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Utility of multi-parametric quantitative magnetic resonance imaging of the lacrimal gland for diagnosing and staging Graves' ophthalmopathy.

Eur J Radiol 2021 Jun 8;141:109815. Epub 2021 Jun 8.

Department of Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, Guangdong Province, China. Electronic address:

Purpose: To explore radiological changes of the lacrimal gland (LG) in Graves' ophthalmopathy (GO) based on multi-parametric quantitative MRI and its clinical utility in LG diagnosis and activity in GO.

Methods: We enrolled 99 consecutive patients with GO (198 eyes) and 12 Graves' Disease (GD) patients (24 eyes) from July 2018 to June 2020. Clinical, laboratory, and MRI data were collected at the first visit. Read More

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A simplified model for simulating anaerobic digesters: Application to valorisation of bagasse and distillery spent wash.

Bioresour Technol 2021 Jun 9;337:125395. Epub 2021 Jun 9.

Multiphase Flows, Reactors and Intensification Group, School of Chemistry and Chemical Engineering, Queen's University Belfast, Belfast BT9 5AG, United Kingdom; Bernal Institute, University of Limerick, Limerick V94T9PX, Ireland. Electronic address:

Current anaerobic digestion (AD) design methods rely on crude empirical models or sophisticated anaerobic digestion models (like ADM1) requiring a large number of parameters which are difficult to obtain experimentally. A simplified model for simulating AD was developed in this work. The model requires knowledge of CH/CO ratio in biogas or indigestible fraction in substrate and batch biomethane potential (BMP) data for estimating three kinetic parameters (maximum specific growth rate, half velocity constant and cell death rate). Read More

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Predictive factors of severe early treatment-related toxicity in patients receiving first-line treatment for metastatic colorectal cancer: Pooled analysis of 2190 patients enrolled in Fédération Francophone de Cancérologie Digestive (FFCD) trials.

Eur J Cancer 2021 Jun 12;153:40-50. Epub 2021 Jun 12.

Assistance Publique - Hôpitaux de Paris, Hôpital Saint Louis, Université de Paris, Paris, France. Electronic address:

Aim: Few studies have explored the association between baseline characteristics and the occurrence of early toxicities in patients treated with first-line chemotherapy for metastatic colorectal cancer (mCRC).

Patients And Methods: Individual patient data of 2190 patients enrolled in 10 prospective FFCD (Fédération Francophone de Cancérologie Digestive) trials were analysed. Severe early toxicity was defined as the occurrence of grade ≥III toxicity within 3 months after initiation of chemotherapy (ET3). Read More

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Analytical performance of the Xpert MTB/XDR® assay for tuberculosis and expanded resistance detection.

Diagn Microbiol Infect Dis 2021 Apr 20;101(1):115397. Epub 2021 Apr 20.

FIND, Geneva, Switzerland; Division of Tropical Medicine, Center of Infectious Diseases, University Hospital of Heidelberg, Heidelberg, Germany.

In a manufacturer-independent laboratory validation study, the Xpert MTB/XDR® assay demonstrated equivalent limit of detection to Xpert MTB/RIF®, detected 100% of tested resistance mutations and showed some utility for resistance detection in strain mixtures. The Xpert MTB/XDR assay is a reliable, sensitive assay for tuberculosis and expanded resistance detection. Read More

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Mat pilates method improve postural alignment women undergoing hormone therapy adjunct to breast cancer treatment. Clinical trial.

Complement Ther Clin Pract 2021 Jun 1;44:101424. Epub 2021 Jun 1.

Department of Physical Education at the Center for Health Sciences and Sports and Professor Postgraduate Program in Human Movement Sciences, Santa Catarina State University, Brazil.

The purpose of the study is to analyze the effects of a mat Pilates intervention on the postural alignment and balance of breast cancer women receiving hormone therapy. A two-arm randomized clinical trial included 34 breast cancer survivors divided randomly between a mat Pilates group (n = 18), that performed 16 weeks of mat Pilates exercises, and a control group (n = 16), who were invited to maintain their daily routine activities and received three educational sessions. Data collection occurred at baseline and at post-intervention time. Read More

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Exosome-based hybrid nanostructures for enhanced tumor targeting and hyperthermia therapy.

Colloids Surf B Biointerfaces 2021 Jun 8;205:111915. Epub 2021 Jun 8.

Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea. Electronic address:

Recently, natural exosomes have attracted attention as an ideal drug carrier to overcome the limitations of existing drug delivery systems which are toxicity induction and low cancer-targeting performance. In this study, we propose an exosome-based hybrid nanostructure (EHN) with improved targeting ability and therapeutic efficacy against colorectal cancer by using exosomes isolated from the tumor cell line as a drug carrier. The proposed EHN can have high biocompatibility by using exosomes, a biologically derived material, and show improved targeting performance by adding a tumor-targeting ligand (folic acid). Read More

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Characterization of chemical constituents and metabolites in rat plasma after oral administration of San Miao Wan by ultra-high performance liquid chromatography tandem Q-Exactive Orbitrap mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 May 28;1178:122793. Epub 2021 May 28.

State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 24 Tongjia Lane, Nanjing, Jiangsu Province, PR China; Department of Pharmacognosy, School of Traditional Chinese Pharmacy, China Pharmaceutical University, No. 24 Tongjia Lane, Nanjing, Jiangsu Province, PR China. Electronic address:

San Miao Wan (SMW), composed of Phellodendri Chinensis Cortex, Atractylodis Lanceae Rhizoma and Achyranthis Bidentatae Radix, is widely used for the treatment of gout, hyperuricemia and other diseases. In the present study, an overall identification strategy based on ultra-high performance liquid chromatography tandem Q-Exactive Orbitrap mass spectrometry (UPLC-Q-Exactive Orbitrap/MS) method was established to characterize the multiple chemical constituents of SMW and its metabolites in rat plasma after oral administration of SMW. A total of 76 constituents including alkaloids, organic acids, lactones, terpenes, saponins, sterones and others types of components were identified in the extract of SMW. Read More

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Isoflavones alter male and female fertility in different development windows.

Biomed Pharmacother 2021 Jun 12;140:111448. Epub 2021 Jun 12.

Department of Pharmacy, State University of Centro-Oeste, Parana, Brazil; Program in Biotechnology in Human and Animal Health - (PPGBiotec), State University of Ceará, Ceará, Brazil. Electronic address:

Isoflavones are a group of secondary metabolites found in plants belonging to the class of phytoestrogens. These, because they have a chemical structure similar to the endogenous hormone 17β-estradiol, act as endocrine disruptors over the different development window periods. This study aimed to evaluate male and female reproductive systems' responses when exposed to isoflavones during the development window. Read More

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Convolutional neural networks to identify malformations of cortical development: A feasibility study.

Seizure 2021 May 31;91:81-90. Epub 2021 May 31.

Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, MA USA.

Objective: To develop and test a deep learning model to automatically detect malformations of cortical development (MCD).

Methods: We trained a deep learning model to distinguish between diffuse cortical malformation (CM), periventricular nodular heterotopia (PVNH), and normal magnetic resonance imaging (MRI). We trained 4 different convolutional neural network (CNN) architectures. Read More

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Nitrogen-carbon materials base on pyrolytic graphene hydrogel for oxygen reduction.

J Colloid Interface Sci 2021 Jun 8;602:274-281. Epub 2021 Jun 8.

Lab of Advanced Nano-structures & Transfer Processes, Department of Chemical Engineering, Tianjin University, Tianjin 300354, China; Chemistry and Chemical Engineering Guangdong Laboratory, Shantou 515031 China. Electronic address:

Hypothesis: Oxygen reduction reaction (ORR) has played a significant role in the utilization of energy nowadays. Nitrogen-doped carbon materials are seen as promising catalysts for ORR, so it is of great significance in studying the functions of different nitrogen moieties.

Experiments: The graphene hydrogel-based nitrogen-arbon materials (GH N-C) were fabricated by first obtaining a gel through hydrothermal treatment using graphene oxide (GO) as precursor, and then calcined in an ammonia atmosphere at different temperatures to form N-doped graphitized materials with divers nitrogen configuration. Read More

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Microplastic degradation methods and corresponding degradation mechanism: Research status and future perspectives.

J Hazard Mater 2021 Jun 10;418:126377. Epub 2021 Jun 10.

Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou 510642, China; Institute of Eco-Environmental Research, Guangxi Academy of Sciences, Nanning 530007, China. Electronic address:

Microplastics (MPs) pollution has become a global environmental concern because of their severe threat to biota. However, limited studies on the elimination of MPs pollution were reported. The conventional treatment methods were not suitable for MPs owing to their smaller size than plastic items. Read More

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Highly efficient nano-Fe/Cu bimetal-loaded mesoporous silica Fe/Cu-MCM-41 for the removal of Cr(VI): Kinetics, mechanism and performance.

J Hazard Mater 2021 Jun 8;418:126344. Epub 2021 Jun 8.

