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The anatomy of agency: Improving academic performance in first year university students.

Anat Sci Educ 2021 Sep 18. Epub 2021 Sep 18.

The School of Biomedical Sciences, The University of Queensland, Brisbane, Australia.

The transition from secondary to tertiary education can be challenging, as students must adapt to independent learning. For students in the allied health and nursing disciplines, this transition may coincide with compulsory first year courses in anatomy, which are traditionally difficult to master. Students' agency - their capacity to make intentional choices to alter the path of their learning - may play a role in their successful completion of first year anatomy courses. Read More

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September 2021

Efficacy and safety of immune checkpoint inhibitors in elderly patients (≥70 years) with squamous cell carcinoma of the head and neck.

Eur J Cancer 2021 Sep 15;157:190-197. Epub 2021 Sep 15.

Department of Head and Neck Oncology, Gustave Roussy Cancer Campus, Villejuif, France.

Background: Recent meta-analysis showed that immune checkpoint inhibitors (ICIs) have comparable activity between younger and older patients. However, little is known about efficacy and safety of ICI in elderly patients with relapsed/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). The aim of this study is to compare the efficacy of ICI for patients aged ≥70 y to that for younger patients, while taking into account potential confounding factors. Read More

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September 2021

Design of a defined grain distribution brazed diamond grinding wheel for ultrasonic assisted grinding and experimental verification.

Ultrasonics 2021 Sep 9;118:106577. Epub 2021 Sep 9.

School of Mechanical Engineering, Jiangsu University of Technology, Changzhou 213001, China.

Ultrasonic assisted grinding (UAG) is a promising manufacturing technology in processing hard and brittle materials, mostly due to its excellent machining performance. In UAG, improvements in grain trajectory interactions and overlapping stemming from kinematic characteristics were identified as the main reasons for reduced grinding forces and improved processing quality. However, in existing studies, the grinding wheels with disordered abrasive grain distributions and irregular grain protrusion heights were generally used. Read More

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September 2021

Highly enhanced adsorption performance to uranium(VI) by facile synthesized hydroxyapatite aerogel.

J Hazard Mater 2021 Sep 10;423(Pt B):127184. Epub 2021 Sep 10.

State Key Laboratory of Environment-friendly Energy Materials, Sichuan Co-Innovation Center for New Energetic Materials, National Co-innovation Center for Nuclear Waste Disposal and Environmental Safety, Nuclear Waste and Environmental Safety Key Laboratory of Defense, School of National Defence Science & Technology, Southwest University of Science and Technology, Mianyang 621010, PR China. Electronic address:

In order to protect environment and save uranium resources, it was necessary to find a highly efficient adsorbent for uranium recovery from wastewater. In this work, we used a freeze-drying-calcination method to synthesize HAP aerogel to effectively remove uranium. Compared with commercially available nano-hydroxyapatite, HAP aerogel presented better adsorption performance. Read More

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September 2021

Effect of ultrasound-guided selective sensory nerve blockade of the knee on pain management compared with periarticular injection for patients undergoing total knee arthroplasty: A prospective randomized controlled trial.

Knee 2021 Sep 15;33:1-10. Epub 2021 Sep 15.

Department of Anesthesiology, King Chulalongkorn Memorial Hospital, The Thai Red Cross Society and Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: Ultrasound-guided selective sensory nerve blockade (SSNB) of the knee, including an adductor canal block (ACB), anterior femoral cutaneous nerve block, and infiltration between the popliteal artery and posterior capsule of the knee may provide effective motor-sparing knee analgesia for total knee arthroplasty (TKA). We hypothesized that the SSNB would manage pain better on ambulation 24 hours postoperatively compared to periarticular infiltration (PAI), when combined with postoperative continuous ACB.

Methods: Seventy-two patients undergoing elective TKA under spinal anesthesia were randomly assigned to either SSNB (SSNB group) or intraoperative PAI (PAI group). Read More

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September 2021

Identification of a novel immune-related prognostic signature associated with tumor microenvironment for breast cancer.

Int Immunopharmacol 2021 Sep 15;100:108122. Epub 2021 Sep 15.

Department of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address:

Background: In the view that immune-related genes play a crucial role in breast cancer progression and long-term patient outcomes, we aimed to identify a novel gene signature based on immune-related genes to improve the prognostic prediction of breast cancer.

