala Cantt, Haryana, India.

Background: Overweight and obesity during adolescence is an important public health problem. However, little is known about the age-and sex-specific mid-upper arm circumference (MUAC) cut-offs for identifying overweight and obese adolescents.

Objectives: The present study was planned to assess diagnostic performance of MUAC in identifying overweight and obese adolescents and estimating age specific MUAC cut-offs, separately for males and females, taking body mass index for age Z-score (BAZ) as the gold standard. Read More

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September 2021

Suppression of reflected signals from substrate as clutters for cell measurements using acoustic impedance microscopy.

Ultrasonics 2021 Sep 15;118:106580. Epub 2021 Sep 15.

Honda Electronics Co., Ltd, Toyahashi, Aichi 441-3193, Japan.

Recently, a method for estimating three-dimensional acoustic impedance profiles in cultured cells and human dermal organs was proposed by interpreting the reflected ultrasonic signal based on a 1-D transmission line model for acoustic impedance microscopy (AIM). However, AIM has a disadvantage that reflected signals from cells overlap with that from a reference substrate. Additionally, the amplitudes of the reflected signals from the specimens are significantly weaker than that from the substrate. Read More

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September 2021

Sex Differences in Recovery Across Multiple Domains among Older Adults with Hip Fracture.

J Gerontol A Biol Sci Med Sci 2021 Sep 23. Epub 2021 Sep 23.

Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.

Background: Hip fractures are a public health problem among older adults, but most research on recovery after hip fracture has been limited to females. With growing numbers of hip fractures among males, it is important to determine how recovery outcomes may differ between the sexes.

Methods: 168 males and 171 females were enrolled within 15 days of hospitalization with follow-up visits at 2, 6, and 12 months post-admission to assess changes in disability, physical performance, cognition, depressive symptoms, body composition, and strength, and all-cause mortality. Read More

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September 2021

24-Month Clinical Performance of a Universal Adhesive on Non-Carious Cervical Lesions: Self-Etch and Etch-and-Rinse Techniques.

J Adhes Dent 2021 Oct;23(5):379-387

Purpose: To evaluate the 24-month clinical performance of Adhese Universal (ADH) (Ivoclar Vivadent) using two different application modes (etch-and-rinse vs self-etch) when restoring non-carious cervical lesions.

Materials And Methods: Twenty-six patients participated in this study. A total of 117 non-carious cervical lesion restorations (N = 117) were assigned to two groups: 1) ADH in the etch-and-rinse mode (n = 59) and 2) ADH in the self-etch mode (n = 58). Read More

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October 2021

Robust method for optimal treatment decision making based on survival data.

Stat Med 2021 Sep 22. Epub 2021 Sep 22.

Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.

Identifying the optimal treatment decision rule, where the best treatment for an individual varies according to his/her characteristics, is of great importance when treatment effect heterogeneity exists. We develop methods for estimating the optimal treatment decision rule based on data with survival time as the primary endpoint. Our methods are based on a flexible semiparametric accelerated failure time model, where only the treatment contrast (ie, the difference in means between treatments) is parameterized and all other aspects are unspecified. Read More

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September 2021

An arithmetic correction for the effect of lipid on carbon stable isotope ratios in muscle and digestive glands of the American lobster (Homarus americanus).

Rapid Commun Mass Spectrom 2021 Sep 21:e9204. Epub 2021 Sep 21.

Canadian Rivers Institute, Biology Department, University of New Brunswick, Fredericton, NB, Canada.

Rationale: Lipid correction models use elemental carbon:nitrogen ratios to estimate the effect of lipids on δ C values and provide a fast and inexpensive alternative to chemically removing lipids. However, the performance of these models varies, especially in whole body invertebrate samples. The generation of tissue-specific lipid-correction models for American lobsters, both an ecologically and an economically important species in Eastern North America, will aid ecological research of this species and our understanding of the function of these models in invertebrates. Read More

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September 2021

Patient-reported outcome changes at the end of life in recurrent platinum-resistant ovarian cancer: An NRG oncology/GOG study.

Gynecol Oncol 2021 Sep 18. Epub 2021 Sep 18.

