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Comparative Analysis of Pain, Muscle Strength, Disability, and Quality of Life in Middle-Aged and Older Adults After Web Video Lower Back Exercise.

Comput Inform Nurs 2021 Jul 20. Epub 2021 Jul 20.

Author Affiliations: Chonnam National University Bitgoel Hospital, The Doctor's Course of Nursing, College of Medicine, Chosun University (Ms Park), Gwangju; and College of Nursing, Gachon University (Dr Song), Incheon, South Korea.

This study analyzed the effect of lower back exercise using Web for each age group to use it as nursing intervention. We conducted a randomized experiment with 54 patients with low back pain, composed of 26 middle-aged and 28 older adult people with low back pain who visited a joint center. The participants were instructed to perform the exercise at least twice a day, four times a week. Read More

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Back to the bones: do muscle area assessment techniques predict functional evolution across a macroevolutionary radiation?

J R Soc Interface 2021 Jul 21;18(180):20210324. Epub 2021 Jul 21.

Department of Archaeology, University of York, PalaeoHub, Wentworth Way, Heslington, York YO10 5DD, UK.

Measures of attachment or accommodation area on the skeleton are a popular means of rapidly generating estimates of muscle proportions and functional performance for use in large-scale macroevolutionary studies. Herein, we provide the first evaluation of the accuracy of these muscle area assessment (MAA) techniques for estimating muscle proportions, force outputs and bone loading in a comparative macroevolutionary context using the rodent masticatory system as a case study. We find that MAA approaches perform poorly, yielding large absolute errors in muscle properties, bite force and particularly bone stress. Read More

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Comparative and functional genomics of the ABC transporter superfamily across arthropods.

BMC Genomics 2021 Jul 19;22(1):553. Epub 2021 Jul 19.

Institute of Molecular Biology & Biotechnology, Foundation for Research & Technology Hellas, 100 N. Plastira Street, 700 13, Heraklion Crete, Greece.

Background: The ATP-binding cassette (ABC) transporter superfamily is comprised predominantly of proteins which directly utilize energy from ATP to move molecules across the plasma membrane. Although they have been the subject of frequent investigation across many taxa, arthropod ABCs have been less well studied. While the manual annotation of ABC transporters has been performed in many arthropods, there has so far been no systematic comparison of the superfamily within this order using the increasing number of sequenced genomes. Read More

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Nutritional supplementation for nonalcohol-related fatty liver disease: a network meta-analysis.

Cochrane Database Syst Rev 2021 Jul 19;7:CD013157. Epub 2021 Jul 19.

Division of Surgery and Interventional Science, University College London, London, UK.

Background: The prevalence of non-alcohol-related fatty liver disease (NAFLD) varies between 19% and 33% in different populations. NAFLD decreases life expectancy and increases risks of liver cirrhosis, hepatocellular carcinoma, and the requirement for liver transplantation. Uncertainty surrounds relative benefits and harms of various nutritional supplements in NAFLD. Read More

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Are European marketed acyclovir 5% cream products similar? Comparison with EU and US reference product.

Drug Dev Ind Pharm 2021 Jul 19:1-36. Epub 2021 Jul 19.

Pharmaceutical Consultant, North Potomac, Maryland, USA.

Objective: The aim was to perform a comparative evaluation of composition and in vitro release performance of multisource acyclovir 5% creams. Significance: The outcome was analysed in relation with the principles of the Topical drug Classification System (TCS). Methods: The in vitro drug release testing (IVRT) was based on selection of an inert artificial membrane and a medium providing sink conditions, and utilizing the vertical diffusion cells. Read More

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Bioinformatic Analysis of the Type VI Secretion System and Effector Prediction.

Front Microbiol 2021 29;12:694824. Epub 2021 Jun 29.

Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.