Methods: RNA sequencing data and clinical information were obtained from The Cancer Genome Atlas (TCGA). Univariate and multivariate Cox regression analyses were conducted to establish the immune-related prognostic signature (IRPS). Read More

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September 2021

Disturbance of functional and effective connectivity of the salience network involved in attention deficits in right temporal lobe epilepsy.

Epilepsy Behav 2021 Sep 15;124:108308. Epub 2021 Sep 15.

Department of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. Electronic address:

The salience network (SN) acts as a switch that generates transient control signals to regulate the executive control network (ECN) and the default mode network (DMN) and has been implicated in cognitive processes. Temporal lobe epilepsy (TLE) is usually accompanied by different types of cognitive deficits, but whether it is associated with dysfunctional connectivity of the SN remains unknown. To address this, thirty-six patients with right TLE (rTLE) and thirty-six healthy controls (HCs) were recruited for the present study. Read More

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September 2021

DR-MIL: deep represented multiple instance learning distinguishes COVID-19 from community-acquired pneumonia in CT images.

Comput Methods Programs Biomed 2021 Sep 9;211:106406. Epub 2021 Sep 9.

Department of Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China. Electronic address:

Background And Objective: Given that the novel coronavirus disease 2019 (COVID-19) has become a pandemic, a method to accurately distinguish COVID-19 from community-acquired pneumonia (CAP) is urgently needed. However, the spatial uncertainty and morphological diversity of COVID-19 lesions in the lungs, and subtle differences with respect to CAP, make differential diagnosis non-trivial.

Methods: We propose a deep represented multiple instance learning (DR-MIL) method to fulfill this task. Read More

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September 2021

Revisiting the T Spectrum Imaging Inverse Problem: Bayesian Regularized Non-Negative Least Squares.

Neuroimage 2021 Sep 15:118582. Epub 2021 Sep 15.

Signal Processing Laboratory (LTS5), École Polytechnique Fédérale de Lausanne (EPFL), EPFL-STI-IEL-LTS5, Station 11, CH-1015, Lausanne, Switzerland; Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Multi-echo T magnetic resonance images contain information about the distribution of T relaxation times of compartmentalized water, from which we can estimate relevant brain tissue properties such as the myelin water fraction (MWF). Regularized non-negative least squares (NNLS) is the tool of choice for estimating non-parametric T spectra. However, the estimation is ill-conditioned, sensitive to noise, and highly affected by the employed regularization weight. Read More

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September 2021

Inhibition of nNOS in the paraventricular nucleus of hypothalamus decreases exercise-induced hyperthermia.

Brain Res Bull 2021 Sep 15. Epub 2021 Sep 15.

Department of Physiology and Biophysics, Institute of Biological Science, Federal University of Minas Gerais (ICB/UFMG), Belo Horizonte, Brazil. Electronic address:

The paraventricular nucleus of the hypothalamus (PVN) is an important site for autonomic control, which integrates thermoregulation centers and sympathetic outflow to thermoeffector organs. PVN neurons express the neuronal isoform of nitric oxide synthase (nNOS) whose expression is locally upregulated by physical exercise. Thus, the aim of the present study was to evaluate the role of nNOS in the PVN in the exercise-induced hyperthermia. Read More

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September 2021

Transplantion of predominant Lactobacilli from native hens to commercial hens could indirectly regulate their ISC activity by improving intestinal microbiota.

Microb Biotechnol 2021 Sep 18. Epub 2021 Sep 18.

Department of Veterinary Medicine, Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China.

In poultry, HyLine (HL) Hens are known for their excellent laying performance. However, ZhenNing (ZN) Hens, a native chicken breed in China, are known for their unique flavour. The intestinal mucosa, which is the main organ for nutrient absorption, could affect livestock product quality. Read More

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September 2021

Clinical Validation of p16/Ki-67 Dual-Stained Cytology Triage of HPV-Positive Women - Results from the IMPACT Trial.

Int J Cancer 2021 Sep 18. Epub 2021 Sep 18.

Ventana Medical Systems Inc./Roche Tissue Diagnostics, Tucson, AZ.