Shaanxi provincial Center for Disease Control and Prevention, Xian 710054, China. Electronic address:

Zero valent iron (Fe) can reduce Cr(VI) in water, where Fe and Fe(Ⅱ) are possible electron donors, but passivation and aggregation easily occur to Fe. To improve the performance of Fe, a new hybridization strategy of Fe/Cu bimetal and silica-based mesoporous molecular sieve MCM-41 for the removal of Cr(VI) from water has been proposed. The results show that the two-dimensional mesoporous structure of MCM-41 can provide skeleton support for Fe, improve the mass transfer rate, and overcome the aggregation bottleneck of Fe. Read More

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Modification of ordered mesoporous carbon for removal of environmental contaminants from aqueous phase: A review.

J Hazard Mater 2021 May 30;418:126266. Epub 2021 May 30.

College of Environmental Science and Engineering, Yangzhou University, Yangzhou 225127, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou 225127, Jiangsu, China; Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, China. Electronic address:

Contamination of water bodies by potentially toxic elements and organic pollutants has aroused extensive concerns worldwide. Thus it is significant to develop effective adsorbents for removing these contaminants. As a new member of carbonaceous material families (activated carbon, biochar, and graphene), ordered mesoporous carbon (OMC) with larger specific surface area, ordered pore structure, and higher pore volume are being evaluated for their use in contaminant removal. Read More

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Efficient heavy metal removal from water by alginate-based porous nanocomposite hydrogels: The enhanced removal mechanism and influencing factor insight.

J Hazard Mater 2021 Jun 8;418:126358. Epub 2021 Jun 8.

School of Hydraulic Engineering, Changsha University of Science & Technology, Changsha 410114, China; Key Laboratory of Dongting Lake Aquatic Eco-Environmental Control and Restoration of Hunan Province, Changsha 410114, China. Electronic address:

Novel porous alginate-based nanocomposite hydrogels were prepared by incorporating polyaniline-polypyrrole modified graphene oxide ([email protected]) as reinforcing fillers into the alginate matrix ([email protected]/SA) for Cr(VI) and Cu(II) removal from water. Different in-situ co-polymerization functionalized GO with Py-to-An mass ratios of monomers (from nil to 1:1) and contents of [email protected] (from nil to 2.0%(w/v)) were embedded into the alginate backbone to improve the sorption performance. Read More

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Foliar absorption and field herbicidal studies of atrazine-loaded polymeric nanoparticles.

J Hazard Mater 2021 Jun 7;418:126350. Epub 2021 Jun 7.

Institute of Science and Technology, São Paulo State University (UNESP), Av. Três de Março 511, 18087-180 Sorocaba, SP, Brazil. Electronic address:

Nanoparticles loaded with atrazine show weed control efficacy even with lower application doses of the active ingredient. Changes in the mode of action of the herbicide through the nanoformulation are key to understanding the efficiency of post-emergence activity of nanoatrazine. Here, we report the leaf absorption and translocation of nanoatrazine and atrazine employing radiometric techniques and compare their herbicidal effects in greenhouse and field conditions. Read More

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Exploring hybrid consensus models to assess roadkill.

J Environ Manage 2021 Jun 12;294:112886. Epub 2021 Jun 12.

Department of Bioenvironmental Systems Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, 10617, Taiwan. Electronic address:

Accurate information provided by reliable models is essential for identifying hotspots and mitigating roadkill. However, existing methods, such as kernel density estimation (KDE) and maximum entropy modeling (ME) may individually identify only a subset of the suitable locations for mitigation, because KDE cannot detect hotspots once local abundances are depressed, and ME may only partially identify current hotspots due to imperfect discrimination skill. Here, we propose a hybrid consensus modeling (HCM) approach that leverages the strengths of both KDE and ME by using their consensus to identify the core subset of hotspots. Read More

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Influence of packing material on the biofiltration of butyric acid: A comparative study from a physico-chemical, olfactometric and microbiological perspective.

J Environ Manage 2021 Jun 12;294:113044. Epub 2021 Jun 12.

Department of Inorganic Chemistry and Chemical Engineering, Area of Chemical Engineering, Universidad de Córdoba, Campus Universitario de Rabanales, Carretera N-IV, Km 396, Edificio Marie Curie, 14071, Córdoba, Spain. Electronic address:

The influence of bed material on the odor removal performance of a biofilter was studied. A compost-wood biofilter and a wood biofilter were treated with a gaseous stream contaminated with butyric acid and comparatively evaluated at pilot scale using olfactometric, physico-chemical and microbiological approaches. The variables analyzed in both biofilters were correlated with specific families of their microbiota composition. Read More

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Cerebrovascular disease, neurodegeneration, and clinical phenotype in dementia with Lewy bodies.