The Type VI Secretion System (T6SS) has important roles relating to bacterial antagonism, subversion of host cells, and niche colonisation. is one of the leading bacterial causes of human gastroenteritis worldwide and is a commensal coloniser of birds. Although recently discovered, the T6SS biological functions and identities of its effectors are still poorly defined in . Read More

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The impact of carbon neutrality on the investment performance: Evidence from the equity mutual funds in BRICS.

J Environ Manage 2021 Jul 14;297:113228. Epub 2021 Jul 14.

Suleman Dawood School of Business (SDSB), Lahore University of Management Sciences, Lahore, Pakistan. Electronic address:

The promotion of carbon-neutral investments is among the primary constituents of developing a carbon-neutral economy. This is even more important for emerging economies that have constrained financial markets. In this paper, using monthly data between 2011 and 2019, we study 6519 actively managed mutual funds in BRICS after sorting them into black, brown, and green categories based on their investment holdings. Read More

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Phosphoproteomics Profiling of Receptor Kinase Mutants.

Methods Mol Biol 2021 ;2358:73-82

State Key Laboratory of Conservation and Utilization of Bio-Resources in Yunnan and Center for Life Science, School of Life Sciences, Yunnan University, Kunming, China.

The transmembrane receptor kinase family is the largest protein kinase family in Arabidopsis. Many members of this family play critical roles in plant signaling pathways. However, many of these kinases have yet uncharacterized functions and very little is known about the direct substrates of these kinases. Read More

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January 2021

AuNP Coupled Rapid Flow-Through Dot-Blot Immuno-Assay for Enhanced Detection of SARS-CoV-2 Specific Nucleocapsid and Receptor Binding Domain IgG.

Int J Nanomedicine 2021 9;16:4739-4753. Epub 2021 Jul 9.

Department of Microbiology, Jahangirnagar University, Savar, Dhaka, 1342, Bangladesh.

Background: Serological tests detecting severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are widely used in seroprevalence studies and evaluating the efficacy of the vaccination program. Some of the widely used serological testing techniques are enzyme-linked immune-sorbent assay (ELISA), chemiluminescence immunoassay (CLIA), and lateral flow immunoassay (LFIA). However, these tests are plagued with low sensitivity or specificity, time-consuming, labor-intensive, and expensive. Read More

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Effect of Capsular Closure After Hip Arthroscopy for Femoroacetabular Impingement Syndrome on Achieving Clinically Meaningful Outcomes: A Meta-analysis of Prospective and Comparative Studies.

Orthop J Sports Med 2021 Jun 28;9(6):23259671211017467. Epub 2021 Jun 28.

Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois, USA.

Background: Recent literature has demonstrated conflicting evidence as to whether capsular closure after hip arthroscopy for femoroacetabular impingement syndrome (FAIS) results in superior outcomes compared with capsulotomy without repair. Additionally, these studies have not explored the effect of capsular management on clinically significant outcome improvement.

Purpose: To perform a meta-analysis of prospective and comparative studies to determine whether capsular management influences the rate of clinically significant outcome improvement after hip arthroscopy for FAIS. Read More

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Validation of the Finnish Version of the Unified Dyskinesia Rating Scale.

Eur Neurol 2021 Jul 14:1-6. Epub 2021 Jul 14.

Department of Neurology, Helsinki University Hospital and Department of Clinical Neurosciences (Neurology), University of Helsinki, Helsinki, Finland.

Introduction: The Unified Dyskinesia Rating Scale (UDysRS) was developed to provide a comprehensive rating tool of dyskinesia in Parkinson's disease (PD). Because dyskinesia therapy trials involve multicenter studies, having a scale that is validated in multiple non-English languages is pivotal to international efforts to treat dyskinesia. The aim of the present study was to organize and perform an independent validation of the UDysRS Finnish version. Read More

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Obstetrician-Gynecologists' Practices in Postpartum Sterilization Without a Valid Medicaid Consent Form.