Division of Gynecologic Oncology, Summa Health System, NEOMED, Akron, OH 44310, United States of America. Electronic address:

Objectives: In a prospective study of platinum-resistant ovarian cancer patients, we examined whether the Disease-related Symptoms-Physical (DRS--P) scale of the NCCN/FACT-Ovarian Cancer Symptom Index-18 (NFOSI-18) is responsive to clinical change in patients estimated by their provider to survive at least six months.

Methods: The NFOSI-18, and other FACT measures, was collected at study entry and 3 and 6 months post-enrollment. Measures were compared for those who died or dropped off study prior to 3 months or prior to 6 months (assumed as health deterioration over time), or those who stayed on study through 6 months (presumed as stable disease over time). Read More

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September 2021

Comparison of impedance cardiography and cardiac magnetic resonance imaging for the evaluation of cardiac function in early-stage breast cancer patients.

Physiol Meas 2021 Sep 21. Epub 2021 Sep 21.

ASTEM Research Centre, School of Sport and Exercise Sciences, College of Engineering, Swansea University, Swansea, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Objective: Breast cancer treatment can negatively impact cardiac function in some breast cancer patients. Current methods (MUGA, echocardiography) used in clinical practice to detect abnormal cardiac changes as a result of treatment suffer from important limitations. Use of alternative techniques that would offer safe, inexpensive and non-invasive cardiac function assessment in this population would be highly advantageous. Read More

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September 2021

Mathematical correlations in two-phase modeling of fluidized bed adsorbers.

J Hazard Mater 2021 Sep 15;423(Pt B):127218. Epub 2021 Sep 15.

Ford Motor Company, Research and Advanced Engineering, Dearborn, MI 48121, USA.

Choosing proper formulas for estimating different variables is imperative when modeling a fluidized bed using two-phase theory. In this study, a two-phase model was used to model the adsorption of volatile organic compounds (VOC) in a multistage fluidized bed adsorber. Two different approaches were used to describe gas flow and mixing in the emulsion phase, perfectly mixed (EGPM: Emulsion Gas - Perfectly Mixed) and plug flow (EGPF: Emulsion Gas - Plug flow). Read More

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September 2021

Evaluation of an mHealth-enabled hierarchical diabetes management intervention in primary care in China (ROADMAP): A cluster randomized trial.

PLoS Med 2021 Sep 21;18(9):e1003754. Epub 2021 Sep 21.

The George Institute for Global Health at Peking University Health Science Center, Beijing, China.

Background: Glycemic control remains suboptimal in developing countries due to critical system deficiencies. An innovative mobile health (mHealth)-enabled hierarchical diabetes management intervention was introduced and evaluated in China with the purpose of achieving better control of type 2 diabetes in primary care.

Methods And Findings: A community-based cluster randomized controlled trial was conducted among registered patients with type 2 diabetes in primary care from June 2017 to July 2019. Read More

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September 2021

Estimating Bleeding Risk in Patients with Cancer-Associated Thrombosis: Evaluation of Existing Risk Scores and Development of a New Risk Score.

Thromb Haemost 2021 Sep 20. Epub 2021 Sep 20.

Department of Acute Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.

Background:  Bleeding risk is highly relevant for treatment decisions in cancer-associated thrombosis (CAT). Several risk scores exist, but have never been validated in patients with CAT and are not recommended for practice.

Objectives:  To compare methods of estimating clinically relevant (major and clinically relevant nonmajor) bleeding risk in patients with CAT: (1) existing risk scores for bleeding in venous thromboembolism, (2) pragmatic classification based on cancer type, and (3) new prediction model. Read More

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September 2021

orthofisher: a broadly applicable tool for automated gene identification and retrieval.

G3 (Bethesda) 2021 Sep;11(9)

Department of Biological Sciences, Vanderbilt University , Nashville, TN 37235, USA.

Identification and retrieval of genes of interest from genomic data are an essential step for many bioinformatic applications. We present orthofisher, a command-line tool for automated identification and retrieval of genes with high sequence similarity to a query profile Hidden Markov Model sequence alignment across a set of proteomes. Performance assessment of orthofisher revealed high accuracy and precision during single-copy orthologous gene identification. Read More

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September 2021

The Modified Pancreatitis Activity Scoring System Shows Distinct Trajectories in Acute Pancreatitis: An International Study.