Neurobiol Aging 2021 May 14;105:252-261. Epub 2021 May 14.

Department of Radiology, Mayo Clinic, Rochester, MN, USA. Electronic address:

We investigated whether cerebrovascular disease contributes to neurodegeneration and clinical phenotype in dementia with Lewy bodies (DLB). Regional cortical thickness and subcortical gray matter volumes were estimated from structural magnetic resonance imaging (MRI) in 165 DLB patients. Cortical and subcortical infarcts were recorded and white matter hyperintensities (WMHs) were assessed. Read More

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Diagnosing Strongylus vulgaris in pooled fecal samples.

Vet Parasitol 2021 Jun 8;296:109494. Epub 2021 Jun 8.

Texas Tech University, School of Veterinary Medicine, Amarillo, TX, USA.

Strongylus vulgaris is the most pathogenic intestinal helminth parasite infecting horses. The migrating larvae in the mesenteric blood vessels can cause non-strangulating intestinal infarctions, which have a guarded prognosis for survival. Infections are typically diagnosed by coproculture, but a PCR test is available in some countries. Read More

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The association between bladder dysfunction, balance and falls in women with multiple sclerosis: The specific contribution of fear of falling.

Gait Posture 2021 Jun 10;88:252-257. Epub 2021 Jun 10.

Department of Physical Therapy, School of Health Professions, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel; Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv, Israel. Electronic address:

Background: Bladder dysfunction is the most common autonomic disturbance in people with MS (PwMS). Only a few studies have examined the relationship between bladder dysfunction and falls in PwMS. Bladder dysfunction has been deemed only a secondary outcome measure, and classified by a gross measure providing a limited perspective of this disturbing symptom. Read More

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Everyday interactions support toddlers' learning of conventional actions on artifacts.

J Exp Child Psychol 2021 Jun 12;210:105201. Epub 2021 Jun 12.

Department of Psychology, University of Chicago, Chicago, IL 60637, USA.

Children learn to perform actions on artifacts in their environments from infancy, but the ways caregivers support this learning during everyday interactions are relatively unexplored. This study investigated how naturalistic caregiver-child teaching interactions promoted conventional action learning in toddlers. Caregivers of 32 24- to 26-month-old children taught their children to perform novel target actions on toys. Read More

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Facile and rapid detection of SARS-CoV-2 antibody based on a noncompetitive fluorescence polarization immunoassay in human serum samples.

Biosens Bioelectron 2021 Jun 5;190:113414. Epub 2021 Jun 5.

Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, Kita 13 Nishi 8, Kita-ku, Sapporo, 060-8628, Japan; Innovative Research Centre for Preventive Medical Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan; Institute of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan. Electronic address:

Antibody detection methods for viral infections have received broad attention due to the COVID-19 pandemic. In addition, there remains an ever-increasing need to quantitatively evaluate the immune response to develop vaccines and treatments for COVID-19. Here, we report an analytical method for the rapid and quantitative detection of SARS-CoV-2 antibody in human serum by fluorescence polarization immunoassay (FPIA). Read More

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Changes in molecular structure of extracellular polymeric substances (EPS) with temperature in relation to sludge macro-physical properties.

Water Res 2021 May 31;201:117316. Epub 2021 May 31.

School of Environmental Studies, China University of Geosciences, Wuhan 430074, Hubei, China; State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Extracellular polymeric substances (EPS) are important components of activated sludge, whose content and composition have important effects on the macro-physical properties of sludge. In this study, the response of EPS in sludge to temperature (-40-200 °C) was systematically investigated using XAD resin fractionation, variable-temperature infrared spectra (VTIS) and two-dimensional correlation spectroscopy (2D-COS). The relationships between the molecular structure of EPS and the macro-physical properties (rheological property and dewatering performance) of waste activated sludge (WAS) at varying temperature were also established. Read More

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Microbial degradation of azo dyes by textile effluent adapted, Enterobacter hormaechei under microaerophilic condition.

Microbiol Res 2021 Jun 9;250:126805. Epub 2021 Jun 9.

Geobiotechnology Laboratory, National College (Autonomous), (Affiliated to Bharathidasan University), Tiruchirapalli, Tamil Nadu, 620001, India; PG and Research Department of Botany, National College (Autonomous), Tiruchirapalli, Tamil Nadu, 620001, India.