Obstet Gynecol 2021 Jul;138(1):66-72

Department of Obstetrics and Gynecology, MetroHealth Medical Center, and the Department of Bioethics, Case Western Reserve University, Cleveland, Ohio; the Department of Obstetrics and Gynecology, University of Tennessee, Knoxville, Tennessee; and the Steve Hicks School of Social Work and the Department of Sociology, University of Texas at Austin, Austin, Texas.

Objective: To explore the practices of obstetrician-gynecologists (ob-gyns) in the United States surrounding postpartum sterilization when the Medicaid consent form was not valid.

Methods: Using the American College of Obstetricians and Gynecologists' online directory, we conducted a qualitative study where we recruited ob-gyns practicing in 10 geographically diverse U.S. Read More

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Seamless Health Monitoring Using 5G NR for Internet of Medical Things.

Wirel Pers Commun 2021 Jul 8:1-31. Epub 2021 Jul 8.

Department of Information Technology, Indian Institute of Information Technology Allahabad, Prayagraj, India.

Nowadays, information and communication technology grows rapidly. The microelectronics and communication mediums also enhance their reachability of coverage and connectivity. 5G enhances the capacity of the network in terms of lowest communication latency, highest speed, enhanced throughput, minimum E2E delay, and minimizing the packet loss. Read More

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A machine learning algorithm can optimize the day of trigger to improve in vitro fertilization outcomes.

Fertil Steril 2021 Jul 10. Epub 2021 Jul 10.

Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California.

Objective: To determine whether a machine learning causal inference model can optimize trigger injection timing to maximize the yield of fertilized oocytes (2PNs) and total usable blastocysts for a given cohort of stimulated follicles.

Design: Descriptive and comparative study of new technology.

Setting: Tertiary academic medical center. Read More

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The need for race-specific reference equations for pulmonary diffusing capacity for nitric oxide.

BMC Pulm Med 2021 Jul 13;21(1):232. Epub 2021 Jul 13.

Department of Respiratory Therapy, Georgia State University, Atlanta, GA, USA.

Background: Few reference equations exist for healthy adults of various races for pulmonary diffusing capacity for nitric oxide (DLNO). The purpose of this study was to collect pilot data to demonstrate that race-specific reference equations are needed for DLNO.

Methods: African Americans (blacks) were chosen as the comparative racial group. Read More

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Comparison of machine learning techniques for the identification of human activities from inertial sensors available in a mobile device after the application of data imputation techniques.

Comput Biol Med 2021 Jul 7;135:104638. Epub 2021 Jul 7.

Instituto de Telecomunicações, Universidade da Beira Interior, 6200-001 Covilhã, Portugal. Electronic address:

Human activity recognition (HAR) is a significant research area due to its wide range of applications in intelligent health systems, security, and entertainment games. Over the past few years, many studies have recognized human daily living activities using different machine learning approaches. However, the performance of a machine learning algorithm varies based on the sensing device type, the number of sensors in that device, and the position of the underlying sensing device. Read More

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Cuttlefish: fast, parallel and low-memory compaction of de Bruijn graphs from large-scale genome collections.

Bioinformatics 2021 07;37(Suppl_1):i177-i186

Department of Computer Science, University of Maryland, College Park, MD 20742, USA.

Motivation: The construction of the compacted de Bruijn graph from collections of reference genomes is a task of increasing interest in genomic analyses. These graphs are increasingly used as sequence indices for short- and long-read alignment. Also, as we sequence and assemble a greater diversity of genomes, the colored compacted de Bruijn graph is being used more and more as the basis for efficient methods to perform comparative genomic analyses on these genomes. Read More

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Transcriptome sequencing and functional characterization of new sesquiterpene synthases from Curcuma wenyujin.

Arch Biochem Biophys 2021 Sep 9;709:108986. Epub 2021 Jul 9.

Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Province, Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Holistic Integrative Pharmacy Institute, Health Science Center, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China. Electronic address:

Tubers of Curcuma wenyujin are rich in essential oils, mainly various sesquiterpenes, showing antibacterial, anti-viral and anti-tumor effects. However, the molecular mechanism of C. wenyujin is deficient and related sesquiterpene synthases are still unclear. Read More

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September 2021

Brain Endothelial Cells: Metabolic Flux and Energy Metabolism.