Clin Gastroenterol Hepatol 2021 Sep 17. Epub 2021 Sep 17.

Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University, Wexner Medical Center, Columbus, Ohio, USA. Electronic address:

Background And Aims: The aims of this study were to: 1) assess the performance of the pancreatitis activity scoring system (PASS) in a large intercontinental AP cohort, 2) investigate whether a modified PASS, yields a similar predictive accuracy and produces distinct early trajectories between severity subgroups.

Methods: Data was prospectively collected through the APPRENTICE consortium (2015-2018) involving 22 centers from four continents. AP severity was categorized per Revised Atlanta Classification. Read More

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September 2021

Genomic signatures of inbreeding in a critically endangered parrot, the kākāpō.

G3 (Bethesda) 2021 Aug 31. Epub 2021 Aug 31.

Department of Zoology, University of Otago, Dunedin 9054, New Zealand.

Events of inbreeding are inevitable in critically endangered species. Reduced population sizes and unique life-history traits can increase the severity of inbreeding, leading to declines in fitness and increased risk of extinction. Here, we investigate levels of inbreeding in a critically endangered flightless parrot, the kākāpō (Strigops habroptilus), wherein a highly inbred island population and one individual from the mainland of New Zealand founded the entire extant population. Read More

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Association Between Anxiety and Cognitive Decline Over 12 Years in a Population-Based Cohort.

J Alzheimers Dis 2021 Sep 16. Epub 2021 Sep 16.

School of Psychology, University of New South Wales, Randwick, Australia.

Background: Findings on the associations between anxiety and cognitive decline are mixed and often confounded.

Objective: We studied whether anxiety symptoms were associated with the risk of cognitive decline after adequate adjustment of confounding factors.

Methods: Our study consists of 2,551 community-dwelling older adults recruited between the ages of 60-64 years and followed up for 12 years in the PATH Through Life cohort study. Read More

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September 2021

Optimizing the setup of multienvironmental hybrid wheat yield trials for boosting the selection capability.

Plant Genome 2021 Sep 19:e20150. Epub 2021 Sep 19.

Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Seeland, D-06466, Germany.

The accuracy of genomic prediction increases with increasing heritability, and thus the challenge of optimizing the design of multienvironment yield trials under a limited budget arises. With this in mind, we aimed to find the best of several options to sparsely distribute a fixed number of plots across different environments to increase the accuracy of hybrid performance prediction. We used a comprehensive published genomic and phenotypic data set of 1,604 winter wheat (Triticum aestivum L. Read More

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September 2021

Estimation of Subglottal Pressure, Vocal Fold Collision Pressure, and Intrinsic Laryngeal Muscle Activation From Neck-Surface Vibration Using a Neural Network Framework and a Voice Production Model.

Front Physiol 2021 1;12:732244. Epub 2021 Sep 1.

Department of Electronic Engineering, Universidad Técnica Federico Santa María, Valparaíso, Chile.

The ambulatory assessment of vocal function can be significantly enhanced by having access to physiologically based features that describe underlying pathophysiological mechanisms in individuals with voice disorders. This type of enhancement can improve methods for the prevention, diagnosis, and treatment of behaviorally based voice disorders. Unfortunately, the direct measurement of important vocal features such as subglottal pressure, vocal fold collision pressure, and laryngeal muscle activation is impractical in laboratory and ambulatory settings. Read More

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September 2021

High diversity of natural Dalmatian pyrethrum based on pyrethrin composition at intra- and interpopulation level.

Phytochemistry 2021 Sep 15;192:112934. Epub 2021 Sep 15.

University of Zagreb, Faculty of Agriculture, Department of Seed Science and Technology, Svetošimunska cesta 25, HR-10000 Zagreb, Croatia; Centre of Excellence for Biodiversity and Molecular Plant Breeding (CoE CroP-BioDiv), Svetošimunska cesta 25, HR-10000 Zagreb, Croatia. Electronic address:

Seeds collected from 10 Dalmatian pyrethrum (Tanacetum cinerariifolium /Trevir./ Sch. Bip. Read More

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September 2021