Triage strategies are needed for primary human papillomavirus (HPV)-based cervical cancer screening to identify women requiring colposcopy/biopsy. We assessed the performance of p16/Ki-67 dual-stained immunocytochemistry (DS) to triage HPV-positive women and compared it to cytology, with or without HPV16/18 genotyping. A prospective observational screening study enrolled 35,263 women aged 25-65 years at 32 U. Read More

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September 2021

Constitutive expression and discovery of antimicrobial peptides in Zygogramma bicolorata (Coleoptera: Chrysomelidae).

Proteins 2021 Sep 18. Epub 2021 Sep 18.

Department of Biochemistry and Biochemical Engineering, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, India.

The expression, identification, and discovery of less toxic antimicrobial peptides (AMPs) are significant in managing infectious pathogens. AMPs triggered in response to the immune system have evolved to defend against pathogens and wounding. The protein composition of Zygogramma bicolorata hemolymph is of diagnostic importance as the open circulatory systems of the insects involve signaling through hemolymph. Read More

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September 2021

Quantitative assessment of liver steatosis using ultrasound: dual-energy CT.

J Med Ultrason (2001) 2021 Sep 18. Epub 2021 Sep 18.

Department of Radiology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-2621, Japan.

Reflecting the growing interest in early diagnosis of non-alcoholic fatty liver disease in recent years, the development of noninvasive and reliable fat quantification methods is needed. Dual-energy computed tomography (DE-CT) is a quantitative diagnostic imaging method that estimates the composition of the imaging target using a material decomposition technique based on the X-ray absorption characteristics peculiar to substances from DE-CT scanning using X-rays generated with different energies (tube voltage). In this review article, we first explain the basic principles and technical aspects of DE-CT. Read More

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September 2021

Limited value of serum neutrophil-to-lymphocyte ratio in the diagnosis of chronic periprosthetic joint infection.

J Orthop Traumatol 2021 Sep 18;22(1):37. Epub 2021 Sep 18.

Department of Orthopedics, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Road, Guangzhou, 510080, China.

Background: Diagnosing chronic periprosthetic joint infection (PJI) is challenging. No single biomarker can accurately recognize PJI preoperatively in a timely manner. Therefore, the aim of the present study was to investigate the usefulness of the serum neutrophil-to-lymphocyte ratio (NLR) in aiding the diagnosis of chronic PJI. Read More

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September 2021

A model integrating Killer Immunoglobulin-like Receptor (KIR) haplotypes for risk prediction of COVID-19 clinical disease severity.

Immunogenetics 2021 Sep 18. Epub 2021 Sep 18.

Department of Hematology, Immunogenetics Laboratory, Faculty of Medicine, Ankara University, Ankara, Turkey.

Associations between inherited Killer Immunoglobulin-like Receptor (KIR) genotypes and the severity of multiple RNA virus infections have been reported. This prospective study was initiated to investigate if such an association exists for COVID-19. In this cohort study performed at Ankara University, 132 COVID-19 patients (56 asymptomatic, 51 mild-intermediate, and 25 patients with severe disease) were genotyped for KIR and ligands. Read More

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September 2021

Development and validation of a PBRM1-associated immune prognostic model for clear cell renal cell carcinoma.

Cancer Med 2021 Sep 18. Epub 2021 Sep 18.

Department of Anesthesiology, Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Alteration in the polybromo-1 (PBRM1) protein encoding gene PBRM1 is the second most frequent mutation in clear cell renal cell carcinoma (ccRCC). It causes a series of changes in the tumorigenesis, progression, prognosis, and immune response of ccRCC patients. This study explored the PBRM1-associated immunological features and identified the immune-related genes (IRGs) linked to PBRM1 mutation using bioinformatics methods. Read More

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September 2021

Inhibition, excitation and bilateral transfer following a unilateral complex finger-tapping task in young and older adults.

Eur J Neurosci 2021 Sep 17. Epub 2021 Sep 17.

Deakin University, Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Geelong, Australia.

Neuroplasticity underpins motor learning, with abnormal neuroplasticity related to age-associated motor declines. Bilateral transfer of motor learning, through rehabilitation, may mitigate these declines, however the magnitude of transfer may be reduced in older populations. This study investigated excitatory and inhibitory pathways in the trained and untrained hemispheres following unilateral training of a complex finger tapping task across ageing. Read More

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September 2021

Physiologically-based pharmacokinetic model predictions of inter-ethnic differences in imatinib pharmacokinetics and dosing regimens.

Br J Clin Pharmacol 2021 Sep 17. Epub 2021 Sep 17.

Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.

Aims: This study implements a physiologically-based pharmacokinetic (PBPK) modelling approach to investigate inter-ethnic differences in imatinib pharmacokinetics and dosing regimens.

Methods: A PBPK model of imatinib was built in the Simcyp Simulator (version 17) integrating in vitro drug metabolism and clinical pharmacokinetic data. The model accounts for ethnic differences in body size and abundance of drug-metabolising enzymes and proteins involved in imatinib disposition. Read More

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September 2021

Brief Report: Improving Fellow Performance of the Pharmacology Section of the American Society of Clinical Oncology In-Training Exam.

J Cancer Educ 2021 Sep 18. Epub 2021 Sep 18.

Division of Oncology, Department of Medicine, University of North Carolina at Chapel Hill, 170 Manning Drive, CB #7305, Chapel Hill, NC, 27599, USA.

Though the electronic medical record has streamlined the process for ordering chemotherapy and reduced medical error, it has come at the cost of potentially hindering medical oncology fellows' acquisition of basic principles of chemotherapy administration. Recognizing the need for improving fellow knowledge and comfort level in chemotherapy prescription, we created an anticancer therapeutics curriculum for fellows at the University of North Carolina (UNC). The curriculum, which was comprised of a self-assessment, review session, and chemotherapy writing workshop, was offered voluntarily to all UNC fellows planning to take the medical oncology boards. Read More

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September 2021

Should there be an "AI" in TEAM? Embryologists selection of high implantation potential embryos improves with the aid of an artificial intelligence algorithm.

J Assist Reprod Genet 2021 Sep 17. Epub 2021 Sep 17.

Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Purpose: A deep learning artificial intelligence (AI) algorithm has been demonstrated to outperform embryologists in identifying euploid embryos destined to implant with an accuracy of 75.3% (1). Our aim was to evaluate the performance of highly trained embryologists in selecting top quality day 5 euploid blastocysts with and without the aid of a deep learning algorithm. Read More

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September 2021

Spatial prediction of soil depth using environmental covariates by quantile regression forest model.

Environ Monit Assess 2021 Sep 18;193(10):660. Epub 2021 Sep 18.

ICAR-National Bureau of Soil Survey and Land Use Planning, Regional Centre, Bangalore, 560024, Karnataka, India.

Prediction of soil depth for larger areas provides primary information on soil depth and its spatial distribution that becomes vital for land resource management, crop, nutrient, and ecosystem modeling. The present study assessed the spatial distribution of soil depth over 160,205 km of Andhra Pradesh, India, using 20 covariables by quantile regression forest (QRF). An aggregate of 2854 soil datasets compiled from various physiographic units were randomly partitioned into 80:20 ratio for calibration (2283 samples) and validation (571 samples). Read More

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September 2021

Functional Specialization of the Medial Temporal Lobes in Human Recognition Memory: Dissociating Effects of Hippocampal versus Parahippocampal Damage.

Cereb Cortex 2021 Sep 17. Epub 2021 Sep 17.

Memory Research Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.

A central debate in the systems neuroscience of memory concerns whether different medial temporal lobe (MTL) structures support different processes in recognition memory. Using two recognition memory paradigms, we tested a rare patient (MH) with a perirhinal lesion that appeared to spare the hippocampus. Consistent with a similar previous case, MH showed impaired familiarity and preserved recollection. Read More

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September 2021

Oxidation-enhanced thermoelectric efficiency in a two-dimensional phosphorene oxide.

Sci Rep 2021 Sep 17;11(1):18525. Epub 2021 Sep 17.

Department of Physics, Kyung Hee University, Seoul, 02447, Korea.

We performed density functional theory calculations to investigate the thermoelectric properties of phosphorene oxide (PO) expected to form by spontaneous oxidation of phosphorene. Since thermoelectric features by nature arise from the consequences of the electron-phonon interaction, we computed the phonon-mediated electron relaxation time, which was fed into the semiclassical Boltzmann transport equation to be solved for various thermoelectric-related quantities. It was found that PO exhibits superior thermoelectric performance compared with its pristine counterpart, which has been proposed to be a candidate for the use of future thermoelectric applications. Read More

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September 2021

Stroke impairs the control of isometric forces and muscle activations in the ipsilesional arm.

Sci Rep 2021 Sep 17;11(1):18533. Epub 2021 Sep 17.