Handb Exp Pharmacol 2021 Jul 13. Epub 2021 Jul 13.

Department of Biomedical Sciences, University of Minnesota Duluth Medical School, Duluth, MN, USA.

The neurovascular unit (NVU) consists of multiple cell types including brain endothelial cells, pericytes, astrocytes, and neurons that function collectively to maintain homeostasis within the CNS microenvironment. As the principal barrier-forming component of the NVU, the endothelial cells perform an array of complex functions that require substantial energy resources. The principal metabolic pathways for producing ATP are glycolysis and mitochondrial oxidative phosphorylation. Read More

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Integrative Studies of Sexual Selection in Manakins, a Clade of Charismatic Tropical Birds.

Integr Comp Biol 2021 Jul 12. Epub 2021 Jul 12.

Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061, USA.

The neotropical manakins (family Pipridae) provide a great opportunity for integrative studies of sexual selection as nearly all of the 51 species are lek-breeding, an extreme form of polygyny, and highly sexually dimorphic both in appearance and behavior. Male courtship displays are often elaborate and include auditory cues, both vocal and mechanical, as well as visual elements. In addition, the displays are often extremely rapid, highly acrobatic, and, in some species, multiple males perform coordinated displays that form the basis of long-term coalitions. Read More

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A comparative study of Bayesian optimal interval (BOIN) design with interval 3+3 (i3+3) design for phase I oncology dose-finding trials.

Stat Biopharm Res 2021 14;13(2):147-155. Epub 2020 Sep 14.

Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Bayesian optimal interval (BOIN) design is a model-assisted phase I dose-finding design to find the maximum tolerated dose (MTD). The hallmark of the BOIN design is its concise decision rule - making the decision of dose escalation and de-escalation by simply comparing the observed dose-limiting toxicity (DLT) rate at the current dose with a pair of optimal dose escalation and de-escalation boundaries. The interval 3+3 (i3+3) design is a recently proposed algorithm-based dose-finding design based on a similar decision rule with some modifications. Read More

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September 2020

Interventional treatments for chronic, axial or radicular, non-cancer, spinal pain: a protocol for a systematic review and network meta-analysis of randomised trials.

BMJ Open 2021 Jul 9;11(7):e046025. Epub 2021 Jul 9.

Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Ontario, Canada

Introduction: Chronic, non-cancer, axial or radicular spinal pain is a common condition associated with considerable socioeconomic burden. Clinicians frequently offer patients various interventional procedures for the treatment of chronic spine pain; however, the comparative effectiveness and safety of available procedures remains uncertain.

Methods: We will conduct a systematic review of randomised controlled trials that explores the effectiveness and harms of interventional procedures for the management of axial or radicular, chronic, non-cancer, spine pain. Read More

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Genome wide association study of agronomic and seed traits in a world collection of proso millet (Panicum miliaceum L.).

BMC Plant Biol 2021 Jul 9;21(1):330. Epub 2021 Jul 9.

Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.

Background: The climate crisis threatens sustainability of crop production worldwide. Crop diversification may enhance food security while reducing the negative impacts of climate change. Proso millet (Panicum milaceum L. Read More

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Exosomes and biomimetic nanovesicles-mediated anti-glioblastoma therapy: A head-to-head comparison.

J Control Release 2021 Jul 6;336:510-521. Epub 2021 Jul 6.

Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China; Hunan Provincial Engineering Research Centre of Translational Medicine and Innovative Drug, Changsha, China; Institute of Clinical Pharmacy, Central South University, Changsha, China. Electronic address:

Exosomes (Exos) are promising vehicles for brain drug delivery due to nanosize and the ability to breach the blood-brain barrier (BBB). But the low yield of natural exosomes limits its application for nanomedicine. The generation of bioinspired nanovesicles (BNVs) that mimicking Exos is attractive, but there is a lack of comparative evaluation of Exos and BNVs. Read More

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Recommendations to plan a national burden of disease study.