Landmark and sustainable eco-friendly dye treatment processes are highly desirous to ameliorate their effect on the environment. The present study investigated the azo dye degradation efficiency of adapted Enterobacter hormaechei SKB 16 from textile effluent polluted soil in optimized culture conditions. The adapted bacteria strain was identified by standard microbiological and molecular techniques. Read More

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Characteristics of driving self-assessments and factors related to inaccurate self-assessment in Japanese older adults.

Accid Anal Prev 2021 Jun 12;159:106235. Epub 2021 Jun 12.

National Research Institute of Police Science, 6-3-1, Kashiwanoha, Kashiwa-shi, Chiba 277-0882, Japan.

Older adults are considered to decide their driving behaviors based their own assessment of their driving performance, and thus it is important that these self-assessments be accurate. Therefore, this study aimed to clarify how older drivers assess their driving performance and examine factors related to the level of inaccuracy in their self-assessments. Japanese drivers aged 70 years or older (N = 181) were asked to assess their own driving performance by questionnaire and then to drive on a public road while wearing an electronic device that measured their actual driving behaviors. Read More

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Clinicopathological characteristics of androgen receptor splicing variant 7 (AR-V7) expression in patients with castration resistant prostate cancer: A systematic review and meta-analysis.

Transl Oncol 2021 Jun 12;14(9):101145. Epub 2021 Jun 12.

Cancer center, Zhejiang University, Hangzhou, Zhejiang Province 310058, China. Electronic address:

Background:  Studies have shown that AR-V7 may be correlated with the poor prognosis of castration resistant prostate cancer (CRPC), however, clinicopathological characteristics of AR-V7 have not been fully elucidated.

Objective: This study aimed at evaluating the clinicopathological features of AR-V7 in CRPC patients.

Materials And Methods: To evaluate the clinicopathological features of AR-V7 in CRPC patients. Read More

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The effect of vascular health factors on white matter microstructure mediates age-related differences in executive function performance.

Cortex 2021 May 25;141:403-420. Epub 2021 May 25.

The University of Texas at Dallas, School of Behavioral and Brain Sciences, Center for Vital Longevity, Dallas, TX, USA. Electronic address:

Even within healthy aging, vascular risk factors can detrimentally influence cognition, with executive functions (EF) particularly vulnerable. Fronto-parietal white matter (WM) connectivity in part, supports EF and may be particularly sensitive to vascular risk. Here, we utilized structural equation modeling in 184 healthy adults (aged 20-94 years of age) to test the hypotheses that: 1) fronto-parietal WM microstructure mediates age effects on EF; 2) higher blood pressure (BP) and white matter hyperintensity (WMH) burden influences this association. Read More

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Performance of the EarlyCDT® Lung test in detection of lung cancer and pulmonary metastases in a high-risk cohort.

Lung Cancer 2021 Jun 10;158:85-90. Epub 2021 Jun 10.

Institute of Regional Health Research, University of Southern Denmark, J.B. Winsløws Vej 19, 3, 5000 Odense C, Denmark; Department of Internal Medicine, Vejle Hospital, University Hospital of Southern Denmark, Beriderbakken 4, 7100 Vejle, Denmark. Electronic address:

Objectives: Early detection of lung cancer is pivotal for an optimal prognosis. CT screening is currently implemented in USA. To decrease the amount of CT scans, the application of a blood-based biomarker as part of screening criteria is desirable. Read More

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Development and validation of a novel sepsis biomarker based on amino acid profiling.

Clin Nutr 2021 May 21;40(6):3668-3676. Epub 2021 May 21.

Department of Laboratory Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Republic of Korea. Electronic address:

Background & Aims: Sepsis is a potentially fatal condition influenced by pathogens and host factors. Current sepsis biomarkers such as white blood cell count and C-reactive protein and procalcitonin levels show unsatisfactory performance in terms of diagnostic sensitivity and specificity in clinical practice. Thus, we developed and validated a new sepsis biomarker based on amino acid profiling. Read More

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Evaluation of arsenic species in leukocytes and granulocytes of acute promyelocytic leukemia patients treated with arsenic trioxide.

J Pharm Biomed Anal 2021 Jun 8;203:114201. Epub 2021 Jun 8.

Department of Pharmacy, First Affiliated Hospital of Harbin Medical University, 23 YouZheng Str, Nangang District, Harbin, China. Electronic address:

Concentrations of arsenic metabolites were important to clarify the sensitivity and resistance of APL (acute promyelocytic leukemia) patients to arsenic trioxide (AsO). Our purpose was to evaluate levels and distributions of arsenic species in leukocytes and granulocytes of APL patients. Inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) were measured by high performance liquid chromatography coupled inductively coupled plasma mass spectrometry (HPLC-ICP-MS). Read More

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