Dept. Informatics, Bioengineering, Robotics and Systems Engineering, University of Genoa, Via Opera Pia 13, 16145, Genoa, Italy.

Stroke often impairs the control of the contralesional arm, thus most survivors rely on the ipsilesional arm to perform daily living activities that require an efficient control of movements and forces. Whereas the ipsilesional arm is often called 'unaffected' or 'unimpaired', several studies suggested that during dynamic tasks its kinematics and joint torques are altered. Is stroke also affecting the ability of the ipsilesional arm to produce isometric force, as when pushing or pulling a handle? Here, we address this question by analyzing behavioral performance and muscles' activity when subjects applied an isometric force of 10 N in eight coplanar directions. Read More

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September 2021

Improving the robustness of MOLLI T1 maps with a dedicated motion correction algorithm.

Sci Rep 2021 Sep 17;11(1):18546. Epub 2021 Sep 17.

Hospital Clínic de Barcelona, Barcelona, Spain.

Myocardial tissue T1 constitutes a reliable indicator of several heart diseases related to extracellular changes (e.g. edema, fibrosis) as well as fat, iron and amyloid content. Read More

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September 2021

Demonstration of valley anisotropy utilized to enhance the thermoelectric power factor.

Nat Commun 2021 Sep 17;12(1):5408. Epub 2021 Sep 17.

State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou, China.

Valley anisotropy is a favorable electronic structure feature that could be utilized for good thermoelectric performance. Here, taking advantage of the single anisotropic Fermi pocket in p-type MgSb, a feasible strategy utilizing the valley anisotropy to enhance the thermoelectric power factor is demonstrated by synergistic studies on both single crystals and textured polycrystalline samples. Compared to the heavy-band direction, a higher carrier mobility by a factor of 3 is observed along the light-band direction, while the Seebeck coefficient remains similar. Read More

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September 2021

Characteristics of older adults with back pain associated with choice of first primary care provider: a cross-sectional analysis from the BACE-N cohort study.

BMJ Open 2021 Sep 17;11(9):e053229. Epub 2021 Sep 17.

Department of Physiotherapy, Oslo Metropolitan University, Oslo, Norway.

Objectives: To describe characteristics of older adults with back pain in primary care, and to assess associations between patient characteristics and type of first primary care provider (general practitioner (GP), physiotherapist (PT) or chiropractor).

Design: Cross-sectional analysis from the Back Complaints in the Elders-Norway cohort study.

Setting: Norwegian GP, PT and chiropractic primary care centres. Read More

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September 2021

Overall Survival of Patients Receiving Cisplatin or Carboplatin for Primary Metastatic Urothelial Carcinoma of the Bladder: A Contemporary Dutch Nationwide Cohort Study.

Eur Urol Focus 2021 Sep 14. Epub 2021 Sep 14.

Department of Research and Development, The Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands; Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Cisplatin is preferred to carboplatin when treating metastatic urothelial carcinoma of the bladder (mUCB), despite its greater toxicity. Randomised studies underpinning this have been performed in noncontemporary populations with limitations in sample sizes and analyses, affecting their validity in current clinical practice.

Objective: To estimate overall survival (OS) and assess the benefit of cisplatin-based regimens over carboplatin-based regimens in a contemporary cohort of patients with mUCB. Read More

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September 2021

Patterns of hospital utilization in the Unified Health System in six Brazilian capitals: comparison between the year before and the first six first months of the COVID-19 pandemic.

BMC Health Serv Res 2021 Sep 17;21(1):976. Epub 2021 Sep 17.

Department of Health Administration and Planning, Sergio Arouca National School of Public Health, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Objective: To analyze the temporal evolution of the pattern of hospital use in the context of the COVID-19 pandemic in Brazil.

Methods: This retrospective observational study compared hospital use and mortality in the Brazilian Unified Health System (SUS) in the first six months of the COVID-19 pandemic with the year before the onset of the pandemic in six Brazilian capitals (São Paulo, Rio de Janeiro, Manaus, Fortaleza, Recife, and Brasilia). It was based on secondary administrative data from the SUS Hospital Information System (SIH), focusing on the number of hospitalizations per fortnight, age, and gender of patients, hospital length of stay, and the proportions of surgical, elective, with the use of ICU, and resulting in death hospitalizations. Read More

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September 2021