Arch Public Health 2021 Jul 7;79(1):126. Epub 2021 Jul 7.

Health Improvement, Public Health England, London, UK.

Background: The InfAct (Information for Action) project is a European Commission Joint Action on Health Information which has promoted the potential role of burden of disease (BoD) approaches to improve the current European Union-Health Information System (EU-HIS). It has done so by raising awareness of the concept, the methods used to calculate estimates and their potential implications and uses in policymaking. The BoD approach is a systematic and scientific effort to quantify and compare the magnitude of health loss due to different diseases, injuries, and risk factors with estimates produced by demographic characteristics and geographies for specific points in time. Read More

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Comparative analysis of the social vulnerability assessment to climate change applied to fisheries from Spain and Turkey.

Sci Rep 2021 Jul 6;11(1):13949. Epub 2021 Jul 6.

Department of Marine Science and Applied Biology, University of Alicante, Alicante, Spain.

The aim of this study is to assess the climate effects on fisheries from a bottom-up approach based on fishers' fishing experience, knowledge, and perceptions. To perform this task, a social vulnerability assessment was conducted in two different fishing areas: one in Spain and the other one in Turkey. The vulnerability was measured using the collected data and information through a structured questionnaire, and surveys were carried out among fishers in the Castelló (Spain) and the Aegean Sea (Turkey) between 2018 and 2019. Read More

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Laparoscopic versus open hepatectomy for malignant liver tumours in the elderly: systematic review and meta-analysis.

Updates Surg 2021 Jul 6. Epub 2021 Jul 6.

Department of General Surgery, Sandwell and West, Birmingham Hospitals NHS Trust, Birmingham, UK.

To evaluate comparative outcomes of laparoscopic versus open hepatectomy for malignant liver tumours in elderly patients. A systematic online search was conducted using the following databases: PubMed, Scopus, Cochrane database, The Virtual Health Library, Clinical trials.gov, and Science Direct. Read More

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Cross-Scale Analyses of Animal and Human Gut Microbiome Assemblies from Metacommunity to Global Landscape.

Zhanshan Sam Ma

mSystems 2021 Jul 6:e0063321. Epub 2021 Jul 6.

Computational Biology and Medical Ecology Lab, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.

Animal (human) gut microbiomes have been coevolving with their hosts for many millions of years. Understanding how the coevolution shapes the processes of microbiome assembly and diversity maintenance is important but rather challenging. An effort may start with the understanding of how and why animals and humans may differ in their microbiome neutrality (stochasticity) levels. Read More

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Novel neuroanatomical integration and scaling define avian brain shape evolution and development.

Elife 2021 07 6;10. Epub 2021 Jul 6.

Division of Paleontology, American Museum of Natural History, New York, United States.

How do large and unique brains evolve? Historically, comparative neuroanatomical studies have attributed the evolutionary genesis of highly encephalized brains to deviations along, as well as from, conserved scaling relationships among brain regions. However, the relative contributions of these concerted (integrated) and mosaic (modular) processes as drivers of brain evolution remain unclear, especially in non-mammalian groups. While proportional brain sizes have been the predominant metric used to characterize brain morphology to date, we perform a high-density geometric morphometric analysis on the encephalized brains of crown birds (Neornithes or Aves) compared to their stem taxa-the non-avialan coelurosaurian dinosaurs and . Read More

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Network response of two cherry tomato (Lycopersicon esculentum) cultivars to Cadmium stress as revealed by transcriptome analysis.

Ecotoxicol Environ Saf 2021 Jul 2;222:112473. Epub 2021 Jul 2.

College of Horticulture, Sichuan Agricultural University, Chengdu 611130, PR China.

Soil cadmium (Cd) contamination severely threatens human health. Therefore, screening and breeding low-Cd absorption cultivars of cherry tomato (Solanum lycopersicum L.) is essential to restrict human Cd intake. Read More

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